Shobha N Bhattachar

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus
    Shobha N Bhattachar
    Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Int J Pharm 236:135-43. 2002
  2. ncbi Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery
    Shobha N Bhattachar
    Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Pharm Biomed Anal 41:152-7. 2006
  3. ncbi Automated approach to couple solubility with final pH and crystallinity for pharmaceutical discovery compounds
    Christopher Seadeek
    Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Pharm Biomed Anal 43:1660-6. 2007
  4. ncbi Solubility: it's not just for physical chemists
    Shobha N Bhattachar
    Research Formulations, Pharmaceutical Sciences, Pfizer Global R and D, Ann Arbor, MI 48105, USA
    Drug Discov Today 11:1012-8. 2006
  5. ncbi Increased dissolution rate and bioavailability through comicronization with microcrystalline cellulose
    Julie K Spence
    Pharmaceutical Research and Development, World Wide Pharmaceutical Sciences, Pfizer Global Research and Development Michigan Laboratories, Ann Arbor, Michigan, USA
    Pharm Dev Technol 10:451-60. 2005
  6. ncbi Solubility measurement of polymorphic compounds via the pH-metric titration technique
    Ann F Fioritto
    Research Formulations, Pharmaceutical Sciences, Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Int J Pharm 330:105-13. 2007
  7. ncbi Evaluation of the vibratory feeder method for assessment of powder flow properties
    Shobha N Bhattachar
    Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, Michigan, MI 48105, USA
    Int J Pharm 269:385-92. 2004

Detail Information

Publications7

  1. ncbi Dissolution testing of a poorly soluble compound using the flow-through cell dissolution apparatus
    Shobha N Bhattachar
    Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Int J Pharm 236:135-43. 2002
    ..The flow rate of 4 ml/min resulted in good particle size discrimination...
  2. ncbi Evaluation of the chemiluminescent nitrogen detector for solubility determinations to support drug discovery
    Shobha N Bhattachar
    Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Pharm Biomed Anal 41:152-7. 2006
    ..Based on the results obtained, it was concluded that the CLND performs satisfactorily for discovery stage thermodynamic solubility measurements...
  3. ncbi Automated approach to couple solubility with final pH and crystallinity for pharmaceutical discovery compounds
    Christopher Seadeek
    Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Pharm Biomed Anal 43:1660-6. 2007
    ..Additionally, a comparison was made between a subset of 10 compounds run on the automated system and a more traditional shake-flask method employing HPLC analysis. In both cases, a favorable comparison was obtained...
  4. ncbi Solubility: it's not just for physical chemists
    Shobha N Bhattachar
    Research Formulations, Pharmaceutical Sciences, Pfizer Global R and D, Ann Arbor, MI 48105, USA
    Drug Discov Today 11:1012-8. 2006
    ..Our ultimate goal is to enable a decision-maker, when presented with solubility data, to have in hand the tools to evaluate not just the magnitude but also the context and appropriateness of those measurements to the drug in question...
  5. ncbi Increased dissolution rate and bioavailability through comicronization with microcrystalline cellulose
    Julie K Spence
    Pharmaceutical Research and Development, World Wide Pharmaceutical Sciences, Pfizer Global Research and Development Michigan Laboratories, Ann Arbor, Michigan, USA
    Pharm Dev Technol 10:451-60. 2005
    ..Physicochemical characterization of the comicronized and neat micronized material is presented to help explain the in-vitro and in-vivo data...
  6. ncbi Solubility measurement of polymorphic compounds via the pH-metric titration technique
    Ann F Fioritto
    Research Formulations, Pharmaceutical Sciences, Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Int J Pharm 330:105-13. 2007
    ....
  7. ncbi Evaluation of the vibratory feeder method for assessment of powder flow properties
    Shobha N Bhattachar
    Pfizer Global R and D, 2800 Plymouth Road, Ann Arbor, Michigan, MI 48105, USA
    Int J Pharm 269:385-92. 2004
    ..A recommended procedure for measurement of powder flow with the vibratory feeder is presented...