Affiliation: Pennsylvania State University
- Glucose transporter asymmetries in the bovine blood-brain barrierI A Simpson
Department of Neuroscience, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 276:12725-9. 2001....
- Supply and demand in cerebral energy metabolism: the role of nutrient transportersIan A Simpson
Department of Neural and Behavioral Sciences College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
J Cereb Blood Flow Metab 27:1766-91. 2007....
- The facilitative glucose transporter GLUT3: 20 years of distinctionIan A Simpson
Department of Neural and Behavioral Sciences, College of Medicine, Penn State University, 500 University Drive, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 295:E242-53. 2008....
- Glucose transport into brain: effects of hypoglycemiaI A Simpson
Department of Neuroscience and Anatomy, Penn State College of Medicine, Hershey, PA 17033, USA
Diabetes Nutr Metab 15:281-4; discussion 284. 2002
- Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type IWilliam J Zinnanti
Jake Gittlen Cancer Research Foundation, Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Clin Invest 117:3258-70. 2007..Blocking brain lysine uptake reduced glutaric acid levels and brain injury. These findings provide what we believe are new monitoring and treatment strategies that may translate for use in human GA-I...
- Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signalingMaria Basile
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Arch Biochem Biophys 446:60-8. 2006..Taken together, paralemmin has been implicated as a potent modulator of cellular cAMP signaling within the brain...
- Analysis of glucose metabolism in diabetic rat retinasM Shamsul Ola
Dept. of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, P.O. Box 850, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 290:E1057-67. 2006..Metabolites upstream of glucose such as the sorbitol pathway (which decreases NADPH) and polyol synthesis are increased...
- Regulation of the profile of iron-management proteins in brain microvasculatureJoseph R Burdo
Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
J Cereb Blood Flow Metab 24:67-74. 2004..The results also indicate that brain iron status dictates the response of the microvascular protein profile to systemic iron manipulation...
- Diabetic retinopathy: seeing beyond glucose-induced microvascular diseaseDavid A Antonetti
Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
Diabetes 55:2401-11. 2006..Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes...
- Developmental switch in brain nutrient transporter expression in the ratSusan J Vannucci
Department of Pediatrics, University, New York, New York 10032, USA
Am J Physiol Endocrinol Metab 285:E1127-34. 2003..The maintenance of nonvascular MCT levels in the adult brain implies a major role for these proteins, in concert with the GLUTs in both neurons and astrocytes, to transfer glycolytic intermediates during cerebral energy metabolism...
- Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrierRichard A Hawkins
Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
FEBS Lett 580:4382-6. 2006..This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain...
- Expression, regulation, and functional role of glucose transporters (GLUTs) in brainDonard S Dwyer
Departments of Psychiatry and Pharmacology, LSU Health Sciences Center, Shreveport, Louisiana 71130, USA
Int Rev Neurobiol 51:159-88. 2002
- Cloning and functional characterization of the mouse fructose transporter, GLUT5Christopher P Corpe
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1576:191-7. 2002....
- An active transport system in the blood-brain barrier may reduce levodopa availabilityRichard A Hawkins
Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Exp Neurol 195:267-71. 2005..The activity of this system reduces the net availability of levodopa...
- Structure of the blood-brain barrier and its role in the transport of amino acidsRichard A Hawkins
Department of Biochemistry and Molecular Biology, Facultad de Medicina y Farmacia, Universidad de Valencia, Valencia, Spain
J Nutr 136:218S-26S. 2006..Pyroglutamate stimulates secondary active AA transporters at the abluminal membrane, thereby reducing the net influx of AAs to the brain. It is now clear that BBB participates in the active regulation of the AA content of the brain...
- Diabetes & Stroke: Impaired wound healing in the brain?Ian A Simpson; Fiscal Year: 2010..abstract_text> ..
- Diabetes & Stroke: Impaired wound healing in the brain?Ian Simpson; Fiscal Year: 2007..This study will investigate which components of the Type II diabetic pathology, such as hyperglycemia, insulin and leptin resistance, and elevated stress hormones are involved in mediating the detrimental recovery from stroke. ..
- Blood-Brain Barrier Nutrient TransportIan Simpson; Fiscal Year: 2006..Taken together these studies will provide new information on the regulation of transport across the BBB and will further our understanding of nutrient and drug delivery to the brain ..