I S Zagon

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Spontaneous episodic decreased tear secretion in rats is related to opioidergic signaling pathways
    Ian S Zagon
    Department of Neural and Behavioral Sciences, M S Hershey Medical Center, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
    Invest Ophthalmol Vis Sci 53:3234-40. 2012
  2. pmc The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Mol Cancer 7:5. 2008
  3. pmc Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
    BMC Cancer 9:369. 2009
  4. ncbi request reprint Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery
    Ian S Zagon
    Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Vasc Surg 37:636-43. 2003
  5. ncbi request reprint Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea
    Ian S Zagon
    Department of Neuroscience and Anatomy, H109, The Milton S Hershey Medical Center, 500 University Drive, PA 17033, USA
    Brain Res 967:37-47. 2003
  6. doi request reprint Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1154-61. 2009
  7. ncbi request reprint Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 33:317-23. 2008
  8. ncbi request reprint Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
    Brain Res Bull 72:18-24. 2007
  9. doi request reprint Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The M S Hershey Medical Center, 500 University Drive, Rm C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 233:968-79. 2008
  10. ncbi request reprint Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Diabetes 51:3055-62. 2002

Research Grants

Collaborators

Detail Information

Publications84

  1. pmc Spontaneous episodic decreased tear secretion in rats is related to opioidergic signaling pathways
    Ian S Zagon
    Department of Neural and Behavioral Sciences, M S Hershey Medical Center, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
    Invest Ophthalmol Vis Sci 53:3234-40. 2012
    ..To elucidate the factors in tear production, this study examined the role of endogenous opioids and opioid receptors in spontaneous episodic reduced tear volume...
  2. pmc The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Mol Cancer 7:5. 2008
    ..The OGF-OGFr axis influences the G0/G1 phase of the cell cycle. In this investigation, we elucidate the pathway of OGF in the cell cycle...
  3. pmc Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
    BMC Cancer 9:369. 2009
    ..This study addressed the question of whether the OGF-OGFr axis is present and functional in human thyroid follicular cell - derived cancer...
  4. ncbi request reprint Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery
    Ian S Zagon
    Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Vasc Surg 37:636-43. 2003
    ..This study was designed to determine the role of OGF in neointimal hyperplasia...
  5. ncbi request reprint Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea
    Ian S Zagon
    Department of Neuroscience and Anatomy, H109, The Milton S Hershey Medical Center, 500 University Drive, PA 17033, USA
    Brain Res 967:37-47. 2003
    ....
  6. doi request reprint Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1154-61. 2009
    ..The identification of this native biological system in neoplasia may be important in understanding the pathophysiology of neoplasia, and in designing treatment modalities that utilize the body's own chemistry...
  7. ncbi request reprint Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 33:317-23. 2008
    ..These data support OGFr gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer...
  8. ncbi request reprint Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
    Brain Res Bull 72:18-24. 2007
    ..Thus, recurrent erosion following abrasion of the diabetic cornea, with preservation of the basal lamina, cannot be explained by structural abnormalities in the reformation of the epithelial adhesion complex...
  9. doi request reprint Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The M S Hershey Medical Center, 500 University Drive, Rm C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 233:968-79. 2008
    ..This exciting new knowledge of the mechanism of imidazoquinolines has important physiological relevance, and allows strategies to be developed for the use of these agents that will enhance effectiveness as well as attenuate side-effects...
  10. ncbi request reprint Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Diabetes 51:3055-62. 2002
    ..These results indicate a delay in reepithelialization that is dependent on the duration of diabetes and that intervention of endogenous opioid-receptor interfacing with an opioid antagonist can facilitate the process of wound healing...
  11. pmc Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, USA
    Arch Ophthalmol 126:501-6. 2008
    ..To determine whether topical application of naltrexone prevents exuberant granulation tissue formation with neovascularization in diabetic rat corneas...
  12. ncbi request reprint Gene expression of OGFr in the developing and adult rat brain and cerebellum
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Brain Res Bull 63:57-63. 2004
    ....
  13. ncbi request reprint Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H 109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 24:1443-8. 2004
    ....
  14. ncbi request reprint Corneal safety of topically applied naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Ocul Pharmacol Ther 22:377-87. 2006
    ..Naltrexone (NTX), an opioid antagonist, accelerates wound healing of corneal epithelium in normal and diabetic animals. This study examined the safety of NTX by topical application in the cornea...
  15. ncbi request reprint Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Cornea 25:821-9. 2006
    ..To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX)...
  16. ncbi request reprint Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 29:489-94. 2006
    ..This information will be relevant in the design of therapeutic modalities, the diagnosis and prognosis of neoplasia, as well as understanding of the processes and mechanisms of carcinogenesis...
  17. ncbi request reprint Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 30:775-83. 2007
    ..These data identify OGFr at the molecular level as integral to regulating the cell replication of human pancreatic cancer, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias...
  18. ncbi request reprint Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Penn State College of Medicine, 500 University Dr, Room C3729, Hershey, PA 17033, USA
    Diabetes 55:1141-7. 2006
    ..These results indicate that intensive therapy with insulin, which establishes normoglycemia in rats with diabetes, prevents the delay in wound healing of ocular surface epithelium observed in poorly controlled diabetic animals...
  19. ncbi request reprint Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, 17033, USA
    Cancer Chemother Pharmacol 56:510-20. 2005
    ..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer...
  20. ncbi request reprint Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Mail Code H109, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 125:1082-8. 2007
    ..To determine whether topical application of insulin normalizes delayed corneal wound healing in rats with diabetes mellitus (DB)...
  21. ncbi request reprint Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Pennsylvania State University, College of Medicine, 500 University Drive, Rm C3727, Hershey, PA 17033, USA
    Anat Rec A Discov Mol Cell Evol Biol 282:24-37. 2005
    ..Moreover, the unique finding that OGFr was found in the cytoplasm and nucleus in NTX-treated specimens may suggest that NTX-OGFr complexes have the same pathway as OGF-OGFr...
  22. ncbi request reprint Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 124:1620-4. 2006
    ..To determine whether molecular manipulation of the opioid growth factor receptor (OGFr) alters corneal reepithelialization following central corneal abrasion in rats...
  23. ncbi request reprint The biology of the opioid growth factor receptor (OGFr)
    Ian S Zagon
    Department of Neuroscience and Anatomy, H 109, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res Brain Res Rev 38:351-76. 2002
    ..This report reviews the history of OGF-OGFr, examines emerging insights into the mechanisms of action of opioid peptide-receptor interfacing, and discusses the clinical significance of these observations...
  24. pmc Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits
    I S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Brain Res Bull 81:248-55. 2010
    ..These studies set the stage for clinical trials using NTX as a therapy for diabetic keratopathy...
  25. doi request reprint Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 234:1383-92. 2009
    ....
  26. ncbi request reprint Opioid growth factor and organ development in rat and human embryos
    I S Zagon
    Department of Neuroscience and Anatomy, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Brain Res 839:313-22. 1999
    ..Irregularities in the role of opioids as growth regulators in relationship to the more than 500,000 newborns suffering from birth defects each year in the US needs to be examined...
  27. ncbi request reprint Cellular dynamics of corneal wound re-epithelialization in the rat. II. DNA synthesis of the ocular surface epithelium following wounding
    I S Zagon
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey 17033, USA
    Brain Res 839:243-52. 1999
    ....
  28. ncbi request reprint Opioids and differentiation in human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, M S Hershey Medical Center, 500 University Drive, H109, Hershey, PA 17033, United States
    Neuropeptides 39:495-505. 2005
    ..The absence of effects on cancer cell differentiation by a variety of other opioids supports the previously reported lack of growth effects of these compounds...
  29. doi request reprint Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Brain Res 1310:154-61. 2010
    ..These results indicate that an endogenous opioid, OGF, inhibits the onset and progression of EAE, and suggest that clinical studies on the use of OGF treatment for MS are merited...
  30. ncbi request reprint Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors
    I S Zagon
    Departments of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res 798:254-60. 1998
    ..These results show that native opioid peptides function in wound healing, and exert a tonically inhibitory influence at the receptor level on repair of corneal epithelial injuries...
  31. doi request reprint B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA
    Immunobiology 216:173-83. 2011
    ..Thus, at least exogenous OGF and perhaps endogenous OGF by paracrine/endocrine sources, can be an immunosuppressant. Modulation of the OGF-OGFr axis may be a novel paradigm for the treatment of autoimmune diseases...
  32. doi request reprint T lymphocyte proliferation is suppressed by the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, United States
    Immunobiology 216:579-90. 2011
    ..The results showing that the OGF-OGFr axis is an immunosuppressant, offers explanation for reports that autoimmune diseases can be modulated by this system...
  33. ncbi request reprint Reepithelialization of the human cornea is regulated by endogenous opioids
    I S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, USA
    Invest Ophthalmol Vis Sci 41:73-81. 2000
    ..To determine the influence of endogenous opioid modulation on reepithelialization of the human cornea...
  34. ncbi request reprint Transplacental transfer of the opioid growth factor, [Met(5)]-enkephalin, in rats
    I S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA
    Brain Res Bull 55:341-6. 2001
    ....
  35. pmc Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 127:1468-73. 2009
    ..To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus...
  36. ncbi request reprint Opioid growth factor regulates the cell cycle of human neoplasias
    I S Zagon
    Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 17:1053-61. 2000
    ..The data on blockade of OGF-OGFr during log phase growth suggest a requisite escorting of the growth peptide and its receptor through the cell cycle...
  37. ncbi request reprint Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activity
    I S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res 882:169-79. 2000
    ..Mitotic cells in the limbus and conjunctiva may be related to replenishment of ocular surface epithelial cells used in the repair process rather than directly supplying the abraded surface...
  38. ncbi request reprint Epithelial adhesion complexes and organ culture of the human cornea
    I S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res 900:205-13. 2001
    ....
  39. ncbi request reprint Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse
    I S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res Mol Brain Res 84:106-14. 2000
    ..These results emphasize the molecular validity of OGFr, and explain the interaction of OGF with respect to normal and abnormal growth in mouse cells and tissues...
  40. pmc Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Exp Eye Res 89:686-92. 2009
    ..These data demonstrate that although NTX or INS accelerates wound healing, concomitant application of NTX and INS to corneal abrasions in diabetic animals does not have an additive effect on re-epithelialization...
  41. ncbi request reprint The opioid growth factor, [Met5]-enkephalin, inhibits DNA synthesis during recornification of mouse tail skin
    R P Wilson
    Department of Comparative Medicine, College of Medicine, The Pennsylvania State University, Hershey 17033 2390, USA
    Cell Prolif 33:63-73. 2000
    ....
  42. ncbi request reprint Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans
    I S Zagon
    Department of Neuroscience, H 109, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey PA, USA
    Brain Res 856:75-83. 2000
    ..3. This OGF receptor has no homology to classical opioid receptors. These results provide molecular validity for the interaction of OGF and OGF receptor in the regulation of growth processes in humans...
  43. ncbi request reprint Topically applied naltrexone restores corneal reepithelialization in diabetic rats
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Ocul Pharmacol Ther 23:89-102. 2007
    ..Complications of diabetes include an increased risk of delayed corneal epithelial wound healing. This study examined the efficacy of naltrexone (NTX), an opioid antagonist, by topical application in facilitating the repair of such lesions...
  44. doi request reprint Passive diffusion of naltrexone into human and animal cells and upregulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 297:R844-52. 2009
    ..Taken together, these results suggested that NTX enters cells by passive diffusion in a nonsaturable manner...
  45. doi request reprint Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis
    Renee N Donahue
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1716-25. 2009
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in human ovarian cancer. This information will be important in designing treatment strategies for this deadly disease...
  46. ncbi request reprint Temporal variation in cellular proliferation during recornification of mouse tail skin
    R P Wilson
    Department of Comparative Medicine, College of Medicine, Pennsylvania State University, Hershey 17033 2390, USA
    Cell Prolif 31:191-201. 1998
    ....
  47. ncbi request reprint Cellular dynamics of corneal wound re-epithelialization in the rat. I. Fate of ocular surface epithelial cells synthesizing DNA prior to wounding
    I S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033
    Brain Res 822:149-63. 1999
    ..However, wound healing appears to require cells with a basal phenotype, presumably because of this cell type's migratory capability...
  48. ncbi request reprint Re-epithelialization of the rabbit cornea is regulated by opioid growth factor
    I S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res 803:61-8. 1998
    ..These results show that an opioid peptide, OGF, plays a direct role in the repair of injury to the corneal epithelium in the rabbit and acts as a receptor-mediated and constitutively expressed inhibitory molecule...
  49. ncbi request reprint Cloning, sequencing, expression and function of a cDNA encoding a receptor for the opioid growth factor, [Met(5)]enkephalin
    I S Zagon
    Department of Neuroscience, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA, USA
    Brain Res 849:147-54. 1999
    ..The molecular organization of the OGFr has no homology to classical opioid receptors. These results provide molecular validity for the interaction of OGF and OGFr in the regulation of growth processes...
  50. ncbi request reprint Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck
    Jeffrey R Jaglowski
    Department of Neural and Behavioral Sciences H109, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Cancer Chemother Pharmacol 56:97-104. 2005
    ..These data suggest that combined chemotherapy (i.e., paclitaxel) and biotherapy (OGF) provides a valuable alternative to the standard of care for SCCHN patients...
  51. ncbi request reprint Characterization of opioid binding sites in murine neuroblastoma
    I S Zagon
    Department of Anatomy, M S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    Brain Res 449:80-8. 1988
    ..The function of these sites is unclear, but previous evidence as to the growth regulatory properties of endogenous opioid systems may suggest that either one, or both, binding sites may be involved in carcinogenic events...
  52. pmc The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, and Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Biol Cell 20:319-27. 2009
    ..Collectively, these results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the OGF-OGFr axis to inhibit cell proliferation in normal cells...
  53. pmc The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer
    Diego M Avella
    Department of Surgery, Division of Surgical Oncology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 298:R459-66. 2010
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in HCC. The findings may provide important insight in designing treatment strategies for this deadly disease...
  54. ncbi request reprint The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cancer Res 67:10511-8. 2007
    ..These data are the first to reveal that the target of cell proliferative inhibitory action of OGF in human HNSCC is a cyclin-dependent kinase inhibitory pathway, and this may be useful in the diagnosis and treatment of HNSCC...
  55. pmc Regulation of Tenon's capsule fibroblast cell proliferation by the opioid growth factor and the opioid growth factor receptor axis
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 51:5054-61. 2010
    ..This study examined whether the interaction of the opioid growth factor (OGF) [Met(5)]-enkephalin with its receptor (OGFr) is a regulator of TCF proliferation...
  56. ncbi request reprint Quantitative analysis of gastrin mRNA and peptide in normal and cancerous human pancreas
    J P Smith
    Department of Medicine and Neuroscience, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 2:309-15. 1998
    ..In contrast to the normal pancreas and gastrinoma tumor, the aggressive behavior of pancreatic adenocarcinoma may be attributed to the autocrine production of gastrin and to the presence of its growth-related receptor...
  57. ncbi request reprint Chronic exposure to the opioid antagonist naltrexone during pregnancy: maternal and offspring effects
    P J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey 17033, USA
    Physiol Behav 62:501-8. 1997
    ....
  58. doi request reprint Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin beta and Ran for nucleocytoplasmic trafficking
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 235:1093-101. 2010
    ..These hierarchical levels of nuclear import provide multiple pathways for the subtle regulation of OGF-OGFr as it relates to the control of cell proliferative events...
  59. pmc Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Brain Res Bull 81:236-47. 2010
    ..g., vitrectomy), and that conventional therapies such as artificial tears and bandage contact lenses often fail, topical application of NTX merits clinical consideration...
  60. ncbi request reprint Elevated levels of opioid growth factor in the plasma of patients with pancreatic cancer
    J P Smith
    Department of Medicine, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Pancreas 21:158-64. 2000
    ..These data indicate that pancreatic cancer is associated with a marked increase in plasma OGF levels and suggest that this peptide may serve as a useful diagnostic tool in the screening for this disease...
  61. pmc Internalization of the opioid growth factor, [Met5]-enkephalin, is dependent on clathrin-mediated endocytosis for downregulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 299:R774-85. 2010
    ..RhoOGF clathrin-mediated endocytosis was unrelated to endosomal or Golgi pathways. Taken together, these results suggest that OGF enters cells by active transport in a saturable manner that requires clathrin-mediated endocytosis...
  62. ncbi request reprint Characterization of the CCK-C (cancer) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 10:689-94. 2002
    ..The term CCK-C or 'cancer' receptor has been proposed to signify the relationship of this receptor to neoplasia...
  63. ncbi request reprint Differential effects of vascular growth factors on arterial and venous angiogenesis
    John Blebea
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    J Vasc Surg 35:532-8. 2002
    ..The differential effects on veins and arteries, however, by any vascular growth factor, have not previously been investigated...
  64. ncbi request reprint Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: maternal and preweaning effects
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, H 109, 500 University Drive, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 71:171-81. 2002
    ....
  65. ncbi request reprint Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Cornea 24:614-9. 2005
    ..This study was designed to determine at the molecular level whether interactions between the opioid growth factor (OGF) and OGF receptor (OGFr) play a role in regulating DNA synthesis in the homeostasis of the corneal epithelium...
  66. doi request reprint Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Exp Biol Med (Maywood) 235:1292-9. 2010
    ..These results suggest that the target of imiquimod on DNA synthesis is dependent on an opioid receptor-mediated pathway, and infers that imiquimod is reliant on the OGF-OGFr axis for modulating cell proliferation...
  67. ncbi request reprint Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, Division of Otolaryngology, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Cancer 97:1701-10. 2003
    ..This study compared protein and gene expression of OGFr in surgical specimens of human squamous cell carcinoma of the head and neck (SCCHN) with normal epithelium...
  68. ncbi request reprint Opioids and the apoptotic pathway in human cancer cells
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, H 109, Hershey, PA 17033, USA
    Neuropeptides 37:79-88. 2003
    ....
  69. ncbi request reprint Opioid growth factor modulation of corneal epithelium: uppers and downers
    Joseph W Sassani
    Department of Ophthalmology, Penn State s Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Curr Eye Res 26:249-62. 2003
    ..This paper presents a concise review of the role of the intrinsic opioid growth regulation system (IOGRS) in homeostasis and wound repair of the corneal epithelium...
  70. ncbi request reprint Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 19:421-8. 2007
    ..These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias...
  71. ncbi request reprint Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:227-32. 2004
    ....
  72. ncbi request reprint Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 28:1577-83. 2006
    ..Gene therapy to reinstate more OGFr, and thus enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression...
  73. ncbi request reprint Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 26:809-16. 2005
    ..These data suggest that the combination of a biotherapy (OGF) and chemotherapy (paclitaxel and carboplatin) may provide an enhanced antitumor effect with respect to SCCHN...
  74. ncbi request reprint Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States
    Neuropeptides 41:441-52. 2007
    ....
  75. ncbi request reprint The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Pancreas 29:271-7. 2004
    ..The aim of this study was to evaluate whether the CCK-C receptor, a splice variant of the CCK-B receptor, in human pancreatic cancer cells was associated with accelerated cancer cell growth...
  76. ncbi request reprint Treatment of advanced pancreatic cancer with opioid growth factor: phase I
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Anticancer Drugs 15:203-9. 2004
    ..Further studies are needed to determine the efficacy of OGF alone or in combination with present modes of therapy for the treatment of pancreatic cancer...
  77. ncbi request reprint Functional significance of gastrin gene expression in human cancer cells
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Regul Pept 117:167-73. 2004
    ..These studies demonstrate that gastrin and the CCK-C receptor form an autocrine loop in human pancreatic cancer that plays a role in regulating growth...
  78. ncbi request reprint The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cells
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Centre, College of Medicine, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Neuropeptides 37:290-7. 2003
    ..These results indicate that the OGF-OGFr axis is present and functions in COS-7 cells, and in the absence of classical opioid receptors...
  79. ncbi request reprint Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Int J Oncol 33:751-7. 2008
    ....
  80. ncbi request reprint Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice
    Patricia J McLaughlin
    Departments of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3727, Hershey, PA 17033 0850, USA
    Cancer Lett 199:209-17. 2003
    ..These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application...
  81. doi request reprint Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer
    David Goldenberg
    Division of Otolaryngology, Department of Surgery, H091, College of Medicine, The Penn State University, Hershey, Pennsylvania 17033, USA
    Thyroid 18:1165-70. 2008
    ..In the present study we examined the presence and distribution of OGF and OGFr in nonmedullary thyroid cancer, including papillary, follicular, and anaplastic, as well as thyroid tissue from patients with nonmalignant disease...
  82. doi request reprint Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 234:532-41. 2009
    ..These results indicate that the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors...
  83. ncbi request reprint Localization of spectrin isoforms in the adult mouse heart
    T Isayama
    Department of Neuroscience and Anatomy, Pennsylvania State University, Milton S Hershey Medical Center, Hershey 17033
    Cell Tissue Res 274:127-33. 1993
    ..This is the first demonstration of two different alpha-spectrin subunits in the mammalian heart...
  84. ncbi request reprint Low-dose naltrexone therapy improves active Crohn's disease
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Gastroenterol 102:820-8. 2007
    ..In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn's disease...

Research Grants2

  1. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  2. Naltrexone as a Novel Treatment for Diabetic Keratopathy
    IAN ZAGON; Fiscal Year: 2007
    ..The proposed use of biotherapy with NTX is an innovative approach whereby the patient's own growth regulatory mechanisms are manipulated to correct complications from diabetes. ..