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Genomes and Genes | I S ZagonSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Spontaneous episodic decreased tear secretion in rats is related to opioidergic signaling pathwaysIan S Zagon
Department of Neural and Behavioral Sciences, M S Hershey Medical Center, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
Invest Ophthalmol Vis Sci 53:3234-40. 2012..To elucidate the factors in tear production, this study examined the role of endogenous opioids and opioid receptors in spontaneous episodic reduced tear volume...- The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancerFan Cheng
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Mol Cancer 7:5. 2008..The OGF-OGFr axis influences the G0/G1 phase of the cell cycle. In this investigation, we elucidate the pathway of OGF in the cell cycle... - Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axisPatricia J McLaughlin
Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
BMC Cancer 9:369. 2009..This study addressed the question of whether the OGF-OGFr axis is present and functional in human thyroid follicular cell - derived cancer... 
Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid arteryIan S Zagon
Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
J Vasc Surg 37:636-43. 2003..This study was designed to determine the role of OGF in neointimal hyperplasia...- Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the corneaIan S Zagon
Department of Neuroscience and Anatomy, H109, The Milton S Hershey Medical Center, 500 University Drive, PA 17033, USA
Brain Res 967:37-47. 2003.... 
Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancersIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Am J Physiol Regul Integr Comp Physiol 297:R1154-61. 2009..The identification of this native biological system in neoplasia may be important in understanding the pathophysiology of neoplasia, and in designing treatment modalities that utilize the body's own chemistry...- Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptorIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Int J Oncol 33:317-23. 2008..These data support OGFr gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer... - Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epitheliumIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
Brain Res Bull 72:18-24. 2007..Thus, recurrent erosion following abrasion of the diabetic cornea, with preservation of the basal lamina, cannot be explained by structural abnormalities in the reformation of the epithelial adhesion complex... - Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune functionIan S Zagon
Department of Neural and Behavioral Sciences, H109, The M S Hershey Medical Center, 500 University Drive, Rm C3729, Hershey, PA 17033, USA
Exp Biol Med (Maywood) 233:968-79. 2008..This exciting new knowledge of the mechanism of imidazoquinolines has important physiological relevance, and allows strategies to be developed for the use of these agents that will enhance effectiveness as well as attenuate side-effects... - Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic ratIan S Zagon
Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey 17033, USA
Diabetes 51:3055-62. 2002..These results indicate a delay in reepithelialization that is dependent on the duration of diabetes and that intervention of endogenous opioid-receptor interfacing with an opioid antagonist can facilitate the process of wound healing... - Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexoneIan S Zagon
Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, USA
Arch Ophthalmol 126:501-6. 2008..To determine whether topical application of naltrexone prevents exuberant granulation tissue formation with neovascularization in diabetic rat corneas... - Gene expression of OGFr in the developing and adult rat brain and cerebellumIan S Zagon
Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
Brain Res Bull 63:57-63. 2004.... - Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cellsIan S Zagon
Department of Neural and Behavioral Sciences, H 109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Int J Oncol 24:1443-8. 2004.... - Corneal safety of topically applied naltrexoneIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Ocul Pharmacol Ther 22:377-87. 2006..Naltrexone (NTX), an opioid antagonist, accelerates wound healing of corneal epithelium in normal and diabetic animals. This study examined the safety of NTX by topical application in the cornea... - Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexoneIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Cornea 25:821-9. 2006..To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX)... - Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancersIan S Zagon
Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
Int J Oncol 29:489-94. 2006..This information will be relevant in the design of therapeutic modalities, the diagnosis and prognosis of neoplasia, as well as understanding of the processes and mechanisms of carcinogenesis... - Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cellsIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Int J Oncol 30:775-83. 2007..These data identify OGFr at the molecular level as integral to regulating the cell replication of human pancreatic cancer, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias... - Insulin treatment ameliorates impaired corneal reepithelialization in diabetic ratsIan S Zagon
Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Penn State College of Medicine, 500 University Dr, Room C3729, Hershey, PA 17033, USA
Diabetes 55:1141-7. 2006..These results indicate that intensive therapy with insulin, which establishes normoglycemia in rats with diabetes, prevents the delay in wound healing of ocular surface epithelium observed in poorly controlled diabetic animals... - Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinomaIan S Zagon
Department of Neural and Behavioral Sciences, H109, Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, 17033, USA
Cancer Chemother Pharmacol 56:510-20. 2005..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer... - Use of topical insulin to normalize corneal epithelial healing in diabetes mellitusIan S Zagon
Department of Neural and Behavioral Sciences, Mail Code H109, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA
Arch Ophthalmol 125:1082-8. 2007..To determine whether topical application of insulin normalizes delayed corneal wound healing in rats with diabetes mellitus (DB)... - Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epitheliumIan S Zagon
Department of Neural and Behavioral Sciences, Pennsylvania State University, College of Medicine, 500 University Drive, Rm C3727, Hershey, PA 17033, USA
Anat Rec A Discov Mol Cell Evol Biol 282:24-37. 2005..Moreover, the unique finding that OGFr was found in the cytoplasm and nucleus in NTX-treated specimens may suggest that NTX-OGFr complexes have the same pathway as OGF-OGFr... - Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNAIan S Zagon
Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Arch Ophthalmol 124:1620-4. 2006..To determine whether molecular manipulation of the opioid growth factor receptor (OGFr) alters corneal reepithelialization following central corneal abrasion in rats... - The biology of the opioid growth factor receptor (OGFr)Ian S Zagon
Department of Neuroscience and Anatomy, H 109, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res Brain Res Rev 38:351-76. 2002..This report reviews the history of OGF-OGFr, examines emerging insights into the mechanisms of action of opioid peptide-receptor interfacing, and discusses the clinical significance of these observations... - Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbitsI S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Brain Res Bull 81:248-55. 2010..These studies set the stage for clinical trials using NTX as a therapy for diabetic keratopathy... - Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosisIan S Zagon
Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
Exp Biol Med (Maywood) 234:1383-92. 2009.... - Opioid growth factor and organ development in rat and human embryosI S Zagon
Department of Neuroscience and Anatomy, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA
Brain Res 839:313-22. 1999..Irregularities in the role of opioids as growth regulators in relationship to the more than 500,000 newborns suffering from birth defects each year in the US needs to be examined... - Cellular dynamics of corneal wound re-epithelialization in the rat. II. DNA synthesis of the ocular surface epithelium following woundingI S Zagon
Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey 17033, USA
Brain Res 839:243-52. 1999.... - Opioids and differentiation in human cancer cellsIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, M S Hershey Medical Center, 500 University Drive, H109, Hershey, PA 17033, United States
Neuropeptides 39:495-505. 2005..The absence of effects on cancer cell differentiation by a variety of other opioids supports the previously reported lack of growth effects of these compounds... - Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitisIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Brain Res 1310:154-61. 2010..These results indicate that an endogenous opioid, OGF, inhibits the onset and progression of EAE, and suggest that clinical studies on the use of OGF treatment for MS are merited... - Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptorsI S Zagon
Departments of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res 798:254-60. 1998..These results show that native opioid peptides function in wound healing, and exert a tonically inhibitory influence at the receptor level on repair of corneal epithelial injuries... - B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseasesIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA
Immunobiology 216:173-83. 2011..Thus, at least exogenous OGF and perhaps endogenous OGF by paracrine/endocrine sources, can be an immunosuppressant. Modulation of the OGF-OGFr axis may be a novel paradigm for the treatment of autoimmune diseases... - T lymphocyte proliferation is suppressed by the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseasesIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, United States
Immunobiology 216:579-90. 2011..The results showing that the OGF-OGFr axis is an immunosuppressant, offers explanation for reports that autoimmune diseases can be modulated by this system... - Reepithelialization of the human cornea is regulated by endogenous opioidsI S Zagon
Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, USA
Invest Ophthalmol Vis Sci 41:73-81. 2000..To determine the influence of endogenous opioid modulation on reepithelialization of the human cornea... - Transplacental transfer of the opioid growth factor, [Met(5)]-enkephalin, in ratsI S Zagon
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA
Brain Res Bull 55:341-6. 2001.... - Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitusIan S Zagon
Department of Neural and Behavioral Sciences, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Arch Ophthalmol 127:1468-73. 2009..To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus... - Opioid growth factor regulates the cell cycle of human neoplasiasI S Zagon
Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
Int J Oncol 17:1053-61. 2000..The data on blockade of OGF-OGFr during log phase growth suggest a requisite escorting of the growth peptide and its receptor through the cell cycle... - Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activityI S Zagon
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res 882:169-79. 2000..Mitotic cells in the limbus and conjunctiva may be related to replenishment of ocular surface epithelial cells used in the repair process rather than directly supplying the abraded surface... - Epithelial adhesion complexes and organ culture of the human corneaI S Zagon
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res 900:205-13. 2001.... - Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouseI S Zagon
Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res Mol Brain Res 84:106-14. 2000..These results emphasize the molecular validity of OGFr, and explain the interaction of OGF with respect to normal and abnormal growth in mouse cells and tissues... - Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic ratsMatthew S Klocek
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Exp Eye Res 89:686-92. 2009..These data demonstrate that although NTX or INS accelerates wound healing, concomitant application of NTX and INS to corneal abrasions in diabetic animals does not have an additive effect on re-epithelialization... - The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skinR P Wilson
Department of Comparative Medicine, College of Medicine, The Pennsylvania State University, Hershey 17033 2390, USA
Cell Prolif 33:63-73. 2000.... - Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humansI S Zagon
Department of Neuroscience, H 109, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey PA, USA
Brain Res 856:75-83. 2000..3. This OGF receptor has no homology to classical opioid receptors. These results provide molecular validity for the interaction of OGF and OGF receptor in the regulation of growth processes in humans... - Topically applied naltrexone restores corneal reepithelialization in diabetic ratsMatthew S Klocek
Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Ocul Pharmacol Ther 23:89-102. 2007..Complications of diabetes include an increased risk of delayed corneal epithelial wound healing. This study examined the efficacy of naltrexone (NTX), an opioid antagonist, by topical application in facilitating the repair of such lesions... - Passive diffusion of naltrexone into human and animal cells and upregulation of cell proliferationFan Cheng
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Regul Integr Comp Physiol 297:R844-52. 2009..Taken together, these results suggested that NTX enters cells by passive diffusion in a nonsaturable manner... - Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axisRenee N Donahue
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Regul Integr Comp Physiol 296:R1716-25. 2009..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in human ovarian cancer. This information will be important in designing treatment strategies for this deadly disease... - Temporal variation in cellular proliferation during recornification of mouse tail skinR P Wilson
Department of Comparative Medicine, College of Medicine, Pennsylvania State University, Hershey 17033 2390, USA
Cell Prolif 31:191-201. 1998.... - Cellular dynamics of corneal wound re-epithelialization in the rat. I. Fate of ocular surface epithelial cells synthesizing DNA prior to woundingI S Zagon
Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033
Brain Res 822:149-63. 1999..However, wound healing appears to require cells with a basal phenotype, presumably because of this cell type's migratory capability... - Re-epithelialization of the rabbit cornea is regulated by opioid growth factorI S Zagon
Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Brain Res 803:61-8. 1998..These results show that an opioid peptide, OGF, plays a direct role in the repair of injury to the corneal epithelium in the rabbit and acts as a receptor-mediated and constitutively expressed inhibitory molecule... - Cloning, sequencing, expression and function of a cDNA encoding a receptor for the opioid growth factor, [Met(5)]enkephalinI S Zagon
Department of Neuroscience, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA, USA
Brain Res 849:147-54. 1999..The molecular organization of the OGFr has no homology to classical opioid receptors. These results provide molecular validity for the interaction of OGF and OGFr in the regulation of growth processes... - Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neckJeffrey R Jaglowski
Department of Neural and Behavioral Sciences H109, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Cancer Chemother Pharmacol 56:97-104. 2005..These data suggest that combined chemotherapy (i.e., paclitaxel) and biotherapy (OGF) provides a valuable alternative to the standard of care for SCCHN patients... - Characterization of opioid binding sites in murine neuroblastomaI S Zagon
Department of Anatomy, M S Hershey Medical Center, Pennsylvania State University, Hershey 17033
Brain Res 449:80-8. 1988..The function of these sites is unclear, but previous evidence as to the growth regulatory properties of endogenous opioid systems may suggest that either one, or both, binding sites may be involved in carcinogenic events... - The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferationFan Cheng
Department of Neural and Behavioral Sciences, and Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Mol Biol Cell 20:319-27. 2009..Collectively, these results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the OGF-OGFr axis to inhibit cell proliferation in normal cells... - The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancerDiego M Avella
Department of Surgery, Division of Surgical Oncology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Am J Physiol Regul Integr Comp Physiol 298:R459-66. 2010..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in HCC. The findings may provide important insight in designing treatment strategies for this deadly disease... - The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancerFan Cheng
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Cancer Res 67:10511-8. 2007..These data are the first to reveal that the target of cell proliferative inhibitory action of OGF in human HNSCC is a cyclin-dependent kinase inhibitory pathway, and this may be useful in the diagnosis and treatment of HNSCC... - Regulation of Tenon's capsule fibroblast cell proliferation by the opioid growth factor and the opioid growth factor receptor axisMatthew S Klocek
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Invest Ophthalmol Vis Sci 51:5054-61. 2010..This study examined whether the interaction of the opioid growth factor (OGF) [Met(5)]-enkephalin with its receptor (OGFr) is a regulator of TCF proliferation... - Quantitative analysis of gastrin mRNA and peptide in normal and cancerous human pancreasJ P Smith
Department of Medicine and Neuroscience, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
Int J Mol Med 2:309-15. 1998..In contrast to the normal pancreas and gastrinoma tumor, the aggressive behavior of pancreatic adenocarcinoma may be attributed to the autocrine production of gastrin and to the presence of its growth-related receptor... - Chronic exposure to the opioid antagonist naltrexone during pregnancy: maternal and offspring effectsP J McLaughlin
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey 17033, USA
Physiol Behav 62:501-8. 1997.... - Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin beta and Ran for nucleocytoplasmic traffickingFan Cheng
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
Exp Biol Med (Maywood) 235:1093-101. 2010..These hierarchical levels of nuclear import provide multiple pathways for the subtle regulation of OGF-OGFr as it relates to the control of cell proliferative events... - Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a reviewPatricia J McLaughlin
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Brain Res Bull 81:236-47. 2010..g., vitrectomy), and that conventional therapies such as artificial tears and bandage contact lenses often fail, topical application of NTX merits clinical consideration... - Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancerJ P Smith
Department of Medicine, The Pennsylvania State University College of Medicine, Hershey 17033, USA
Pancreas 21:158-64. 2000..These data indicate that pancreatic cancer is associated with a marked increase in plasma OGF levels and suggest that this peptide may serve as a useful diagnostic tool in the screening for this disease... - Internalization of the opioid growth factor, [Met5]-enkephalin, is dependent on clathrin-mediated endocytosis for downregulation of cell proliferationFan Cheng
Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 299:R774-85. 2010..RhoOGF clathrin-mediated endocytosis was unrelated to endosomal or Golgi pathways. Taken together, these results suggest that OGF enters cells by active transport in a saturable manner that requires clathrin-mediated endocytosis... - Characterization of the CCK-C (cancer) receptor in human pancreatic cancerJill P Smith
Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
Int J Mol Med 10:689-94. 2002..The term CCK-C or 'cancer' receptor has been proposed to signify the relationship of this receptor to neoplasia... - Differential effects of vascular growth factors on arterial and venous angiogenesisJohn Blebea
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
J Vasc Surg 35:532-8. 2002..The differential effects on veins and arteries, however, by any vascular growth factor, have not previously been investigated... - Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: maternal and preweaning effectsPatricia J McLaughlin
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, H 109, 500 University Drive, Hershey, PA 17033, USA
Pharmacol Biochem Behav 71:171-81. 2002.... - Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epitheliumIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
Cornea 24:614-9. 2005..This study was designed to determine at the molecular level whether interactions between the opioid growth factor (OGF) and OGF receptor (OGFr) play a role in regulating DNA synthesis in the homeostasis of the corneal epithelium... - Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptorsPatricia J McLaughlin
Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
Exp Biol Med (Maywood) 235:1292-9. 2010..These results suggest that the target of imiquimod on DNA synthesis is dependent on an opioid receptor-mediated pathway, and infers that imiquimod is reliant on the OGF-OGFr axis for modulating cell proliferation... - Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neckPatricia J McLaughlin
Department of Neuroscience and Anatomy, Division of Otolaryngology, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033, USA
Cancer 97:1701-10. 2003..This study compared protein and gene expression of OGFr in surgical specimens of human squamous cell carcinoma of the head and neck (SCCHN) with normal epithelium... - Opioids and the apoptotic pathway in human cancer cellsIan S Zagon
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, H 109, Hershey, PA 17033, USA
Neuropeptides 37:79-88. 2003.... - Opioid growth factor modulation of corneal epithelium: uppers and downersJoseph W Sassani
Department of Ophthalmology, Penn State s Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Curr Eye Res 26:249-62. 2003..This paper presents a concise review of the role of the intrinsic opioid growth regulation system (IOGRS) in homeostasis and wound repair of the corneal epithelium... - Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neckPatricia J McLaughlin
Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Int J Mol Med 19:421-8. 2007..These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias... - Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administrationPatricia J McLaughlin
Department of Neuroscience and Anatomy, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
Int J Oncol 24:227-32. 2004.... - Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptorPatricia J McLaughlin
Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
Int J Oncol 28:1577-83. 2006..Gene therapy to reinstate more OGFr, and thus enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression... - Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factorPatricia J McLaughlin
Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Int J Oncol 26:809-16. 2005..These data suggest that the combination of a biotherapy (OGF) and chemotherapy (paclitaxel and carboplatin) may provide an enhanced antitumor effect with respect to SCCHN... - Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cellsIan S Zagon
Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States
Neuropeptides 41:441-52. 2007.... - The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancerJill P Smith
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Pancreas 29:271-7. 2004..The aim of this study was to evaluate whether the CCK-C receptor, a splice variant of the CCK-B receptor, in human pancreatic cancer cells was associated with accelerated cancer cell growth... - Treatment of advanced pancreatic cancer with opioid growth factor: phase IJill P Smith
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Anticancer Drugs 15:203-9. 2004..Further studies are needed to determine the efficacy of OGF alone or in combination with present modes of therapy for the treatment of pancreatic cancer... - Functional significance of gastrin gene expression in human cancer cellsJill P Smith
Department of Medicine, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Regul Pept 117:167-73. 2004..These studies demonstrate that gastrin and the CCK-C receptor form an autocrine loop in human pancreatic cancer that plays a role in regulating growth... - The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cellsIan S Zagon
Department of Neuroscience and Anatomy, The Milton S Hershey Medical Centre, College of Medicine, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
Neuropeptides 37:290-7. 2003..These results indicate that the OGF-OGFr axis is present and functions in COS-7 cells, and in the absence of classical opioid receptors... - Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptorPatricia J McLaughlin
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
Int J Oncol 33:751-7. 2008.... - Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude micePatricia J McLaughlin
Departments of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3727, Hershey, PA 17033 0850, USA
Cancer Lett 199:209-17. 2003..These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application... - Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancerDavid Goldenberg
Division of Otolaryngology, Department of Surgery, H091, College of Medicine, The Penn State University, Hershey, Pennsylvania 17033, USA
Thyroid 18:1165-70. 2008..In the present study we examined the presence and distribution of OGF and OGFr in nonmedullary thyroid cancer, including papillary, follicular, and anaplastic, as well as thyroid tissue from patients with nonmalignant disease... - Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferationFan Cheng
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
Exp Biol Med (Maywood) 234:532-41. 2009..These results indicate that the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors... - Localization of spectrin isoforms in the adult mouse heartT Isayama
Department of Neuroscience and Anatomy, Pennsylvania State University, Milton S Hershey Medical Center, Hershey 17033
Cell Tissue Res 274:127-33. 1993..This is the first demonstration of two different alpha-spectrin subunits in the mammalian heart... - Low-dose naltrexone therapy improves active Crohn's diseaseJill P Smith
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Gastroenterol 102:820-8. 2007..In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn's disease...
Research Grants
- Gene Gun Technology, Opioids, and Corneal DiseasesIAN ZAGON; Fiscal Year: 2003..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
- Naltrexone as a Novel Treatment for Diabetic KeratopathyIAN ZAGON; Fiscal Year: 2007..The proposed use of biotherapy with NTX is an innovative approach whereby the patient's own growth regulatory mechanisms are manipulated to correct complications from diabetes. ..