Affiliation: Pennsylvania State University
Steiner J, Bardgett M, Wolfgang L, Lang C, Stocker S. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol. 2014;112:2597-604 pubmed publisher
..Collectively, these findings suggest that dexamethasone attenuates the sympathoexcitatory actions of insulin through a disruption of ARC neuronal function downstream of Akt or mammalian target of rapamycin (mTOR) signaling. ..
Stocker S, Gordon K. Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation. J Neurophysiol. 2015;113:1302-9 pubmed publisher
..These drug treatments did not alter any variable in animals infused with saline. Altogether, these findings suggest that glutamatergic NMDA neurotransmission in the PVH contributes to insulin-induced sympathoexcitation. ..
Stocker S, Lang S, Simmonds S, Wenner M, Farquhar W. Cerebrospinal Fluid Hypernatremia Elevates Sympathetic Nerve Activity and Blood Pressure via the Rostral Ventrolateral Medulla. Hypertension. 2015;66:1184-90 pubmed publisher
Tucker A, Stocker S. Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats. Am J Physiol Regul Integr Comp Physiol. 2016;311:R451-6 pubmed publisher
..These findings suggest that TRPV1 channels are not necessary for VP secretion and thirst stimulated by hypernatremia. ..
Kinsman B, Cowles J, Lay J, Simmonds S, Browning K, Stocker S. Osmoregulatory thirst in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) and/or type 4 (TRPV4) receptor. Am J Physiol Regul Integr Comp Physiol. 2014;307:R1092-100 pubmed publisher
..Collectively, these findings suggest that TRPV1 and/or TRPV4 channels are not the primary mechanism by which the central nervous system responds to cellular dehydration during hypernatremia or hyperosmolality to increase thirst. ..
Nation H, Nicoleau M, Kinsman B, Browning K, Stocker S. DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite. J Neurophysiol. 2016;115:3123-9 pubmed publisher
..These findings demonstrate that DREADD-induced activation of SFO neurons stimulates thirst and that DREADDs are a useful tool to acutely or chronically manipulate neuronal circuits influencing body fluid homeostasis. ..