Jill P Smith

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression
    Gail L Matters
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17011, USA
    Pancreas 38:e151-61. 2009
  2. ncbi request reprint Characterization of the CCK-C (cancer) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 10:689-94. 2002
  3. pmc Cholecystokinin and pancreatic cancer: the chicken or the egg?
    Jill P Smith
    6707 Democracy Blvd, Rm 655, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Am J Physiol Gastrointest Liver Physiol 306:G91-G101. 2014
  4. pmc Safety and tolerability of low-dose naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study
    Jill P Smith
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Clin Gastroenterol 47:339-45. 2013
  5. ncbi request reprint Functional significance of gastrin gene expression in human cancer cells
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Regul Pept 117:167-73. 2004
  6. ncbi request reprint Treatment of advanced pancreatic cancer with opioid growth factor: phase I
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Anticancer Drugs 15:203-9. 2004
  7. pmc Amantadine therapy for chronic hepatitis C
    Jill P Smith
    Department of Medicine, Pennsylvania State College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    J Gen Intern Med 19:662-8. 2004
  8. ncbi request reprint The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Pancreas 29:271-7. 2004
  9. pmc Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial
    Jill P Smith
    Department of Medicine, The Pennsylvania State University, College of Medicine, GI Medicine H 045, 500 University Drive, Hershey, PA 17033, USA
    Dig Dis Sci 56:2088-97. 2011
  10. pmc Role of endogenous cholecystokinin on growth of human pancreatic cancer
    Gail L Matters
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 38:593-601. 2011

Collaborators

Detail Information

Publications19

  1. pmc Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression
    Gail L Matters
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17011, USA
    Pancreas 38:e151-61. 2009
    ..This study evaluated the effects of gastrin messenger RNA (mRNA) down-regulation on growth of human pancreatic cancer...
  2. ncbi request reprint Characterization of the CCK-C (cancer) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 10:689-94. 2002
    ..The term CCK-C or 'cancer' receptor has been proposed to signify the relationship of this receptor to neoplasia...
  3. pmc Cholecystokinin and pancreatic cancer: the chicken or the egg?
    Jill P Smith
    6707 Democracy Blvd, Rm 655, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Am J Physiol Gastrointest Liver Physiol 306:G91-G101. 2014
    ..This review will summarize what is known regarding CCK, its receptors, and pancreatic cancer, and also what is unknown and requires further investigation to determine which comes first, the chicken or the egg, "CCK or the cancer." ..
  4. pmc Safety and tolerability of low-dose naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study
    Jill P Smith
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Clin Gastroenterol 47:339-45. 2013
    ..There is an unmet need for safe and effective medicines to treat children with Crohn's disease. Recently, investigations have shown an association between endogenous opioid peptides and inflammatory cells...
  5. ncbi request reprint Functional significance of gastrin gene expression in human cancer cells
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Regul Pept 117:167-73. 2004
    ..These studies demonstrate that gastrin and the CCK-C receptor form an autocrine loop in human pancreatic cancer that plays a role in regulating growth...
  6. ncbi request reprint Treatment of advanced pancreatic cancer with opioid growth factor: phase I
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Anticancer Drugs 15:203-9. 2004
    ..Further studies are needed to determine the efficacy of OGF alone or in combination with present modes of therapy for the treatment of pancreatic cancer...
  7. pmc Amantadine therapy for chronic hepatitis C
    Jill P Smith
    Department of Medicine, Pennsylvania State College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    J Gen Intern Med 19:662-8. 2004
    ....
  8. ncbi request reprint The functional significance of the cholecystokinin-C (CCK-C) receptor in human pancreatic cancer
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Pancreas 29:271-7. 2004
    ..The aim of this study was to evaluate whether the CCK-C receptor, a splice variant of the CCK-B receptor, in human pancreatic cancer cells was associated with accelerated cancer cell growth...
  9. pmc Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial
    Jill P Smith
    Department of Medicine, The Pennsylvania State University, College of Medicine, GI Medicine H 045, 500 University Drive, Hershey, PA 17033, USA
    Dig Dis Sci 56:2088-97. 2011
    ..We hypothesize that the endogenous opioid system is involved in inflammatory bowel disease, and antagonism of the opioid-opioid receptor will lead to reversal of inflammation...
  10. pmc Role of endogenous cholecystokinin on growth of human pancreatic cancer
    Gail L Matters
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 38:593-601. 2011
    ..Pancreatic cancer cells produce CCK and gastrin; however, the autocrine production of gastrin is more important for stimulating tumor growth...
  11. ncbi request reprint Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, 17033, USA
    Cancer Chemother Pharmacol 56:510-20. 2005
    ..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer...
  12. pmc Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat
    Gail L Matters
    Department of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA
    Dig Dis Sci 59:1180-91. 2014
    ..Obesity and dietary fat are associated with increased risk of several malignancies including pancreatic cancer. The incidence of pancreatic cancer is increased in countries that consume diets high in fat...
  13. pmc Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis
    Kristin K Fino
    Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, 17033, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1244-52. 2012
    ..Strategies to decrease the CCK-BR expression and activity may be beneficial for the development of new methods to improve the treatment for patients with pancreatic cancer...
  14. ncbi request reprint Low-dose naltrexone therapy improves active Crohn's disease
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Gastroenterol 102:820-8. 2007
    ..In an open-labeled pilot prospective trial, the safety and efficacy of low-dose naltrexone (LDN), an opioid antagonist, were tested in patients with active Crohn's disease...
  15. ncbi request reprint Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer
    Diana M Tacelosky
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Discov Med 13:275-85. 2012
    ..We will also examine novel applications of CPSNPs and PDT for the treatment of leukemia to illustrate their potential utility in cancer therapeutics...
  16. pmc Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo
    Brian M Barth
    Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    ACS Nano 4:1279-87. 2010
    ..These bioconjugated CPNPs have the potential to perform as a theranostic modality, simultaneously enhancing drug delivery, targeting, and imaging of breast and pancreatic cancer tumors...
  17. ncbi request reprint Amantadine therapy for chronic hepatitis C: a dose escalation study
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, The M S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Am J Gastroenterol 99:1099-104. 2004
    ..The secondary aim was to test the efficacy of higher dose of amantadine against hepatitis C...
  18. ncbi request reprint The opioid antagonist naltrexone improves murine inflammatory bowel disease
    Gail L Matters
    Departments of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Immunotoxicol 5:179-87. 2008
    ..The mechanism by which NTX acts to reverse colitis is related in part to the decreased expression of pro-inflammatory cytokines...
  19. pmc Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop
    Dana K Andersen
    From the Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Department of Surgery, Karolinska Institute, Stockholm, Sweden Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Medicine and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN Department of Epidemiology, Mayo Graduate School of Medicine, Rochester, MN and Departments of Medicine, Cell Biology and Physiology, and Human Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Pancreas 42:1227-37. 2013
    ..A broad spectrum of expertise of the speakers and the discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article. ..

Research Grants22

  1. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2003
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  2. Effects of naltrexone on active Crohn's disease
    Jill Smith; Fiscal Year: 2007
    ..Durability of response will be evaluated in a 1-month follow-up. This trial is based upon novel innovative preclinical and clinical data and may lead to a larger multi-center trial in the future. ..
  3. Treatment of Advanced Pancreatic Cancer with Growth Fac*
    Jill Smith; Fiscal Year: 2005
    ..Abstract Not Provided ..
  4. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2004
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  5. TREATMENT OF CHRONIC HEPATITIS C WITH AMANTADINE HYDROCHLORIDE
    Jill Smith; Fiscal Year: 2002
    ..Response to therapy will be assessed by a reduction in the hepatitis C viral RNA level and hepatic alanine aminotransferase levels. ..
  6. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2002
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  7. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2001
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  8. TREATMENT OF HEPATITIS C WITH AMANTADINE: DOSE ESCALATION STUDY
    Jill Smith; Fiscal Year: 2000
    ..The purpose of this study is to evaluate the efficacy of amantadine in hepatitis C with higher doses of the drug. ..
  9. TREATING ADVANCED PANCREATIC CANCER WITH OPIOID GROWTH FACTOR, PHASE I
    Jill Smith; Fiscal Year: 2000
    ..The purpose of this study is to determine the appropriate dose, route of administration, side effects and duration of effects after the administration of opioid growth factor. ..
  10. Effects of silencing RNAs for gastrin and CCK on human pancreatic cancer
    Jill Smith; Fiscal Year: 2007
    ..These studies are the first step in bridging the results from basic science studies into the clinical realm. If shown to be effective in the animal model, we plan to proceed to treating subjects with pancreatic cancer. ..
  11. TREATMENT OF CHRONIC HEPATITIS C WITH AMANTADINE HYDROCHLORIDE
    Jill Smith; Fiscal Year: 2001
    ..Response to therapy will be assessed by a reduction in the hepatitis C viral RNA level and hepatic alanine aminotransferase levels. ..
  12. The Cholecystokinin-C (CCK-C) Receptor for Early Detection of Pancreatic Cancer
    Jill Smith; Fiscal Year: 2009
    ..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..
  13. TREATMENT OF CHRONIC HEPATITIS C WITH AMANTADINE HYDROCHLORIDE
    Jill Smith; Fiscal Year: 2000
    ..We speculate that melatonin will cause a decrease in muscle sympathetic nerve activity and a further decrease in blood pressure during simulated upright posture. ..
  14. PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2002
    ..abstract_text> ..
  15. The Cholecystokinin-C (CCK-C) Receptor for Early Detection of Pancreatic Cancer
    Jill P Smith; Fiscal Year: 2010
    ..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..
  16. The Cholecystokinin-C (CCK-C) Receptor for Early Detection of Pancreatic Cancer
    Jill Smith; Fiscal Year: 2007
    ..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..
  17. TREATMENT OF CHRONIC HEPATITIS C WITH AMANTADINE HYDROCHLORIDE
    Jill Smith; Fiscal Year: 1999
    ..We speculate that melatonin will cause a decrease in muscle sympathetic nerve activity and a further decrease in blood pressure during simulated upright posture. ..