JOHN VANDEN HEUVEL

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint Mechanistic examination of walnuts in prevention of breast cancer
    John P Vanden Heuvel
    Department of Nutritional Sciences, Center of Excellence in Nutrigenomics, The Pennsylvania State University, University Park, PA, USA
    Nutr Cancer 64:1078-86. 2012
  2. pmc Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
    Jun Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
    Nutr Metab (Lond) 8:61. 2011
  3. ncbi request reprint Cardiovascular disease-related genes and regulation by diet
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 11:448-55. 2009
  4. ncbi request reprint The PPAR resource page
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Sciences Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
    Biochim Biophys Acta 1771:1108-12. 2007
  5. ncbi request reprint Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X rec
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
    Toxicol Sci 92:476-89. 2006
  6. ncbi request reprint Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37
    J P Vanden Heuvel
    Department of Veterinary Science and Molecular Toxicology Program, Penn State University, University Park, Pennsylvania 16802, USA
    Toxicol Appl Pharmacol 152:107-18. 1998
  7. ncbi request reprint Diet, fatty acids, and regulation of genes important for heart disease
    John P Vanden Heuvel
    Department of Veterinary Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 6:432-40. 2004
  8. ncbi request reprint Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643
    John P Vanden Heuvel
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
    Toxicol Appl Pharmacol 188:185-98. 2003
  9. ncbi request reprint Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis
    J P Vanden Heuvel
    Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 47:1-8. 1999
  10. ncbi request reprint Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator
    Eric S Tien
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:24053-63. 2004

Research Grants

  1. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2003
  2. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Mechanistic examination of walnuts in prevention of breast cancer
    John P Vanden Heuvel
    Department of Nutritional Sciences, Center of Excellence in Nutrigenomics, The Pennsylvania State University, University Park, PA, USA
    Nutr Cancer 64:1078-86. 2012
    ..Taken together, these data support an effect of walnut and its bioactive constituents on mammary epithelial cells and that multiple molecular targets may be involved...
  2. pmc Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
    Jun Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
    Nutr Metab (Lond) 8:61. 2011
    ..abstract:..
  3. ncbi request reprint Cardiovascular disease-related genes and regulation by diet
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 11:448-55. 2009
    ....
  4. ncbi request reprint The PPAR resource page
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Sciences Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, Penn State University, University Park, PA 16802, USA
    Biochim Biophys Acta 1771:1108-12. 2007
    ..Receiving greater than 300 unique visits per week, the PPAR resource page has become a useful tool for researchers of these important NRs...
  5. ncbi request reprint Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X rec
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
    Toxicol Sci 92:476-89. 2006
    ..Compared to naturally occurring long-chain fatty acids, e.g. linoleic and alpha-linolenic acids, these perfluorinated fatty acid analogs were more selective and less potent in their activation of the NRs...
  6. ncbi request reprint Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37
    J P Vanden Heuvel
    Department of Veterinary Science and Molecular Toxicology Program, Penn State University, University Park, Pennsylvania 16802, USA
    Toxicol Appl Pharmacol 152:107-18. 1998
    ....
  7. ncbi request reprint Diet, fatty acids, and regulation of genes important for heart disease
    John P Vanden Heuvel
    Department of Veterinary Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 6:432-40. 2004
    ..Three nuclear receptors are emphasized as fatty acid receptors that respond to dietary and endogenous ligands: peroxisome proliferator activated receptors, retinoid X receptors, and liver X receptors...
  8. ncbi request reprint Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643
    John P Vanden Heuvel
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
    Toxicol Appl Pharmacol 188:185-98. 2003
    ..These enzymes not only would affect growth factor signaling and cell cycle control but also could represent feedback control mechanisms and modulate the activity of PPARalpha...
  9. ncbi request reprint Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis
    J P Vanden Heuvel
    Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 47:1-8. 1999
    ..In the present article, the current understanding of how PPARs are involved in tumorigenesis, and what this may mean to human risk assessment, will be discussed...
  10. ncbi request reprint Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator
    Eric S Tien
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:24053-63. 2004
    ..The results described here suggest that CIT-ED2 is a coactivator of PPARalpha and that both proteins may participate in signaling cascades of hypoxic response and angiogenesis...
  11. ncbi request reprint Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity
    Wasana K Sumanasekera
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 42:10726-35. 2003
    ..Thus, we describe the chaperone complex as being a regulator of PPARalpha and PPARbeta activity and have identified a novel, subtype-specific, inhibitory role for Hsp90...
  12. ncbi request reprint Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes
    Eric S Tien
    Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cancer Res 63:5767-80. 2003
    ....
  13. pmc Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 93:243-52. 2011
    ..Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses...
  14. pmc Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities
    Curtis J Omiecinski
    Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 120:S49-75. 2011
    ..This review will briefly summarize these developments and investigate the expanding roles of xenobiotic receptor biology in the underlying basis of toxicological response to chemical agents...
  15. ncbi request reprint Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake Erie
    Joshua P Gray
    Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, 226 Fenske Laboratory, University Park, PA 16802, USA
    Aquat Toxicol 64:343-58. 2003
    ..Taken together, these studies show that sediment in Presque Isle Bay is highly contaminated with AhR ligands including dioxins and PAHs, but the brown bullhead are either not exposed or are non-responsive to these carcinogenic compounds...
  16. doi request reprint Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
    Yunkyoung Lee
    Integrative Biosciences, The Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr Biochem 20:848-59, 859.e1-5. 2009
    ....
  17. ncbi request reprint Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review)
    Seher A Khan
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
    J Nutr Biochem 14:554-67. 2003
    ..Also, the regulation of gene expression by Conjugated Linoleic Acids (CLA), a family of dienoic fatty acids with a variety of beneficial effects, will be discussed...
  18. ncbi request reprint The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha
    Joshua P Gray
    Department of Veterinary Sciences and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 89:535-46. 2006
    ..These studies show that rpL11 inhibits PPARalpha activity and adds further evidence that ribosomal proteins play roles in the control of transcriptional regulation...
  19. pmc Regulation of peroxisome proliferator-activated receptor-alpha by MDM2
    Lakshmi Gopinathan
    The Huck Institutes of the Life Sciences, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 108:48-58. 2009
    ..These studies identify a role for MDM2 in regulating PPARalpha-mediated pathways of lipid metabolism...
  20. pmc Modulation of PPAR activity via phosphorylation
    Katherine A Burns
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA
    Biochim Biophys Acta 1771:952-60. 2007
    ..The review will summarize the known PPAR kinases that directly act on these receptors, the sites affected and the result of this modification on receptor activity...
  21. ncbi request reprint Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2
    Wasana K Sumanasekera
    Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 278:4467-73. 2003
    ..This is the first demonstration that PPARalpha is stably associated with other proteins in tissue extracts and the first nuclear receptor shown to functionally interact with XAP2...
  22. pmc The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)
    Jeffrey D Coleman
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
    Free Radic Biol Med 42:1155-64. 2007
    ..This research established 4-HNE as an endogenous modulator of PPARbeta/delta activity and raises the possibility that agonists of this nuclear receptor may be utilized to prevent or treat liver disease associated with oxidative damage...
  23. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma
    Cynthia Mueller
    Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 418:186-96. 2003
    ..T cells from these ciglitazone treated mice also produced less IFNgamma, IL-4, and IL-2 upon rechallenge in vitro with the model allergen. Our results suggest that ligands for PPARgamma may be effective treatments for asthmatic patients...
  24. ncbi request reprint Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C
    Joshua P Gray
    Department of Veterinary Science, Center for Molecular Toxicology and Carcinogenesis, 325 Life Sciences Building, University Park, Pennsylvania 16802, USA
    Biochemistry 44:10313-21. 2005
    ..Together, these studies demonstrate a direct role for PKC in the regulation of PPARalpha, and suggest several PKCs can regulate PPARalpha activity through multiple phosphorylation sites...
  25. ncbi request reprint Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters
    Moses T Bility
    Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Toxicol Sci 82:170-82. 2004
    ....
  26. doi request reprint Selenium attenuates pro-inflammatory gene expression in macrophages
    Hema Vunta
    Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis and Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, PA 16801, USA
    Mol Nutr Food Res 52:1316-23. 2008
    ..In summary, our results indicate that Se plays an important role as an anti-inflammatory agent by tightly regulating the expression of pro-inflammatory genes in immune cells...
  27. ncbi request reprint Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells
    Michael B Dancu
    Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, Fenske Lab, University Park, USA
    Arterioscler Thromb Vasc Biol 24:2088-94. 2004
    ....
  28. ncbi request reprint Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2
    Cheryl E Rockwell
    Department of Pharmacology and Toxicology, Michigan State University, 315 National Food Safety and Toxicology Building, East Lansing, MI 48824 1317, USA
    Mol Pharmacol 70:101-11. 2006
    ..Together, the aforementioned studies identify PPARgamma as a novel intracellular target of 2-AG, which mediates the suppression of IL-2 by 2-AG in a manner that is independent of CB1 and/or CB2...
  29. ncbi request reprint Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar)
    Christopher B Rees
    Department of Fisheries and Wildlife, 13 Natural Resources Building, Michigan State University, East Lansing, MI 48824, USA
    Aquat Toxicol 62:67-78. 2003
    ..In addition, the results obtained demonstrate that quantitative PCR analysis of CYP1A expression is useful in studying ecotoxicity in populations of Atlantic salmon in the wild...
  30. ncbi request reprint Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Biochem Biophys Res Commun 336:909-17. 2005
    ..The results indicate that the anti-inflammatory effects of polyunsaturated fatty acids may be, in part, due to the inhibition of NF-kappaB activation via activation of PPARgamma...

Research Grants13

  1. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2003
    ..Taken together the proposed studies will greatly increase our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of chemical carcinogens. ..
  2. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2007
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..