Research Topics
Species | JOHN VANDEN HEUVELSummaryAffiliation: Pennsylvania State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37J P Vanden Heuvel
Department of Veterinary Science and Molecular Toxicology Program, Penn State University, University Park, Pennsylvania 16802, USA
Toxicol Appl Pharmacol 152:107-18. 1998....- Cardiovascular disease-related genes and regulation by dietJohn P Vanden Heuvel
Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
Curr Atheroscler Rep 11:448-55. 2009.... - The PPAR resource pageJohn P Vanden Heuvel
Department of Veterinary and Biomedical Sciences Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
Biochim Biophys Acta 1771:1108-12. 2007..Receiving greater than 300 unique visits per week, the PPAR resource page has become a useful tool for researchers of these important NRs... - Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X recJohn P Vanden Heuvel
Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
Toxicol Sci 92:476-89. 2006..Compared to naturally occurring long-chain fatty acids, e.g. linoleic and alpha-linolenic acids, these perfluorinated fatty acid analogs were more selective and less potent in their activation of the NRs... 
Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cellsJun Zhang
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
Nutr Metab (Lond) 8:61. 2011..abstract:..- Diet, fatty acids, and regulation of genes important for heart diseaseJohn P Vanden Heuvel
Department of Veterinary Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
Curr Atheroscler Rep 6:432-40. 2004..Three nuclear receptors are emphasized as fatty acid receptors that respond to dietary and endogenous ligands: peroxisome proliferator activated receptors, retinoid X receptors, and liver X receptors... - Peroxisome proliferator-activated receptors (PPARS) and carcinogenesisJ P Vanden Heuvel
Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802, USA
Toxicol Sci 47:1-8. 1999..In the present article, the current understanding of how PPARs are involved in tumorigenesis, and what this may mean to human risk assessment, will be discussed... - Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643John P Vanden Heuvel
Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
Toxicol Appl Pharmacol 188:185-98. 2003..These enzymes not only would affect growth factor signaling and cell cycle control but also could represent feedback control mechanisms and modulate the activity of PPARalpha... - Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulatorEric S Tien
Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 279:24053-63. 2004..The results described here suggest that CIT-ED2 is a coactivator of PPARalpha and that both proteins may participate in signaling cascades of hypoxic response and angiogenesis... - Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activityWasana K Sumanasekera
Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Biochemistry 42:10726-35. 2003..Thus, we describe the chaperone complex as being a regulator of PPARalpha and PPARbeta activity and have identified a novel, subtype-specific, inhibitory role for Hsp90... - Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genesEric S Tien
Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Cancer Res 63:5767-80. 2003.... - Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesCurtis J Omiecinski
Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, Pennsylvania 16802, USA
Toxicol Sci 120:S49-75. 2011..This review will briefly summarize these developments and investigate the expanding roles of xenobiotic receptor biology in the underlying basis of toxicological response to chemical agents... - Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemiaAnn C Skulas-Ray
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
Am J Clin Nutr 93:243-52. 2011..Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses... - Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake ErieJoshua P Gray
Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, 226 Fenske Laboratory, University Park, PA 16802, USA
Aquat Toxicol 64:343-58. 2003..Taken together, these studies show that sediment in Presque Isle Bay is highly contaminated with AhR ligands including dioxins and PAHs, but the brown bullhead are either not exposed or are non-responsive to these carcinogenic compounds... 
Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7Yunkyoung Lee
Integrative Biosciences, The Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr Biochem 20:848-59, 859.e1-5. 2009....- Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review)Seher A Khan
Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
J Nutr Biochem 14:554-67. 2003..Also, the regulation of gene expression by Conjugated Linoleic Acids (CLA), a family of dienoic fatty acids with a variety of beneficial effects, will be discussed... - Regulation of peroxisome proliferator-activated receptor-alpha by MDM2Lakshmi Gopinathan
The Huck Institutes of the Life Sciences, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Toxicol Sci 108:48-58. 2009..These studies identify a role for MDM2 in regulating PPARalpha-mediated pathways of lipid metabolism... - The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alphaJoshua P Gray
Department of Veterinary Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Toxicol Sci 89:535-46. 2006..These studies show that rpL11 inhibits PPARalpha activity and adds further evidence that ribosomal proteins play roles in the control of transcriptional regulation... - Modulation of PPAR activity via phosphorylationKatherine A Burns
Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
Biochim Biophys Acta 1771:952-60. 2007..The review will summarize the known PPAR kinases that directly act on these receptors, the sites affected and the result of this modification on receptor activity... - The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)Jeffrey D Coleman
Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
Free Radic Biol Med 42:1155-64. 2007..This research established 4-HNE as an endogenous modulator of PPARbeta/delta activity and raises the possibility that agonists of this nuclear receptor may be utilized to prevent or treat liver disease associated with oxidative damage... - Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2Wasana K Sumanasekera
Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 278:4467-73. 2003..This is the first demonstration that PPARalpha is stably associated with other proteins in tissue extracts and the first nuclear receptor shown to functionally interact with XAP2... - Regulation of peroxisome proliferator-activated receptor alpha by protein kinase CJoshua P Gray
Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, University Park, Pennsylvania 16802, USA
Biochemistry 44:10313-21. 2005..Together, these studies demonstrate a direct role for PKC in the regulation of PPARalpha, and suggest several PKCs can regulate PPARalpha activity through multiple phosphorylation sites... - Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoestersMoses T Bility
Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
Toxicol Sci 82:170-82. 2004.... - Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthmaCynthia Mueller
Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
Arch Biochem Biophys 418:186-96. 2003..T cells from these ciglitazone treated mice also produced less IFNgamma, IL-4, and IL-2 upon rechallenge in vitro with the model allergen. Our results suggest that ligands for PPARgamma may be effective treatments for asthmatic patients... - Selenium attenuates pro-inflammatory gene expression in macrophagesHema Vunta
Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis and Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, PA 16801, USA
Mol Nutr Food Res 52:1316-23. 2008..In summary, our results indicate that Se plays an important role as an anti-inflammatory agent by tightly regulating the expression of pro-inflammatory genes in immune cells... - Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cellsMichael B Dancu
Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, Fenske Lab, University Park, USA
Arterioscler Thromb Vasc Biol 24:2088-94. 2004.... - Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar)Christopher B Rees
Department of Fisheries and Wildlife, 13 Natural Resources Building, Michigan State University, East Lansing, MI 48824, USA
Aquat Toxicol 62:67-78. 2003..In addition, the results obtained demonstrate that quantitative PCR analysis of CYP1A expression is useful in studying ecotoxicity in populations of Atlantic salmon in the wild... - Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2Cheryl E Rockwell
Department of Pharmacology and Toxicology, Michigan State University, 315 National Food Safety and Toxicology Building, East Lansing, MI 48824-1317, USA
Mol Pharmacol 70:101-11. 2006..Together, the aforementioned studies identify PPARgamma as a novel intracellular target of 2-AG, which mediates the suppression of IL-2 by 2-AG in a manner that is independent of CB1 and/or CB2... - Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cellsGuixiang Zhao
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
Biochem Biophys Res Commun 336:909-17. 2005..The results indicate that the anti-inflammatory effects of polyunsaturated fatty acids may be, in part, due to the inhibition of NF-kappaB activation via activation of PPARgamma...
Research Grants
- BIOCHEMICAL CHARACTERIZATION OF PPARJOHN VANDEN HEUVEL; Fiscal Year: 2003..Taken together the proposed studies will greatly increase our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of chemical carcinogens. ..
- BIOCHEMICAL CHARACTERIZATION OF PPARJOHN VANDEN HEUVEL; Fiscal Year: 2007..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..