E R Peskind

Summary

Country: USA

Publications

  1. ncbi request reprint Increased CSF cortisol in AD is a function of APOE genotype
    E R Peskind
    Mental Illness Research, Education, and Clinical Center MIRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurology 56:1094-8. 2001
  2. ncbi request reprint Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 64:2063-8. 2005
  3. ncbi request reprint Increased plasma norepinephrine response to yohimbine in elderly men
    E C Petrie
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
    J Gerontol A Biol Sci Med Sci 55:M155-9. 2000
  4. pmc Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Psychoneuroendocrinology 32:72-9. 2007
  5. ncbi request reprint The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series
    D Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    Arch Neurol 56:1489-95. 1999
  6. ncbi request reprint Human glucocorticoid feedback inhibition is reduced in older individuals: evening study
    C W Wilkinson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 86:545-50. 2001
  7. ncbi request reprint Effects of Alzheimer's disease and gender on the hypothalamic-pituitary-adrenal axis response to lumbar puncture stress
    E C Petrie
    Mental Health Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Psychoneuroendocrinology 24:385-95. 1999
  8. ncbi request reprint CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
    G Li
    Mental Illness Research, Education, and Clinical Center and Department of Psychiatry, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Neurology 69:631-9. 2007
  9. ncbi request reprint Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    G Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Neurology 69:878-85. 2007
  10. pmc ABCB1 genotype and CSF beta-amyloid in Alzheimer disease
    R Kohen
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Geriatr Psychiatry Neurol 24:63-6. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Increased CSF cortisol in AD is a function of APOE genotype
    E R Peskind
    Mental Illness Research, Education, and Clinical Center MIRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurology 56:1094-8. 2001
    ..Presence of the APOE-epsilon4 allele increases risk for AD. Increased cortisol concentrations in apoE-deficient mice suggest that APOE genotype may influence cortisol concentrations in AD...
  2. ncbi request reprint Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 64:2063-8. 2005
    ..To determine the efficacy of testosterone (T) supplementation on cognition in a sample of men with Alzheimer disease (AD) or mild cognitive impairment (MCI)...
  3. ncbi request reprint Increased plasma norepinephrine response to yohimbine in elderly men
    E C Petrie
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
    J Gerontol A Biol Sci Med Sci 55:M155-9. 2000
    ....
  4. pmc Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Psychoneuroendocrinology 32:72-9. 2007
    ..The objective of this study was to compare the cognitive responses of older, eugonadal men in whom moderate or large increases in serum testosterone levels was induced by exogenous testosterone supplementation...
  5. ncbi request reprint The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series
    D Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    Arch Neurol 56:1489-95. 1999
    ..Since these samples are particularly enriched with patients with AD and the APOE epsilon4 allele, results may not be generalizable to patients seen in the general medical community...
  6. ncbi request reprint Human glucocorticoid feedback inhibition is reduced in older individuals: evening study
    C W Wilkinson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 86:545-50. 2001
    ..Our studies support the hypothesis that glucocorticoid responses to stress in aging individuals are likely to be prolonged due to blunted and delayed inhibition of ACTH secretion, thus increasing the total exposure to glucocorticoids...
  7. ncbi request reprint Effects of Alzheimer's disease and gender on the hypothalamic-pituitary-adrenal axis response to lumbar puncture stress
    E C Petrie
    Mental Health Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Psychoneuroendocrinology 24:385-95. 1999
    ..HPA-axis responsiveness also differed by gender, with higher peaks and prolonged elevations in elderly female subjects than in elderly males...
  8. ncbi request reprint CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
    G Li
    Mental Illness Research, Education, and Clinical Center and Department of Psychiatry, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Neurology 69:631-9. 2007
    ..While many studies have evaluated CSF tau and Abeta(42) as biomarkers of the dementia or prodromal stages of AD, we are unaware of any study to evaluate these potential CSF biomarkers of latent AD...
  9. ncbi request reprint Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    G Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Neurology 69:878-85. 2007
    ..We investigated whether antecedent statin exposure is associated with neuritic plaque (NP) or neurofibrillary tangle (NFT) burden in a population-based sample of human subjects...
  10. pmc ABCB1 genotype and CSF beta-amyloid in Alzheimer disease
    R Kohen
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Geriatr Psychiatry Neurol 24:63-6. 2011
    ..In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of Aβ. No strong evidence for association was found...
  11. ncbi request reprint Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease
    P Szot
    Northwest Network Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 84:135-40. 2000
    ..These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease...
  12. ncbi request reprint The alpha1-adrenergic antagonist prazosin ameliorates combat trauma nightmares in veterans with posttraumatic stress disorder: a report of 4 cases
    M A Raskind
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center, University of Washington, Department of Psychiatry and Behavioral Sciences, Seattle, USA
    J Clin Psychiatry 61:129-33. 2000
    ..This observation prompted an open-label feasibility trial of prazosin for combat trauma nightmares in chronic combat-induced PTSD...
  13. ncbi request reprint Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder
    E D Kanter
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Biol Psychiatry 50:238-45. 2001
    ..CONCLUSIONS: These observations suggest decreased adrenocortical responsiveness may be an additional or alternative mechanism accounting for low cortisol in PTSD...
  14. ncbi request reprint Plasma catecholamine and cardiovascular responses to physostigmine in Alzheimer's disease and aging
    E C Petrie
    Mental Health Service S 116, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Psychoneuroendocrinology 26:147-64. 2001
    ..As a result, plasma catecholamine responses to physostigmine do not appear to be useful peripheral neuroendocrine estimates of the severity of brain cholinergic deficits in mild to moderate AD...
  15. pmc Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
    L M Bekris
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 32:556.e13-23. 2011
    ..These results suggest that genetic variation within ADAM10, an APP processing gene, influences CSF APPα levels in an AD specific manner...
  16. pmc Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA
    Neuroscience 146:471-80. 2007
    ..These changes in postsynaptic AR would suggest a reduced function of the PFC. Consequence of this reduced function of the PFC in dementia is still unknown but it may affect memory and behavior...
  17. ncbi request reprint Chronic cortisol suppresses pituitary and hypothalamic peptide message expression in pigtailed macaques
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neuroscience 126:241-6. 2004
    ..Chronic therapeutic administration of glucocorticoids in humans may have unintended consequences for hypothalamic and pituitary function...
  18. ncbi request reprint Increased alpha 2-adrenergic receptor binding in locus coeruleus projection areas in dementia with Lewy bodies
    J B Leverenz
    Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 22:555-61. 2001
    ..Either mechanism could lower the threshold for increased agitation in response to noradrenergic outflow in these dementing disorders...
  19. ncbi request reprint Alzheimer's disease and related disorders
    M A Raskind
    Northwest Network Veterans Affairs Mental Illness Research, Education and Clinical Center (MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Med Clin North Am 85:803-17. 2001
    ..Studies suggest that low-dose treatment with risperidone, 1 mg/d, or olanzapine, 5 mg/d, offers the optimal ratio of therapeutic to adverse effects...
  20. ncbi request reprint Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder
    A Radant
    Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, VA Puget Sound 116, 1660 S Columbian Way, Seattle, WA 98108, USA
    Psychiatry Res 102:203-15. 2001
    ..However, the capacity of these traits to distinguish PTSD from non-PTSD patients and their familial pattern must be better defined before they can be employed in genetic studies...
  21. ncbi request reprint Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
    E R Peskind
    Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurochem Int 39:409-13. 2001
    ..These results suggest increased CNS expression of S100B in the earlier stages of AD, and are consistent with a role for S100B in the initiation and/or facilitation of neuritic plaque formation in AD brain...
  22. ncbi request reprint Serum cholesterol and risk of Alzheimer disease: a community-based cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
    Neurology 65:1045-50. 2005
    ..To examine the association of serum total cholesterol (TC) and high density lipoprotein (HDL) levels and subsequent incidence of dementia and Alzheimer disease (AD) in a population-based cohort study...
  23. ncbi request reprint The role of aromatization in testosterone supplementation: effects on cognition in older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA
    Neurology 64:290-6. 2005
    ..To determine the contribution of conversion of testosterone (T) to estradiol on cognitive processing in a population of healthy older men who received T supplementation...
  24. ncbi request reprint Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition
    P S Aisen
    Department of Neurology, Georgetown University Medical Center, 1Bles Building, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Psychoneuroendocrinology 28:113-20. 2003
    ..These results support a relationship between gender, apolipoprotein E genotype and glucose metabolism, but do not indicate that mild changes in glucose have an important impact on cognitive function...
  25. ncbi request reprint In Alzheimer disease, increased wake fragmentation found in those with lower hypocretin-1
    L F Friedman
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Neurology 68:793-4. 2007
  26. ncbi request reprint Insulin increases CSF Abeta42 levels in normal older adults
    G S Watson
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Neurology 60:1899-903. 2003
    ..In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden...