Ian Simpson

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi Glucose transporter asymmetries in the bovine blood-brain barrier
    I A Simpson
    Department of Neuroscience, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 276:12725-9. 2001
  2. ncbi Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    Ian A Simpson
    Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Cereb Blood Flow Metab 27:1766-91. 2007
  3. ncbi The facilitative glucose transporter GLUT3: 20 years of distinction
    Ian A Simpson
    Department of Neural and Behavioral Sciences, College of Medicine, Penn State University, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 295:E242-53. 2008
  4. ncbi Glucose transport into brain: effects of hypoglycemia
    I A Simpson
    Department of Neuroscience and Anatomy, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes Nutr Metab 15:281-4; discussion 284. 2002
  5. ncbi Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I
    William J Zinnanti
    Jake Gittlen Cancer Research Foundation, Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 117:3258-70. 2007
  6. ncbi Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling
    Maria Basile
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Arch Biochem Biophys 446:60-8. 2006
  7. ncbi Analysis of glucose metabolism in diabetic rat retinas
    M Shamsul Ola
    Dept. of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, P.O. Box 850, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 290:E1057-67. 2006
  8. ncbi Regulation of the profile of iron-management proteins in brain microvasculature
    Joseph R Burdo
    Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 24:67-74. 2004
  9. ncbi Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
  10. ncbi Developmental switch in brain nutrient transporter expression in the rat
    Susan J Vannucci
    Department of Pediatrics, University, New York, New York 10032, USA
    Am J Physiol Endocrinol Metab 285:E1127-34. 2003

Research Grants

  1. Diabetes & Stroke: Impaired wound healing in the brain?
    Ian A Simpson; Fiscal Year: 2010
  2. Diabetes & Stroke: Impaired wound healing in the brain?
    Ian Simpson; Fiscal Year: 2007
  3. Blood-Brain Barrier Nutrient Transport
    Ian Simpson; Fiscal Year: 2006

Collaborators

Detail Information

Publications15

  1. ncbi Glucose transporter asymmetries in the bovine blood-brain barrier
    I A Simpson
    Department of Neuroscience, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 276:12725-9. 2001
    ....
  2. ncbi Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    Ian A Simpson
    Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Cereb Blood Flow Metab 27:1766-91. 2007
    ....
  3. ncbi The facilitative glucose transporter GLUT3: 20 years of distinction
    Ian A Simpson
    Department of Neural and Behavioral Sciences, College of Medicine, Penn State University, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 295:E242-53. 2008
    ....
  4. ncbi Glucose transport into brain: effects of hypoglycemia
    I A Simpson
    Department of Neuroscience and Anatomy, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes Nutr Metab 15:281-4; discussion 284. 2002
  5. ncbi Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I
    William J Zinnanti
    Jake Gittlen Cancer Research Foundation, Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 117:3258-70. 2007
    ..Blocking brain lysine uptake reduced glutaric acid levels and brain injury. These findings provide what we believe are new monitoring and treatment strategies that may translate for use in human GA-I...
  6. ncbi Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling
    Maria Basile
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Arch Biochem Biophys 446:60-8. 2006
    ..Taken together, paralemmin has been implicated as a potent modulator of cellular cAMP signaling within the brain...
  7. ncbi Analysis of glucose metabolism in diabetic rat retinas
    M Shamsul Ola
    Dept. of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, P.O. Box 850, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 290:E1057-67. 2006
    ..Metabolites upstream of glucose such as the sorbitol pathway (which decreases NADPH) and polyol synthesis are increased...
  8. ncbi Regulation of the profile of iron-management proteins in brain microvasculature
    Joseph R Burdo
    Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 24:67-74. 2004
    ..The results also indicate that brain iron status dictates the response of the microvascular protein profile to systemic iron manipulation...
  9. ncbi Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
    ..Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes...
  10. ncbi Developmental switch in brain nutrient transporter expression in the rat
    Susan J Vannucci
    Department of Pediatrics, University, New York, New York 10032, USA
    Am J Physiol Endocrinol Metab 285:E1127-34. 2003
    ..The maintenance of nonvascular MCT levels in the adult brain implies a major role for these proteins, in concert with the GLUTs in both neurons and astrocytes, to transfer glycolytic intermediates during cerebral energy metabolism...
  11. ncbi Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    FEBS Lett 580:4382-6. 2006
    ..This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain...
  12. ncbi Expression, regulation, and functional role of glucose transporters (GLUTs) in brain
    Donard S Dwyer
    Departments of Psychiatry and Pharmacology, LSU Health Sciences Center, Shreveport, Louisiana 71130, USA
    Int Rev Neurobiol 51:159-88. 2002
  13. ncbi Cloning and functional characterization of the mouse fructose transporter, GLUT5
    Christopher P Corpe
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1576:191-7. 2002
    ....
  14. ncbi An active transport system in the blood-brain barrier may reduce levodopa availability
    Richard A Hawkins
    Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 195:267-71. 2005
    ..The activity of this system reduces the net availability of levodopa...
  15. ncbi Structure of the blood-brain barrier and its role in the transport of amino acids
    Richard A Hawkins
    Department of Biochemistry and Molecular Biology, Facultad de Medicina y Farmacia, Universidad de Valencia, Valencia, Spain
    J Nutr 136:218S-26S. 2006
    ..Pyroglutamate stimulates secondary active AA transporters at the abluminal membrane, thereby reducing the net influx of AAs to the brain. It is now clear that BBB participates in the active regulation of the AA content of the brain...

Research Grants11

  1. Diabetes & Stroke: Impaired wound healing in the brain?
    Ian A Simpson; Fiscal Year: 2010
    ..abstract_text> ..
  2. Diabetes & Stroke: Impaired wound healing in the brain?
    Ian Simpson; Fiscal Year: 2007
    ..This study will investigate which components of the Type II diabetic pathology, such as hyperglycemia, insulin and leptin resistance, and elevated stress hormones are involved in mediating the detrimental recovery from stroke. ..
  3. Blood-Brain Barrier Nutrient Transport
    Ian Simpson; Fiscal Year: 2006
    ..Taken together these studies will provide new information on the regulation of transport across the BBB and will further our understanding of nutrient and drug delivery to the brain ..