Lisa Shantz

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy
    L M Shantz
    Department of Cellular and Molecular Physiology H166, P O Box 850, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem J 358:25-32. 2001
  2. pmc Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival
    Theresa D Carr
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Prev Res (Phila) 5:1394-404. 2012
  3. pmc Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model
    Shannon L Nowotarski
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:31885-94. 2010
  4. ncbi request reprint Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential
    L M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Amino Acids 33:213-23. 2007
  5. ncbi request reprint Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway
    L M Shantz
    Department of Cellular and Molecular Physiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 1703, USA
    Int J Biochem Cell Biol 31:107-22. 1999
  6. ncbi request reprint Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 23:657-64. 2002
  7. pmc Transcriptional and translational control of ornithine decarboxylase during Ras transformation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Biochem J 377:257-64. 2004
  8. ncbi request reprint Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds
    David J Feith
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Carcinog 46:453-65. 2007
  9. ncbi request reprint Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis
    David J Feith
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Carcinogenesis 27:1090-8. 2006
  10. ncbi request reprint Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis
    David J Feith
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cancer Res 65:572-8. 2005

Research Grants

Collaborators

  • ANTHONY PEGG
  • V A Levin
  • D E McCloskey
  • C S Coleman
  • Claudio Muscari
  • Janet Sawicki
  • Benedetta Tantini
  • David J Feith
  • Sofia Origanti
  • Paula L Shoop
  • Theresa D Carr
  • Shannon L Nowotarski
  • Joshua L Deignan
  • Oleg Nisenberg
  • Suzanne Sass-Kuhn
  • Yoshihiko Ikeguchi
  • John DiGiovanni
  • Christopher J Lynch
  • Ramaswamy K Iyer
  • Chethana Prakashagowda
  • Stephen D Cederbaum
  • William E O'Brien
  • Wayne W Grody
  • Justin C Livesay
  • Kerry A Keefer
  • Kerry Keefer
  • Patricia A Welsh
  • David K Bol
  • Joan M Carboni
  • Mark J Lynch
  • Guirong Hu
  • Xiaojing Wang
  • Paul Nelson

Detail Information

Publications17

  1. pmc Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy
    L M Shantz
    Department of Cellular and Molecular Physiology H166, P O Box 850, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem J 358:25-32. 2001
    ..Therefore these mice provide a model to study the in vivo co-operativity between high ODC activity and activation of other pathways leading to hypertrophy in the heart...
  2. pmc Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival
    Theresa D Carr
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Prev Res (Phila) 5:1394-404. 2012
    ..Our findings underscore the importance of both mTOR complexes in mediating UVB-induced signaling in keratinocytes and provide new insight into the pathogenesis of skin cancer...
  3. pmc Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model
    Shannon L Nowotarski
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:31885-94. 2010
    ..Together, these data support the hypothesis that HuR plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript...
  4. ncbi request reprint Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential
    L M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Amino Acids 33:213-23. 2007
    ..The ODC irreversible inactivator DFMO has proven to be not only a valuable tool in the study of ODC in cancer, but also shows promise as a chemopreventive and chemotherapeutic agent in certain types of malignancies...
  5. ncbi request reprint Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway
    L M Shantz
    Department of Cellular and Molecular Physiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 1703, USA
    Int J Biochem Cell Biol 31:107-22. 1999
    ..In contrast, the amino acid sequence that is encoded by the upstream ORF is critical for polyamine regulation of AdoMetDC synthesis and polyamines may affect synthesis by interaction with the putative peptide, MAGDIS...
  6. ncbi request reprint Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 23:657-64. 2002
    ....
  7. pmc Transcriptional and translational control of ornithine decarboxylase during Ras transformation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Biochem J 377:257-64. 2004
    ..Results show that the phosphoinositide 3-kinase pathway regulates phosphorylation of both proteins, whereas the Raf/MEK/ERK pathway affects only the eukaryotic initiation factor 4E phosphorylation...
  8. ncbi request reprint Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds
    David J Feith
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Carcinog 46:453-65. 2007
    ..These studies demonstrate a tumor-suppressive effect of AZ in C57BL/6 and DBA/2 mice, and confirm the importance of ODC and polyamines in tumor development...
  9. ncbi request reprint Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis
    David J Feith
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Carcinogenesis 27:1090-8. 2006
    ..These results indicate that the principal effect of AZ may be to slow cell growth primarily by increasing G2/M transit time...
  10. ncbi request reprint Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis
    David J Feith
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cancer Res 65:572-8. 2005
    ..The results establish ODC activation as an important component of the Raf/MEK/ERK pathway, and identify K14-MEK mice as a valuable model with which to study the regulation of ODC in ras carcinogenesis...
  11. pmc Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice
    Oleg Nisenberg
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, P O Box 850, 500 University Drive, Hershey, PA 17033, USA
    Biochem J 393:295-302. 2006
    ....
  12. ncbi request reprint Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways
    Sofia Origanti
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Cancer Res 67:4834-42. 2007
    ..When these pathways are inhibited in Ras-transformed cells, cell cycle arrest does not occur and ODC IRES activity increases, helping to maintain high ODC activity...
  13. pmc Characterization of transgenic mice with widespread overexpression of spermine synthase
    Yoshihiko Ikeguchi
    Department of Cellular and Molecular Physiology, The Milton S Hershey Medical Center, Pennsylvania State University College of Medicine P O Box 850, Hershey, PA 17033, USA
    Biochem J 381:701-7. 2004
    ....
  14. ncbi request reprint Polyamine homeostasis in arginase knockout mice
    Joshua L Deignan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Am J Physiol Cell Physiol 293:C1296-301. 2007
    ..These results suggest that endogenous arginase-derived ornithine may not directly contribute to polyamine homeostasis in mice. Alternate sources such as diet may provide sufficient polyamines for maintenance in mammalian tissues...
  15. ncbi request reprint Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine
    Victor A Levin
    Dept of Neuro Oncology, Unit 431, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Histochem Cytochem 52:1467-74. 2004
    ....
  16. ncbi request reprint Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia
    Benedetta Tantini
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Cell Cardiol 40:775-82. 2006
    ..In conclusion, this finding may suggest novel pharmacological approaches for the protection of cardiomyocytes injury caused by ischemia...
  17. ncbi request reprint Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy
    Victor A Levin
    Department of Neuro Oncology and M D Anderson Clinical Oncology Program, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2279-83. 2007
    ..3 nmol/30 min/mug protein. This study shows that Ab-ODC-Alexa 647 fluorescence intensity can be used as a surrogate marker of ODC biochemical activity in AGs and can predict PFS to DFMO-based chemotherapy...

Research Grants9

  1. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..