Jun Yang

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    Jun Yang
    Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    Blood 115:51-60. 2010
  2. pmc Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia
    Jun Yang
    Penn State Cancer Institute, Department of Medicine, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Blood 111:1610-6. 2008
  3. pmc Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
    Aijun Liao
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Blood 118:2793-800. 2011
  4. pmc Network model of survival signaling in large granular lymphocyte leukemia
    Ranran Zhang
    Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 105:16308-13. 2008
  5. pmc Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
    Xin Liu
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Blood 116:4192-201. 2010
  6. doi request reprint An association between microscopic colitis and celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Clin Gastroenterol Hepatol 7:1210-6. 2009
  7. pmc Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses
    Gary A Visner
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
    Transplantation 88:330-8. 2009
  8. ncbi request reprint Cutting edge: L-selectin (CD62L) expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigen
    Richard L Hengel
    Division of Infectious Diseases, Department of Medicine, Georgetown University School of Medicine, Washington, DC 20053, USA
    J Immunol 170:28-32. 2003
  9. ncbi request reprint Metanephric mesenchyme contains embryonic renal stem cells
    Juan A Oliver
    Department of Medicine, Columbia University, New York 10032, USA
    Am J Physiol Renal Physiol 283:F799-809. 2002
  10. ncbi request reprint Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat
    Jun Yang
    Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529000, China
    Neurosci Lett 412:154-8. 2007

Collaborators

  • Xin Liu
  • Mark Kester
  • Fanxue Meng
  • Wayne W Hancock
  • Jong K Yun
  • Gary A Visner
  • Richard L Hengel
  • Irini Sereti
  • Juan A Oliver
  • Jing Fei Dong
  • S Kottilil
  • Hong Zhang
  • Scott F Gallagher
  • Thais Federici
  • Atsuhisa Ueda
  • Yoshiaki Ishigatsubo
  • Michel M Murr
  • Takeyuki Suzuki
  • Nobuaki Kobayashi
  • Da Luo
  • Jing Zhang
  • Jiang Hong Luo
  • Aijun Liao
  • Thomas P Loughran
  • Mithun Vinod Shah
  • Peter H R Green
  • Rebecca Stadel
  • Masatsugu Tanaka
  • Ranran Zhang
  • Haruko Ideguchi
  • Zheng Wang
  • Tadayuki Yago
  • Mitsuhiro Takeno
  • Mohammad Ishaq
  • Hong Gao
  • Lin Weng
  • Qingshan Teng
  • James K Liu
  • Nicholas M Boulis
  • Yue Xia Jia
  • Antje Habicht
  • Bin Geng
  • Jaw Kang Chang
  • Chun Shui Pan
  • Jing Zhao
  • Yong Fen Qi
  • Chao Shu Tang
  • Xiao He Hu
  • Zhong Zhao
  • Zhi cheng Dong
  • Yanhua Peng
  • Krista Haines
  • Kathryn Baksh
  • P K Epling-Burnette
  • Zheng song Peng
  • Ming juan Zhang
  • J Randall Good
  • Karim Fizazi
  • Svetlana Minakhina
  • Leah Hirsch
  • Lindsay Ryland
  • Nancy Ruth Jarbadan
  • Andrew Rogers
  • Alden Dewey
  • Kathleen Broeg
  • Shantu Amin
  • Kendall Thomas Baab
  • Kelly Loughran
  • Todd Fox
  • Jason Liao
  • Cesar Aliaga
  • Lucy Q Zhang
  • Hong Gang Wang
  • Dhimant Desai
  • Su Fern Tan
  • Yongping Li
  • Rebecca Watters
  • Govind Bhagat
  • Jianfeng Cheng
  • Anne R Lee
  • Jason W Harper
  • Satoshi Tabata
  • Masaki Yamamoto
  • Julia W Nalwalk
  • Jose A Lopez
  • Xianzhong Feng
  • Tao Wu
  • Jonathan J Miner
  • Mike Ambrose
  • Lindsay B Hough

Detail Information

Publications44

  1. pmc Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    Jun Yang
    Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    Blood 115:51-60. 2010
    ..These results suggest that targeting of PDGF-BB, a pivotal regulator for the long-term survival of leukemic LGLs, may be an important therapeutic strategy...
  2. pmc Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia
    Jun Yang
    Penn State Cancer Institute, Department of Medicine, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Blood 111:1610-6. 2008
    ..Our results demonstrate that expanded T cells in patients with LGL leukemia display both functional and phenotypic characteristics of prior antigen activation in vivo and display reduced capacity for Fas-mediated DISC formation...
  3. pmc Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
    Aijun Liao
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Blood 118:2793-800. 2011
    ..These data demonstrate that therapeutic benefit of FTY720 may result from both altered sphingolipid metabolism as well as enhanced degradation of a key component of survival signaling...
  4. pmc Network model of survival signaling in large granular lymphocyte leukemia
    Ranran Zhang
    Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 105:16308-13. 2008
    ..The model will be useful in identifying potential therapeutic targets for T-LGL leukemia and generating long-term competent CTL necessary for tumor and cancer vaccine development...
  5. pmc Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
    Xin Liu
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Blood 116:4192-201. 2010
    ..These data suggest that in vivo targeting of survivin through delivery of nanoliposomal C₆-ceramide may be a promising therapeutic approach for a fatal leukemia...
  6. doi request reprint An association between microscopic colitis and celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Clin Gastroenterol Hepatol 7:1210-6. 2009
    ..Microscopic colitis has been associated with celiac disease. We aimed to determine the extent and significance of this relationship...
  7. pmc Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses
    Gary A Visner
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
    Transplantation 88:330-8. 2009
    ..In this study, we tested the hypothesis that pirfenidone has immune modulating activities and evaluated its effects on the function of T-cell subsets, which play important roles in allograft rejection...
  8. ncbi request reprint Cutting edge: L-selectin (CD62L) expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigen
    Richard L Hengel
    Division of Infectious Diseases, Department of Medicine, Georgetown University School of Medicine, Washington, DC 20053, USA
    J Immunol 170:28-32. 2003
    ..These findings suggest that CD62L expression facilitates immune surveillance by programming CD4+ T cell blood and lymph node recirculation, irrespective of naive or memory CD4+ T cell phenotype...
  9. ncbi request reprint Metanephric mesenchyme contains embryonic renal stem cells
    Juan A Oliver
    Department of Medicine, Columbia University, New York 10032, USA
    Am J Physiol Renal Physiol 283:F799-809. 2002
    ..The pluripotency of the 7.1.1 cells is self-renewing. The data suggest that the metanephric mesenchyme contains embryonic renal stem cells...
  10. ncbi request reprint Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat
    Jun Yang
    Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529000, China
    Neurosci Lett 412:154-8. 2007
    ..The data suggest that AVP in PAG, which relates with pain modulation, comes from PVN...
  11. ncbi request reprint Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals
    Jun Yang
    The Berman Gund Laboratory for Study of Retinal Degenerations, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hum Mol Genet 16:1017-29. 2007
    ..We propose that Mpp4 organizes a presynaptic protein complex that includes PMCAs and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors...
  12. ncbi request reprint A means for targeting therapeutics to peripheral nervous system neurons with axonal damage
    Thais Federici
    Neurosurgery 60:911-8; discussion 911-8. 2007
    ..Because nerve cell bodies are important in initiating and controlling axonal regeneration, targeted delivery is an appealing strategy to deliver therapeutic proteins after peripheral nerve injury...
  13. ncbi request reprint RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex
    Nobuaki Kobayashi
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama City 236 0004, Japan
    Gene 396:236-47. 2007
    ..Finally, we confirmed the cellular localization of these proteins. Taken together, our results reveal that RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells...
  14. ncbi request reprint Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:151-9. 2007
    ..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression...
  15. ncbi request reprint Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cells
    Mohammad Ishaq
    Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 179:3851-8. 2007
    ..To summarize, our data demonstrate an important role for Zap70 signaling in GR-mediated transactivation in T lymphocytes and also point out a crucial role of this kinase in maintaining normal ANXA1 levels in these cells...
  16. pmc Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain
    Jun Yang
    Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Mol Biol 8:101. 2007
    ..In this study, we aimed to identify if HDGF is a DNA binding protein, map the functional DNA binding domain and DNA binding element for HDGF...
  17. ncbi request reprint GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes
    Hong Gao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
    Endocrine 32:90-5. 2007
    ..These results indicate that GLP-1 and its analogue exendin-4 can amplify insulin signaling in 3T3-L1 adipocytes by up-regulation of some crucial insulin signaling molecules...
  18. pmc High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain
    Rebecca Stadel
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
    Drug Metab Dispos 36:614-21. 2008
    ..Finally, CC12 is a new, potent inhibitor of CYP2B6 and CYP2C19 that may be a valuable tool for P450 research...
  19. doi request reprint Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alpha
    Takeyuki Suzuki
    Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Biochem J 411:581-91. 2008
    ..Furthermore, ARMc8 knockdown inhibited alpha-catenin degradation and prolonged the half-life of alpha-catenin. We conclude that ARMc8alpha associates with alpha-catenin and up-regulates its degradation...
  20. pmc Genetic control of floral zygomorphy in pea (Pisum sativum L.)
    Zheng Wang
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Proc Natl Acad Sci U S A 105:10414-9. 2008
    ..Based on the genetic analysis in pea, we suggest that variation in both the functions and interactions of these regulators could give rise to the wide spectrum of floral symmetries among legume species and other flowering plants...
  21. pmc Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
    Tadayuki Yago
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 118:3195-207. 2008
    ..We conclude that in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbalpha on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding...
  22. ncbi request reprint Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB
    Michel M Murr
    Department of Surgery, James A Haley VA Hospital, University of South Florida, Tampa, Florida, USA
    J Gastrointest Surg 7:20-5. 2003
    ..The seemingly limited duration of NF-kappaB activation may be important in "switching off" the cytokine cascade during acute pancreatitis...
  23. ncbi request reprint Arginine vasopressin enhances periaqueductal gray synthesis and secretion of enkephalin and endorphin in the rat
    Jun Yang
    Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529000, China
    Brain Res Bull 71:193-9. 2006
    ..The data suggest that AVP enhances PAG synthesizing and secreting enkephalin and endorphin rather than dynorphin through V(2) receptors...
  24. ncbi request reprint Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats
    Yue Xia Jia
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
    Eur J Pharmacol 549:117-23. 2006
    ..These results suggest that the intermedin receptor system was up-regulated in isoproterenol-induced myocardial ischemic injury and intermedin1-53 might play a pivotal cardioprotective role in such injury...
  25. ncbi request reprint Neuronal affinity of a C7C loop peptide identified through phage display
    Thais Federici
    Department of Neuroscience and Center for Neurological Restoration, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA
    J Drug Target 14:263-71. 2006
    ..The neuronal binding properties of this peptide may be applied in the development of neurotropic viral vectors...
  26. ncbi request reprint Characterization of the common wheat (Triticum aestivum L.) mutation line producing three pistils in a floret
    Zheng song Peng
    Department of Biology, China West Normal University, Nanchong, Sichuan, PR China
    Hereditas 141:15-8. 2004
    ..According to the Recommended rules for gene symbolization in wheat, the name of the dominant gene for three pistils trait in the line TP was suggested as Pis1...
  27. pmc Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers
    Jun Yang
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Biophys J 87:1951-63. 2004
    ..However, the functional assays do suggest that small oligomers may be more fusogenic than either monomers or large aggregates...
  28. ncbi request reprint New ouabain-conjugated peptide found from phage displayed peptide library
    Ming juan Zhang
    Department of Cardiology, the Second Hospital and School of Medicine, Xi an Jiao Tong University, Xi an, People s Republic of China
    Am J Hypertens 17:619-23. 2004
    ..The purpose of this study was to find ouabain-conjugated peptides (OCP) to block or to antagonize actions between endogenous ouabain (EO) and sodium pump, to serve as theoretical and experimental bases of EO in hypertension...
  29. ncbi request reprint Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblasts
    Karim Fizazi
    Departments of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2587-97. 2003
    ....
  30. ncbi request reprint TagA, a putative serine protease/ABC transporter of Dictyostelium that is required for cell fate determination at the onset of development
    J Randall Good
    Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 130:2953-65. 2003
    ....
  31. ncbi request reprint Tamo selectively modulates nuclear import in Drosophila
    Svetlana Minakhina
    Waksman Institute, Department of Molecular Biology and Biochemistry, NJ Cancer Center, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Genes Cells 8:299-310. 2003
    ..An important aspect of all NF-kappaB/Rel pathways is the translocation of the Rel proteins from the cytoplasm to the nucleus, where they function as transcription factors...
  32. pmc Centrifugation of human lung epithelial carcinoma a549 cells up-regulates interleukin-1beta gene expression
    Jun Yang
    Clin Diagn Lab Immunol 9:1142-3. 2002
  33. pmc Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM
    Haruko Ideguchi
    First Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Japan
    Biochem J 367:87-95. 2002
    ..Finally, ubiquitin conjugation to RanBPM was inhibited in a dose-dependent manner by the addition of recombinant USP11. We conclude that RanBPM was the enzymic substrate for USP11 and was deubiquitinated specifically...
  34. ncbi request reprint Acute pancreatitis induces FasL gene expression and apoptosis in the liver
    Scott F Gallagher
    Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
    J Surg Res 122:201-9. 2004
    ..We previously demonstrated that Kupffer cell-derived cytokines mediate liver injury. In this work, we sought to characterize the role of Fas Ligand (FasL) in liver injury during acute pancreatitis...
  35. ncbi request reprint Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat hearts
    Jing Hui Yang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Peptides 26:501-7. 2005
    ..01), respectively. Interestingly, the above IMD effects were similar to those of adrenomedullin (10(-8)mol/L). These results suggest that IMD, like adrenomedullin, exerts cardio-protective effects against myocardial I/R injury...
  36. ncbi request reprint Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae
    Hong Zhang
    Z BioMed Inc, 15725 Crabbs Branch Way, Rockville, MD 20855, USA
    Microbes Infect 8:2172-85. 2006
    ..The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly...
  37. ncbi request reprint Only arginine vasopressin, not oxytocin and endogenous opiate peptides, in hypothalamic paraventricular nucleus play a role in acupuncture analgesia in the rat
    Jun Yang
    Department of Nuclear Medicine, Nanfang Hospital, Guangzhou 510515, China
    Brain Res Bull 68:453-8. 2006
    ..The results suggested that only AVP, not OXT and endogenous opiate peptides in PVH involved acupuncture analgesia in the rat...
  38. ncbi request reprint Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas
    Jing Hui Yang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Biochem Biophys Res Commun 341:567-72. 2006
    ..All these results suggest that IMD1-53 might regulate vessel function homeostasis via upregulating the L-Arg/NOS/NO pathway...
  39. ncbi request reprint Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection
    Antje Habicht
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA 02115, USA
    J Immunol 176:36-42. 2006
    ..These data have important implications for targeting the sphingosine 1-phosphate receptor 1 in solid organ transplantation...
  40. ncbi request reprint Different expression patterns of duplicated PHANTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf development
    Jiang Hong Luo
    National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Shanghai 200032, China
    Cell Res 15:665-77. 2005
    ..Our data suggest that LjPHANa and LjPHANb play important but divergent roles in regulating adaxial-abaxial polarity of compound leaves in L. japonicus...
  41. ncbi request reprint Effect of relaxin on myocardial ischemia injury induced by isoproterenol
    Jing Zhang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Peptides 26:1632-9. 2005
    ....
  42. pmc Floral patterning in Lotus japonicus
    Zhi cheng Dong
    National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Physiol 137:1272-82. 2005
    ..Our findings suggest that gene duplication, change in expression pattern, gain or loss of functional domains, and alteration of key gene functions all contribute to the divergence of floral patterning in L. japonicus...
  43. ncbi request reprint Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis
    Scott F Gallagher
    Departments of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
    J Gastrointest Surg 9:467-74; discussion 474-5. 2005
    ..The manipulation of interactions between Kupffer cell-derived FasL and hepatocytes may have important therapeutic implications...
  44. ncbi request reprint Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1
    Masatsugu Tanaka
    First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Biol Chem 277:10719-26. 2002
    ..We conclude that the transcription of aurora A is positively regulated by E4TF1, a ubiquitously expressed ETS family protein, and that the CDE/CHR element was essential for the G(2)/M-specific transcription of aurora A...