Research Topics
Genomes and Genes
| Shao-Cong SunSummaryAffiliation: Pennsylvania State University Country: USA Publications
| Collaborators
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Detail Information
Publications
Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgammaS C Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
AIDS Res Hum Retroviruses 16:1591-6. 2000..The Tax/IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits, IKKalpha and IKKbeta, and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK...- Activation of NF-kappaB by HTLV-I and implications for cell transformationShao Cong Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Oncogene 24:5952-64. 2005..Clarifying the precise nature and consequences of the constitutive NF-kappaB activation in ATL cells is important for developing rational therapeutic strategies for this T-cell malignancy... 
IkappaB kinase is an essential component of the Tpl2 signaling pathwayMichael Waterfield
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Mol Cell Biol 24:6040-8. 2004..These findings suggest that IKKbeta exerts its immune-regulatory functions by targeting different downstream signaling pathways...- Deregulation of NF-kappaB and its upstream kinases in cancerShao Cong Sun
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Cancer Metastasis Rev 22:405-22. 2003..In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation... - An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathwayMatthew D Morrison
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
J Biol Chem 280:10018-24. 2005..These findings suggest that the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway... - Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulationGeetha R Babu
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA
Biochim Biophys Acta 1763:174-81. 2006..However, the p105-bound Tpl2 is unable to phosphorylate its physiological target, MEK1. These findings suggest that p105 functions as a competitive inhibitor of Tpl2 that blocks its access by MEK1... - Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradationGongxian Liao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 279:26243-50. 2004..These results suggest that induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation... - Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinaseNicole S Harhaj
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
J Biol Chem 282:4185-92. 2007..Together, these results demonstrate that Tax induces relocalization of the IKK complex in a ubiquitin-dependent manner, and dynamic changes in the subcellular localization of the IKK complex may be critical for Tax function... - Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylationGutian Xiao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 279:30099-105. 2004..These data also provide the first evidence for explaining why overexpression of IKKalpha or its activation by many other stimuli such as tumor necrosis factor and mitogens fails to induce p100 processing... - Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cellsGeetha Babu
Department of Microbiology and Immunology, Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 281:14041-7. 2006..Finally, Tpl2/Cot participates in the activation of NF-kappaB by Tax. These findings indicate that deregulated activation of Tpl2/Cot may occur in human cancer cells... - Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLDAto Wright
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Dev Cell 13:705-16. 2007..These findings establish CYLD as a pivotal deubiquitinating enzyme (DUB) that regulates germ cell apoptosis and spermatogenesis and suggest an essential role for CYLD in controlling the RIP1/NF-kappaB signaling axis in testis... - Negative regulation of JNK signaling by the tumor suppressor CYLDWilliam Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Biol Chem 279:55161-7. 2004..These findings identify the JNK signaling pathway as a major downstream target of CYLD and suggest a receptor-dependent role of CYLD in regulating the IkappaB kinase pathway... - Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responsesWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Exp Med 204:1475-85. 2007..These results emphasize a critical role for CYLD in preventing spontaneous activation of the Tak1 axis of T cell signaling and, thereby, maintaining normal T cell function... - Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylationWilliam Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Mol Cell Biol 25:3886-95. 2005..These findings suggest that CYLD serves as a novel target of IKK and that the site-specific phosphorylation of CYLD regulates its signaling function... - Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKKXuefeng Wu
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, PO Box 850, Hershey, Pennsylvania 17033, USA
EMBO Rep 8:510-5. 2007..These findings show a pathological mechanism of IKK activation by Tax and provide an example for how IKK is persistently activated in cancer cells... - beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870Chunyang Liang
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P O Box 850, Hershey, Pennsylvania 17033, USA
Cell Signal 18:1309-17. 2006..These data suggest that p100 processing involves its phosphorylation at specific terminal serines, which form a binding site for beta-TrCP thereby regulating p100 ubiquitination... - Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cellsWei Jin
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 282:15884-93. 2007..These findings demonstrate a critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells... - Regulation of T cell development by the deubiquitinating enzyme CYLDWilliam W Reiley
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Nat Immunol 7:411-7. 2006..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells... - Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathwayEdward W Harhaj
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, Miami, FL 33136, USA
Virology 333:145-58. 2005..Collectively, these results indicate that CD40 is a novel Tax-regulated gene, and the regulation of CD40 by Tax may play a role in cellular activation and HTLV-I-induced disease pathogenesis... - Study of T-cell signaling by somatic cell mutagenesis and complementation cloningMary Ellen Cvijic
Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Immunol Methods 278:293-304. 2003..Clearly, creation of a somatic cell genetic system can yield exciting new advances in deciphering signal transduction events by discovery of novel pathway participants... - S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100Abraham Fong
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Biol Chem 277:40697-702. 2002..Finally, we provide genetic evidence for the essential role of S9 in the inducible processing of p100... - Regulation of NF-kappaB2/p100 processing by its nuclear shuttlingGongxian Liao
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Oncogene 22:4868-74. 2003..These results suggest that nuclear shuttling is a mechanism regulating the processing of NF-kappaB2/p100... - TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavageWenyi Zhang
Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, USA
Am J Physiol Cell Physiol 290:C1146-59. 2006..Inhibition of TRPM2-L function by reduction in TRPM2 levels, interaction with TRPM2-S, or Ca(2+) chelation antagonizes this important cell death pathway... - Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100Abraham Fong
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 277:22111-4. 2002..Interestingly the constitutive processing of p100 mutants was independent of beta-TrCP. These results suggest that beta-TrCP is an essential component of NIK-induced p100 processing... - Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in miceWei Jin
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 118:1858-66. 2008..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis... - Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLDMinying Zhang
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 283:18621-6. 2008..These findings establish CYLD as a key negative regulator of IKKepsilon/TBK1 and suggest a role for CYLD in the control of RIG-I ubiquitination... 
Deubiquitylation and regulation of the immune responseShao Cong Sun
Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
Nat Rev Immunol 8:501-11. 2008..As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses...