Research Topics
Genomes and GenesSpecies | Kenneth WeissSummaryAffiliation: Pennsylvania State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Is life law-like?Kenneth M Weiss
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 188:761-71. 2011..To the extent that this is true, causal effects are not asymptotically predictable, and new ways of understanding life may be required...
The unkindest cupKenneth M Weiss
Department of Anthropology, Penn State University, University Park, PA 16802, USA
Lancet 363:1489-90. 2004- Commentary: evolution of action in cells and organismsKenneth M Weiss
Department of Anthropology, Penn State University, USA
Int J Epidemiol 35:1159-60. 2006 - Perspectives fulfilled: the work and thought of J. V. Neel (1915-2000)Kenneth M Weiss
Department of Anthropology, Penn State University, University Park, PA 16802 3404, USA
Perspect Biol Med 45:46-64. 2002..Because his perspective was populational, he cautioned that the most serious health problems faced by our species should not be approached as if they have a genetic solution... - Linkage disequilibrium and the mapping of complex human traitsKenneth M Weiss
Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802 3404, USA
Trends Genet 18:19-24. 2002..The LD map should be based on adequately justified criteria defined by sound population genetic principles... - Evolution by phenotype: a biomedical perspectiveKenneth M Weiss
Department of Anthropology, Penn State University, University Park, PA 16802, USA
Perspect Biol Med 46:159-82. 2003..We may even be forced to re-conceive complex biological causation... - In search of human variationK M Weiss
Departments of Anthropology and Biology, Pennsylvania State University, University Park, Pennsylvania 16802 USA
Genome Res 8:691-7. 1998..However, both fields have been using conceptual models that are oversimplified, and this may lead to unrealistic expectations of the questions that can be answered from genetic data... - Perspectives on genetic aspects of dental patterningK Weiss
Department of Anthropology, Penn State University, University Park, PA 16082, USA
Eur J Oral Sci 106:55-63. 1998.... - Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipaseA G Clark
Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Am J Hum Genet 63:595-612. 1998..These data suggest that the design and interpretation of disease-association studies may not be as straightforward as often is assumed... - Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teethD W Stock
Department of Anthropology, Pennsylvania State University, University Park 16802, USA
Genomics 37:234-7. 1996..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process... - Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphismS M Fullerton
Institute of Molecular Evolutionary Genetics, Department of Biology, and Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Am J Hum Genet 67:881-900. 2000.... - SCPP gene evolution and the dental mineralization continuumK Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
J Dent Res 87:520-31. 2008..These tissues thus form a mineralized-tissue continuum. Contemporary dental tissues have evolved from an ancestral continuum through lineage-specific modifications... - The evolution of the vertebrate Dlx gene familyD W Stock
Department of Anthropology, Pennsylvania State University, University Park 16802, USA
Proc Natl Acad Sci U S A 93:10858-63. 1996..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue... - Distal-less and other homeobox genes in the development of the dentitionK M Weiss
Department of Anthropology, Penn State University, University Park 16802
J Exp Zool 270:273-84. 1994..The screening approach with degenerate primers is a successful way to identify new as well as previously known regulatory genes expressed in developing tooth embryos... - Dlx and other homeobox genes in the morphological development of the dentitionK M Weiss
Graduate Program in Genetics, Penn State University, University Park, Pennsylvania 16802, USA
Connect Tissue Res 32:35-40. 1995..The Msx and Dlx genes are the best current candidates for a combinatorial mechanism that controls the differentiation of structures within and between teeth, and perhaps also the evolution of those structures... - Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene clusterKazuhiko Kawasaki
Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 100:4060-5. 2003..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates... - Cryptic causation of human disease: reading between the (germ) linesKenneth M Weiss
Departments of Anthropology and Biology, Penn State University, University Park, PA 16802, USA
Trends Genet 21:82-8. 2005..Better technologies to detect and characterize SM are becoming available. However, until it is studied directly, SM will remain a cryptic etiological force, even for diseases that are essentially "genetic"... - Phenogenetic drift in evolution: the changing genetic basis of vertebrate teethKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, 16802, USA
Proc Natl Acad Sci U S A 102:18063-8. 2005..These findings illustrate the complexity of the homology concept in understanding evolution, particularly the evolution of mineralized tissues... - Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein familyKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Exp Zoolog B Mol Dev Evol 306:295-316. 2006..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted... - Out of the veil of death rode the one million! Neandertals and their genesKenneth M Weiss
Department of Anthropology, Penn State University, PA 16802, USA
Bioessays 29:105-10. 2007..The data are an exciting and interesting new contribution, but are not surprising, and a sense of history and question helps put them in perspective... - Gene duplication and the evolution of vertebrate skeletal mineralizationKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Cells Tissues Organs 186:7-24. 2007..As a consequence, phenogenetic drift occurred: while mineralized skeleton is maintained by natural selection, the underlying genetic basis has changed... - Genomic structure and functional control of the Dlx3-7 bigene clusterKenta Sumiyama
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 99:780-5. 2002..This observation is consistent with a cis-regulatory enhancer-sharing model within the Dlx bigene cluster... - ForSim: a tool for exploring the genetic architecture of complex traits with controlled truthBrian W Lambert
Department of Anthropology, Penn State University, University Park, PA, USA
Bioinformatics 24:1821-2. 2008..Simulation is useful for exploring these issues as well as the choice of study design inferential methods. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online... - Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causationKenneth M Weiss
Department of Anthropology and Integrated Biosciences Genetics Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 179:1741-56. 2008.... - The phenogenetic logic of lifeKenneth M Weiss
Department of Anthropology, 409 Carpenter Building, University Park, Penn State University, Pennsylvania 16802, USA
Nat Rev Genet 6:36-45. 2005..This logic provides a general explanation of the nature and source of organismal design, and a powerful programme for research... - Genetic basis for the evolution of vertebrate mineralized tissueKazuhiko Kawasaki
Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 101:11356-61. 2004..We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution... - Thomas Henry Huxley (1825-1895) puts us in our placeKenneth M Weiss
Department of Anthropology, Penn State University, University Park, Pennsylvania, 16802, USA
J Exp Zool B Mol Dev Evol 302:196-206. 2004..Huxley was one of many who have had trouble accepting Darwin's gradual natural selection as the central evolutionary mechanism, and views spanning the antipodes of gradualism and saltation find advocates even in our genetic era... - Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sampleStephanie M Fullerton
Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park 16802, USA
Hum Genet 111:75-87. 2002..The deficit of polymorphism is consistent with a population-specific non-neutral increase in the relative frequency of several haplotypes in Jackson... - The effects of scale: variation in the APOA1/C3/A4/A5 gene clusterStephanie M Fullerton
Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802, USA
Hum Genet 115:36-56. 2004..The implications of these findings for other haplotype-based descriptions of human variation are discussed... - Not guilty by reason of doubt?Kenneth M Weiss
Department of Anthropology, Pennsylvania State University, University Park 16802, USA
Epidemiology 14:122-4; discussion 124-6. 2003 - Richard H. Ward, Ph.D. (June 7, 1943-February 14, 2003): wild ride of the ValkyriesKenneth M Weiss
Department of Anthropolgy, Penn State University, University Park, PA, USA
Am J Hum Genet 72:1079-83. 2003 - Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolismJari H Stengård
National Public Health Institute, Helsinki, Finland
Am J Hum Genet 71:501-17. 2002.... - Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'Joseph D Terwilliger
Department of Psychiatry, Columbia Genome Center, Columbia University, New York, NY 10032, USA
Ann Med 35:532-44. 2003.... - THINK! Being a student of Frank B. LivingstoneKenneth M Weiss
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Hum Biol 75:625-8. 2003 - Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboonsLeslea J Hlusko
Department of Anthropology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Am J Phys Anthropol 117:182-9. 2002..Therefore, if variables like actual crown area and estimated crown area are to be used in phylogenetic parsimony analyses, we suggest that researchers account for the effects of covariates such as sex and body size in their analyses... - Dissecting complex disease: the quest for the Philosopher's Stone?Anne V Buchanan
Department of Anthropology, Penn State University, University Park, PA 16802, USA
Int J Epidemiol 35:562-71. 2006..Finally, we ask whether most complex diseases are even good candidates for the kind of prediction and prevention that we have come to expect based on experience with infectious and Mendelian disease... - Race, ancestry, and genes: implications for defining disease riskRick A Kittles
National Human Genome Center, Howard University, Washington, D C 20060, USA
Annu Rev Genomics Hum Genet 4:33-67. 2003..But in that context race reflects deeply confounded cultural as well as biological factors, and a careful distinction must be made between race as a statistical risk factor and causal genetic variables...
Research Grants
- MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASEKenneth Weiss; Fiscal Year: 2001..These studies will provide an unprecedented ..