Thomas C Stover

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug
    Thomas C Stover
    Department of Pharmacology, 500 University Drive, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Biomaterials 29:359-69. 2008
  2. ncbi Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains
    Todd E Fox
    Department of Pharmacology College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:12450-7. 2007
  3. ncbi Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma
    Thomas C Stover
    Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Clin Cancer Res 11:3465-74. 2005

Collaborators

  • Mark Kester
  • Jong K Yun
  • Todd E Fox
  • Stanley J Naides
  • Onur Unal
  • Sean M O'Neill
  • Murali Nagarajan
  • Kristy L Houck
  • Pawel T Pomianowski

Detail Information

Publications3

  1. ncbi Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug
    Thomas C Stover
    Department of Pharmacology, 500 University Drive, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Biomaterials 29:359-69. 2008
    ..The designed thermoresponsive and biodegradable linear-dendritic nanoparticles have great potential for thermally targeted and sustained release of C(6) for the treatment of solid tumors with hyperthermia...
  2. ncbi Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains
    Todd E Fox
    Department of Pharmacology College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:12450-7. 2007
    ..Taken together, these data demonstrate that structured membrane microdomains are necessary for ceramide-induced activation of PKC zeta and resultant diminished Akt activity, leading to vascular smooth muscle cell growth arrest...
  3. ncbi Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma
    Thomas C Stover
    Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Clin Cancer Res 11:3465-74. 2005
    ..Together, these results indicate that bioactive ceramide analogues can be incorporated into pegylated liposomal vehicles for improved solubility, drug delivery, and antineoplastic efficacy...