Joseph C Cappelleri

..To estimate the annualized differences in direct medical and indirect costs associated with improvement in fibromyalgia (FM) severity among pregabalin-treated patients...

..Our working hypothesis was that, as with other populations, percentage changes in peak VO2 in pediatric patients with PAH are reliable and are associated with changes in other clinical endpoints...

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..abstract:..

..The purpose of this study was to determine whether some of the clinical features of fibromyalgia (FM) that patients would like to see improved aggregate into definable clusters...

..These scientific contributions are likely to remain influential in coming years...

..7% (450 mg/day), and 12.5% (600 mg/day) more than placebo responders. This novel approach demonstrates that responder profiles can provide an enhanced interpretation of pain outcomes for patient care and symptom management...

..Sleep disturbances are a common and bothersome symptom of fibromyalgia (FM). This study reports psychometric properties of a single-item scale to assess sleep quality among individuals with FM...

..Erectile dysfunction (ED) can negatively impact psychosocial measures of a patient's sexual life...

..The 21-item Three-Factor Eating Questionnaire (TFEQ-R21) is a scale that measures three domains of eating behavior: cognitive restraint (CR), uncontrolled eating (UE) and emotional eating (EE)...

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..75) on the Total Craving Score and on Factors 1 and 2. This research supports the validity and reliability of the instrument and confirms the proposed two-dimensional structure of self-reported craving as measured by the QSU-Brief...

..To estimate the minimal clinically meaningful improvement (MCMI) on the Self-Esteem And Relationship (SEAR) questionnaire...

..Each of these instruments represents a significant contribution to sexual medicine research and, when used judiciously and appropriately, can help to provide optimal patient care and management...

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..No psychometric analyses of this version have been published. The objectives of this investigation were to perform a factor analysis and to further assess the psychometric properties of the MNWS...

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..Nonetheless, such data has been often analysed by examining individuals in isolation, which falls short of capturing their truly interpersonal and non-independent nature...

..Sleep problems are a common symptom of fibromyalgia (FM). The objective of this study was to evaluate the Medical Outcomes Study (MOS) Sleep Scale as a measure of FM-related sleep problems...

..To determine how patient-rated osteoarthritis (OA) severity correlates with other patient-reported and clinical outcomes in the European clinical setting...

..The Erection Hardness Score (EHS), a validated single-item patient-reported outcome (PRO), may provide a simple method to capture erectile dysfunction (ED) symptoms and to monitor treatment outcome...

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..To introduce an application of area-under-the-curve (AUC) that can enrich interpretation of response analysis and illustrate this method on sleep quality scores in patients with fibromyalgia...

..CRCs for PROs in urology can provide a clear, transparent and meaningful visual depiction of efficacy data that can supplement and complement other analyses...

..Both methods generally meet at least the nominal coverage. Both methods are illustrated with examples...

..Rapid onset of symptomatic improvement is a desirable characteristic of new generalized anxiety disorder (GAD) treatments. A validated rating scale is needed to assess GAD symptoms during the first days of treatment...

..The Rasch rating scale, a one-parameter logistic item response model, may enhance FKSI-DRS interpretation and validate its measurement properties...

..The objective of this study was to determine how patient-reported OA severity correlates with patient-reported outcomes including pain, function and productivity...

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..But this methodology has not been widely utilized to assess drug safety in pediatrics for children aged between 0 and 18 years...

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..These analyses were undertaken to help define a minimally important difference (MID) in exercise capacity, measured by the 6-min walk distance (6MWD), and HRQoL, measured by the Short Form-36 (SF-36) questionnaire in patients with PAH...

..The Power of Food Scale (PFS) was developed to assess the psychological impact of today's food-abundant environments...

..0001). The SEAR questionnaire possesses strong psychometric properties that support its validity and reliability for measuring sexual relationship, confidence, and particularly self-esteem...

..Mean dyad scores < 4.13 classified patients as having SPMS with 73% accuracy (sensitivity), whereas scores > or = 4.13 classified patients as having RRMS with 80% accuracy (specificity)...

..However, the SHIM has not been compared with patient self-assessment of ED...

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..Our objective was to compare patient satisfaction between inhaled insulin and subcutaneous insulin...

..The fact that the GCI approach is suitable for confidence interval estimation and obtaining P-values makes the GCI approach a suitable candidate for making inference about interrater reliability...

..Overall, the modified large-sample approach provides the most satisfactory performance of the three methods...

..The Sexual Function Questionnaire (SFQ) is a self-report outcome measure of female sexual function. It has recently been refined to create a 28-item version (SFQ28) including the addition of a new arousal-cognitive domain...

..This study examined the HRQOL of patients with metastatic RCC treated with axitinib, a new targeted therapy that affects the vessels supplying blood to the tumor...

..II) using structural equation modeling (SEM); and 2) to assess its concurrent validity using medication adherence criteria...

..Virtually perfect inter- and intra-rater reliability was achieved. Study 1 produced similar results. BARS showed psychometrically valid properties for measurement of behavioral activity in acutely agitated patients with psychosis...

..It is unknown whether inhalation delivery of insulin improves patient satisfaction...

..However, many clinicians and decision-makers may be unfamiliar with the underlying principles and assumptions made within meta-regression leading to incorrect interpretation of their results...

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..The absence of a single brief measure that assesses function and health-related quality of life (HRQoL) hinders evaluation of the sexual experience in men with erectile dysfunction (ED)...

..However, the work done to date requires continued development. Continued research is needed that provides information about benefits and addresses limitations of current approaches...

..001; objective response rate, 31% v 6%, respectively; P < .001). We report health-related quality-of-life (QOL) results from this trial...

..Erection hardness is a fundamental component of erectile function, and is a very specific and easily monitored outcome. The Erection Hardness Score (EHS) is a single-item, patient-reported outcome (PRO) for scoring erection hardness...

..Health-related quality-of-life measures are included in clinical trials of drug treatment to assess the impact of therapy on the patient's functioning. HRQL guidance could allow for use of this data in drug labeling and promotion...

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..The 2 types of indices are not mutually exclusive and can be used together in a single research study or in the clinical setting...

..001). CONCLUSIONS: The SEAR questionnaire is responsive to effective treatment of erectile dysfunction. These data suggest that the SEAR questionnaire is a valid instrument for detecting psychosocial gains from beneficial intervention...

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..We investigated long-term improvement, and correlations between improved erectile function and confidence, self-esteem and sexual relationship satisfaction in men with erectile dysfunction...

..Men with erectile dysfunction (ED) often have low self-esteem, confidence, and sexual relationship satisfaction...

..Erectile dysfunction (ED) can significantly impact a man's relationships and well-being...

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..Applying the law of iterated logarithm to cumulative meta-analysis of a continuous endpoint. Statistica Sinica 2003; 13: 1135-45) proposed an approach based on the law of iterated logarithm (LIL) to this problem for the continuous case...