Jeffrey S Shenberger

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes
    Jeffrey S Shenberger
    Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    Free Radic Biol Med 43:844-52. 2007
  2. pmc Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation
    Jeffrey S Shenberger
    Department of Pediatrics, The Pennsylvania State University College of Medicine, USA
    Int J Biochem Cell Biol 39:1828-42. 2007
  3. pmc Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation
    Jeffrey S Shenberger
    Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire, USA
    Am J Physiol Lung Cell Mol Physiol 288:L442-9. 2005
  4. pmc Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1
    Lianqin Zhang
    Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Free Radic Biol Med 46:1500-9. 2009
  5. doi request reprint Hyperoxia-induced alterations in the pulmonary proteome of juvenile rats
    Wesley M Konsavage
    Child Research, Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Exp Lung Res 39:107-17. 2013
  6. doi request reprint Hyperoxia-induced activation of the integrated stress response in the newborn rat lung
    Wesley M Konsavage
    Department of Pediatrics, The Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 302:L27-35. 2012
  7. pmc Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism
    Michael D Dennis
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 62:2204-14. 2013
  8. doi request reprint Hyperoxia inhibits protein synthesis and increases eIF2α phosphorylation in the newborn rat lung
    Wesley Konsavage
    Departments of Pediatrics, The Pennsylvania State College of Medicine, Hershey Pennsylvania
    Am J Physiol Lung Cell Mol Physiol 298:L678-86. 2010
  9. pmc Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells
    Ryan M McAdams
    Department of Pediatrics, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA
    Am J Physiol Lung Cell Mol Physiol 291:L166-74. 2006
  10. ncbi request reprint Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1
    Jeffrey S Shenberger
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Am J Respir Cell Mol Biol 27:250-6. 2002

Research Grants

  1. Regulation of elF4E activity during oxidant stress
    JEFFREY SHENBERGER; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. pmc Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes
    Jeffrey S Shenberger
    Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    Free Radic Biol Med 43:844-52. 2007
    ..Increases in VEGF in ELF may represent an adaptive response fostering cell survival and type II cell proliferation in O(2)-induced lung injury...
  2. pmc Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation
    Jeffrey S Shenberger
    Department of Pediatrics, The Pennsylvania State University College of Medicine, USA
    Int J Biochem Cell Biol 39:1828-42. 2007
    ....
  3. pmc Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation
    Jeffrey S Shenberger
    Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire, USA
    Am J Physiol Lung Cell Mol Physiol 288:L442-9. 2005
    ..These findings suggest that hyperoxia diminishes protein synthesis by increasing eIF4E phosphorylation and enhancing the affinity of 4E-BP1 for eIF4E...
  4. pmc Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1
    Lianqin Zhang
    Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Free Radic Biol Med 46:1500-9. 2009
    ..These findings are consistent with PRAS40 functioning as a negative regulator of insulin-stimulated mTORC1 activity during oxidant stress...
  5. doi request reprint Hyperoxia-induced alterations in the pulmonary proteome of juvenile rats
    Wesley M Konsavage
    Child Research, Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Exp Lung Res 39:107-17. 2013
    ..In addition, hyperoxia selectively enhances the expression of some proteins whose transcripts contain sequence motifs, which impart translational regulation...
  6. doi request reprint Hyperoxia-induced activation of the integrated stress response in the newborn rat lung
    Wesley M Konsavage
    Department of Pediatrics, The Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 302:L27-35. 2012
    ..These findings demonstrate that Ox activates the ISR within the newborn lung and highlight regional and cell-specific alterations in the expression ISR transcription factors that regulate redox balance...
  7. pmc Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism
    Michael D Dennis
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 62:2204-14. 2013
    ..Taken together, these data provide evidence for a novel mechanism whereby O-GlcNAcylation of 4E-BP1 mediates translational control of hepatic gene expression. ..
  8. doi request reprint Hyperoxia inhibits protein synthesis and increases eIF2α phosphorylation in the newborn rat lung
    Wesley Konsavage
    Departments of Pediatrics, The Pennsylvania State College of Medicine, Hershey Pennsylvania
    Am J Physiol Lung Cell Mol Physiol 298:L678-86. 2010
    ..These findings illustrate that hyperoxia-induced suppression of mRNA translation in the newborn lung is accompanied by increased phosphorylation of eIF2α in the epithelium...
  9. pmc Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells
    Ryan M McAdams
    Department of Pediatrics, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA
    Am J Physiol Lung Cell Mol Physiol 291:L166-74. 2006
    ..Our results suggest that cyclic stretch, as applied in this study, can minimize the detrimental effects of hyperoxia on alveolar epithelial A549 cells...
  10. ncbi request reprint Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1
    Jeffrey S Shenberger
    Department of Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Am J Respir Cell Mol Biol 27:250-6. 2002
    ..These findings suggest that oxidant-mediated alterations in protein synthesis and cell morphology occur in concert with changes in factors known to regulate translation kinetics...

Research Grants2

  1. Regulation of elF4E activity during oxidant stress
    JEFFREY SHENBERGER; Fiscal Year: 2007
    ..These studies will generate new information concerning the inter-dependence of translation and cell growth and form a novel basis for pharmacological intervention to minimize oxidative injury. ..