Thomas C Stover
Affiliation: Pennsylvania State University
- Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drugThomas C Stover
Department of Pharmacology, 500 University Drive, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
Biomaterials 29:359-69. 2008..The designed thermoresponsive and biodegradable linear-dendritic nanoparticles have great potential for thermally targeted and sustained release of C(6) for the treatment of solid tumors with hyperthermia...
- Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomainsTodd E Fox
Department of Pharmacology College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
J Biol Chem 282:12450-7. 2007..Taken together, these data demonstrate that structured membrane microdomains are necessary for ceramide-induced activation of PKC zeta and resultant diminished Akt activity, leading to vascular smooth muscle cell growth arrest...
- Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinomaThomas C Stover
Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
Clin Cancer Res 11:3465-74. 2005..Together, these results indicate that bioactive ceramide analogues can be incorporated into pegylated liposomal vehicles for improved solubility, drug delivery, and antineoplastic efficacy...