Research Topics
| Jun YangSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathwayJun Yang
Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
Blood 115:51-60. 2010..These results suggest that targeting of PDGF-BB, a pivotal regulator for the long-term survival of leukemic LGLs, may be an important therapeutic strategy...- Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemiaJun Yang
Penn State Cancer Institute, Department of Medicine, College of Medicine, Penn State University, Hershey, PA 17033, USA
Blood 111:1610-6. 2008..Our results demonstrate that expanded T cells in patients with LGL leukemia display both functional and phenotypic characteristics of prior antigen activation in vivo and display reduced capacity for Fas-mediated DISC formation... - Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemiaAijun Liao
Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Blood 118:2793-800. 2011..These data demonstrate that therapeutic benefit of FTY720 may result from both altered sphingolipid metabolism as well as enhanced degradation of a key component of survival signaling... - Network model of survival signaling in large granular lymphocyte leukemiaRanran Zhang
Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Proc Natl Acad Sci U S A 105:16308-13. 2008..The model will be useful in identifying potential therapeutic targets for T-LGL leukemia and generating long-term competent CTL necessary for tumor and cancer vaccine development... - Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemiaXin Liu
Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
Blood 116:4192-201. 2010..These data suggest that in vivo targeting of survivin through delivery of nanoliposomal C₆-ceramide may be a promising therapeutic approach for a fatal leukemia... 
An association between microscopic colitis and celiac diseasePeter H R Green
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
Clin Gastroenterol Hepatol 7:1210-6. 2009..Microscopic colitis has been associated with celiac disease. We aimed to determine the extent and significance of this relationship...- Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponsesGary A Visner
Department of Medicine, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA
Transplantation 88:330-8. 2009..In this study, we tested the hypothesis that pirfenidone has immune modulating activities and evaluated its effects on the function of T-cell subsets, which play important roles in allograft rejection... 
Cutting edge: L-selectin (CD62L) expression distinguishes small resting memory CD4+ T cells that preferentially respond to recall antigenRichard L Hengel
Division of Infectious Diseases, Department of Medicine, Georgetown University School of Medicine, Washington, DC 20053, USA
J Immunol 170:28-32. 2003..These findings suggest that CD62L expression facilitates immune surveillance by programming CD4+ T cell blood and lymph node recirculation, irrespective of naive or memory CD4+ T cell phenotype...- Metanephric mesenchyme contains embryonic renal stem cellsJuan A Oliver
Department of Medicine, Columbia University, New York 10032, USA
Am J Physiol Renal Physiol 283:F799-809. 2002..The pluripotency of the 7.1.1 cells is self-renewing. The data suggest that the metanephric mesenchyme contains embryonic renal stem cells... - Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the ratJun Yang
Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529000, China
Neurosci Lett 412:154-8. 2007..The data suggest that AVP in PAG, which relates with pain modulation, comes from PVN... - Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminalsJun Yang
The Berman Gund Laboratory for Study of Retinal Degenerations, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Hum Mol Genet 16:1017-29. 2007..We propose that Mpp4 organizes a presynaptic protein complex that includes PMCAs and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors... - A means for targeting therapeutics to peripheral nervous system neurons with axonal damageThais Federici
Neurosurgery 60:911-8; discussion 911-8. 2007..Small peptides can be easily fused to larger proteins without significantly modifying their function and can be used to alter the binding and uptake properties of these proteins... - RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complexNobuaki Kobayashi
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama City 236 0004, Japan
Gene 396:236-47. 2007..Finally, we confirmed the cellular localization of these proteins. Taken together, our results reveal that RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells... - Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremiaShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 46:151-9. 2007..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression... - Zap70 signaling pathway mediates glucocorticoid receptor-dependent transcriptional activation: role in the regulation of annexin 1 expression in T cellsMohammad Ishaq
Laboratory of Molecular Cell Biology, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 179:3851-8. 2007..To summarize, our data demonstrate an important role for Zap70 signaling in GR-mediated transactivation in T lymphocytes and also point out a crucial role of this kinase in maintaining normal ANXA1 levels in these cells... - Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domainJun Yang
Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
BMC Mol Biol 8:101. 2007..In this study, we aimed to identify if HDGF is a DNA binding protein, map the functional DNA binding domain and DNA binding element for HDGF... - GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytesHong Gao
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
Endocrine 32:90-5. 2007..These results indicate that GLP-1 and its analogue exendin-4 can amplify insulin signaling in 3T3-L1 adipocytes by up-regulation of some crucial insulin signaling molecules... - High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brainRebecca Stadel
Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Ave, Albany, NY 12208, USA
Drug Metab Dispos 36:614-21. 2008..Finally, CC12 is a new, potent inhibitor of CYP2B6 and CYP2C19 that may be a valuable tool for P450 research... - Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8alphaTakeyuki Suzuki
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Biochem J 411:581-91. 2008..Furthermore, ARMc8 knockdown inhibited alpha-catenin degradation and prolonged the half-life of alpha-catenin. We conclude that ARMc8alpha associates with alpha-catenin and up-regulates its degradation... - Genetic control of floral zygomorphy in pea (Pisum sativum L.)Zheng Wang
National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Proc Natl Acad Sci U S A 105:10414-9. 2008..Based on the genetic analysis in pea, we suggest that variation in both the functions and interactions of these regulators could give rise to the wide spectrum of floral symmetries among legume species and other flowering plants... - Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWFTadayuki Yago
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Clin Invest 118:3195-207. 2008..We conclude that in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbalpha on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding... - Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaBMichel M Murr
Department of Surgery, James A Haley VA Hospital, University of South Florida, Tampa, Florida, USA
J Gastrointest Surg 7:20-5. 2003..The seemingly limited duration of NF-kappaB activation may be important in "switching off" the cytokine cascade during acute pancreatitis... - Arginine vasopressin enhances periaqueductal gray synthesis and secretion of enkephalin and endorphin in the ratJun Yang
Institute for Pharmaceuticals and Medical Science, Guangdong Bangmin Pharmaceutical Co Ltd, Jianghai Distract, Jiangmen, Guangdong 529000, China
Brain Res Bull 71:193-9. 2006..The data suggest that AVP enhances PAG synthesizing and secreting enkephalin and endorphin rather than dynorphin through V(2) receptors... - Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in ratsYue Xia Jia
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
Eur J Pharmacol 549:117-23. 2006..These results suggest that the intermedin receptor system was up-regulated in isoproterenol-induced myocardial ischemic injury and intermedin1-53 might play a pivotal cardioprotective role in such injury... - Neuronal affinity of a C7C loop peptide identified through phage displayThais Federici
Department of Neuroscience and Center for Neurological Restoration, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA
J Drug Target 14:263-71. 2006..The neuronal binding properties of this peptide may be applied in the development of neurotropic viral vectors... - Characterization of the common wheat (Triticum aestivum L.) mutation line producing three pistils in a floretZheng song Peng
Department of Biology, China West Normal University, Nanchong, Sichuan, PR China
Hereditas 141:15-8. 2004..According to the Recommended rules for gene symbolization in wheat, the name of the dominant gene for three pistils trait in the line TP was suggested as Pis1... - Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomersJun Yang
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
Biophys J 87:1951-63. 2004..However, the functional assays do suggest that small oligomers may be more fusogenic than either monomers or large aggregates... - New ouabain-conjugated peptide found from phage displayed peptide libraryMing juan Zhang
Department of Cardiology, the Second Hospital and School of Medicine, Xi an Jiao Tong University, Xi an, People s Republic of China
Am J Hypertens 17:619-23. 2004..The purpose of this study was to find ouabain-conjugated peptides (OCP) to block or to antagonize actions between endogenous ouabain (EO) and sodium pump, to serve as theoretical and experimental bases of EO in hypertension... - Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblastsKarim Fizazi
Departments of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2587-97. 2003..These data also provide a rationale for developing therapeutic strategies designed to target these molecular changes... - TagA, a putative serine protease/ABC transporter of Dictyostelium that is required for cell fate determination at the onset of developmentJ Randall Good
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
Development 130:2953-65. 2003.... - Tamo selectively modulates nuclear import in DrosophilaSvetlana Minakhina
Waksman Institute, Department of Molecular Biology and Biochemistry, NJ Cancer Center, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
Genes Cells 8:299-310. 2003..An important aspect of all NF-kappaB/Rel pathways is the translocation of the Rel proteins from the cytoplasm to the nucleus, where they function as transcription factors... - Centrifugation of human lung epithelial carcinoma a549 cells up-regulates interleukin-1beta gene expressionJun Yang
Clin Diagn Lab Immunol 9:1142-3. 2002 - Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPMHaruko Ideguchi
First Department of Internal Medicine, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Japan
Biochem J 367:87-95. 2002..Finally, ubiquitin conjugation to RanBPM was inhibited in a dose-dependent manner by the addition of recombinant USP11. We conclude that RanBPM was the enzymic substrate for USP11 and was deubiquitinated specifically... - Acute pancreatitis induces FasL gene expression and apoptosis in the liverScott F Gallagher
Department of Surgery, James A Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
J Surg Res 122:201-9. 2004..We previously demonstrated that Kupffer cell-derived cytokines mediate liver injury. In this work, we sought to characterize the role of Fas Ligand (FasL) in liver injury during acute pancreatitis... - Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat heartsJing Hui Yang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Peptides 26:501-7. 2005..01), respectively. Interestingly, the above IMD effects were similar to those of adrenomedullin (10(-8)mol/L). These results suggest that IMD, like adrenomedullin, exerts cardio-protective effects against myocardial I/R injury... - Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniaeHong Zhang
Z BioMed Inc, 15725 Crabbs Branch Way, Rockville, MD 20855, USA
Microbes Infect 8:2172-85. 2006..The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly... - Only arginine vasopressin, not oxytocin and endogenous opiate peptides, in hypothalamic paraventricular nucleus play a role in acupuncture analgesia in the ratJun Yang
Department of Nuclear Medicine, Nanfang Hospital, Guangzhou 510515, China
Brain Res Bull 68:453-8. 2006..The results suggested that only AVP, not OXT and endogenous opiate peptides in PVH involved acupuncture analgesia in the rat... - Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortasJing Hui Yang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Biochem Biophys Res Commun 341:567-72. 2006..All these results suggest that IMD1-53 might regulate vessel function homeostasis via upregulating the L-Arg/NOS/NO pathway... - Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejectionAntje Habicht
Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital, Boston, MA 02115, USA
J Immunol 176:36-42. 2006..These data have important implications for targeting the sphingosine 1-phosphate receptor 1 in solid organ transplantation... - Different expression patterns of duplicated PHANTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf developmentJiang Hong Luo
National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Shanghai 200032, China
Cell Res 15:665-77. 2005..Our data suggest that LjPHANa and LjPHANb play important but divergent roles in regulating adaxial-abaxial polarity of compound leaves in L. japonicus... - Effect of relaxin on myocardial ischemia injury induced by isoproterenolJing Zhang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Peptides 26:1632-9. 2005.... - Floral patterning in Lotus japonicusZhi-cheng Dong
National Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Plant Physiol 137:1272-82. 2005..Our findings suggest that gene duplication, change in expression pattern, gain or loss of functional domains, and alteration of key gene functions all contribute to the divergence of floral patterning in L. japonicus... - Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosisScott F Gallagher
Departments of Surgery, James A. Haley Veterans Affairs Medical Center, University of South Florida Health Sciences Center, Tampa, Florida, USA
J Gastrointest Surg 9:467-74; discussion 474-5. 2005..The manipulation of interactions between Kupffer cell-derived FasL and hepatocytes may have important therapeutic implications... - Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1Masatsugu Tanaka
First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
J Biol Chem 277:10719-26. 2002..We conclude that the transcription of aurora A is positively regulated by E4TF1, a ubiquitously expressed ETS family protein, and that the CDE/CHR element was essential for the G(2)/M-specific transcription of aurora A...