Eva R Chin

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. pmc Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism
    Troy A Hornberger
    School of Kinesiology, University of Illinois at Chicago, 901 W Roosevelt, Chicago, IL 60608, USA
    Biochem J 380:795-804. 2004
  2. pmc Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin
    Eva R Chin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NB11 200, Dallas, TX 75235 8573, USA
    J Physiol 547:649-63. 2003
  3. ncbi The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis
    Eva R Chin
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Rd, MS8220 3120, Groton, CT 06340, USA
    Proc Nutr Soc 63:279-86. 2004
  4. ncbi Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity
    Eva R Chin
    Research Pharmacology, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, CA 92121, USA
    J Appl Physiol 99:414-23. 2005
  5. ncbi Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue
    Simeon P Cairns
    Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland, New Zealand
    J Appl Physiol 103:359-68. 2007
  6. ncbi Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine, Centre for Neuromuscular Diseases, Faculty of Medicine, University of Ottawa, Ottawa, Ont, Canada K1H 8M5
    Hum Mol Genet 15:1423-35. 2006
  7. ncbi Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction
    Lindsay M Angus
    Department of Cellular and Molecular Medicine, and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Cell Physiol 289:C908-17. 2005
  8. ncbi Calcineurin and skeletal muscle growth
    Robin N Michel
    Neuromuscular Research Laboratory, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
    Proc Nutr Soc 63:341-9. 2004
  9. pmc Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 100:7791-6. 2003
  10. ncbi Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression
    Robin N Michel
    Department of Chemistry and Biochemistry, Concordia University, The Richard J Renaud Science Complex, Montreal, QC H4B 1R6, Canada
    Appl Physiol Nutr Metab 32:921-9. 2007

Collaborators

Detail Information

Publications10

  1. pmc Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism
    Troy A Hornberger
    School of Kinesiology, University of Illinois at Chicago, 901 W Roosevelt, Chicago, IL 60608, USA
    Biochem J 380:795-804. 2004
    ..Thus mechanical stimuli and growth factors provide distinct inputs through which mTOR co-ordinates an increase in the translational efficiency...
  2. pmc Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin
    Eva R Chin
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NB11 200, Dallas, TX 75235 8573, USA
    J Physiol 547:649-63. 2003
    ....
  3. ncbi The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis
    Eva R Chin
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Rd, MS8220 3120, Groton, CT 06340, USA
    Proc Nutr Soc 63:279-86. 2004
    ..Future studies will be important in determining whether insights from the adaptational response of muscle to increased loads will provide pharmacological approaches for increasing muscle strength or endurance to counter muscle wasting...
  4. ncbi Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity
    Eva R Chin
    Research Pharmacology, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, CA 92121, USA
    J Appl Physiol 99:414-23. 2005
    ....
  5. ncbi Stimulation pulse characteristics and electrode configuration determine site of excitation in isolated mammalian skeletal muscle: implications for fatigue
    Simeon P Cairns
    Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland, New Zealand
    J Appl Physiol 103:359-68. 2007
    ..Using this new understanding, we showed that disrupted propagation of action potentials along the surface membrane is a major cause of fatigue in soleus muscle that is focally and continuously stimulated at 125 Hz...
  6. ncbi Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine, Centre for Neuromuscular Diseases, Faculty of Medicine, University of Ottawa, Ottawa, Ont, Canada K1H 8M5
    Hum Mol Genet 15:1423-35. 2006
    ..Finally, our results further support the concept that strategies aimed at promoting the slow oxidative myofiber program in muscle may be effective in altering the relentless progression of DMD...
  7. ncbi Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction
    Lindsay M Angus
    Department of Cellular and Molecular Medicine, and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Am J Physiol Cell Physiol 289:C908-17. 2005
    ..Together, these studies indicate that the synaptic expression of utrophin is also driven by calcineurin-NFAT signaling and occurs in conjunction with signaling events that involve GABP and PGC-1alpha...
  8. ncbi Calcineurin and skeletal muscle growth
    Robin N Michel
    Neuromuscular Research Laboratory, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
    Proc Nutr Soc 63:341-9. 2004
    ..Increased understanding of these mediators of muscle growth may provide strategies for the development of effective therapeutics to counter muscle weakness and muscular dystrophy...
  9. pmc Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling
    Joe V Chakkalakal
    Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 100:7791-6. 2003
    ..Together, these results indicate that expression of utrophin A is related to the oxidative capacity of muscle fibers, and implicate calcineurin and its effector NFAT in this mechanism...
  10. ncbi Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression
    Robin N Michel
    Department of Chemistry and Biochemistry, Concordia University, The Richard J Renaud Science Complex, Montreal, QC H4B 1R6, Canada
    Appl Physiol Nutr Metab 32:921-9. 2007
    ....