Shao-Cong Sun

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma
    S C Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    AIDS Res Hum Retroviruses 16:1591-6. 2000
  2. ncbi request reprint Activation of NF-kappaB by HTLV-I and implications for cell transformation
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Oncogene 24:5952-64. 2005
  3. pmc IkappaB kinase is an essential component of the Tpl2 signaling pathway
    Michael Waterfield
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Mol Cell Biol 24:6040-8. 2004
  4. ncbi request reprint Deregulation of NF-kappaB and its upstream kinases in cancer
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Metastasis Rev 22:405-22. 2003
  5. ncbi request reprint An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway
    Matthew D Morrison
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:10018-24. 2005
  6. ncbi request reprint Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation
    Geetha R Babu
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Biochim Biophys Acta 1763:174-81. 2006
  7. ncbi request reprint Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:26243-50. 2004
  8. ncbi request reprint Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    Nicole S Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 282:4185-92. 2007
  9. ncbi request reprint Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    Gutian Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:30099-105. 2004
  10. ncbi request reprint Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells
    Geetha Babu
    Department of Microbiology and Immunology, Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 281:14041-7. 2006

Collaborators

  • Wei Jin
  • Gutian Xiao
  • Gongxian Liao
  • L Good
  • Mary Ellen Cvijic
  • Tadaatsu Imaizumi
  • Edward W Harhaj
  • Minying Zhang
  • Xuefeng Wu
  • William Reiley
  • William W Reiley
  • Ato Wright
  • Mikyoung Chang
  • Michael Waterfield
  • Abraham Fong
  • Nicole S Harhaj
  • Andrew Joon Lee
  • Christopher C Norbury
  • Chunyang Liang
  • Wenyi Zhang
  • Geetha R Babu
  • Geetha Babu
  • Matthew D Morrison
  • Andrew J Lee
  • Eric F Tewalt
  • Timothy O Leonard
  • Leo Fitzpatrick
  • Keri B Donohue
  • Joseph Y Cheung
  • Dwayne L Barber
  • Lourdes Norman
  • Linda Penn
  • Barbara A Miller
  • Iwona Hirschler-Laszkiewicz
  • Mandy Losiewicz
  • Kathleen Conrad
  • Qin Tong
  • Richard Stahl
  • David J Carey
  • Erica Granger
  • John Neely

Detail Information

Publications27

  1. ncbi request reprint Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma
    S C Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    AIDS Res Hum Retroviruses 16:1591-6. 2000
    ..The Tax/IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits, IKKalpha and IKKbeta, and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK...
  2. ncbi request reprint Activation of NF-kappaB by HTLV-I and implications for cell transformation
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Oncogene 24:5952-64. 2005
    ..Clarifying the precise nature and consequences of the constitutive NF-kappaB activation in ATL cells is important for developing rational therapeutic strategies for this T-cell malignancy...
  3. pmc IkappaB kinase is an essential component of the Tpl2 signaling pathway
    Michael Waterfield
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Mol Cell Biol 24:6040-8. 2004
    ..These findings suggest that IKKbeta exerts its immune-regulatory functions by targeting different downstream signaling pathways...
  4. ncbi request reprint Deregulation of NF-kappaB and its upstream kinases in cancer
    Shao Cong Sun
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Metastasis Rev 22:405-22. 2003
    ..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation...
  5. ncbi request reprint An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway
    Matthew D Morrison
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:10018-24. 2005
    ..These findings suggest that the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway...
  6. ncbi request reprint Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation
    Geetha R Babu
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Biochim Biophys Acta 1763:174-81. 2006
    ..However, the p105-bound Tpl2 is unable to phosphorylate its physiological target, MEK1. These findings suggest that p105 functions as a competitive inhibitor of Tpl2 that blocks its access by MEK1...
  7. ncbi request reprint Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:26243-50. 2004
    ..These results suggest that induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation...
  8. ncbi request reprint Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    Nicole S Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 282:4185-92. 2007
    ..Together, these results demonstrate that Tax induces relocalization of the IKK complex in a ubiquitin-dependent manner, and dynamic changes in the subcellular localization of the IKK complex may be critical for Tax function...
  9. ncbi request reprint Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    Gutian Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:30099-105. 2004
    ..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing...
  10. ncbi request reprint Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells
    Geetha Babu
    Department of Microbiology and Immunology, Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 281:14041-7. 2006
    ..Finally, Tpl2/Cot participates in the activation of NF-kappaB by Tax. These findings indicate that deregulated activation of Tpl2/Cot may occur in human cancer cells...
  11. ncbi request reprint Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
    Ato Wright
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Dev Cell 13:705-16. 2007
    ..These findings establish CYLD as a pivotal deubiquitinating enzyme (DUB) that regulates germ cell apoptosis and spermatogenesis and suggest an essential role for CYLD in controlling the RIP1/NF-kappaB signaling axis in testis...
  12. ncbi request reprint Negative regulation of JNK signaling by the tumor suppressor CYLD
    William Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 279:55161-7. 2004
    ..These findings identify the JNK signaling pathway as a major downstream target of CYLD and suggest a receptor-dependent role of CYLD in regulating the IkappaB kinase pathway...
  13. pmc Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Exp Med 204:1475-85. 2007
    ..These results emphasize a critical role for CYLD in preventing spontaneous activation of the Tak1 axis of T cell signaling and, thereby, maintaining normal T cell function...
  14. pmc Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation
    William Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Mol Cell Biol 25:3886-95. 2005
    ..These findings suggest that CYLD serves as a novel target of IKK and that the site-specific phosphorylation of CYLD regulates its signaling function...
  15. pmc Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
    Xuefeng Wu
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PO Box 850, Hershey, Pennsylvania 17033, USA
    EMBO Rep 8:510-5. 2007
    ..These findings show a pathological mechanism of IKK activation by Tax and provide an example for how IKK is persistently activated in cancer cells...
  16. ncbi request reprint beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
    Chunyang Liang
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P O Box 850, Hershey, Pennsylvania 17033, USA
    Cell Signal 18:1309-17. 2006
    ..These data suggest that p100 processing involves its phosphorylation at specific terminal serines, which form a binding site for beta-TrCP thereby regulating p100 ubiquitination...
  17. ncbi request reprint Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells
    Wei Jin
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:15884-93. 2007
    ..These findings demonstrate a critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells...
  18. ncbi request reprint Regulation of T cell development by the deubiquitinating enzyme CYLD
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nat Immunol 7:411-7. 2006
    ..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells...
  19. ncbi request reprint Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway
    Edward W Harhaj
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
    Virology 333:145-58. 2005
    ..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis...
  20. ncbi request reprint Study of T-cell signaling by somatic cell mutagenesis and complementation cloning
    Mary Ellen Cvijic
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Immunol Methods 278:293-304. 2003
    ..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants...
  21. ncbi request reprint S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100
    Abraham Fong
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Biol Chem 277:40697-702. 2002
    ..Finally, we provide genetic evidence for the essential role of S9 in the inducible processing of p100...
  22. ncbi request reprint Regulation of NF-kappaB2/p100 processing by its nuclear shuttling
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Oncogene 22:4868-74. 2003
    ..These results suggest that nuclear shuttling is a mechanism regulating the processing of NF-kappaB2/p100...
  23. ncbi request reprint TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage
    Wenyi Zhang
    Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, USA
    Am J Physiol Cell Physiol 290:C1146-59. 2006
    ..Inhibition of TRPM2-L function by reduction in TRPM2 levels, interaction with TRPM2-S, or Ca(2+) chelation antagonizes this important cell death pathway...
  24. ncbi request reprint Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100
    Abraham Fong
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:22111-4. 2002
    ..Interestingly the constitutive processing of p100 mutants was independent of beta-TrCP. These results suggest that beta-TrCP is an essential component of NIK-induced p100 processing...
  25. pmc Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
    Wei Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1858-66. 2008
    ..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis...
  26. pmc Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
    Minying Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:18621-6. 2008
    ..These findings establish CYLD as a key negative regulator of IKKepsilon/TBK1 and suggest a role for CYLD in the control of RIG-I ubiquitination...
  27. doi request reprint Deubiquitylation and regulation of the immune response
    Shao Cong Sun
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nat Rev Immunol 8:501-11. 2008
    ..As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses...