Research Topics
| David J VandenberghSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
Simple tests to detect errors in high-throughput genotype data in the molecular laboratoryDavid J Vandenbergh
Center for Developmental and Health Genetics, Department of Biobehavioral Health, and Life Sciences Consortium, The Pennsylvania State University, University Park, PA 16802, USA
J Biomol Tech 14:9-16. 2003..A set of 96 dinucleotide repeat markers that are polymorphic between the C57BL/6J and DBA/2J mouse strains and can be multiplexed is reported for use in other genotyping projects...
Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be differentDavid J Vandenbergh
Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, 225 Research Building E, University Park, PA 16802 2321, USA
Nicotine Tob Res 4:333-40. 2002..We have also developed an improved set of polymerase chain reaction conditions to increase the frequency of successful amplification of DAT'sw VNTR, which is a long, G+C-rich repeat...- A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme geneDavid J Vandenbergh
Department of Biobehavioral Health, The Pennsylvania State University, 225 Research Building E, 101 Amy Gardener House, University Park, PA 16802, USA
Mol Cell Probes 17:319-20. 2003..A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74... - Optimizing DNA yield from buccal swabs in the elderly: attempts to promote buccal cell growth in cultureDavid J Vandenbergh
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Am J Hum Biol 15:637-42. 2003..Thus, an inexpensive and efficient method exists for genetic studies of population-based samples... - Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviorsDavid J Vandenbergh
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802 2321, USA
Addict Biol 12:106-16. 2007..020) and trouble sleeping (P = 0.015). An interaction between DRD2 and DRD3 was found for trouble concentrating (P = 0.020). These relationships present possible dopamine-related responses to nicotine that warrant further study... - Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with ageDean H Lang
Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Bone Miner Res 24:1608-17. 2009..Further exploration of these and other mechanisms through which genes function will aid in development of individualized interventions able to exploit the numerous complex pathways contributing to skeletal health... - Adjusting data to body size: a comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypesDean H Lang
Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Bone Miner Res 20:748-57. 2005..It was found that dividing skeletal phenotypes by body mass index induced erroneous QTL results. The preferred method of body size adjustment was multiple regression... - Quantitative trait loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred miceDean H Lang
The Biomechanics Laboratory, Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, USA
Aging Clin Exp Res 22:8-19. 2010..The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains... - QTL analysis of trabecular bone in BXD F2 and RI miceAbbey L Bower
The Biomechanics Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802 5702, USA
J Bone Miner Res 21:1267-75. 2006..QTLs for bone in the proximal tibial metaphysis were identified on several chromosomes indicating regions containing genes that regulate properties of trabecular bone... - Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influencesDavid A Blizard
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, PA 16802, USA
Physiol Genomics 36:158-66. 2009..Evidence for a role for mitochondrial DNA was found for both HR and SBP. QTL for HR and SBP may differ in males and females and may be sensitive to different environmental contexts... - Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL/6J and DBA/2J miceJennifer E Foreman
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802 2317, USA
Physiol Genomics 23:295-303. 2005.... - Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old miceArimantas Lionikas
Center for Developmental and Health Genetics, The Pennsylvania State University, 101 Amy Gardner House, University Park, PA 16802, USA
Mamm Genome 17:615-28. 2006..05 for TA muscle in males (between 200 and 800 days) and females (between 500 and 800 days), respectively. Analysis of all age groups supported previous findings that the genetic effects may be muscle-, age-, and sex-specific... - QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effectsFrank Johannes
Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, 101 Amy Gardner House, University Park, PA 16803, USA
Mamm Genome 17:689-99. 2006..Baseline serum hematocrit is influenced by several QTL that appear to vary with the age and sex of the animal. These QTL primarily overlap with QTL that have been shown to regulate hematopoietic stem cell phenotypes... 
Learning in the 2-bottle alcohol preference testDavid A Blizard
Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Alcohol Clin Exp Res 32:2041-6. 2008..The 2-bottle preference test is a popular protocol for characterizing a rodent's selection of a variety of solutions. Little attention has been paid, however, to the role of learning in this procedure...- Activity-related behaviors in the hole-board predict nicotine consumption in C57B6 mice perinatally exposed to nicotineJoseph Gyekis
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, PA 16802, USA
Behav Brain Res 206:139-42. 2010..These results show that hole-board behaviors predict subsequent nicotine intake in mice exposed to nicotine perinatally, especially after habituation to the apparatus... - Perinatal nicotine exposure delays genital development in miceJoseph Gyekis
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, PA 16802, USA
Reprod Toxicol 29:378-80. 2010..Nicotine's perinatal effects on genital development in mice, which is interpreted as a measure of endocrine disrupting activity, were evaluated in this report... - Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred miceDean H Lang
The Center for Locomotion Studies, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Bone Miner Res 20:88-99. 2005..QTLs for skeletal traits co-located with each other and with correlated traits such as body weight and length, adipose mass, and serum alkaline phosphatase... - Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experimentLaura Cousino Klein
Department of Biobehavioral Health, Center for Developmental and Health Genetics, 315 East Health and Human Development Building, The Pennsylvania State University, University Park, PA 16802, USA
Pharmacol Biochem Behav 78:13-25. 2004..Sex differences in nicotine consumption, but not in cotinine levels, suggest sex differences in pharmacokinetic processes that may contribute to oral nicotine consumption behavior during periadolescence... - Anogenital distance measured at weaning is correlated with measures of blood chemistry and behaviors in 450-day-old female miceTara K Kerin
Center for Developmental and Health Genetics, Pennsylvania State University, 101 Amy Gardner House, University Park, PA 16802, USA
Physiol Behav 78:697-702. 2003..These findings suggest that in utero proximity to males, as indexed by AGDWTRES, may have effects on fundamental aspects of blood chemistry and behavior that extend well into mouse middle age, and could play an important role in health... - An examination of early smoking experiences and smoking status in a national cross-sectional sampleLynn T Kozlowski
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16801, USA
Addiction 100:1352-7. 2005..Overall, this study supports the literature suggesting that early experiences, particularly liking smoking, are associated with becoming a regular smoker... - Effects of periadolescent ethanol exposure on alcohol preference in two BALB substrainsDavid A Blizard
Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, PA 16802, USA
Alcohol 34:177-85. 2004.... - Using a telephone survey to acquire genetic and behavioral data related to cigarette smoking in "made-anonymous" and "registry" samplesLynn T Kozlowski
Department of Biobehavioral Health, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
Am J Epidemiol 156:68-77. 2002..The authors conclude that random digit dialing surveys coupled with mail collection of DNA may constitute a practical method of obtaining DNA samples for biobehavioral research... - Laternal nicotine exposure increases nicotine preference in periadolescent male but not female C57B1/6J miceLaura Cousino Klein
Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Nicotine Tob Res 5:117-24. 2003..Differential outcomes for males and females suggest that different processes underlie sex differences in nicotine consumption following maternal nicotine exposure... - Effect of the monoamine oxidase inhibition on rewarding effects of nicotine in rodentsChristine H Kapelewski
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA
Curr Drug Abuse Rev 4:110-21. 2011..These data will enhance our understanding of the neuropharmacological effects of smoking and the value of implementing MAO inhibitors as pharmacotherapies for smoking cessation... - Gustatory, trigeminal, and olfactory aspects of nicotine intake in three mouse strainsJoseph P Gyekis
Department of Biobehavioral Health, Pennsylvania State University, 201 Research Building D, University Park, PA 16802, USA
Behav Genet 42:820-9. 2012.... - Dopaminergic polymorphisms in Tourette syndrome: association with the DAT gene (SLC6A3)Dustin Y Yoon
Department of Neurology, Johns Hopkins University School of Medicine, Harriet Lane Children s Health Building, Wolfe Street, Baltimore, Maryland 21205, USA
Am J Med Genet B Neuropsychiatr Genet 144:605-10. 2007..Since abnormalities of the dopamine transporter have been hypothesized in the pathophysiology of TS, it is possible that this could be a functional allele associated with clinical expression... - DAT's not all, but it may be more than we realizeDavid J Vandenbergh
Nicotine Tob Res 4:251-2. 2002 - Genetic effects on children's conversational language useLaura S DeThorne
University of Illinois at Urbana Champaign, 901 South Sixth Street, Champaign, IL 61820, USA
J Speech Lang Hear Res 51:423-35. 2008..The present study examined the extent of genetic and environmental influences on individual differences in children's conversational language use... - Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant associationChristopher A Rippel
Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Psychiatr Genet 16:179-80. 2006..Further research with additional NET polymorphisms and larger sample sizes are indicated in the pursuit of biomarkers for therapeutic responders...