Ronald W Clark

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Arterioscler Thromb Vasc Biol 24:490-7. 2004
  2. pmc Crystal structures of cholesteryl ester transfer protein in complex with inhibitors
    Shenping Liu
    Department of Structural Biology and Biophysics, Pfizer Groton Laboratories, Groton, Connecticut 06340, USA
    J Biol Chem 287:37321-9. 2012
  3. pmc Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    J Lipid Res 51:967-74. 2010
  4. ncbi request reprint Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action
    Ronald W Clark
    Department of Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA
    J Lipid Res 47:537-52. 2006
  5. ncbi request reprint Raising high-density lipoprotein with cholesteryl ester transfer protein inhibitors
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA
    Curr Opin Pharmacol 6:162-8. 2006
  6. ncbi request reprint Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules
    Xiayang Qiu
    Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06430, USA
    Nat Struct Mol Biol 14:106-13. 2007
  7. ncbi request reprint Polymorphisms in the CETP gene and association with CETP mass and HDL levels
    John F Thompson
    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Atherosclerosis 167:195-204. 2003
  8. ncbi request reprint Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    Margaret E Brousseau
    Lipid Research Laboratory, Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    N Engl J Med 350:1505-15. 2004

Detail Information

Publications8

  1. ncbi request reprint Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Arterioscler Thromb Vasc Biol 24:490-7. 2004
    ....
  2. pmc Crystal structures of cholesteryl ester transfer protein in complex with inhibitors
    Shenping Liu
    Department of Structural Biology and Biophysics, Pfizer Groton Laboratories, Groton, Connecticut 06340, USA
    J Biol Chem 287:37321-9. 2012
    ..An enhanced understanding of the inhibitor binding site may provide opportunities to design novel CETP inhibitors possessing more drug-like physical properties, distinct modes of action, or alternative pharmacological profiles...
  3. pmc Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    J Lipid Res 51:967-74. 2010
    ....
  4. ncbi request reprint Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action
    Ronald W Clark
    Department of Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA
    J Lipid Res 47:537-52. 2006
    ..In summary, these data are consistent with a mechanism whereby this series of inhibitors block all of the major lipid transfer functions of plasma CETP by inducing a nonproductive complex between the transfer protein and HDL...
  5. ncbi request reprint Raising high-density lipoprotein with cholesteryl ester transfer protein inhibitors
    Ronald W Clark
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA
    Curr Opin Pharmacol 6:162-8. 2006
    ..Upcoming results from Phase III trials of torcetrapib should provide anatomical measurements of atherosclerosis and thus the first assessment of therapeutic benefit...
  6. ncbi request reprint Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules
    Xiayang Qiu
    Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06430, USA
    Nat Struct Mol Biol 14:106-13. 2007
    ..Point mutations blocking the middle of the tunnel abolish lipid-transfer activities, suggesting that neutral lipids pass through this continuous tunnel...
  7. ncbi request reprint Polymorphisms in the CETP gene and association with CETP mass and HDL levels
    John F Thompson
    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Atherosclerosis 167:195-204. 2003
    ..The ethnic diversity of some SNPs and complex interplay among them dictate careful analysis of the whole gene prior to conclusions about the role of individual polymorphisms...
  8. ncbi request reprint Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    Margaret E Brousseau
    Lipid Research Laboratory, Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    N Engl J Med 350:1505-15. 2004
    ..Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels...