Kenneth M Weiss

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint The phenogenetic logic of life
    Kenneth M Weiss
    Department of Anthropology, 409 Carpenter Building, University Park, Penn State University, Pennsylvania 16802, USA
    Nat Rev Genet 6:36-45. 2005
  2. doi request reprint The Red Queen and her king: cooperation at all levels of life
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Am J Phys Anthropol 146:3-18. 2011
  3. ncbi request reprint Cryptic causation of human disease: reading between the (germ) lines
    Kenneth M Weiss
    Departments of Anthropology and Biology, Penn State University, University Park, PA 16802, USA
    Trends Genet 21:82-8. 2005
  4. ncbi request reprint Out of the veil of death rode the one million! Neandertals and their genes
    Kenneth M Weiss
    Department of Anthropology, Penn State University, PA 16802, USA
    Bioessays 29:105-10. 2007
  5. pmc Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation
    Kenneth M Weiss
    Department of Anthropology and Integrated Biosciences Genetics Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 179:1741-56. 2008
  6. pmc Non-Darwinian estimation: my ancestors, my genes' ancestors
    Kenneth M Weiss
    Penn State University, University Park, PA 16802, USA
    Genome Res 19:703-10. 2009
  7. doi request reprint The cooperative genome: organisms as social contracts
    Kenneth M Weiss
    Departments of Anthropology, Penn State University, University Park, 16802, USA
    Int J Dev Biol 53:753-63. 2009
  8. ncbi request reprint Having a Jolly good time--together! Evolution by cooperative interaction
    Kenneth M Weiss
    Department of Anthropology at Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802 3404, USA
    Curr Anthropol 50:235-45. 2009
  9. pmc When the time seems ripe: eugenics, the annals, and the subtle persistence of typological thinking
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, Pennsylvania, USA
    Ann Hum Genet 75:334-43. 2011
  10. ncbi request reprint Thomas Henry Huxley (1825-1895) puts us in our place
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, Pennsylvania, 16802, USA
    J Exp Zool B Mol Dev Evol 302:196-206. 2004

Detail Information

Publications35

  1. ncbi request reprint The phenogenetic logic of life
    Kenneth M Weiss
    Department of Anthropology, 409 Carpenter Building, University Park, Penn State University, Pennsylvania 16802, USA
    Nat Rev Genet 6:36-45. 2005
    ..This logic provides a general explanation of the nature and source of organismal design, and a powerful programme for research...
  2. doi request reprint The Red Queen and her king: cooperation at all levels of life
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Am J Phys Anthropol 146:3-18. 2011
    ..In a sense, our culture has its metaphors reversed. The red royal family is a more accurate symbol for the true nature of life, human or otherwise...
  3. ncbi request reprint Cryptic causation of human disease: reading between the (germ) lines
    Kenneth M Weiss
    Departments of Anthropology and Biology, Penn State University, University Park, PA 16802, USA
    Trends Genet 21:82-8. 2005
    ..Better technologies to detect and characterize SM are becoming available. However, until it is studied directly, SM will remain a cryptic etiological force, even for diseases that are essentially "genetic"...
  4. ncbi request reprint Out of the veil of death rode the one million! Neandertals and their genes
    Kenneth M Weiss
    Department of Anthropology, Penn State University, PA 16802, USA
    Bioessays 29:105-10. 2007
    ..The data are an exciting and interesting new contribution, but are not surprising, and a sense of history and question helps put them in perspective...
  5. pmc Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation
    Kenneth M Weiss
    Department of Anthropology and Integrated Biosciences Genetics Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 179:1741-56. 2008
    ....
  6. pmc Non-Darwinian estimation: my ancestors, my genes' ancestors
    Kenneth M Weiss
    Penn State University, University Park, PA 16802, USA
    Genome Res 19:703-10. 2009
    ..Despite superficial appearances, these interpretations of genetic data are often based on typological rather than Darwinian thinking, raising important issues about the questions that are actually being asked...
  7. doi request reprint The cooperative genome: organisms as social contracts
    Kenneth M Weiss
    Departments of Anthropology, Penn State University, University Park, 16802, USA
    Int J Dev Biol 53:753-63. 2009
    ..Reconciling these two points of view involves changing the scale of observation, and a different understanding of evolution, in which cooperation and tolerance are more important than competition and intolerance...
  8. ncbi request reprint Having a Jolly good time--together! Evolution by cooperative interaction
    Kenneth M Weiss
    Department of Anthropology at Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802 3404, USA
    Curr Anthropol 50:235-45. 2009
    ..A careful look leads us to challenge the nature of the Darwinian explanations that have been the standard for more than a century...
  9. pmc When the time seems ripe: eugenics, the annals, and the subtle persistence of typological thinking
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, Pennsylvania, USA
    Ann Hum Genet 75:334-43. 2011
    ..The online availability of the original issues will be useful to those interested in the history of both eugenics and human genetics and will provide a reminder of how the careless use of genetical concepts can go astray...
  10. ncbi request reprint Thomas Henry Huxley (1825-1895) puts us in our place
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, Pennsylvania, 16802, USA
    J Exp Zool B Mol Dev Evol 302:196-206. 2004
    ..Huxley was one of many who have had trouble accepting Darwin's gradual natural selection as the central evolutionary mechanism, and views spanning the antipodes of gradualism and saltation find advocates even in our genetic era...
  11. ncbi request reprint Not guilty by reason of doubt?
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Epidemiology 14:122-4; discussion 124-6. 2003
  12. ncbi request reprint The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster
    Stephanie M Fullerton
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802, USA
    Hum Genet 115:36-56. 2004
    ..The implications of these findings for other haplotype-based descriptions of human variation are discussed...
  13. ncbi request reprint Gene duplication and the evolution of vertebrate skeletal mineralization
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Cells Tissues Organs 186:7-24. 2007
    ..As a consequence, phenogenetic drift occurred: while mineralized skeleton is maintained by natural selection, the underlying genetic basis has changed...
  14. ncbi request reprint Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein family
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Exp Zool B Mol Dev Evol 306:295-316. 2006
    ..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted...
  15. pmc Phenogenetic drift in evolution: the changing genetic basis of vertebrate teeth
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, 16802, USA
    Proc Natl Acad Sci U S A 102:18063-8. 2005
    ..These findings illustrate the complexity of the homology concept in understanding evolution, particularly the evolution of mineralized tissues...
  16. doi request reprint Biomineralization in humans: making the hard choices in life
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Genet 43:119-42. 2009
    ..These new genes are the basis for a novel genetic system for various mineralized tissues in skeleton and teeth. In addition, any tissue can be abnormally mineralized, and many pathologies of mineralization in humans are known...
  17. ncbi request reprint Evolution by phenotype: a biomedical perspective
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Perspect Biol Med 46:159-82. 2003
    ..We may even be forced to re-conceive complex biological causation...
  18. pmc Genetic basis for the evolution of vertebrate mineralized tissue
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 101:11356-61. 2004
    ..We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution...
  19. ncbi request reprint Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sample
    Stephanie M Fullerton
    Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park 16802, USA
    Hum Genet 111:75-87. 2002
    ..The deficit of polymorphism is consistent with a population-specific non-neutral increase in the relative frequency of several haplotypes in Jackson...
  20. pmc ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth
    Brian W Lambert
    Department of Anthropology, Penn State University, University Park, PA, USA
    Bioinformatics 24:1821-2. 2008
    ..Simulation is useful for exploring these issues as well as the choice of study design inferential methods. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...
  21. ncbi request reprint Dissecting complex disease: the quest for the Philosopher's Stone?
    Anne V Buchanan
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Int J Epidemiol 35:562-71. 2006
    ..Finally, we ask whether most complex diseases are even good candidates for the kind of prediction and prevention that we have come to expect based on experience with infectious and Mendelian disease...
  22. pmc What are genes "for" or where are traits "from"? What is the question?
    Anne V Buchanan
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA
    Bioessays 31:198-208. 2009
    ..Even the basic question is unclear: what does one need to know to "understand" the genetic basis of complex traits? New operational ideas about how to deal with biological complexity are needed...
  23. pmc Richard H. Ward, Ph.D. (June 7, 1943-February 14, 2003): wild ride of the Valkyries
    Kenneth M Weiss
    Department of Anthropolgy, Penn State University, University Park, PA, USA
    Am J Hum Genet 72:1079-83. 2003
  24. ncbi request reprint Linkage disequilibrium and the mapping of complex human traits
    Kenneth M Weiss
    Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802 3404, USA
    Trends Genet 18:19-24. 2002
    ..The LD map should be based on adequately justified criteria defined by sound population genetic principles...
  25. ncbi request reprint Statistical genetic comparison of two techniques for assessing molar crown size in pedigreed baboons
    Leslea J Hlusko
    Department of Anthropology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Am J Phys Anthropol 117:182-9. 2002
    ..Therefore, if variables like actual crown area and estimated crown area are to be used in phylogenetic parsimony analyses, we suggest that researchers account for the effects of covariates such as sex and body size in their analyses...
  26. ncbi request reprint Commentary: evolution of action in cells and organisms
    Kenneth M Weiss
    Department of Anthropology, Penn State University, USA
    Int J Epidemiol 35:1159-60. 2006
  27. pmc Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster
    Kazuhiko Kawasaki
    Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 100:4060-5. 2003
    ..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates...
  28. ncbi request reprint The unkindest cup
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Lancet 363:1489-90. 2004
  29. ncbi request reprint THINK! Being a student of Frank B. Livingstone
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Hum Biol 75:625-8. 2003
  30. pmc Is life law-like?
    Kenneth M Weiss
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 188:761-71. 2011
    ..To the extent that this is true, causal effects are not asymptotically predictable, and new ways of understanding life may be required...
  31. ncbi request reprint Perspectives fulfilled: the work and thought of J. V. Neel (1915-2000)
    Kenneth M Weiss
    Department of Anthropology, Penn State University, University Park, PA 16802 3404, USA
    Perspect Biol Med 45:46-64. 2002
    ..Because his perspective was populational, he cautioned that the most serious health problems faced by our species should not be approached as if they have a genetic solution...
  32. pmc Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism
    Jari H Stengård
    National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:501-17. 2002
    ....
  33. pmc Genomic structure and functional control of the Dlx3-7 bigene cluster
    Kenta Sumiyama
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 99:780-5. 2002
    ..This observation is consistent with a cis-regulatory enhancer-sharing model within the Dlx bigene cluster...
  34. ncbi request reprint Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'
    Joseph D Terwilliger
    Department of Psychiatry, Columbia Genome Center, Columbia University, New York, NY 10032, USA
    Ann Med 35:532-44. 2003
    ....
  35. ncbi request reprint Race, ancestry, and genes: implications for defining disease risk
    Rick A Kittles
    National Human Genome Center, Howard University, Washington, D C 20060, USA
    Annu Rev Genomics Hum Genet 4:33-67. 2003
    ..But in that context race reflects deeply confounded cultural as well as biological factors, and a careful distinction must be made between race as a statistical risk factor and causal genetic variables...