Cara Lynne Schengrund

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint Cholesterol, GM1, and autism
    Cara Lynne Schengrund
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neurochem Res 37:1201-7. 2012
  2. pmc Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)
    Sandra Urdaneta
    Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Retrovirology 2:28. 2005
  3. doi request reprint Lipid rafts: keys to neurodegeneration
    Cara Lynne Schengrund
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
    Brain Res Bull 82:7-17. 2010
  4. ncbi request reprint Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A
    Kimberly A Petro
    Department of Biochemistry and Molecular Biology, H171, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Toxicon 48:1035-45. 2006
  5. ncbi request reprint Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b
    Brian C Yowler
    Department of Biochemistry and Molecular Biology, H171, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 43:9725-31. 2004
  6. ncbi request reprint Glycosphingolipids-sweets for botulinum neurotoxin
    Brian C Yowler
    Department of Biochemistry and Molecular Biology H171, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Glycoconj J 21:287-93. 2004
  7. ncbi request reprint Synthesis of novel, multivalent glycodendrimers as ligands for HIV-1 gp120
    Richard D Kensinger
    Department of Biochemistry and Molecular Biology H171, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Bioconjug Chem 15:349-58. 2004
  8. ncbi request reprint Glycoconjugates: roles in neural diseases caused by exogenous pathogens
    Cara Lynne Schengrund
    The Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    CNS Neurol Disord Drug Targets 5:381-9. 2006
  9. ncbi request reprint Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I
    Brian C Yowler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:32815-9. 2002
  10. ncbi request reprint Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1
    Sandra Urdaneta Hartmann
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, USA
    J Hum Lact 22:61-74. 2006

Research Grants

  1. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2000
  2. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2001
  3. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2002
  4. Can mannosylated dendrimers inhibit HIV-1 infection of DC-SIGN expressing cells
    Cara Lynne Schengrund; Fiscal Year: 2007

Collaborators

  • Brian Wigdahl
  • Fred C Krebs
  • James R Connor
  • Brian C Yowler
  • Kimberly A Petro
  • Matthew C Blome
  • Richard D Kensinger
  • Fatima Ali-Rahmani
  • Sandra Urdaneta Hartmann
  • Hung Mo Lin
  • Cheston M Berlin
  • Elizabeth B Neely
  • Mary K Howett
  • Sandra Urdaneta
  • Rory Stine
  • Elizabeth Neely
  • Sang Lee
  • Patricia S Grigson
  • Maureen A Dyer
  • Alan J Benesi
  • Bradley J Catalone
  • Michael V Pishko

Detail Information

Publications17

  1. doi request reprint Cholesterol, GM1, and autism
    Cara Lynne Schengrund
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neurochem Res 37:1201-7. 2012
    ....
  2. pmc Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS)
    Sandra Urdaneta
    Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Retrovirology 2:28. 2005
    ..Microbicidal treatment was at 37 degrees C or room temperature for 10 min. SDS removal was performed with a commercially available resin. Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment...
  3. doi request reprint Lipid rafts: keys to neurodegeneration
    Cara Lynne Schengrund
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
    Brain Res Bull 82:7-17. 2010
    ..It concludes with some questions that need to be addressed in order to provide investigators with the basis for identifying small molecule agonists or antagonists to test as potential therapeutics...
  4. ncbi request reprint Disruption of lipid rafts enhances activity of botulinum neurotoxin serotype A
    Kimberly A Petro
    Department of Biochemistry and Molecular Biology, H171, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Toxicon 48:1035-45. 2006
    ..While our results indicate that disruption of lipid rafts enhances BoNT/A activity, disruption of clathrin-dependent endocytosis appeared to be inhibitory...
  5. ncbi request reprint Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b
    Brian C Yowler
    Department of Biochemistry and Molecular Biology, H171, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 43:9725-31. 2004
    ..The apparent K(D) values obtained for the binding of BoNT/A to ganglioside GT1b ranged from 2.83 x 10(-7) to 1.86 x 10(-7) M, depending on the ionic strength of the buffer...
  6. ncbi request reprint Glycosphingolipids-sweets for botulinum neurotoxin
    Brian C Yowler
    Department of Biochemistry and Molecular Biology H171, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Glycoconj J 21:287-93. 2004
    ....
  7. ncbi request reprint Synthesis of novel, multivalent glycodendrimers as ligands for HIV-1 gp120
    Richard D Kensinger
    Department of Biochemistry and Molecular Biology H171, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Bioconjug Chem 15:349-58. 2004
    ....
  8. ncbi request reprint Glycoconjugates: roles in neural diseases caused by exogenous pathogens
    Cara Lynne Schengrund
    The Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    CNS Neurol Disord Drug Targets 5:381-9. 2006
    ....
  9. ncbi request reprint Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I
    Brian C Yowler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:32815-9. 2002
    ....
  10. ncbi request reprint Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1
    Sandra Urdaneta Hartmann
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, USA
    J Hum Lact 22:61-74. 2006
    ..Therefore, the use of alkyl sulfate microbicides to treat milk from HIV-1-positive women may be a simple, practical, and nutritionally sound way to prevent or reduce transmission of HIV-1 while still feeding with mother's own milk...
  11. pmc Novel polysulfated galactose-derivatized dendrimers as binding antagonists of human immunodeficiency virus type 1 infection
    Richard D Kensinger
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 48:1614-23. 2004
    ..The results indicate that the PS Gal 64mer inhibited infection by the HIV-1 isolates tested as well as DxS...
  12. doi request reprint H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment
    Fatima Ali-Rahmani
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, USA Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Neurobiol Aging 35:1511.e1-12. 2014
    ..These results indicate that the alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD. ..
  13. doi request reprint Membrane raft disruption promotes axonogenesis in n2a neuroblastoma cells
    Kimberly A Petro
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA
    Neurochem Res 34:29-37. 2009
    ..The results indicate that the processes formed were axonal in nature and their expression was accompanied by changes in both ganglioside content as well as the subcellular localization of GM1...
  14. pmc Surface plasmon resonance analysis of ricin binding to plasma membranes isolated from NIH 3T3 cells
    Matthew C Blome
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Anal Biochem 396:212-6. 2010
    ....
  15. ncbi request reprint "Multivalent" saccharides: development of new approaches for inhibiting the effects of glycosphingolipid-binding pathogens
    Cara Lynne Schengrund
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey 17033, USA
    Biochem Pharmacol 65:699-707. 2003
    ..Also discussed are areas of promise that should be investigated and pitfalls that might be encountered in the development of "multivalent" saccharides as pharmacologic agents...
  16. doi request reprint Multivalent binding of ricin to bovine serum albumin-based neoglycoconjugates
    Matthew C Blome
    Department of Biochemistry and Molecular Biology, H171, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Toxicon 51:1214-24. 2008
    ..Results of binding studies done using surface plasmon resonance indicated that the RTB subunit of ricin exhibited a multivalent effect when it bound to the neoglycoconjugates...
  17. ncbi request reprint Heat-stabilized glycosphingolipid films for biosensing applications
    Rory Stine
    Departments of Chemical Engineering, Chemistry, Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Langmuir 20:6501-6. 2004
    ..Potential sites for nonspecific adsorption were blocked using serum albumin without sacrificing toxin specificity...

Research Grants5

  1. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2000
    ..They may also provide the basis for development of an inhibitor able to block adherence of HIV-1 to its GSL fusion co-factor thereby blocking its entry into the cell. ..
  2. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2001
    ..They may also provide the basis for development of an inhibitor able to block adherence of HIV-1 to its GSL fusion co-factor thereby blocking its entry into the cell. ..
  3. ROLES(S) OF GLYCOSPHINGOLIPIDS IN NEURAL AIDS
    Cara Lynne Schengrund; Fiscal Year: 2002
    ..They may also provide the basis for development of an inhibitor able to block adherence of HIV-1 to its GSL fusion co-factor thereby blocking its entry into the cell. ..
  4. Can mannosylated dendrimers inhibit HIV-1 infection of DC-SIGN expressing cells
    Cara Lynne Schengrund; Fiscal Year: 2007
    ..It is these possibilities that make this research worth the risk. ..