David J Dooley
Affiliation: Pfizer Global Research and Development
- Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalinD J Dooley
Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
J Pharmacol Exp Ther 295:1086-93. 2000..This type of modulation of neurotransmitter release may be integral to the clinical pharmacology of these drugs...
- Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slicesDavid J Dooley
Department of CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
Synapse 45:171-90. 2002..These findings suggest a selective modulation of P/Q-type VSCC that are implicated in neurotransmission and several GBP-responsive pathologies...
- Ca2+ channel alpha2delta ligands: novel modulators of neurotransmissionDavid J Dooley
Department of CNS Pharmacology, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
Trends Pharmacol Sci 28:75-82. 2007..This modulation is characterized by a reduction of the excessive neurotransmitter release that is observed in certain neurological and psychiatric disorders...
- Carboxylate bioisosteres of gabapentinCarmen E Burgos-Lepley
Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
Bioorg Med Chem Lett 16:2333-6. 2006..Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1...
- Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortexKlaus Fink
Department of Pharmacology and Toxicology, University of Bonn Medical School, Reuterstrasse 2b, 53113 Bonn, Germany
Neuropharmacology 42:229-36. 2002....
- Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitroMark O Cunningham
Department of Physiology, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Eur J Neurosci 20:1566-76. 2004....
- Comparison of the ORL1 receptor-mediated inhibition of noradrenaline release in human and rat neocortical slicesAxel Rominger
Sektion Klinische Neuropharmakologie der Neurologischen Universitätsklinik, Neurozentrum, Breisacherstr 64, D 79106 Freiburg, Germany
Br J Pharmacol 135:800-6. 2002..This study provides the first evidence that N/OFQ modulates [(3)H]-NA release in human neocortex via specific ORL1 receptors most likely located on noradrenergic axon terminals...