Chris G Barber

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 14:3227-30. 2004
  2. ncbi request reprint Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines
    Paul V Fish
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK
    J Med Chem 50:2341-51. 2007
  3. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 12:181-4. 2002
  4. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 12:185-7. 2002
  5. ncbi request reprint CCR5 antagonists for the treatment of HIV
    Chris G Barber
    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Curr Opin Investig Drugs 5:851-61. 2004
  6. doi request reprint 1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2
    Christopher G Barber
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1499-503. 2009
  7. doi request reprint 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1
    Christopher G Barber
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1075-9. 2009
  8. doi request reprint The design and discovery of novel amide CCR5 antagonists
    David C Pryde
    Department of Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1084-8. 2009
  9. ncbi request reprint Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides
    David C Pryde
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    J Med Chem 49:4409-24. 2006
  10. ncbi request reprint A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability
    Charlotte M N Allerton
    Discovery Chemistry, Lead Discovery, and Discovery Biology, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
    J Med Chem 49:3581-94. 2006

Detail Information

Publications12

  1. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 14:3227-30. 2004
    ..Compound 13j (UK-356,202) combines excellent potency and selectivity, and has been selected as a candidate for clinical evaluation...
  2. ncbi request reprint Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines
    Paul V Fish
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, UK
    J Med Chem 50:2341-51. 2007
    ..On the basis of this profile, compound 26 (UK-371,804) was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers...
  3. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 12:181-4. 2002
    ..g., 27 and 28) as selective inhibitors of urokinase-type plasminogen activator (uPA) is described. The X-ray crystal structure of 27 has been determined, and modelling has been used to predict binding in the enzyme active site...
  4. ncbi request reprint Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines
    Christopher G Barber
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 12:185-7. 2002
    ..Compound 36 has a K(i) of 0.17 microM and greater than 300-fold selectivity with respect to tPA and plasmin...
  5. ncbi request reprint CCR5 antagonists for the treatment of HIV
    Chris G Barber
    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Curr Opin Investig Drugs 5:851-61. 2004
    ..A number of CCR5 antagonists are currently in clinical trials. This review details the status of leading agents and highlights recent advances in the development of new CCR5 antagonists...
  6. doi request reprint 1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2
    Christopher G Barber
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1499-503. 2009
    ..Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption...
  7. doi request reprint 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1
    Christopher G Barber
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1075-9. 2009
    ..Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel...
  8. doi request reprint The design and discovery of novel amide CCR5 antagonists
    David C Pryde
    Department of Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Bioorg Med Chem Lett 19:1084-8. 2009
    ....
  9. ncbi request reprint Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides
    David C Pryde
    Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    J Med Chem 49:4409-24. 2006
    ..This led ultimately to the prototype development candidate R-13, for which detailed pharmacology and pharmacokinetic parameters are presented.(1)..
  10. ncbi request reprint A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability
    Charlotte M N Allerton
    Discovery Chemistry, Lead Discovery, and Discovery Biology, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
    J Med Chem 49:3581-94. 2006
    ..5-(5-Acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(1-ethyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (2) was selected for progression into the clinic...
  11. doi request reprint 'OnePoint'--combining OneNote and SharePoint to facilitate knowledge transfer
    Christopher G Barber
    Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Drug Discov Today 14:845-50. 2009
    ..Demand from drug project teams for this 'solution' has now resulted in site-wide deployment to over 500 people across research...
  12. ncbi request reprint Stereoselective synthesis of 2,3-difunctionalised thioesters using nucleophilic epoxidation of 1-arylthio-1-nitroalkenes
    Lyndsay Ann Evans
    Department of Chemistry, Dainton Building, The University of Sheffield, Brook Hill, Sheffield, UK
    Org Biomol Chem 5:3156-63. 2007
    ..Together with the oxazolidinone precursor anti-alpha-bromo thioester 15a, the absolute and relative stereochemistry of these compounds has been determined by X-ray crystallography...