M D Shriver

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Comparison of narrow-band reflectance spectroscopy and tristimulus colorimetry for measurements of skin and hair color in persons of different biological ancestry
    M D Shriver
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 112:17-27. 2000
  2. doi request reprint Ancestry estimation and correction for population stratification in molecular epidemiologic association studies
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 17:471-7. 2008
  3. pmc Modeling 3D facial shape from DNA
    Peter Claes
    Medical Image Computing, ESAT PSI, Department of Electrical Engineering, KU Leuven, Medical Imaging Research Center, KU Leuven and UZ Leuven, iMinds KU Leuven Future Health Department, Leuven, Belgium
    PLoS Genet 10:e1004224. 2014
  4. pmc Measuring and using admixture to study the genetics of complex diseases
    Indrani Halder
    Department of Anthropology, Pennsylvania State University, University Park, PA 16801, USA
    Hum Genomics 1:52-62. 2003
  5. pmc Natural selection among Eurasians at genomic regions associated with HIV-1 control
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Evol Biol 11:173. 2011
  6. ncbi request reprint Genetic ancestry and the search for personalized genetic histories
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 5:611-8. 2004
  7. ncbi request reprint Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Adv Exp Med Biol 588:89-100. 2006
  8. ncbi request reprint Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
  9. pmc Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 2:81-9. 2005
  10. pmc The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 1:274-86. 2004

Research Grants

Detail Information

Publications55

  1. ncbi request reprint Comparison of narrow-band reflectance spectroscopy and tristimulus colorimetry for measurements of skin and hair color in persons of different biological ancestry
    M D Shriver
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 112:17-27. 2000
    ....
  2. doi request reprint Ancestry estimation and correction for population stratification in molecular epidemiologic association studies
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106 5065, USA
    Cancer Epidemiol Biomarkers Prev 17:471-7. 2008
  3. pmc Modeling 3D facial shape from DNA
    Peter Claes
    Medical Image Computing, ESAT PSI, Department of Electrical Engineering, KU Leuven, Medical Imaging Research Center, KU Leuven and UZ Leuven, iMinds KU Leuven Future Health Department, Leuven, Belgium
    PLoS Genet 10:e1004224. 2014
    ....
  4. pmc Measuring and using admixture to study the genetics of complex diseases
    Indrani Halder
    Department of Anthropology, Pennsylvania State University, University Park, PA 16801, USA
    Hum Genomics 1:52-62. 2003
    ..Finally, the article discusses some limitations of this approach that should be considered when designing an effective AM study...
  5. pmc Natural selection among Eurasians at genomic regions associated with HIV-1 control
    Yann C Klimentidis
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Evol Biol 11:173. 2011
    ....
  6. ncbi request reprint Genetic ancestry and the search for personalized genetic histories
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 5:611-8. 2004
  7. ncbi request reprint Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, University Park, PA 16802, USA
    Adv Exp Med Biol 588:89-100. 2006
    ..There is great promise that together these methods will facilitate the discovery of genes influencing hypoxic response...
  8. ncbi request reprint Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..The implications and applications of ancestry estimates in biomedical research are discussed...
  9. pmc Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variation
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 2:81-9. 2005
    ....
  10. pmc The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs
    Mark D Shriver
    Penn State University, University Park, Pennsylvania, USA
    Hum Genomics 1:274-86. 2004
    ..These maps clearly illustrate a non-uniform distribution of human genetic substructure, an instructional and useful paradigm for education and research...
  11. ncbi request reprint Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina
    E J Parra
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 114:18-29. 2001
    ..Thus, even in the presence of genetic structure due to continuous gene flow or some other factor, it is possible to differentiate associations due to linkage from spurious associations due to genetic structure...
  12. pmc Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium
    C L Pfaff
    Department of Anthropology, Pennsylvania State University, University Park, PA, 16802, USA
    Am J Hum Genet 68:198-207. 2001
    ....
  13. pmc A genomewide admixture mapping panel for Hispanic/Latino populations
    Xianyun Mao
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16801, USA
    Am J Hum Genet 80:1171-8. 2007
    ..This genomewide AM panel will make it possible to apply AM approaches in many admixed populations throughout the Americas...
  14. ncbi request reprint Genetic evidence for the convergent evolution of light skin in Europeans and East Asians
    Heather L Norton
    Department of Anthropology, The Pennsylvania State University, PA, USA
    Mol Biol Evol 24:710-22. 2007
    ..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
  15. doi request reprint The relationship between European genetic admixture and body composition among Hispanics and Native Americans
    Y C Klimentidis
    Department of Anthropology, University of New Mexico, Albuquerque, NM 87130, USA
    Am J Hum Biol 21:377-82. 2009
    ..We compare our findings to previous research, and discuss their implications for understanding health disparities within and between ethnic groups...
  16. pmc Measurement of admixture proportions and description of admixture structure in different U.S. populations
    Indrani Halder
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA
    Hum Mutat 30:1299-309. 2009
    ..EC Hispanics had higher mean African admixture and the WC Hispanics had higher mean Indigenous American admixture, possibly reflecting their different continental origins...
  17. pmc Measuring European population stratification with microarray genotype data
    Marc Bauchet
    Department of Anthropology, Pennsylvania State University, University Park, PA 16801, USA
    Am J Hum Genet 80:948-56. 2007
    ..The Coriell Caucasian and CEPH (Centre d'Etude du Polymorphisme Humain) Utah sample panels, often used as proxies for European populations, are found to reflect different subsets of the continent's ancestry...
  18. doi request reprint Genetic admixture, self-reported ethnicity, self-estimated admixture, and skin pigmentation among Hispanics and Native Americans
    Yann C Klimentidis
    Department of Anthropology, University of New Mexico, Albuquerque, NM 87130, USA
    Am J Phys Anthropol 138:375-83. 2009
    ..Such results highlight the interplay between culture and biology in how individuals identify and view themselves, and have implications for how ethnicity and disease risk are assessed in a medical setting...
  19. ncbi request reprint Admixture analysis of a rural population of the state of Guerrero, Mexico
    Carolina Bonilla
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 128:861-9. 2005
    ..We suggest that heterogeneity is a major characteristic of Mexican populations and, as a consequence, should not be disregarded when designing epidemiological studies of Mexican and Mexican American populations...
  20. ncbi request reprint Spanish genetic admixture is associated with larger V(O2) max decrement from sea level to 4338 m in Peruvian Quechua
    Tom D Brutsaert
    Department of Anthropology, The University at Albany, Albany, NY 12222, USA
    J Appl Physiol (1985) 95:519-28. 2003
    ..The results of this study are consistent with the evolutionary hypothesis and point to a better gas-exchange system in Quechua...
  21. ncbi request reprint Melting curve SNP (McSNP) genotyping: a useful approach for diallelic genotyping in forensic science
    Jian Ye
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    J Forensic Sci 47:593-600. 2002
    ..As such, McSNP is one of the least expensive genotyping methods available and can and should be useful in forensic science...
  22. ncbi request reprint Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives
    Tom D Brutsaert
    Department of Anthropology, 1400 Washington Ave, University at Albany, State University of New York, Albany, NY 12222, USA
    Am J Physiol Regul Integr Comp Physiol 289:R225-34. 2005
    ..On the basis of these ancestry associations and on the fact that developmental effects were completely controlled by study design, we suggest both a genetic basis and an evolutionary origin for these traits in Quechua...
  23. ncbi request reprint Skin responses to ultraviolet radiation: effects of constitutive pigmentation, sex, and ancestry
    Jennifer K Wagner
    Department of Anthropology, The Pennsylvania State University, PA 16802, USA
    Pigment Cell Res 15:385-90. 2002
    ....
  24. pmc Estimating genetic ancestry proportions from faces
    Yann C Klimentidis
    Department of Anthropology, University of New Mexico, Albuquerque, NM, USA
    PLoS ONE 4:e4460. 2009
    ..We compare our findings to those of previous studies and discuss their implications...
  25. ncbi request reprint Skin and hair pigmentation variation in Island Melanesia
    Heather L Norton
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Phys Anthropol 130:254-68. 2006
    ....
  26. pmc Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua
    Abigail W Bigham
    Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania, USA
    High Alt Med Biol 9:167-78. 2008
    ..001). This suggests that the I-allele effect on Sa(O(2)) is not mediated by the peripheral control of breathing, but rather by some other central cardiopulmonary effect of the ACE gene on the renin-angiotensin-aldosterone system (RAAS)...
  27. pmc Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array
    Hajime Matsuzaki
    Affymetrix, Inc, Santa Clara, California 95051, USA
    Genome Res 14:414-25. 2004
    ....
  28. pmc Confirmation of the type 2 myotonic dystrophy (CCTG)n expansion mutation in patients with proximal myotonic myopathy/proximal myotonic dystrophy of different European origins: a single shared haplotype indicates an ancestral founder effect
    Linda L Bachinski
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 73:835-48. 2003
    ..Taken together, these data suggest a single founding mutation in DM2 patients of European origin. We estimate the age of the founding haplotype and of the DM2 (CCTG) expansion mutation to be approximately 200-540 generations...
  29. ncbi request reprint Association of African genetic admixture with resting metabolic rate and obesity among women
    Jose R Fernandez
    Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Obes Res 11:904-11. 2003
    ....
  30. ncbi request reprint The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans
    Carolina Bonilla
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 494 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, OH 43210, USA
    Hum Genet 116:402-6. 2005
    ..Further study is needed to reveal how interactions between ASIP and several other genes, such as MC1R and P, predict human pigmentation...
  31. pmc Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES)
    Tobias Gerhard
    College of Pharmacy, University of Florida, Gainesville, FL 32610 0486, USA
    Am Heart J 156:397-404. 2008
    ..The alpha-adducin (ADD1) Gly460Trp polymorphism has been associated with hypertension and response to diuretic therapy, but controversy exists...
  32. pmc Control of confounding of genetic associations in stratified populations
    Clive J Hoggart
    Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
    Am J Hum Genet 72:1492-1504. 2003
    ..With only 32 markers informative for ancestry, the efficiency of the analysis is 70%. These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary...
  33. ncbi request reprint Using genetic admixture to explain racial differences in insulin-related phenotypes
    Barbara A Gower
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
    Diabetes 52:1047-51. 2003
    ....
  34. pmc Interrogating a high-density SNP map for signatures of natural selection
    Joshua M Akey
    Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
    Genome Res 12:1805-14. 2002
    ..Our work provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation...
  35. ncbi request reprint Genetic diversity and evolution of the human leptin locus tetranucleotide repeat
    Susan Moffett
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hum Genet 110:412-7. 2002
    ..These findings emphasize the complex evolutionary history of this locus and raise cautions about the pooling of alleles at this locus in association studies...
  36. ncbi request reprint Adjusting for population structure in admixed populations
    Carrie L Pfaff
    Genet Epidemiol 22:196-201. 2002
  37. ncbi request reprint Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city
    Carolina Bonilla
    National Human Genome Center, Howard University, Washington, DC 20060, USA
    Hum Genet 115:57-68. 2004
    ..065, P=0.042), but no such correlation was evident with BMI or the remaining body composition measurements. We discuss the implications of our findings for the potential use of this Hispanic population for admixture mapping...
  38. pmc Population history and natural selection shape patterns of genetic variation in 132 genes
    Joshua M Akey
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 2:e286. 2004
    ..More generally, our results have important implications for mapping genes underlying complex human diseases...
  39. ncbi request reprint Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors
    Veronica L Martinez-Marignac
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Rd Room 4026, South Bldg, L5L 1C6, Mississauga, ON, Canada
    Hum Genet 120:807-19. 2007
    ..Sample sizes of about 2,000 cases will be required to detect any locus that contributes an ancestry risk ratio of at least 1.5...
  40. ncbi request reprint SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  41. pmc Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury
    Li Gao
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 34:487-95. 2006
    ..These data strongly implicate MYLK genetic variants to confer increased risk of sepsis and sepsis-associated ALI...
  42. ncbi request reprint Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)
    Hongyan Wang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, 421 Curie Boulevard, Philadephia, PA 19104, USA
    Hum Mol Genet 13:2659-69. 2004
    ..52, P < 0.0002). None of the minor alleles were individually associated with PPROM. These findings demonstrate the functional significance of SNP haplotypes in the MMP8 gene and associations with obstetrical outcomes...
  43. ncbi request reprint Female migration rate might not be greater than male rate
    Mark D Shriver
    Eur J Hum Genet 13:131-2. 2005
  44. ncbi request reprint TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations
    Joshua M Akey
    Department of Genome Sciences, University of Washington, Seattle, WA 98195 7730, USA
    Hum Mol Genet 15:2106-13. 2006
    ..These data strongly suggest that the TRPV6 haplotype defined by the derived alleles at C157R, M378V and M681T conferred a selective advantage that varied spatially, and perhaps temporally, during human history...
  45. ncbi request reprint Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005
    ..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
  46. ncbi request reprint ICAM gene cluster SNPs and prostate cancer risk in African Americans
    Hankui Chen
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, 494 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, OH 43210, USA
    Hum Genet 120:69-76. 2006
    ..01). Our results replicate previous findings of association of the ICAM gene cluster with prostate cancer and suggest that common genetic variation within ICAM1 and not ICAM5 may be an important risk factor for prostate cancer...
  47. ncbi request reprint Mitochondrial DNA (mtDNA) haplotypes reveal maternal population genetic affinities of Sea Island Gullah-speaking African Americans
    David C McLean
    Division of Endocrinology, Diabetes, and Medical Genetics, Department of Medicine, Sea Island Families Project and Project Sugar, Medical University of South Carolina, Charleston, SC 20425, USA
    Am J Phys Anthropol 127:427-38. 2005
    ....
  48. pmc A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans
    Hongyan Wang
    Center for Research on Reproduction and Women s Health and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:13463-7. 2006
    ..0000045) association between the -656 T allele and PPROM. The SERPINH1 -656 T allele is the first example of an ancestry-informative marker associated with preterm birth in African Americans...
  49. ncbi request reprint The genetic architecture of normal variation in human pigmentation: an evolutionary perspective and model
    Brian McEvoy
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Hum Mol Genet 15:R176-81. 2006
    ..However, these should be viewed as complements, rather than replacements of, functional studies including linkage and association analyses, which can directly refine our understanding of the trait...
  50. ncbi request reprint Population stratification confounds genetic association studies among Latinos
    Shweta Choudhry
    University of California, San Francisco, 94143 0833, USA
    Hum Genet 118:652-64. 2006
    ..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations...
  51. pmc Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region
    Shweta Choudhry
    Institute for Human Genetics, University of California, San Francisco, CA, USA
    Hum Genet 123:455-68. 2008
    ..3 region. Our results provide strong evidence that the previously linked 5q23 region is associated with asthma in Puerto Ricans. The detection of causative variants in this region will require fine mapping and functional validation...
  52. doi request reprint SLC24A5: exchanging genetic and biochemical knowledge
    Ellen E Quillen
    Pigment Cell Melanoma Res 21:344-5. 2008
  53. doi request reprint A 12-bp deletion in the 5'-flanking region of the SERPINH1 gene affects promoter activity and protects against preterm premature rupture of membranes in African Americans
    Hongyan Wang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University School of Life Science, Shanghai, China
    Hum Mutat 29:332. 2008
    ..These studies define a new haplotype in the SERPINH1 gene that modifies risk of an adverse obstetrical outcome...
  54. pmc KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST)
    Amber L Beitelshees
    Department of Pharmacy Practice, University of Florida, College of Pharmacy, Gainesville, USA
    Pharmacogenet Genomics 17:719-29. 2007
    ....
  55. pmc cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans
    Craig T Miller
    HHMI and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 131:1179-89. 2007
    ..These experiments suggest that regulatory changes in Kitlg contribute to natural variation in vertebrate pigmentation, and that similar genetic mechanisms may underlie rapid evolutionary change in fish and humans...

Research Grants10

  1. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 1999
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  2. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 2005
    ..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. ..
  3. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 2004
    ..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. ..
  4. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 2001
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  5. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 2000
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  6. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 1999
  7. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 2006
    ..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. ..