D M Thiboutot

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients
    Melanie C Dispenza
    Department of Dermatology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 132:2198-205. 2012
  2. pmc Patient experiences with oily skin: the qualitative development of content for two new patient reported outcome questionnaires
    Robert Arbuckle
    Mapi Values Ltd, Adelphi Mill, Grimshaw Lane, Bollington, Cheshire, UK
    Health Qual Life Outcomes 6:80. 2008
  3. ncbi request reprint A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide
    Diane Thiboutot
    Penn State College of Medicine, Hershey, PA 17033, USA
    Cutis 84:48-55. 2009
  4. ncbi request reprint Acne: hormonal concepts and therapy
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University, College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Clin Dermatol 22:419-28. 2004
  5. ncbi request reprint Acne counseling to improve adherence
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Cutis 81:81-6. 2008
  6. doi request reprint New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, USA
    J Am Acad Dermatol 60:S1-50. 2009
  7. ncbi request reprint Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study
    Diane M Thiboutot
    Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Skinmed 4:138-46. 2005
  8. ncbi request reprint Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 120:905-14. 2003
  9. ncbi request reprint Update and future of hormonal therapy in acne
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Penn, USA
    Dermatology 206:57-67. 2003
  10. ncbi request reprint Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 57:791-9. 2007

Collaborators

Detail Information

Publications53

  1. pmc Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients
    Melanie C Dispenza
    Department of Dermatology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 132:2198-205. 2012
    ..The modulation of TLR-2 expression on monocytes has important implications in other inflammatory disorders characterized by TLR-2 dysregulation...
  2. pmc Patient experiences with oily skin: the qualitative development of content for two new patient reported outcome questionnaires
    Robert Arbuckle
    Mapi Values Ltd, Adelphi Mill, Grimshaw Lane, Bollington, Cheshire, UK
    Health Qual Life Outcomes 6:80. 2008
    ....
  3. ncbi request reprint A 3-step acne system containing solubilized benzoyl peroxide versus clindamycin-benzoyl peroxide
    Diane Thiboutot
    Penn State College of Medicine, Hershey, PA 17033, USA
    Cutis 84:48-55. 2009
    ..The 3-step acne system is at least as effective as clindamycin-BPO in reducing noninflammatory lesion counts in the early weeks of treatment in the absence of an antibiotic, which is likely attributed to the solubilized BPO formulation...
  4. ncbi request reprint Acne: hormonal concepts and therapy
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University, College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Clin Dermatol 22:419-28. 2004
    ..Hormonal therapy is an option in women with acne not responding to conventional treatment or with signs of endocrine abnormalities...
  5. ncbi request reprint Acne counseling to improve adherence
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Cutis 81:81-6. 2008
    ....
  6. doi request reprint New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, USA
    J Am Acad Dermatol 60:S1-50. 2009
    ..As in the original supplement, the authors have based recommendations on published evidence as much as possible...
  7. ncbi request reprint Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study
    Diane M Thiboutot
    Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Skinmed 4:138-46. 2005
    ....
  8. ncbi request reprint Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 120:905-14. 2003
    ..These data demonstrate that the skin is in fact a steroidogenic tissue. The clinical significance of this finding in mediating androgenic skin disorders such as acne, hirsutism, or androgenetic alopecia remains to be established...
  9. ncbi request reprint Update and future of hormonal therapy in acne
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Penn, USA
    Dermatology 206:57-67. 2003
    ..The knowledge gained from this work may provide an impetus for future drug discovery in the hormonal treatment of acne and lead to improvements in the care of our patients with acne...
  10. ncbi request reprint Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 57:791-9. 2007
    ..A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne...
  11. ncbi request reprint Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, USA
    Arch Dermatol 142:597-602. 2006
    ..To assess the maintenance effect of adapalene gel, 0.1%, relative to gel vehicle in subjects successfully treated in a previous 12-week study of adapalene-doxycycline, 100 mg, combination therapy...
  12. ncbi request reprint Endocrinological evaluation and hormonal therapy for women with difficult acne
    D M Thiboutot
    Section of Dermatology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Eur Acad Dermatol Venereol 15:57-61. 2001
    ..Various options for hormonal therapy are then described, including a further discussion of oral contraceptives (OCs) in the treatment of acne...
  13. ncbi request reprint Immunolocalization of 5alpha-reductase isozymes in acne lesions and normal skin
    D Thiboutot
    Section of Dermatology, UPC 2, Room 4300, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Arch Dermatol 136:1125-9. 2000
    ..Since specific inhibition of 5alpha-reductase type 1 may represent a novel therapeutic approach to acne, it is important to define the localization of these isozymes in normal sebaceous follicles and acne lesions...
  14. ncbi request reprint Pharmacokinetics of dapsone gel, 5% for the treatment of acne vulgaris
    Diane M Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Clin Pharmacokinet 46:697-712. 2007
    ..As dapsone is administered topically, it was expected that systemic absorption would be considerably lower than that observed with oral dapsone therapy, thereby avoiding any adverse haematological effects...
  15. pmc TRAIL contributes to the apoptotic effect of 13-cis retinoic acid in human sebaceous gland cells
    A M Nelson
    The Jake Gittlen Cancer Research Foundation and Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Br J Dermatol 165:526-33. 2011
    ..13-cis RA induces key genes in sebocytes that are involved in apoptosis, including Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL)...
  16. pmc Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne
    K R Lumsden
    The Jake Gittlen Cancer Research Foundation, Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Br J Dermatol 165:302-10. 2011
    ..Recently, the protein neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes...
  17. ncbi request reprint Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea
    James J Leyden
    Skin Study Center, Broomall, Pennsylvania, USA
    Cutis 73:11-7. 2004
    ..647 (BP/C) and 0.722 (vehicle) on the OGI scale (P < .001). These results showed that BP/C was significantly more effective than vehicle in improving papules and pustules associated with rosacea...
  18. pmc IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway
    Terry M Smith
    The Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
    J Invest Dermatol 128:1286-93. 2008
    ..Specific targeted interruption of this pathway in the sebaceous gland could be a desirable approach to reducing sebum production and improving acne...
  19. ncbi request reprint Efficacy and tolerability of adapalene 0.3% gel compared to tazarotene 0.1% gel in the treatment of acne vulgaris
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Drugs Dermatol 7:s3-10. 2008
    ..5% versus 14%, respectively). Once daily therapy with adapalene 0.3% gel provided similar efficacy (noninferior) to tazarotene 0.1% gel in the treatment of acne vulgaris, but demonstrated a superior tolerability profile...
  20. ncbi request reprint Acne and rosacea. New and emerging therapies
    D M Thiboutot
    Section of Dermatology, Pennsylvania State University, College of Medicine, Hershey, USA
    Dermatol Clin 18:63-71, viii. 2000
    ..75% metronidazole gel, and data regarding the controversial association of rosacea with Helicobacter pylori infection...
  21. ncbi request reprint Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Ther 27:216-24. 2005
    ..Despite published data showing the efficacy of topical retinoids in treating inflammatory acne, in clinical practice topical retinoids tend to be used most commonly for noninflammatory acne...
  22. doi request reprint Hormonal therapy for acne
    Rosalyn George
    Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Semin Cutan Med Surg 27:188-96. 2008
    ..In this article, we discuss the effects of hormones on the pathogenesis of acne, evaluation of women with suspected endocrine abnormalities, and the myriad of treatment options available...
  23. doi request reprint An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients
    Diane Thiboutot
    Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 59:792-800. 2008
    ..We sought to evaluate efficacy, safety, and tolerability of a combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% (clindamycin-BPO 2.5%) aqueous gel in moderate to severe acne vulgaris...
  24. ncbi request reprint Antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 82:5-12. 2008
    ....
  25. ncbi request reprint A randomized, parallel, vehicle-controlled comparison of two erythromycin/benzoyl peroxide preparations for acne vulgaris
    Diane Thiboutot
    Pennsylvania State University College of Medicine, Hershey, USA
    Clin Ther 24:773-85. 2002
    ..Topical erythromycin/benzoyl peroxide (EBP), marketed for acne treatment, must be compounded by a pharmacist and requires subsequent refrigeration, warranting the development of alternate formulations...
  26. ncbi request reprint Azelaic acid gel 15%: clinical versatility in the treatment of rosacea
    James Q Del Rosso
    Department of Dermatology, University of Nevada School of Medicine, Las Vegas, USA
    Cutis 78:6-19. 2006
    ..In a roundtable discussion, information leaders discussed the pathophysiology of rosacea and other issues of importance to successful rosacea management, such as skin care regimens, quality of life (QOL), and compliance...
  27. ncbi request reprint Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    J Drugs Dermatol 7:13-6. 2008
    ..7% of patients. The majority of patients were more satisfied with AzA than with previous therapies. AzA 15% gel represents a new therapeutic option for the treatment of acne vulgaris...
  28. ncbi request reprint Regulation of human sebaceous glands
    Diane Thiboutot
    The Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA, USA
    J Invest Dermatol 123:1-12. 2004
  29. ncbi request reprint Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?
    K R Smith
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Lipid Res 49:271-81. 2008
    ..This review seeks to present an update on the physiology of the sebaceous glands, with particular emphasis on the production of sebaceous lipids...
  30. ncbi request reprint Cutaneous androgen metabolism: basic research and clinical perspectives
    WenChieh Chen
    Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Invest Dermatol 119:992-1007. 2002
    ..Pharmacologic development of more potent specific isoenzyme antagonists may lead to better clinical treatment or even prevention of androgen-dependent dermatoses...
  31. ncbi request reprint Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Am Acad Dermatol 48:836-45. 2003
    ..Rosacea is a common, chronic dermatosis for which safe and effective new treatment options are needed...
  32. ncbi request reprint Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial
    Diane Thiboutot
    Department of Dermatology, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 54:242-50. 2006
    ..A new 0.3% gel formulation of adapalene has been developed...
  33. ncbi request reprint Acne: 1991-2001
    Diane Thiboutot
    Division of Dermatology, Pennsylvania State College of Medicine, 500 University Drive, UPC 2, Suite 4300, Hershey, PA 17033, USA
    J Am Acad Dermatol 47:109-17. 2002
  34. ncbi request reprint Expert committee recommendations for acne management
    Andrea L Zaenglein
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Pediatrics 118:1188-99. 2006
    ..Because of their effect on the microcomedo, topical retinoids also are recommended as an important facet of maintenance therapy...
  35. ncbi request reprint Azelaic acid 15% gel once daily versus twice daily in papulopustular rosacea
    Diane M Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Drugs Dermatol 7:541-6. 2008
    ..In order to test this hypothesis, an exploratory study was conducted...
  36. ncbi request reprint Diagnosing and managing the patient with rosacea
    Christine L Mackley
    Milton S Hershey Medical Center, Pennsylvania, USA
    Cutis 75:25-9. 2005
    ..Treatments include topical agents, oral antibiotics, laser therapies, surgical treatments, and the role of cosmetics and skin care...
  37. ncbi request reprint Long-term safety and efficacy study of adapalene 0.3% gel
    Jonathan S Weiss
    Gwinnett Dermatology, Snellville, GA, USA
    J Drugs Dermatol 7:s24-8. 2008
    ..Adapalene 0.3% gel was safe and effective in the long-term (up to 1 year) treatment of subjects with acne vulgaris...
  38. ncbi request reprint Effects of tazarotene 0.1 % cream in the treatment of facial acne vulgaris: pooled results from two multicenter, double-blind, randomized, vehicle-controlled, parallel-group trials
    Alan R Shalita
    State University of New York Health Sciences Center, Brooklyn, New York, USA
    Clin Ther 26:1865-73. 2004
    ..The effects of the gel formulation of the topical retinoid tazarotene have been widely reported, but few data on the cream formulation are available...
  39. ncbi request reprint The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: A randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle
    David M Pariser
    Virginia Clinical Research, Inc, Norfolk, USA
    Cutis 76:145-51. 2005
    ..The results of this study show that adapalene gel 0.3% was superior to adapalene gel 0.1% and vehicle in the treatment of moderate to moderately severe acne while retaining a similar safety and tolerability profile to adapalene 0.1% gel...
  40. ncbi request reprint Overview of acne and its treatment
    Diane M Thiboutot
    Pennsylvania State University College of Medicine, Hershey Laboratories, USA
    Cutis 81:3-7. 2008
    ..Further investigation into agents that can reduce sebum production is warranted...
  41. ncbi request reprint Comparison of tazarotene and minocycline maintenance therapies in acne vulgaris: a multicenter, double-blind, randomized, parallel-group study
    James Leyden
    Skin Study Center, Broomall, PA, USA
    Arch Dermatol 142:605-12. 2006
    ..To evaluate the efficacy of 3 maintenance regimens (topical tazarotene, oral minocycline hydrochloride, or both) in sustaining improvement in acne...
  42. ncbi request reprint Treatment considerations for inflammatory acne: clinical evidence for adapalene 0.1% in combination therapies
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    J Drugs Dermatol 5:785-94. 2006
    ..This review evaluates the rationale and clinical evidence for the use of adapalene in combination therapy for inflammatory acne...
  43. ncbi request reprint Guidelines of care for acne vulgaris management
    John S Strauss
    Department of Dermatology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    J Am Acad Dermatol 56:651-63. 2007
    ..The ultimate judgment regarding the propriety of any specific therapy must be made by the physician and the patient in light of all the circumstances presented by the individual patient...
  44. ncbi request reprint Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications
    Shari B Clarke
    The Department of Dermatology, The Pennsylvania State University College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Dermatol Clin 25:137-46, v. 2007
    ..This article focuses on the mechanisms by which these treatment modalities act on the sebaceous glands and their clinical use in the practice of medicine...
  45. ncbi request reprint Peroxisome proliferator-activated receptors increase human sebum production
    Nishit R Trivedi
    The Jake Gittlen Cancer Research Institute, Hershey, Pennsylvania 17033, USA
    J Invest Dermatol 126:2002-9. 2006
    ..These data indicate that PPARs play a role in regulating sebum production and that selective modulation of their activity may represent a novel therapeutic strategy for the treatment of acne...
  46. ncbi request reprint Pathogenesis of acne: recent research advances
    Julie C Harper
    University of Alabama, Birmingham, Alabama, USA
    Adv Dermatol 19:1-10. 2003
    ....
  47. ncbi request reprint American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: summary and recommendations
    Lowell A Goldsmith
    American Academy of Dermatology, University of Rochester, Rochester, New York, USA
    J Am Acad Dermatol 50:900-6. 2004
  48. pmc Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells
    Amanda M Nelson
    Jake Gittlen Cancer Research Foundation
    J Clin Invest 118:1468-78. 2008
    ....
  49. ncbi request reprint Diet and acne revisited
    Diane M Thiboutot
    Arch Dermatol 138:1591-2. 2002
  50. ncbi request reprint Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1
    Terry M Smith
    The Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
    J Invest Dermatol 126:1226-32. 2006
    ..These data indicate that activation of the IGF-1 receptor increases lipogenesis in SEB-1 cells through both SREBP-dependent and SREBP-independent pathways...
  51. ncbi request reprint 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes
    Amanda M Nelson
    The Jake Gittlen Cancer Research Foundation, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    J Invest Dermatol 126:2178-89. 2006
    ..Taken together these data indicate that 13-cis RA causes cell cycle arrest and induces apoptosis in SEB-1 sebocytes by a RAR-independent mechanism, which contributes to its sebosuppressive effect and the resolution of acne...
  52. ncbi request reprint Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling
    Nishit R Trivedi
    The Jake Gittlen Cancer Research Foundation, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Invest Dermatol 126:1071-9. 2006
    ..These studies are the first describing the comprehensive changes in gene expression in inflammatory acne lesions and are valuable in identifying potential therapeutic targets in inflammatory acne...
  53. ncbi request reprint Improving outcomes through collaboration
    Diane M Thiboutot
    Pennsylvania State University College of Medicine, Hershey, USA
    Cutis 81:26-31. 2008
    ..Female patients should be advised to see their gynecologists annually for breast and pelvic examinations and to discuss their concerns surrounding the use of OCs...

Research Grants9

  1. Regulation of Lipid Metabolism in Human Sebaceous Glands
    Diane Thiboutot; Fiscal Year: 2002
    ..Data generated from the proposed experiments will advance our understanding of the mechanisms regulating sebum production and can lead to identification of potential additional therapeutic target sites in the treatment of acne. ..
  2. Regulation of Lipid Metabolism in Human Sebaceous Glands
    Diane Thiboutot; Fiscal Year: 2003
    ..Data generated from the proposed experiments will advance our understanding of the mechanisms regulating sebum production and can lead to identification of potential additional therapeutic target sites in the treatment of acne. ..
  3. Regulation of Lipid Metabolism in Human Sebaceous Glands
    Diane Thiboutot; Fiscal Year: 2004
    ..Data generated from the proposed experiments will advance our understanding of the mechanisms regulating sebum production and can lead to identification of potential additional therapeutic target sites in the treatment of acne. ..
  4. Regulation of Lipid Metabolism in Human Sebaceous Glands
    Diane Thiboutot; Fiscal Year: 2005
    ..Data generated from the proposed experiments will advance our understanding of the mechanisms regulating sebum production and can lead to identification of potential additional therapeutic target sites in the treatment of acne. ..
  5. Regulation of Lipid Metabolism in Human Sebaceous Glands
    Diane Thiboutot; Fiscal Year: 2006
    ..Data generated from the proposed experiments will advance our understanding of the mechanisms regulating sebum production and can lead to identification of potential additional therapeutic target sites in the treatment of acne. ..
  6. Regulation of human sebaceous glands by 13-cis retinoic acid
    Diane Thiboutot; Fiscal Year: 2007
    ..The findings of these studies not only have the potential to advance our understanding of retinoid action in acne, but can lead to advances in the understanding of these agents in cancer biology and in innate immunity as well. ..
  7. Regulation of human sebaceous glands by 13-cis retinoic acid
    Diane Thiboutot; Fiscal Year: 2008
    ..The findings of these studies not only have the potential to advance our understanding of retinoid action in acne, but can lead to advances in the understanding of these agents in cancer biology and in innate immunity as well. ..
  8. Regulation of human sebaceous glands by 13-cis retinoic acid
    Diane Thiboutot; Fiscal Year: 2009
    ..The findings of these studies not only have the potential to advance our understanding of retinoid action in acne, but can lead to advances in the understanding of these agents in cancer biology and in innate immunity as well. ..
  9. Regulation of human sebaceous glands by 13-cis retinoic acid
    Diane M Thiboutot; Fiscal Year: 2010
    ..The findings of these studies not only have the potential to advance our understanding of retinoid action in acne, but can lead to advances in the understanding of these agents in cancer biology and in innate immunity as well. ..