Stephan C Schuster

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Comparison of sequencing platforms for single nucleotide variant calls in a human sample
    Aakrosh Ratan
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, PA, USA
    PLoS ONE 8:e55089. 2013
  2. pmc inGAP: an integrated next-generation genome analysis pipeline
    Ji Qi
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, Pennsylvania 16802, USA
    Bioinformatics 26:127-9. 2010
  3. pmc Sequencing and analysis of a South Asian-Indian personal genome
    Ravi Gupta
    SciGenom Labs Pvt Ltd, Kakkanad, Cochin, Kerala, India
    BMC Genomics 13:440. 2012
  4. pmc Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation
    Elizabeth A Tindall
    Cancer Genetics Group, Children s Cancer Institute Australia for Medical Research, Sydney Children s Hospital, High Street, Randwick, NSW 2031, Australia
    BMC Res Notes 3:39. 2010
  5. pmc Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea
    Christian Lange
    Institute for Molecular Biosciences, Johann Wolfgang Goethe University, Max von Laue Strasse 9, 60438 Frankfurt a, M, Germany
    BMC Genomics 8:415. 2007
  6. pmc Analysis of complete mitochondrial genomes from extinct and extant rhinoceroses reveals lack of phylogenetic resolution
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100, Denmark
    BMC Evol Biol 9:95. 2009
  7. pmc Methods for comparative metagenomics
    Daniel H Huson
    Center for Bioinformatics ZBIT, Tubingen University, Sand 14, 72076 Tubingen, Germany
    BMC Bioinformatics 10:S12. 2009
  8. doi request reprint Next-generation sequencing transforms today's biology
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
    Nat Methods 5:16-8. 2008
  9. pmc Complete Khoisan and Bantu genomes from southern Africa
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
    Nature 463:943-7. 2010
  10. pmc A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome
    Travis N Mavrich
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:1073-83. 2008

Collaborators

Detail Information

Publications52

  1. pmc Comparison of sequencing platforms for single nucleotide variant calls in a human sample
    Aakrosh Ratan
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, PA, USA
    PLoS ONE 8:e55089. 2013
    ....
  2. pmc inGAP: an integrated next-generation genome analysis pipeline
    Ji Qi
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, Pennsylvania 16802, USA
    Bioinformatics 26:127-9. 2010
    ..All the detected SNPs/indels can be further evaluated by a graphical editor in our pipeline. inGAP also provides functions of multiple genomes comparison and assistance of bacterial genome assembly...
  3. pmc Sequencing and analysis of a South Asian-Indian personal genome
    Ravi Gupta
    SciGenom Labs Pvt Ltd, Kakkanad, Cochin, Kerala, India
    BMC Genomics 13:440. 2012
    ..In this study we have sequenced and analyzed the genome of a South Asian Indian female (SAIF) from the Indian state of Kerala...
  4. pmc Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation
    Elizabeth A Tindall
    Cancer Genetics Group, Children s Cancer Institute Australia for Medical Research, Sydney Children s Hospital, High Street, Randwick, NSW 2031, Australia
    BMC Res Notes 3:39. 2010
    ..We highlight applications for interpretation of Illumina generated genotype cluster plots to maximise data inclusion and reduce genotyping errors...
  5. pmc Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea
    Christian Lange
    Institute for Molecular Biosciences, Johann Wolfgang Goethe University, Max von Laue Strasse 9, 60438 Frankfurt a, M, Germany
    BMC Genomics 8:415. 2007
    ..Additional species have not been investigated yet. Particularly, until now no global study of translational control with any prokaryotic species was available...
  6. pmc Analysis of complete mitochondrial genomes from extinct and extant rhinoceroses reveals lack of phylogenetic resolution
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100, Denmark
    BMC Evol Biol 9:95. 2009
    ..One notable example concerns the rhinoceroses, a group for which several contradictory phylogenies were proposed on the basis of morphology, then apparently resolved using mitochondrial DNA fragments...
  7. pmc Methods for comparative metagenomics
    Daniel H Huson
    Center for Bioinformatics ZBIT, Tubingen University, Sand 14, 72076 Tubingen, Germany
    BMC Bioinformatics 10:S12. 2009
    ..Increasingly, there is a need for new ways of comparing multiple metagenomics datasets, and for fast and user-friendly implementations of such approaches...
  8. doi request reprint Next-generation sequencing transforms today's biology
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
    Nat Methods 5:16-8. 2008
    ..However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years...
  9. pmc Complete Khoisan and Bantu genomes from southern Africa
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
    Nature 463:943-7. 2010
    ..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
  10. pmc A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome
    Travis N Mavrich
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:1073-83. 2008
    ..3' NFRs may be important for transcription termination and anti-sense initiation. We present a high-resolution genome-wide map of TFIIB locations that implicates 3' NFRs in gene looping...
  11. doi request reprint Sequencing the nuclear genome of the extinct woolly mammoth
    Webb Miller
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
    Nature 456:387-90. 2008
    ..This study shows that nuclear genome sequencing of extinct species can reveal population differences not evident from the fossil record, and perhaps even discover genetic factors that affect extinction...
  12. pmc Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration
    Weisheng Wu
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 21:1659-71. 2011
    ..These determine permissiveness for expression, with subsequent induction or repression mediated by distinctive combinations of transcription factors...
  13. pmc Characterization of meiotic crossovers and gene conversion by whole-genome sequencing in Saccharomyces cerevisiae
    Ji Qi
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 10:475. 2009
    ..Differences at the nucleotide level associated with COs and NCOs enable us to detect these recombination events and their distributions...
  14. pmc Nucleosome organization in the Drosophila genome
    Travis N Mavrich
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 453:358-62. 2008
    ..At thousands of genes, RNA polymerase II engages the +1 nucleosome and pauses. How the transcription initiation machinery contends with the +1 nucleosome seems to be fundamentally different across major eukaryotic lines...
  15. pmc Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar
    George H Perry
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 110:5823-8. 2013
    ..To help facilitate future ecological- and conservation-motivated population genomic analyses by noncomputational biologists, the analytical toolkit used in this study is available on the Galaxy Web site...
  16. pmc Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)
    Webb Miller
    Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 108:12348-53. 2011
    ..Using a genetically characterized breeding stock based on the genome sequence will enable preservation of the extant genetic diversity in future Tasmanian devil populations...
  17. pmc Polar and brown bear genomes reveal ancient admixture and demographic footprints of past climate change
    Webb Miller
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 109:E2382-90. 2012
    ....
  18. doi request reprint Complete genome of Candidatus Chloracidobacterium thermophilum, a chlorophyll-based photoheterotroph belonging to the phylum Acidobacteria
    Amaya M Garcia Costas
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Environ Microbiol 14:177-90. 2012
    ..Some transposases were homologous to those of mat community members from other phyla...
  19. ncbi request reprint A mutation burst during the acute phase of Helicobacter pylori infection in humans and rhesus macaques
    Bodo Linz
    1 Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA 2 Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Commun 5:4165. 2014
    ..The elevated frequency of mutations in outer membrane protein genes suggests that the mutation burst facilitates rapid host adaptation of the bacteria. ..
  20. pmc Tracking the past: interspersed repeats in an extinct Afrotherian mammal, Mammuthus primigenius
    Fangqing Zhao
    Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 19:1384-92. 2009
    ..Comparisons of the transposable elements (TEs) between mammoth and other mammals may shed light on the evolutionary history of TEs in various mammalian lineages...
  21. pmc Polymorphic integrations of an endogenous gammaretrovirus in the mule deer genome
    Daniel Elleder
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Virol 86:2787-96. 2012
    ..The discovery of a novel transcriptionally active and insertionally polymorphic retrovirus in mammals could provide a useful model system to study the dynamic interaction between the host genome and an invading retrovirus...
  22. doi request reprint Ancestral polyploidy in seed plants and angiosperms
    Yuannian Jiao
    Intercollege Graduate Degree Program in Plant Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 473:97-100. 2011
    ....
  23. pmc The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus)
    Webb Miller
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, Pennsylvania 16802, USA
    Genome Res 19:213-20. 2009
    ..This study therefore adds to the growing evidence that extensive sequencing of museum collections is both feasible and desirable, and can yield complete genomes...
  24. pmc Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens
    Jihye Park
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, USA
    BMC Genomics 13:545. 2012
    ..The compelling picture from previous comparisons of the three sequenced genomes was of genome degradation, with substantial loss of genome content (up to 24%) associated with adaptation to humans...
  25. pmc Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium
    Gue Su Chang
    Center for Eukaryotic Gene Regulation and Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Genome Res 22:1098-106. 2012
    ..Indeed, we find a strong phylogenetic relationship between the presence of the NELF pausing factor and positioning of the +1 nucleosome. Pausing and +1 nucleosome positioning may have coevolved in animals...
  26. pmc Calling SNPs without a reference sequence
    Aakrosh Ratan
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, USA
    BMC Bioinformatics 11:130. 2010
    ....
  27. pmc Nodeomics: pathogen detection in vertebrate lymph nodes using meta-transcriptomics
    Nicola E Wittekindt
    Department of Biochemistry and Molecular Biology, Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 5:e13432. 2010
    ..Our research advances the use of meta-transcriptomics to study microbiota in wildlife tissues, which will facilitate detection of novel organisms with pathogenic potential to human and animals...
  28. pmc Chestnut resistance to the blight disease: insights from transcriptome analysis
    Abdelali Barakat
    The School of Forest Resources, and The Huck Institutes of the Life Sciences, Pennsylvania State University, 326 Forest Resources Building, University Park, PA 16802, USA
    BMC Plant Biol 12:38. 2012
    ....
  29. pmc Metatranscriptomic analyses of chlorophototrophs of a hot-spring microbial mat
    Zhenfeng Liu
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    ISME J 5:1279-90. 2011
    ....
  30. pmc Comparison of next generation sequencing technologies for transcriptome characterization
    P Kerr Wall
    Department of Biology, Institute of Molecular Evolutionary Genetics, and The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 10:347. 2009
    ..19). We also generated 454-GS20 sequences and de novo assemblies for the basal eudicot California poppy (Eschscholzia californica) and the magnoliid avocado (Persea americana) using a variety of methods for cDNA synthesis...
  31. pmc Metagenomic signatures of the Peru Margin subseafloor biosphere show a genetically distinct environment
    Jennifer F Biddle
    Astrobiology Research Center, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 105:10583-8. 2008
    ..These findings show that the marine subsurface is a distinct microbial habitat and is different from environments studied by metagenomics, especially because of the predominance of uncultivated archaeal groups...
  32. pmc Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression
    Yong Cheng
    Center for Comparative Genomics and Bioinformatics of the Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 19:2172-84. 2009
    ..More broadly, these studies illustrate how a "master regulator" transcription factor coordinates tissue differentiation through a panoply of DNA and protein interactions...
  33. pmc Helicobacter pylori genomic microevolution during naturally occurring transmission between adults
    Bodo Linz
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 8:e82187. 2013
    ..In contrast, virulence factor genes were not affected by the genomic changes. We propose a model of the genomic changes that are associated with the transmission and adaptation of H. pylori to a new human host. ..
  34. pmc Poor Man's 1000 Genome Project: Recent Human Population Expansion Confounds the Detection of Disease Alleles in 7,098 Complete Mitochondrial Genomes
    Hie Lim Kim
    Center for Comparative Genomics and Bioinformatics, Pennsylvania State University University Park, PA, USA
    Front Genet 4:13. 2013
    ..This result showed the difficulty of detecting a pathogenic mutation within an abundance of rare variants in the human population, even with a large number of genomes available for study...
  35. ncbi request reprint Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome
    Istvan Albert
    Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 446:572-6. 2007
    ..Transcriptional start sites tended to reside about one helical turn inside the nucleosome border. These findings reveal an intimate relationship between chromatin architecture and the underlying DNA sequence it regulates...
  36. ncbi request reprint Characterization of large-insert DNA libraries from soil for environmental genomic studies of Archaea
    Alexander H Treusch
    Institute of Microbiology and Genetics, Darmstadt University of Technology, Schnittspahnstrasse 10, 64287 Darmstadt, Germany
    Environ Microbiol 6:970-80. 2004
    ..We thereby extend the genomic information of uncultivated crenarchaeota from soil and offer hints to specific metabolic traits present in this group...
  37. ncbi request reprint Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli
    Holger Lüttgen
    Lehrstuhl fur Organische Chemie und Biochemie, Technische Universitat Munchen, Garching, Germany
    J Mol Biol 316:875-85. 2002
    ..Replacement of bases in the terminal segments of the boxA RNA motif caused minor chemical shift changes as compared to base exchanges in the central part of the dodecameric boxA motif...
  38. pmc Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans
    Kwang Zin Lee
    Abteilung für Evolutionsbiologie, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 37, 72076 Tubingen, Germany
    Nucleic Acids Res 31:2553-60. 2003
    ..Thus, intrachromosomal rearrange ments occur frequently in nematodes, limiting the likelihood of identifying orthologous genes of P.pacificus and C.elegans based on positional information within the two genomes...
  39. ncbi request reprint Construction and usage of a onefold-coverage shotgun DNA microarray to characterize the metabolism of the archaeon Haloferax volcanii
    Alexander Zaigler
    J W Goethe Universitat, Biozentrum Niederursel, Institut fur Mikrobiologie, Marie Curie Str 9, D 60439 Frankfurt, Germany
    Mol Microbiol 48:1089-105. 2003
    ..Analysis of the results revealed that onefold-coverage shotgun DNA microarrays are well suited to characterize the regulation of metabolic pathways as well as protein complexes in response to changes in environmental conditions...
  40. ncbi request reprint Whole-genome shotgun sequencing of mitochondria from ancient hair shafts
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 317:1927-30. 2007
    ..The method therefore sets the stage for molecular-genetic analysis of museum collections...
  41. ncbi request reprint Complete genome sequence of the myxobacterium Sorangium cellulosum
    Susanne Schneiker
    Department of Genetics, Bielefeld University, PO Box 100131, D 33501 Bielefeld, Germany
    Nat Biotechnol 25:1281-9. 2007
    ..Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry...
  42. ncbi request reprint Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors
    Henri L Saenz
    Focal Area Infection Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nat Genet 39:1469-76. 2007
    ..bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability...
  43. pmc Comprehensive mutation identification in an evolved bacterial cooperator and its cheating ancestor
    Gregory J Velicer
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 103:8107-12. 2006
    ..These results provide insight into the genetic basis of two large adaptive transitions in a social bacterium...
  44. pmc Microbial community gene expression in ocean surface waters
    Jorge Frias-Lopez
    Departments of Civil and Environmental Engineering and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:3805-10. 2008
    ..Thus, microbial community transcriptomic analyses revealed not only indigenous gene- and taxon-specific expression patterns but also gene categories undetected in previous DNA-based metagenomic surveys...
  45. ncbi request reprint Metagenomics to paleogenomics: large-scale sequencing of mammoth DNA
    Hendrik N Poinar
    McMaster Ancient DNA Center, McMaster University, 1280 Main Street West, Hamilton ON, L8S 4L9 Canada
    Science 311:392-4. 2006
    ..The sample includes a surprisingly small diversity of environmental DNAs. The high percentage of endogenous DNA recoverable from this single mammoth would allow for completion of its genome, unleashing the field of paleogenomics...
  46. pmc Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence
    Frank Thieme
    Martin Luther Universitat, Institut fur Genetik, Weinbergweg 10, D 06120 Halle Saale, Germany
    J Bacteriol 187:7254-66. 2005
    ..Comparisons with other completely sequenced plant pathogens predicted six novel type III effector proteins and several other virulence factors, including adhesins, cell wall-degrading enzymes, and extracellular polysaccharides...
  47. ncbi request reprint BACCardI--a tool for the validation of genomic assemblies, assisting genome finishing and intergenome comparison
    Daniela Bartels
    Universitat Bielefeld, Center for Biotechnology CeBiTec D 33594 Bielefeld, Germany
    Bioinformatics 21:853-9. 2005
    ..The time-consuming task of building physical maps can be circumvented by virtual clone maps derived from read pair information of large insert libraries...
  48. ncbi request reprint Whole-genome prokaryotic phylogeny
    Stefan R Henz
    Center for Bioinformatics Tübingen ZBIT, Sand 14, Tubingen 72076, Germany
    Bioinformatics 21:2329-35. 2005
    ..In this approach, first Blast is used to compare genomes, then a distance matrix is computed, and finally a tree- or network-reconstruction method such as UPGMA, Neighbor-Joining, BioNJ or Neighbor-Net is applied...
  49. pmc Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax by use of genomic and biochemical data
    Bettina Siebers
    Department of Microbiology, Universitat Duisburg Essen, 45117 Essen, Germany
    J Bacteriol 186:2179-94. 2004
    ..Almost all genes necessary for glycogen and trehalose metabolism were identified in the T. tenax genome...
  50. ncbi request reprint A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective
    Snjezana Rendulic
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 303:689-92. 2004
    ..A plethora of paralogous gene families coding for enzymes, such as hydrolases and transporters, are used throughout the life cycle of B. bacteriovorus for prey entry, prey killing, and the uptake of complex molecules...
  51. pmc Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 105:8327-32. 2008
    ..Modeling of protein structures failed to indicate any important functional difference between genomes belonging to the two clades, suggesting that the loss of clade II more likely is due to genetic drift than a selective sweep...
  52. ncbi request reprint OSLay: optimal syntenic layout of unfinished assemblies
    Daniel C Richter
    Center for Bioinformatics ZBIT, Institute for Computer Science, Tubingen University, 72076 Tubingen, Germany
    Bioinformatics 23:1573-9. 2007
    ..The tool provides an interactive visualization of the computed layout and the result can be imported into the assembly editing tool Consed to support the design of primer pairs for gap closure...