Alexandros Vgontzas

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Insulin resistance and circadian rhythm of cardiac autonomic modulation
    Sol M Rodriguez-Colon
    Department of Public Health Sciences, Penn State University College of Medicine, 600 Centerview Dr, Suite 2200, A210, Hershey, PA, USA
    Cardiovasc Diabetol 9:85. 2010
  2. pmc Psychological symptom patterns and vital exhaustion in outpatients with chronic obstructive pulmonary disease
    Athanasios Tselebis
    Psychiatric Department, Sotiria General Hospital of Chest Diseases, Athens, Greece
    Ann Gen Psychiatry 10:32. 2011
  3. pmc Prevalence of alexithymia and its association with anxiety and depression in a sample of Greek chronic obstructive pulmonary disease (COPD) outpatients
    Athanasios Tselebis
    Psychiatric Department, Sotiria General Hospital of Chest Diseases, Athens, Greece
    Ann Gen Psychiatry 9:16. 2010
  4. ncbi request reprint Sleep and its disorders
    A N Vgontzas
    Department of Psychiatry, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Annu Rev Med 50:387-400. 1999
  5. ncbi request reprint Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
    A N Vgontzas
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:2119-26. 2004
  6. ncbi request reprint Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
  7. ncbi request reprint Sleep apnea is a manifestation of the metabolic syndrome
    Alexandros N Vgontzas
    Department of Psychiatry H073, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Sleep Med Rev 9:211-24. 2005
  8. ncbi request reprint IL-6 and its circadian secretion in humans
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    Neuroimmunomodulation 12:131-40. 2005
  9. ncbi request reprint Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
    A N Vgontzas
    Penn State Univ College of Medicine, Dept of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E253-61. 2007
  10. ncbi request reprint Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance
    A N Vgontzas
    Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Intern Med 254:32-44. 2003

Research Grants

  1. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2003
  2. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009

Collaborators

Detail Information

Publications48

  1. pmc Insulin resistance and circadian rhythm of cardiac autonomic modulation
    Sol M Rodriguez-Colon
    Department of Public Health Sciences, Penn State University College of Medicine, 600 Centerview Dr, Suite 2200, A210, Hershey, PA, USA
    Cardiovasc Diabetol 9:85. 2010
    ..Therefore, we conducted this investigation to exam the association between IR and the circadian oscillations of CAM in a community-dwelling middle-aged sample...
  2. pmc Psychological symptom patterns and vital exhaustion in outpatients with chronic obstructive pulmonary disease
    Athanasios Tselebis
    Psychiatric Department, Sotiria General Hospital of Chest Diseases, Athens, Greece
    Ann Gen Psychiatry 10:32. 2011
    ..abstract:..
  3. pmc Prevalence of alexithymia and its association with anxiety and depression in a sample of Greek chronic obstructive pulmonary disease (COPD) outpatients
    Athanasios Tselebis
    Psychiatric Department, Sotiria General Hospital of Chest Diseases, Athens, Greece
    Ann Gen Psychiatry 9:16. 2010
    ..This observation suggests that alexithymia should be taken into consideration when drafting specific psychotherapeutic interventions for these patients...
  4. ncbi request reprint Sleep and its disorders
    A N Vgontzas
    Department of Psychiatry, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Annu Rev Med 50:387-400. 1999
    ..Therapeutic naps, medications, and supportive therapy are recommended for narcolepsy and hypersomnia; continuous positive airway pressure, weight loss, surgery, and oral devices are the common treatments for sleep apnea...
  5. ncbi request reprint Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
    A N Vgontzas
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:2119-26. 2004
    ..Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution...
  6. ncbi request reprint Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
    ..9 vs. 3.1 min), suggests that proinflammatory cytokines contribute to the pathogenesis of OSA/sleepiness...
  7. ncbi request reprint Sleep apnea is a manifestation of the metabolic syndrome
    Alexandros N Vgontzas
    Department of Psychiatry H073, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Sleep Med Rev 9:211-24. 2005
    ....
  8. ncbi request reprint IL-6 and its circadian secretion in humans
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    Neuroimmunomodulation 12:131-40. 2005
    ..We conclude that IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep...
  9. ncbi request reprint Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
    A N Vgontzas
    Penn State Univ College of Medicine, Dept of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E253-61. 2007
    ..The redistribution of cortisol secretion and the prolonged suppression of IL-6 secretion are beneficial, as they improve alertness and performance...
  10. ncbi request reprint Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance
    A N Vgontzas
    Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Intern Med 254:32-44. 2003
    ....
  11. ncbi request reprint Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:2087-95. 2003
    ....
  12. ncbi request reprint Circadian interleukin-6 secretion and quantity and depth of sleep
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 84:2603-7. 1999
    ..Sleep deprivation increases daytime IL-6 and causes somnolence and fatigue during the next day, whereas postdeprivation decreases nighttime IL-6 and is associated with deeper sleep...
  13. ncbi request reprint Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1151-8. 2000
    ..We conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition...
  14. ncbi request reprint Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications
    A N Vgontzas
    Sleep Research and Treatment Center and Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Psychosom Med 62:220-6. 2000
    ..The aim of this study was to assess whether polysomnography aids in the differential diagnosis of these two disorders...
  15. ncbi request reprint Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:517-20. 2001
    ..These data support our proposal that, independently of gender, sleep apnea might be a manifestation of an endocrine/metabolic abnormality in which insulin resistance plays a principal role...
  16. ncbi request reprint Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:1489-95. 2001
    ..We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age...
  17. ncbi request reprint Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
    ..The therapeutic goal in insomnia should be to decrease the overall level of physiologic and emotional arousal, and not just to improve the nighttime sleep...
  18. ncbi request reprint Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders
    Alexandros N Vgontzas
    Department of Psychiatry, Pennsylvania State University, College of Medicine, H073 500 University Dr, Hershey, PA 17033, USA
    Endocrinol Metab Clin North Am 31:15-36. 2002
    ..Sleep deprivation leads to sleepiness and daytime hypersecretion of IL-6. Combined, these findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans...
  19. ncbi request reprint Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry H073, Penn State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 55:1076-82. 2006
    ..We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance...
  20. pmc Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population study
    Julio Fernandez-Mendoza
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 33:459-65. 2010
    ..To examine the joint effect of insomnia and objective short sleep duration on neuropsychological performance...
  21. pmc Lack of regular exercise, depression, and degree of apnea are predictors of excessive daytime sleepiness in patients with sleep apnea: sex differences
    Maria Basta
    Sleep Research and Treatment Center, Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Clin Sleep Med 4:19-25. 2008
    ..Exercise is beneficial for apnea, depression, and metabolic abnormalities; however, its association with EDS is not known...
  22. pmc Sleep-disordered breathing in obese children is associated with prevalent excessive daytime sleepiness, inflammation, and metabolic abnormalities
    Marina Tsaoussoglou
    Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 95:143-50. 2010
    ..In this study, we examined the joint effect of SDB and obesity in EDS as well as proinflammatory and metabolic markers...
  23. pmc Sleep disordered breathing in children in a general population sample: prevalence and risk factors
    Edward O Bixler
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, PA 17033, USA
    Sleep 32:731-6. 2009
    ..Assess the prevalence based on clinically meaningful criteria (i.e., blood pressure) and identify risk factors of sleep disordered breathing (SDB) in a representative sample of elementary school children...
  24. pmc Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause
    Edward O Bixler
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Sleep Res 18:221-8. 2009
    ..This gender dimorphism in sleep regulation may have been to protect women from the demands of infant and child care, and in part, might contribute to women's lower cardiovascular risks and greater longevity...
  25. pmc Insomnia with objective short sleep duration is associated with a high risk for hypertension
    Alexandros N Vgontzas
    Sleep Research and Treatment Center Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 32:491-7. 2009
    ..To examine the joint effect of insomnia and objective short sleep duration on hypertension risk...
  26. pmc Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes Care 32:1980-5. 2009
    ..We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk...
  27. pmc No relationship between neurocognitive functioning and mild sleep disordered breathing in a community sample of children
    Susan L Calhoun
    Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Clin Sleep Med 5:228-34. 2009
    ....
  28. pmc Sleep-disordered breathing in children is associated with impairment of sleep stage-specific shift of cardiac autonomic modulation
    Duanping Liao
    Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    J Sleep Res 19:358-65. 2010
    ....
  29. pmc Medical complaints are more common in young school-aged children with parent reported insomnia symptoms
    Ravi Singareddy
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Clin Sleep Med 5:549-53. 2009
    ..In this study, we examined prevalence of medical complaints in children with insomnia symptoms in a large general population of school aged children...
  30. pmc Prenatal and perinatal complications: is it the link between race and SES and childhood sleep disordered breathing?
    Susan L Calhoun
    Sleep Research and Treatment Center, Penn State University, College of Medicine, Hershey, PA, USA
    J Clin Sleep Med 6:264-9. 2010
    ....
  31. pmc Insomnia with short sleep duration and mortality: the Penn State cohort
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 33:1159-64. 2010
    ..Because insomnia with objective short sleep duration is associated with increased morbidity, we examined the effects of this insomnia subtype on all-cause mortality...
  32. ncbi request reprint Obesity and sleep disturbances: meaningful sub-typing of obesity
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    Arch Physiol Biochem 114:224-36. 2008
    ..This proposed sub-typing may lead to novel, preventive and therapeutic strategies for obesity and its associated sleep disturbances...
  33. ncbi request reprint Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance?
    Alexandros N Vgontzas
    Department of Psychiatry, Sleep Research and Treatment Center, Hershey, PA 17033, USA
    Arch Physiol Biochem 114:211-23. 2008
    ..g. hypofunctioning hypothalamic CRH, play a major role in the pathogenesis of sleep apnoea, sleepiness, and the associated cardiovascular co-morbidities...
  34. pmc Blood pressure associated with sleep-disordered breathing in a population sample of children
    Edward O Bixler
    Department of Psychiatry, Penn State University College of Medicine, Sleep Research and Treatment Center, Hershey, PA 17033, USA
    Hypertension 52:841-6. 2008
    ..Clinically, the data support the threshold of AHI >or=5 for the initiation of treatment for SDB. Additional research is indicated to assess the efficacy of SDB treatment on reducing blood pressure...
  35. pmc ADHD subtypes and comorbid anxiety, depression, and oppositional-defiant disorder: differences in sleep problems
    Susan Dickerson Mayes
    Department of Psychiatry, Milton S Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    J Pediatr Psychol 34:328-37. 2009
    ..Sleep problems were analyzed in children with ADHD (Attention-deficit hyperactivity disorder)...
  36. ncbi request reprint Obesity-related sleepiness and fatigue: the role of the stress system and cytokines
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Ann N Y Acad Sci 1083:329-44. 2006
    ....
  37. doi request reprint Nonsignificance of sleep relative to IQ and neuropsychological scores in predicting academic achievement
    Susan Dickerson Mayes
    Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Dev Behav Pediatr 29:206-12. 2008
    ..The goal of the study was to determine the relative importance of sleep, IQ, neuropsychological, and attention-deficit/hyperactivity disorder (ADHD) scores in predicting academic achievement...
  38. pmc Sleep-disordered breathing and cardiac autonomic modulation in children
    Duanping Liao
    Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Sleep Med 11:484-8. 2010
    ..To investigate the adverse cardiac autonomic effects of sleep-disordered breathing (SDB) in a large population-based sample and a clinical sample of children...
  39. ncbi request reprint Sleep is increased in mice with obesity induced by high-fat food
    Joe B Jenkins
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Room C5654, 500 University Drive, PA 17033, USA
    Physiol Behav 87:255-62. 2006
    ..These results indicate that the obese animals have increased sleep pressure and difficulties in maintaining wakefulness during the active phase...
  40. pmc Sleep is increased by weight gain and decreased by weight loss in mice
    Zhiwei Guan
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 31:627-33. 2008
    ..To determine whether weight loss could reverse excessive sleep in high-fat diet-induced obesity...
  41. ncbi request reprint Interleukin-6 levels fluctuate with the light-dark cycle in the brain and peripheral tissues in rats
    Zhiwei Guan
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 10733, USA
    Brain Behav Immun 19:526-9. 2005
    ....
  42. ncbi request reprint Complexity and non-linear description of diurnal cortisol and growth hormone secretory patterns before and after sleep deprivation
    Ioannis Ilias
    Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece
    Endocr Regul 36:63-72. 2002
    ....
  43. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  44. ncbi request reprint Metabolic abnormalities in obesity and sleep apnea are in a continuum
    Maria Basta
    Sleep Med 8:5-7. 2007
  45. doi request reprint Insomnia and sleep quality among primary care physicians with low and high burnout levels
    Antonio Vela-Bueno
    Department of Psychiatry, School of Medicine, Autonomous University of Madrid, Spain
    J Psychosom Res 64:435-42. 2008
    ..The aim of this study was to assess insomnia and sleep quality in primary care physicians with low and high burnout scores...
  46. ncbi request reprint Neuroendocrine aspects of chronic fatigue syndrome
    Dimitris A Papanicolaou
    Department of Medicine Endocrinology, Emory University, Atlanta, GA, USA
    Neuroimmunomodulation 11:65-74. 2004
    ..This paper represents the consensus of the panel of experts who participated in this meeting...
  47. ncbi request reprint The diagnosis and treatment of chronic insomnia in adults
    Alexandros N Vgontzas
    Sleep 28:1047-8. 2005
  48. ncbi request reprint Board Review Corner: the case of the sleepy middle-aged woman
    Alexandros N Vgontzas
    J Clin Sleep Med 3:85; author reply 86. 2007

Research Grants8

  1. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2003
    ..These studies collectively will provide additional evidence for a role of TNFalpha and IL-6 in EDS and lay the foundation for the development of potential therapeutic interventions. ..
  2. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..