Jill P Smith

..This study evaluated the effects of gastrin messenger RNA (mRNA) down-regulation on growth of human pancreatic cancer...

..The term CCK-C or 'cancer' receptor has been proposed to signify the relationship of this receptor to neoplasia...

..We hypothesize that the endogenous opioid system is involved in inflammatory bowel disease, and antagonism of the opioid-opioid receptor will lead to reversal of inflammation...

..The aim of this study was to evaluate whether the CCK-C receptor, a splice variant of the CCK-B receptor, in human pancreatic cancer cells was associated with accelerated cancer cell growth...

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..Further studies are needed to determine the efficacy of OGF alone or in combination with present modes of therapy for the treatment of pancreatic cancer...

..These studies demonstrate that gastrin and the CCK-C receptor form an autocrine loop in human pancreatic cancer that plays a role in regulating growth...

..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer...

..Pancreatic cancer cells produce CCK and gastrin; however, the autocrine production of gastrin is more important for stimulating tumor growth...

..Strategies to decrease the CCK-BR expression and activity may be beneficial for the development of new methods to improve the treatment for patients with pancreatic cancer...

..In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn's disease...

..We will also examine novel applications of CPSNPs and PDT for the treatment of leukemia to illustrate their potential utility in cancer therapeutics...

..These bioconjugated CPNPs have the potential to perform as a theranostic modality, simultaneously enhancing drug delivery, targeting, and imaging of breast and pancreatic cancer tumors...

..CONCLUSIONS: Amantadine given at a dose of 300 mg daily is safe, and significantly lowers ALT blood levels more than 200 mg daily. The enzyme response rate does not significantly improve above 300 mg, but toxicity increases...

..The mechanism by which NTX acts to reverse colitis is related in part to the decreased expression of pro-inflammatory cytokines...

..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..

..Abstract Not Provided ..

..These studies are the first step in bridging the results from basic science studies into the clinical realm. If shown to be effective in the animal model, we plan to proceed to treating subjects with pancreatic cancer. ..

..Durability of response will be evaluated in a 1-month follow-up. This trial is based upon novel innovative preclinical and clinical data and may lead to a larger multi-center trial in the future. ..

..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..

..Response to therapy will be assessed by a reduction in the hepatitis C viral RNA level and hepatic alanine aminotransferase levels. ..

..We speculate that melatonin will cause a decrease in muscle sympathetic nerve activity and a further decrease in blood pressure during simulated upright posture. ..

..The purpose of this study is to determine the appropriate dose, route of administration, side effects and duration of effects after the administration of opioid growth factor. ..

..The purpose of this study is to evaluate the efficacy of amantadine in hepatitis C with higher doses of the drug. ..

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..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..