G Ramesh

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint Netrin-1: a novel universal biomarker of human kidney injury
    G Ramesh
    Division of Nephrology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Transplant Proc 42:1519-22. 2010
  2. pmc Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery
    Ganesan Ramesh
    Division of Nephrology, H040, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Clin J Am Soc Nephrol 5:395-401. 2010
  3. doi request reprint Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury
    W Brian Reeves
    Division of Nephrology, H040, Pennsylvania State Univ College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F731-8. 2008
  4. doi request reprint Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion
    Osun Kwon
    Dept of Medicine, Div of Nephrology, Penn State Milton S Hershey Medical Ctr, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033 0850, USA
    Am J Physiol Renal Physiol 296:F25-33. 2009
  5. doi request reprint Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
  6. pmc Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney
    Weiwei Wang
    Division of Nephrology, H040, Pennsylvania State Univ College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F739-47. 2008
  7. doi request reprint Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    John Bylander
    Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F480-90. 2008
  8. pmc Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis
    Weiwei Wang
    Division of Nephrology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Pathol 175:1010-8. 2009
  9. ncbi request reprint Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice
    Ganesan Ramesh
    Division of Nephrology, Pennsylvania State College of Medicine, 500 Univ Dr, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 293:F325-32. 2007
  10. ncbi request reprint TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure
    Ganesan Ramesh
    Division of Nephrology, Pennsylvania State College of Medicine, Hershey 17033, USA
    Am J Physiol Renal Physiol 285:F610-8. 2003

Collaborators

Detail Information

Publications19

  1. doi request reprint Netrin-1: a novel universal biomarker of human kidney injury
    G Ramesh
    Division of Nephrology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Transplant Proc 42:1519-22. 2010
    ..The level of NGAL was similarly increased in transplant patients. In conclusion, urinary netrin-1 levels are increased in patients with various forms of AKI/ATN and may serve as a universal biomarker for AKI...
  2. pmc Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery
    Ganesan Ramesh
    Division of Nephrology, H040, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Clin J Am Soc Nephrol 5:395-401. 2010
    ..Here, we determined the utility of urinary netrin-1 levels to predict AKI in humans undergoing cardiopulmonary bypass (CPB)...
  3. doi request reprint Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury
    W Brian Reeves
    Division of Nephrology, H040, Pennsylvania State Univ College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F731-8. 2008
    ..Immunohistochemical localization showed that netrin-1 is highly expressed in tubular epithelial cells in transplanted human kidney. We conclude that urinary netrin-1 is a promising early biomarker of renal injury...
  4. doi request reprint Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion
    Osun Kwon
    Dept of Medicine, Div of Nephrology, Penn State Milton S Hershey Medical Ctr, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033 0850, USA
    Am J Physiol Renal Physiol 296:F25-33. 2009
    ....
  5. doi request reprint Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
    ..Our studies demonstrate that netrin-1 acting through UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation...
  6. pmc Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney
    Weiwei Wang
    Division of Nephrology, H040, Pennsylvania State Univ College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F739-47. 2008
    ..These results suggest that downregulation of netrin-1 in vascular endothelial cells may promote endothelial cell activation and infiltration of leukocytes into the kidney thereby enhancing tubular injury...
  7. doi request reprint Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    John Bylander
    Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F480-90. 2008
    ..These studies indicate that meprin-beta is important in the pathogenesis of renal injury following I/R and that the redistribution of active meprin-alpha/beta is a major contributor to renal injury and subsequent inflammation...
  8. pmc Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis
    Weiwei Wang
    Division of Nephrology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Pathol 175:1010-8. 2009
    ..These results suggest that netrin-1 protects renal tubular epithelial cells against ischemia reperfusion-induced injury by increasing proliferation and suppressing apoptosis...
  9. ncbi request reprint Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice
    Ganesan Ramesh
    Division of Nephrology, Pennsylvania State College of Medicine, 500 Univ Dr, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 293:F325-32. 2007
    ..These results indicate that cisplatin and LPS act synergistically to produce nephrotoxicity which may involve proinflammatory cytokine production...
  10. ncbi request reprint TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure
    Ganesan Ramesh
    Division of Nephrology, Pennsylvania State College of Medicine, Hershey 17033, USA
    Am J Physiol Renal Physiol 285:F610-8. 2003
    ..These results indicate that TNFR2 participates in cisplatin-induced renal injury in mice and may play an important role in TNF-alpha-mediated inflammation in the kidney in response to cisplatin...
  11. ncbi request reprint Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha
    Ganesan Ramesh
    Division of Nephrology, The Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Kidney Int 65:490-9. 2004
    ..The purpose of this study was to determine if the protective effects of salicylate were mediated through inhibition of TNF-alpha in vivo and to explore the mechanism of inhibition in vitro...
  12. doi request reprint Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor
    Weiwei Wang
    Div of Nephrology, H040, Penn State Univ College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 296:F723-9. 2009
    ..Moreover, the increase in cell proliferation, but not migration, was mediated via activation of Akt and ERK pathways...
  13. pmc Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge
    Renee E Yura
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 Univ Drive, H171, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 296:F135-44. 2009
    ..These data indicate that meprin A contributes to the renal and urogenital pathogenesis of endotoxicity...
  14. ncbi request reprint Cisplatin increases TNF-alpha mRNA stability in kidney proximal tubule cells
    Ganesan Ramesh
    The Penn State College of Medicine, Division of Nephrology, Hershey, Pennsylvania 17033, USA
    Ren Fail 28:583-92. 2006
    ..The stabilization of TNF-alpha mRNA by cisplatin may involve the binding of certain proteins to AU-rich regions in the 3'UTR...
  15. ncbi request reprint Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells
    B Zhang
    Division of Nephrology, Department of Medicine, Penn State Milton S, Hershey Medical Center and College of Medicine, Hershey, Pennsylvania 17033, USA
    Kidney Int 72:37-44. 2007
    ..We conclude that the production of TNF-alpha by renal parenchymal cells, rather than by bone marrow-derived infiltrating immune cells, is responsible for cisplatin-induced nephrotoxicity...
  16. ncbi request reprint p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice
    Ganesan Ramesh
    Division of Nephrology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 289:F166-74. 2005
    ..We conclude that hydroxyl radicals, either directly or indirectly, activate p38 MAPK and that p38 MAPK plays an important role in mediating cisplatin-induced acute renal injury and inflammation, perhaps through production of TNF-alpha...
  17. doi request reprint Segment-specific expression of netrin-1 receptors in normal and ischemic mouse kidney
    Weiwei Wang
    Division of Nephrology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Nephrol 30:186-93. 2009
    ..Kidney is known to express three netrin-1 receptors mRNA (UNC5B, UNC5C and neogenin) abundantly. However, the intrarenal localization of these receptors is unknown...
  18. pmc TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity
    Binzhi Zhang
    Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Am Soc Nephrol 19:923-32. 2008
    ..Targeting the TLR4 signaling pathways may be a feasible therapeutic strategy to prevent cisplatin-induced AKI in humans...
  19. pmc TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
    Ganesan Ramesh
    Division of Nephrology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Invest 110:835-42. 2002
    ..TNF-alpha appears to play a central role in the activation of this cytokine response and also in the pathogenesis of cisplatin renal injury...