THOMAS VARY

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. Vary T, Deiter G, Goodman S. Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Am J Physiol Heart Circ Physiol. 2005;288:H121-8 pubmed
    ..eIF4E complex formation, which appear to be independent of changes in phosphorylation of eIF4G but dependent on mTOR. ..
  2. Vary T, Anthony J, Jefferson L, Kimball S, Lynch C. Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. Am J Physiol Endocrinol Metab. 2007;293:E188-96 pubmed
    ..The latter observation implies that the effects observed with rapamycin were the result of modulation of skeletal muscle signaling mechanisms responsible for eIF4G phosphorylation. ..
  3. Vary T, Lang C. IGF-I activates the eIF4F system in cardiac muscle in vivo. Mol Cell Biochem. 2005;272:209-20 pubmed
    ..Furthermore, the results are consistent with a role for assembly of active eIF4G.eIF4E complex and activation of S6K1 in mediating the stimulation of mRNA translation initiation by IGF-I through a PKB/mTOR signaling pathway. ..
  4. Vary T, Lynch C. Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation. Am J Physiol Endocrinol Metab. 2006;290:E631-42 pubmed
    ..eIF4E complex assembly through increased phosphorylation of eIF4G and decreased association of 4E-BP1 with eIF4E. ..
  5. Vary T, Deiter G, Lynch C. Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts. J Nutr. 2007;137:1857-62 pubmed
    ..Furthermore, the rapamycin-sensitive reductions in phosphorylation of eIF4G may also lead to decreased formation of active eIF4G-eIF4E complex. ..
  6. Vary T, Deiter G, Kimball S. Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis. Am J Physiol Endocrinol Metab. 2002;283:E1032-9 pubmed
    ..Furthermore, the study presents the first demonstration of changes in eIF2Bepsilon phosphorylation in vivo. ..
  7. Vary T, Deiter G. Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart. Metabolism. 2005;54:212-9 pubmed
    ..We conclude that translational control mechanisms appear to be important in regulating the expression of myocardial proteins during long-term ethanol intoxication. ..
  8. Vary T, Lynch C, Lang C. Effects of chronic alcohol consumption on regulation of myocardial protein synthesis. Am J Physiol Heart Circ Physiol. 2001;281:H1242-51 pubmed
    ..These data suggest that a chronic alcohol-induced impairment in myocardial protein synthesis results in part from inhibition in peptide chain initiation secondary to marked changes in eIF4E availability and p70(S6K) phosphorylation...
  9. Vary T, Jefferson L, Kimball S. Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1. Am J Physiol Endocrinol Metab. 2001;281:E1045-53 pubmed
    ..Thus the inability of insulin to stimulate protein synthesis during sepsis may be related to a defect in signaling to a step in translation initiation involved in assembly of an active eIF4F complex...

More Information

Publications14

  1. Vary T, Deiter G, Lang C. Diminished ERK 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis. Shock. 2004;22:548-54 pubmed
  2. Vary T, Goodman S, Kilpatrick L, Lynch C. Nutrient regulation of PKCepsilon is mediated by leucine, not insulin, in skeletal muscle. Am J Physiol Endocrinol Metab. 2005;289:E684-94 pubmed
  3. Vary T. Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr. 2007;137:2074-9 pubmed
    ..We conclude that Leu stimulates a PKB-independent signal pathway elevating the eIF4G-eIF4E complex assembly through increased phosphorylation of eIF4G and decreased association of 4E-BP1 with eIF4E in skeletal muscle during sepsis. ..
  4. Vary T, Lang C. Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. Cardiovasc Toxicol. 2008;8:23-32 pubmed publisher
  5. Vary T, Deiter G, Lang C. Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis. Shock. 2006;26:631-6 pubmed
    ..Furthermore, the findings support a role of IL-1 as the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G. ..