Wen Jie Zhang

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Genetic control of interleukin-4-induced activation of the human signal transducer and activator of transcription 6 signaling pathway
    Wen Jie Zhang
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Hum Immunol 64:402-15. 2003
  2. ncbi request reprint Phenotyping of IL4-induced nuclear Stat6 activity in humans: quantitation after gel shift assay using immortalized cell lines
    Wen Jie Zhang
    Department of Surgery H137, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Oncol Rep 10:1281-8. 2003
  3. ncbi request reprint Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma
    Wen Jie Zhang
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:447-53. 2004
  4. ncbi request reprint Stat6(null phenotype) human lymphocytes exhibit increased apoptosis
    Eva Galka
    Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Section of Colon and Rectal Surgery, MCH137, Hershey, Pennsylvania, USA
    J Surg Res 122:14-20. 2004
  5. doi request reprint Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 162:290-8. 2010
  6. ncbi request reprint Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis
    Fu Guo Chen
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai 200011, China
    J Cell Sci 120:2875-83. 2007
  7. doi request reprint IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells
    Ben Hui Li
    Department of Medical Oncology, Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan, Hubei 430071, China
    Biochem Biophys Res Commun 369:554-60. 2008
  8. doi request reprint IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells
    Wen Jie Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China
    Cytokine 42:39-47. 2008
  9. ncbi request reprint A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
    Changwon Park
    Department of Pathology and Immunology, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Development 131:2749-62. 2004
  10. ncbi request reprint Gene targeting strategies for the isolation of hematopoietic and endothelial precursors from differentiated ES cells
    Wen Jie Zhang
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8118, St Louis, Missouri 63110, USA
    Methods Enzymol 365:186-202. 2003

Collaborators

  • Lisa S Poritz
  • Michael J Chorney
  • Cheng Dong
  • Hui Liu
  • Wei Liu
  • Eva Galka
  • A Rosendahl
  • Yun Shin Chung
  • Ben Hui Li
  • Fu Guo Chen
  • Guang Han
  • Cong Hua Xie
  • Mingsheng Zhang
  • Changwon Park
  • Elizabeth Arentson
  • Kyunghee Choi
  • Xian Zi Yang
  • Jia Yuan
  • Pin Dong Li
  • Qin Yuan
  • Xiao Hong Liu
  • Fan Fan Chen
  • Yilin Cao
  • Lei Cui
  • Dan Bi
  • Lian Zhu
  • Xian Wei
  • Zhi Guo Luo
  • Yun Chen
  • Yunfeng Zhou
  • Ming Sheng Zhang
  • Gong Zhang
  • Conghua Xie
  • Jian ping Wu
  • Fu Xiang Zhou
  • Fuxiang Zhou
  • Yun Feng Zhou
  • Zhen Cao
  • Ji Chen
  • Iva Afrikanova
  • Guo hua Fong Gh
  • Paul D Kingsley
  • James Palis

Detail Information

Publications13

  1. ncbi request reprint Genetic control of interleukin-4-induced activation of the human signal transducer and activator of transcription 6 signaling pathway
    Wen Jie Zhang
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Hum Immunol 64:402-15. 2003
    ..The Stat6(null) phenotype may result from a defect in Stat6 signaling, which has important implications with respect to the pathogenesis of cancer and Th1/Th2 cytokine imbalance in autoimmune diseases in general...
  2. ncbi request reprint Phenotyping of IL4-induced nuclear Stat6 activity in humans: quantitation after gel shift assay using immortalized cell lines
    Wen Jie Zhang
    Department of Surgery H137, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Oncol Rep 10:1281-8. 2003
    ..In addition, the defective Stat6null lines discovered here may serve as a natural human model for comprehensive study in the same way as a Stat6 knockout null animal model does...
  3. ncbi request reprint Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma
    Wen Jie Zhang
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:447-53. 2004
    ..Moreover, observations from signal transduction studies in our human B lymphocyte model may be compatible with those in the chosen mouse B lymphocyte for establishing signaling networks by the Alliance for Cellular Signaling (AfCS)...
  4. ncbi request reprint Stat6(null phenotype) human lymphocytes exhibit increased apoptosis
    Eva Galka
    Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Section of Colon and Rectal Surgery, MCH137, Hershey, Pennsylvania, USA
    J Surg Res 122:14-20. 2004
    ....
  5. doi request reprint Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 162:290-8. 2010
    ..This has been termed Stat6(null) and Stat6(high) is the normal phenotype. The purpose of this study was to investigate the defect in Stat6 activation in Stat6(null) cells...
  6. ncbi request reprint Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis
    Fu Guo Chen
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai 200011, China
    J Cell Sci 120:2875-83. 2007
    ....
  7. doi request reprint IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells
    Ben Hui Li
    Department of Medical Oncology, Zhongnan Hospital and Cancer Research Center, Wuhan University, Wuhan, Hubei 430071, China
    Biochem Biophys Res Commun 369:554-60. 2008
    ..These findings, together with the observation of constitutive Stat6 activation in many human malignancies, suggest that Stat6 activities could be a biomarker for cancer cell's invasive/metastatic capability...
  8. doi request reprint IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells
    Wen Jie Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China
    Cytokine 42:39-47. 2008
    ....
  9. ncbi request reprint A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells
    Changwon Park
    Department of Pathology and Immunology, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Development 131:2749-62. 2004
    ....
  10. ncbi request reprint Gene targeting strategies for the isolation of hematopoietic and endothelial precursors from differentiated ES cells
    Wen Jie Zhang
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8118, St Louis, Missouri 63110, USA
    Methods Enzymol 365:186-202. 2003
  11. ncbi request reprint STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells
    Mingsheng Zhang
    Department of Cancer Radio Chemotherapy, Wuhan University Zhongnan Hospital and Cancer Research Center, 169 Donghu Road, Wuhan, Hubei 430071, China
    Cancer Lett 243:38-46. 2006
    ..These findings suggest that Stat6 signaling pathway plays a role in the regulation of cell proliferation and apoptosis in colon cancer cells, which promises further investigation for targeted cancer therapy...
  12. ncbi request reprint Chinese medicine Angelica sinensis suppresses radiation-induced expression of TNF-alpha and TGF-beta1 in mice
    Cong Hua Xie
    Department of Cancer Radio Chemotherapy, Wuhan University Zhongnan Hospital and Cancer Research Center, Wuhan, Hubei 430071, P R China
    Oncol Rep 15:1429-36. 2006
    ..Moreover, effective down-regulation of TNF-alpha and TGF-beta1 in irradiated lung tissue by Angelica Sinensis is, at least in part, indicative of its clinical efficacy in treating radiation-induced pneumonitis...
  13. ncbi request reprint Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression
    Yun Shin Chung
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Development 129:5511-20. 2002
    ..Replating studies demonstrate that hematopoietic progenitors are enriched within FLK1(+)CD4(+) and FLK1(-)CD4(+) cells, while endothelial cells develop from FLK1(+)CD4(+) and FLK1(+)CD4(-) cell populations...