Kenneth Weiss

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Is life law-like?
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 188:761-71. 2011
  2. ncbi request reprint The unkindest cup
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Lancet 363:1489-90. 2004
  3. ncbi request reprint Commentary: evolution of action in cells and organisms
    Kenneth M Weiss
    Department of Anthropology, Penn State University, USA
    Int J Epidemiol 35:1159-60. 2006
  4. ncbi request reprint Perspectives fulfilled: the work and thought of J. V. Neel (1915-2000)
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802 3404, USA
    Perspect Biol Med 45:46-64. 2002
  5. ncbi request reprint Linkage disequilibrium and the mapping of complex human traits
    Kenneth M Weiss
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802 3404, USA
    Trends Genet 18:19-24. 2002
  6. ncbi request reprint Evolution by phenotype: a biomedical perspective
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Perspect Biol Med 46:159-82. 2003
  7. ncbi request reprint In search of human variation
    K M Weiss
    Departments of Anthropology and Biology, Pennsylvania State University, University Park, Pennsylvania 16802 USA
    Genome Res 8:691-7. 1998
  8. ncbi request reprint Perspectives on genetic aspects of dental patterning
    K Weiss
    Department of Anthropology, Penn State University, University Park, PA 16082, USA
    Eur J Oral Sci 106:55-63. 1998
  9. pmc Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
    A G Clark
    Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Am J Hum Genet 63:595-612. 1998
  10. ncbi request reprint Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Genomics 37:234-7. 1996

Research Grants

Detail Information

Publications37

  1. pmc Is life law-like?
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 188:761-71. 2011
    ..To the extent that this is true, causal effects are not asymptotically predictable, and new ways of understanding life may be required...
  2. ncbi request reprint The unkindest cup
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Lancet 363:1489-90. 2004
  3. ncbi request reprint Commentary: evolution of action in cells and organisms
    Kenneth M Weiss
    Department of Anthropology, Penn State University, USA
    Int J Epidemiol 35:1159-60. 2006
  4. ncbi request reprint Perspectives fulfilled: the work and thought of J. V. Neel (1915-2000)
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802 3404, USA
    Perspect Biol Med 45:46-64. 2002
    ..Because his perspective was populational, he cautioned that the most serious health problems faced by our species should not be approached as if they have a genetic solution...
  5. ncbi request reprint Linkage disequilibrium and the mapping of complex human traits
    Kenneth M Weiss
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802 3404, USA
    Trends Genet 18:19-24. 2002
    ..The LD map should be based on adequately justified criteria defined by sound population genetic principles...
  6. ncbi request reprint Evolution by phenotype: a biomedical perspective
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Perspect Biol Med 46:159-82. 2003
    ..We may even be forced to re-conceive complex biological causation...
  7. ncbi request reprint In search of human variation
    K M Weiss
    Departments of Anthropology and Biology, Pennsylvania State University, University Park, Pennsylvania 16802 USA
    Genome Res 8:691-7. 1998
    ..However, both fields have been using conceptual models that are oversimplified, and this may lead to unrealistic expectations of the questions that can be answered from genetic data...
  8. ncbi request reprint Perspectives on genetic aspects of dental patterning
    K Weiss
    Department of Anthropology, Penn State University, University Park, PA 16082, USA
    Eur J Oral Sci 106:55-63. 1998
    ....
  9. pmc Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
    A G Clark
    Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Am J Hum Genet 63:595-612. 1998
    ..These data suggest that the design and interpretation of disease-association studies may not be as straightforward as often is assumed...
  10. ncbi request reprint Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Genomics 37:234-7. 1996
    ..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process...
  11. pmc Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism
    S M Fullerton
    Institute of Molecular Evolutionary Genetics, Department of Biology, and Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Am J Hum Genet 67:881-900. 2000
    ....
  12. ncbi request reprint SCPP gene evolution and the dental mineralization continuum
    K Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    J Dent Res 87:520-31. 2008
    ..These tissues thus form a mineralized-tissue continuum. Contemporary dental tissues have evolved from an ancestral continuum through lineage-specific modifications...
  13. pmc The evolution of the vertebrate Dlx gene family
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Proc Natl Acad Sci U S A 93:10858-63. 1996
    ..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue...
  14. ncbi request reprint Distal-less and other homeobox genes in the development of the dentition
    K M Weiss
    Department of Anthropology, Penn State University, University Park 16802
    J Exp Zool 270:273-84. 1994
    ..The screening approach with degenerate primers is a successful way to identify new as well as previously known regulatory genes expressed in developing tooth embryos...
  15. ncbi request reprint Dlx and other homeobox genes in the morphological development of the dentition
    K M Weiss
    Graduate Program in Genetics, Penn State University, University Park, Pennsylvania 16802, USA
    Connect Tissue Res 32:35-40. 1995
    ..The Msx and Dlx genes are the best current candidates for a combinatorial mechanism that controls the differentiation of structures within and between teeth, and perhaps also the evolution of those structures...
  16. pmc Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 100:4060-5. 2003
    ..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates...
  17. ncbi request reprint Cryptic causation of human disease: reading between the (germ) lines
    Kenneth M Weiss
    Departments of Anthropology and Biology, Penn State University, University Park, PA 16802, USA
    Trends Genet 21:82-8. 2005
    ..Better technologies to detect and characterize SM are becoming available. However, until it is studied directly, SM will remain a cryptic etiological force, even for diseases that are essentially "genetic"...
  18. pmc Phenogenetic drift in evolution: the changing genetic basis of vertebrate teeth
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, 16802, USA
    Proc Natl Acad Sci U S A 102:18063-8. 2005
    ..These findings illustrate the complexity of the homology concept in understanding evolution, particularly the evolution of mineralized tissues...
  19. ncbi request reprint Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Exp Zool B Mol Dev Evol 306:295-316. 2006
    ..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted...
  20. ncbi request reprint Out of the veil of death rode the one million! Neandertals and their genes
    Kenneth M Weiss
    Department of Anthropology, Penn State University, PA 16802, USA
    Bioessays 29:105-10. 2007
    ..The data are an exciting and interesting new contribution, but are not surprising, and a sense of history and question helps put them in perspective...
  21. ncbi request reprint Gene duplication and the evolution of vertebrate skeletal mineralization
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Cells Tissues Organs 186:7-24. 2007
    ..As a consequence, phenogenetic drift occurred: while mineralized skeleton is maintained by natural selection, the underlying genetic basis has changed...
  22. pmc Genomic structure and functional control of the Dlx3-7 bigene cluster
    Kenta Sumiyama
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 99:780-5. 2002
    ..This observation is consistent with a cis-regulatory enhancer-sharing model within the Dlx bigene cluster...
  23. pmc ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth
    Brian W Lambert
    Department of Anthropology, Penn State University, University Park, PA, USA
    Bioinformatics 24:1821-2. 2008
    ..Simulation is useful for exploring these issues as well as the choice of study design inferential methods. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...
  24. pmc Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation
    Kenneth M Weiss
    Department of Anthropology and Integrated Biosciences Genetics Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 179:1741-56. 2008
    ....
  25. ncbi request reprint The phenogenetic logic of life
    Kenneth M Weiss
    Department of Anthropology, 409 Carpenter Building, University Park, Penn State University, Pennsylvania 16802, USA
    Nat Rev Genet 6:36-45. 2005
    ..This logic provides a general explanation of the nature and source of organismal design, and a powerful programme for research...
  26. pmc Genetic basis for the evolution of vertebrate mineralized tissue
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 101:11356-61. 2004
    ..We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution...
  27. ncbi request reprint Thomas Henry Huxley (1825-1895) puts us in our place
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, Pennsylvania, 16802, USA
    J Exp Zool B Mol Dev Evol 302:196-206. 2004
    ..Huxley was one of many who have had trouble accepting Darwin's gradual natural selection as the central evolutionary mechanism, and views spanning the antipodes of gradualism and saltation find advocates even in our genetic era...
  28. ncbi request reprint Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sample
    Stephanie M Fullerton
    Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park 16802, USA
    Hum Genet 111:75-87. 2002
    ..The deficit of polymorphism is consistent with a population-specific non-neutral increase in the relative frequency of several haplotypes in Jackson...
  29. ncbi request reprint The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster
    Stephanie M Fullerton
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802, USA
    Hum Genet 115:36-56. 2004
    ..The implications of these findings for other haplotype-based descriptions of human variation are discussed...
  30. ncbi request reprint Not guilty by reason of doubt?
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Epidemiology 14:122-4; discussion 124-6. 2003
  31. pmc Richard H. Ward, Ph.D. (June 7, 1943-February 14, 2003): wild ride of the Valkyries
    Kenneth M Weiss
    Department of Anthropolgy, Penn State University, University Park, PA, USA
    Am J Hum Genet 72:1079-83. 2003
  32. pmc Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:501-17. 2002
    ....
  33. ncbi request reprint Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'
    Joseph D Terwilliger
    Department of Psychiatry, Columbia Genome Center, Columbia University, New York, NY 10032, USA
    Ann Med 35:532-44. 2003
    ....
  34. ncbi request reprint THINK! Being a student of Frank B. Livingstone
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Hum Biol 75:625-8. 2003
  35. ncbi request reprint Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboons
    Leslea J Hlusko
    Department of Anthropology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Am J Phys Anthropol 117:182-9. 2002
    ..Therefore, if variables like actual crown area and estimated crown area are to be used in phylogenetic parsimony analyses, we suggest that researchers account for the effects of covariates such as sex and body size in their analyses...
  36. ncbi request reprint Dissecting complex disease: the quest for the Philosopher's Stone?
    Anne V Buchanan
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Int J Epidemiol 35:562-71. 2006
    ..Finally, we ask whether most complex diseases are even good candidates for the kind of prediction and prevention that we have come to expect based on experience with infectious and Mendelian disease...
  37. ncbi request reprint Race, ancestry, and genes: implications for defining disease risk
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, D C 20060, USA
    Annu Rev Genomics Hum Genet 4:33-67. 2003
    ..But in that context race reflects deeply confounded cultural as well as biological factors, and a careful distinction must be made between race as a statistical risk factor and causal genetic variables...

Research Grants5

  1. MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASE
    Kenneth Weiss; Fiscal Year: 2001
    ..These studies will provide an unprecedented ..