Jay G Calvert

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. pmc CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses
    Jay G Calvert
    Veterinary Medicine Research and Development, Animal Health Division, Pfizer Incl, Kalamazoo, MI 49001, USA
    J Virol 81:7371-9. 2007
  2. ncbi request reprint Construction and evaluation of genetically engineered replication-defective porcine reproductive and respiratory syndrome virus vaccine candidates
    Siao Kun Wan Welch
    Veterinary Medicine Biological Discovery, Pfizer Animal Health, Kalamazoo, MI 49009, USA
    Vet Immunol Immunopathol 102:277-90. 2004
  3. doi request reprint A brief review of CD163 and its role in PRRSV infection
    Siao Kun W Welch
    Global Biologics Research, Pfizer Animal Health, 333 Portage Street, Kalamazoo, MI 49007, USA
    Virus Res 154:98-103. 2010
  4. ncbi request reprint Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and their potential as vaccine vectors
    Dongwan Yoo
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont, N1G 2W1, Canada
    Vet Immunol Immunopathol 102:143-54. 2004
  5. ncbi request reprint A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity
    Changhee Lee
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Virology 331:47-62. 2005
  6. ncbi request reprint Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication
    Changhee Lee
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Virology 346:238-50. 2006
  7. ncbi request reprint The nuclear localization signal of the PRRS virus nucleocapsid protein viral replication in vitro and antibody response in vivo
    Changhee Lee
    University of Guelph, Ontario, Canada
    Adv Exp Med Biol 581:145-8. 2006
  8. ncbi request reprint Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV)
    Dal Young Kim
    Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Virus Res 128:106-14. 2007
  9. doi request reprint Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association
    Yanlong Pei
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada
    Virus Res 135:107-14. 2008

Collaborators

Detail Information

Publications9

  1. pmc CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses
    Jay G Calvert
    Veterinary Medicine Research and Development, Animal Health Division, Pfizer Incl, Kalamazoo, MI 49001, USA
    J Virol 81:7371-9. 2007
    ..Cell lines were phenotypically stable over 80 cell passages, and PRRSV could be serially passed at least 60 times, yielding in excess of 10(5) 50% tissue culture infective doses/ml...
  2. ncbi request reprint Construction and evaluation of genetically engineered replication-defective porcine reproductive and respiratory syndrome virus vaccine candidates
    Siao Kun Wan Welch
    Veterinary Medicine Biological Discovery, Pfizer Animal Health, Kalamazoo, MI 49009, USA
    Vet Immunol Immunopathol 102:277-90. 2004
    ..However, we did show that the cDNA clone of PRRSV can be a useful tool to genetically engineer PRRSV vaccine candidates and to study pathogenesis and viral gene functions...
  3. doi request reprint A brief review of CD163 and its role in PRRSV infection
    Siao Kun W Welch
    Global Biologics Research, Pfizer Animal Health, 333 Portage Street, Kalamazoo, MI 49007, USA
    Virus Res 154:98-103. 2010
    ..We provide a brief review of current knowledge regarding CD163 in relation to PRRSV infection, and propose a structure-based prediction of amino acid sequences involved in PRRSV interaction...
  4. ncbi request reprint Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and their potential as vaccine vectors
    Dongwan Yoo
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont, N1G 2W1, Canada
    Vet Immunol Immunopathol 102:143-54. 2004
    ..Utilizing these infectious clones as tools, a new generation of safe and efficacious PRRS vaccines may be constructed...
  5. ncbi request reprint A DNA-launched reverse genetics system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity
    Changhee Lee
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Virology 331:47-62. 2005
    ....
  6. ncbi request reprint Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication
    Changhee Lee
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Virology 346:238-50. 2006
    ..These results show that N protein nuclear localization is non-essential for PRRSV multiplication but may play an important role in viral attenuation and in pathogenesis in vivo...
  7. ncbi request reprint The nuclear localization signal of the PRRS virus nucleocapsid protein viral replication in vitro and antibody response in vivo
    Changhee Lee
    University of Guelph, Ontario, Canada
    Adv Exp Med Biol 581:145-8. 2006
  8. ncbi request reprint Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV)
    Dal Young Kim
    Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Virus Res 128:106-14. 2007
    ..Sequencing of a fluorescent-negative EGFP virus showed that the EGFP remained intact, except for the appearance of arginine to cysteine mutation at position 96, which may interfere with chromophore formation or function...
  9. doi request reprint Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association
    Yanlong Pei
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada
    Virus Res 135:107-14. 2008
    ..No reversion to functional NLS was detected in either mutant from any pig. These data demonstrate that N protein nuclear localization is indeed associated with viral pathogenesis and host response to PRRS...