Research Topics
Species | Alexandros N VgontzasSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apneaAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry H073, Penn State University College of Medicine, Hershey, PA 17033, USA
Metabolism 55:1076-82. 2006..We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance...- Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance?Alexandros N Vgontzas
Department of Psychiatry, Sleep Research and Treatment Center, Hershey, PA 17033, USA
Arch Physiol Biochem 114:211-23. 2008..g. hypofunctioning hypothalamic CRH, play a major role in the pathogenesis of sleep apnoea, sleepiness, and the associated cardiovascular co-morbidities... 
Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population studyJulio Fernandez-Mendoza
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Sleep 33:459-65. 2010..To examine the joint effect of insomnia and objective short sleep duration on neuropsychological performance...- Persistent insomnia: the role of objective short sleep duration and mental healthAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Sleep 35:61-8. 2012..Furthermore, none of these studies have examined the role of polysomnographic (PSG) variables such as sleep duration or sleep apnea on the persistence of insomnia... 
Short sleep duration and obesity: the role of emotional stress and sleep disturbancesA N Vgontzas
Department of Psychiatry, Sleep Research and Treatment Center, Penn State University College of Medicine, Hershey, PA 17033, USA
Int J Obes (Lond) 32:801-9. 2008..How the degree of obesity or other clinical characteristics of the obese individuals, such as sleep disturbances or emotional stress, define this relation is not known...- Insomnia with short sleep duration and mortality: the Penn State cohortAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Sleep 33:1159-64. 2010..Because insomnia with objective short sleep duration is associated with increased morbidity, we examined the effects of this insomnia subtype on all-cause mortality... - Selective effects of CPAP on sleep apnoea-associated manifestationsA N Vgontzas
Penn State University College of Medicine, Department of Psychiatry, Hershey, PA 17033, USA
Eur J Clin Invest 38:585-95. 2008..The objectives of this study are to simultaneously test these associations at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy... - Obesity-related sleepiness and fatigue: the role of the stress system and cytokinesAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Ann N Y Acad Sci 1083:329-44. 2006.... - Obesity and sleep disturbances: meaningful sub-typing of obesityAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
Arch Physiol Biochem 114:224-36. 2008..This proposed sub-typing may lead to novel, preventive and therapeutic strategies for obesity and its associated sleep disturbances... - Insomnia with objective short sleep duration is associated with a high risk for hypertensionAlexandros N Vgontzas
Sleep Research and Treatment Center Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Sleep 32:491-7. 2009..To examine the joint effect of insomnia and objective short sleep duration on hypertension risk... - Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based studyAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Diabetes Care 32:1980-5. 2009..We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk... - Hypothalamic-pituitary-adrenal axis activity in obese men with and without sleep apnea: effects of continuous positive airway pressure therapyA N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, H073, Penn State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
J Clin Endocrinol Metab 92:4199-207. 2007..Previous studies on the association between the hypothalamic-pituitary-adrenal axis activity and sleep apnea (SA) and obesity are inconsistent and/or limited... - Prevalence and risk factors of excessive daytime sleepiness in a community sample of young children: the role of obesity, asthma, anxiety/depression, and sleepSusan L Calhoun
Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Sleep 34:503-7. 2011..Few studies have researched the prevalence and predictors of EDS in young children, none in a general population sample of children, and the results are inconsistent... - Sleep disordered breathing in children in a general population sample: prevalence and risk factorsEdward O Bixler
Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, PA 17033, USA
Sleep 32:731-6. 2009..Assess the prevalence based on clinically meaningful criteria (i.e., blood pressure) and identify risk factors of sleep disordered breathing (SDB) in a representative sample of elementary school children... - Sleep-disordered breathing in children is associated with impairment of sleep stage-specific shift of cardiac autonomic modulationDuanping Liao
Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
J Sleep Res 19:358-65. 2010.... - Insulin resistance and circadian rhythm of cardiac autonomic modulationSol M Rodriguez-Colon
Department of Public Health Sciences, Penn State University College of Medicine, 600 Centerview Dr, Suite 2200, A210, Hershey, PA, USA
Cardiovasc Diabetol 9:85. 2010..Therefore, we conducted this investigation to exam the association between IR and the circadian oscillations of CAM in a community-dwelling middle-aged sample... - Clinical and polysomnographic predictors of the natural history of poor sleep in the general populationJulio Fernandez-Mendoza
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, USA
Sleep 35:689-97. 2012..e., poor sleep). However, few longitudinal studies have examined risk factors of the natural history of poor sleep, and none have examined the role of polysomnographic (PSG) variables... - Risk factors for incident chronic insomnia: a general population prospective studyRavi Singareddy
Sleep Research and Treatment Center, Penn State University College of Medicine, Hershey, PA, United States
Sleep Med 13:346-53. 2012..We prospectively examined the associations between demographics, behavioral factors, psychiatric and medical disorders, and polysomnography with incident chronic insomnia... - Insomnia with objective short sleep duration and incident hypertension: the Penn State CohortJulio Fernandez-Mendoza
Sleep Research and Treatment Center, Pennylvania State University College of Medicine, Department of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
Hypertension 60:929-35. 2012..Objective short sleep duration in insomnia may serve as a useful predictor of the biological severity of the disorder... - Medical complaints are more common in young school-aged children with parent reported insomnia symptomsRavi Singareddy
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
J Clin Sleep Med 5:549-53. 2009..In this study, we examined prevalence of medical complaints in children with insomnia symptoms in a large general population of school aged children... - Systemic inflammation and circadian rhythm of cardiac autonomic modulationXian Li
Department of Public Health Sciences, Penn State University College of Medicine, 600 Centerview Drive, Hershey, PA 17033, USA
Auton Neurosci 162:72-6. 2011..86 (0.38) ms, respectively, both p-values <0.05]. SI is adversely associated with circadian pattern of CAM, suggesting that the cardiac risk associated with SI may be partially mediated via inflammation-related changes in CAM... - Sleep misperception and chronic insomnia in the general population: role of objective sleep duration and psychological profilesJulio Fernandez-Mendoza
Sleep Research and Treatment Center, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Psychosom Med 73:88-97. 2011..The frequency and the determinants of sleep misperception in general population samples are unknown... - Sleep is increased by weight gain and decreased by weight loss in miceZhiwei Guan
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Sleep 31:627-33. 2008..To determine whether weight loss could reverse excessive sleep in high-fat diet-induced obesity... - Learning, attention/hyperactivity, and conduct problems as sequelae of excessive daytime sleepiness in a general population study of young childrenSusan L Calhoun
Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USA
Sleep 35:627-32. 2012..We investigated the association of EDS with objective neurocognitive measures and parent reported learning, attention/hyperactivity, and conduct problems in a large general population sample of children... - Blood pressure associated with sleep-disordered breathing in a population sample of childrenEdward O Bixler
Department of Psychiatry, Penn State University College of Medicine, Sleep Research and Treatment Center, Hershey, PA 17033, USA
Hypertension 52:841-6. 2008..Clinically, the data support the threshold of AHI >or=5 for the initiation of treatment for SDB. Additional research is indicated to assess the efficacy of SDB treatment on reducing blood pressure... - Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopauseEdward O Bixler
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
J Sleep Res 18:221-8. 2009..This gender dimorphism in sleep regulation may have been to protect women from the demands of infant and child care, and in part, might contribute to women's lower cardiovascular risks and greater longevity... - Leptin and hunger levels in young healthy adults after one night of sleep lossSlobodanka Pejovic
Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
J Sleep Res 19:552-8. 2010.... - Prenatal and perinatal complications: is it the link between race and SES and childhood sleep disordered breathing?Susan L Calhoun
Sleep Research and Treatment Center, Penn State University, College of Medicine, Hershey, PA, USA
J Clin Sleep Med 6:264-9. 2010.... - Lack of regular exercise, depression, and degree of apnea are predictors of excessive daytime sleepiness in patients with sleep apnea: sex differencesMaria Basta
Sleep Research and Treatment Center, Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Clin Sleep Med 4:19-25. 2008..Exercise is beneficial for apnea, depression, and metabolic abnormalities; however, its association with EDS is not known... - The Spanish version of the Insomnia Severity Index: a confirmatory factor analysisJulio Fernandez-Mendoza
Sleep Research and Treatment Center, Department of Psychiatry, College of Medicine, Penn State University, Hershey, PA 17033, USA
Sleep Med 13:207-10. 2012..To examine the psychometric properties of the Spanish version of the Insomnia Severity Index (ISI) and to determine its factor structure with confirmatory factor analysis (CFA)... - Obesity is associated with impaired cardiac autonomic modulation in childrenSol M Rodriguez-Colon
Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
Int J Pediatr Obes 6:128-34. 2011..To examine the cross-sectional association between measurements of obesity and subclinical impairment of cardiac autonomic modulation (CAM) in a population-based sample of children... - Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implicationsAlexandros N Vgontzas
Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Clin Endocrinol Metab 88:2087-95. 2003.... - Sleep apnea is a manifestation of the metabolic syndromeAlexandros N Vgontzas
Department of Psychiatry H073, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Sleep Med Rev 9:211-24. 2005.... - ADHD subtypes and comorbid anxiety, depression, and oppositional-defiant disorder: differences in sleep problemsSusan Dickerson Mayes
Department of Psychiatry, Milton S Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
J Pediatr Psychol 34:328-37. 2009..Sleep problems were analyzed in children with ADHD (Attention-deficit hyperactivity disorder)... - No relationship between neurocognitive functioning and mild sleep disordered breathing in a community sample of childrenSusan L Calhoun
Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, PA, USA
J Clin Sleep Med 5:228-34. 2009.... - Sleep-disordered breathing in obese children is associated with prevalent excessive daytime sleepiness, inflammation, and metabolic abnormalitiesMarina Tsaoussoglou
Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Clin Endocrinol Metab 95:143-50. 2010..In this study, we examined the joint effect of SDB and obesity in EDS as well as proinflammatory and metabolic markers... - Acute effects of fine particulate air pollution on ST segment height: a longitudinal studyFan He
Department of Public Health Sciences, Penn State University College of Medicine, A210, 600 Centerview Dr, Suite 2200, Hershey, PA 17033, USA
Environ Health 9:68. 2010..The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms... - Sleep-disordered breathing and cardiac autonomic modulation in childrenDuanping Liao
Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
Sleep Med 11:484-8. 2010..To investigate the adverse cardiac autonomic effects of sleep-disordered breathing (SDB) in a large population-based sample and a clinical sample of children... - Sleep is increased in mice with obesity induced by high-fat foodJoe B Jenkins
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Room C5654, 500 University Drive, PA 17033, USA
Physiol Behav 87:255-62. 2006..These results indicate that the obese animals have increased sleep pressure and difficulties in maintaining wakefulness during the active phase... - Sleep apnoea and visceral adiposity in middle-aged male and female subjectsIlia Kritikou
Dept of Psychiatry, Pennsylvania State University College of Medicine, PA, USA
Eur Respir J 41:601-9. 2013..Short-term CPAP treatment does not affect general, abdominal or intra-hepatic adiposity... - Nonsignificance of sleep relative to IQ and neuropsychological scores in predicting academic achievementSusan Dickerson Mayes
Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Dev Behav Pediatr 29:206-12. 2008..The goal of the study was to determine the relative importance of sleep, IQ, neuropsychological, and attention-deficit/hyperactivity disorder (ADHD) scores in predicting academic achievement... - Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disordersAlexandros N Vgontzas
Department of Psychiatry, Pennsylvania State University, College of Medicine, H073 500 University Dr, Hershey, PA 17033, USA
Endocrinol Metab Clin North Am 31:15-36. 2002..Sleep deprivation leads to sleepiness and daytime hypersecretion of IL-6. Combined, these findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans... - Interleukin-6 levels fluctuate with the light-dark cycle in the brain and peripheral tissues in ratsZhiwei Guan
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 10733, USA
Brain Behav Immun 19:526-9. 2005.... - Neuroendocrine aspects of chronic fatigue syndromeDimitris A Papanicolaou
Department of Medicine/Endocrinology, Emory University, Atlanta, GA, USA
Neuroimmunomodulation 11:65-74. 2004..This paper represents the consensus of the panel of experts who participated in this meeting... - Metabolic abnormalities in obesity and sleep apnea are in a continuumMaria Basta
Sleep Med 8:5-7. 2007 - Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression... - Board Review Corner: the case of the sleepy middle-aged womanAlexandros N Vgontzas
J Clin Sleep Med 3:85; author reply 86. 2007 - Complexity and non-linear description of diurnal cortisol and growth hormone secretory patterns before and after sleep deprivationIoannis Ilias
Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece
Endocr Regul 36:63-72. 2002.... - The diagnosis and treatment of chronic insomnia in adultsAlexandros N Vgontzas
Sleep 28:1047-8. 2005 - Insomnia and sleep quality among primary care physicians with low and high burnout levelsAntonio Vela-Bueno
Department of Psychiatry, School of Medicine, Autonomous University of Madrid, Spain
J Psychosom Res 64:435-42. 2008..The aim of this study was to assess insomnia and sleep quality in primary care physicians with low and high burnout scores...