Research Topics
| David ProctorSummaryAffiliation: Pennsylvania State University Country: USA Publications
Research Grants
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Detail Information
Publications
Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active menDavid N Proctor
Noll Physiological Research Center, Department of Kinesiology, The Pennsylvania State University, University Park, 16802 6900, USA
J Appl Physiol 94:1859-69. 2003..younger men. These results suggest that the ability to augment active limb blood flow and O(2) extraction during submaximal large muscle mass exercise is not impaired but is well preserved with age in healthy men who are normally active...- Longitudinal changes in physical functional performance among the oldest old: insight from a study of Swedish twinsDavid N Proctor
Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA
Aging Clin Exp Res 18:517-30. 2006.... - Impaired leg vasodilation during dynamic exercise in healthy older womenDavid N Proctor
Noll Physiological Research Center, The Pennsylvania State University, University Park 16802 6900, USA
J Appl Physiol 95:1963-70. 2003.... - Is there a difference in vascular reactivity of the arms and legs?David N Proctor
Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
Med Sci Sports Exerc 38:1819-28. 2006..The article concludes with recent data from our laboratory indicating that limb-specific variation in arterial function may be age-, sex-, and physical activity dependent... - Vasodilation and vascular control in contracting muscle of the aging humanDavid N Proctor
Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
Microcirculation 13:315-27. 2006..Systematic research involving both humans and animal models will be necessary to fully elucidate the mechanisms underlying compromised muscle blood flow in old age... - Leg blood flow and VO2 during peak cycle exercise in younger and older womenDavid N Proctor
Noll Physiological Research Center, The Pennsylvania State University, University Park, PA16802 6900, USA
Med Sci Sports Exerc 36:623-31. 2004..To test the hypothesis that leg blood flow and leg O2 extraction during peak exercise are reduced with age in healthy normally active women... - Age and regional specificity of peak limb vascular conductance in menDavid N Proctor
Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802 6900, USA
J Appl Physiol 98:193-202. 2005..This could reflect regional differences in habitual muscle use with aging in normally active men... - Sex-specific influence of aging on exercising leg blood flowBeth A Parker
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
J Appl Physiol 104:655-64. 2008..Collectively, these findings suggest that local factors contribute to the sex-specific effects of aging on exercising leg hemodynamics in healthy adults... - Blood flow to exercising limbs varies with age, gender, and training statusDennis W Koch
Dept. of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
Can J Appl Physiol 30:554-75. 2005..Such information will be important for designing future interventions aimed at improving muscle blood supply and functional capacity in older persons... - Sex differences in leg vasodilation during graded knee extensor exercise in young adultsBeth A Parker
Dept of Kinesiology, The Pennsylvania State Univ, 105 Noll Laboratory, Univ Park, PA 16802 6900, USA
J Appl Physiol 103:1583-91. 2007..0 +/- 0.6 ml.min(-1)xmmHg(-1); women, 22.6 +/- 1.4 mlxmin(-1)xmmHg(-1); P < 0.01). Collectively, these findings suggest that the vasodilatory response to dynamic leg exercise is greater in young women vs. men... 
Age and sex influence the balance between maximal cardiac output and peripheral vascular reserveSamuel J Ridout
Noll Laboratory, The Pennsylvania State Univesity, University Park, PA 16802 6900, USA
J Appl Physiol 108:483-9. 2010..05), with no change in women. These data suggest that 1) aerobic capacity is associated with peripheral vascular reserve in men but not women, and 2) aging is accompanied by a more pronounced sex difference in this relationship...- Evidence for reduced sympatholysis in leg resistance vasculature of healthy older womenBeth A Parker
Department of Kinesiology, Pennsylvania State University, 105 Noll Laboratory, University Park, PA 16802 6900, USA
Am J Physiol Heart Circ Physiol 292:H1148-56. 2007..8 +/- 0.2 mm). These results confirm previous findings of diminished reactivity in the conduit arteries of older humans and provide the first evidence of reduced sympatholysis in the leg resistance vasculature of older women... - Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance trainingSean C Newcomer
Department of Kinesiology, Pennsylvania State University, University Park, USA
Am J Physiol Heart Circ Physiol 289:H308-15. 2005.... 
Age and microvascular responses to knee extensor exercise in womenBeth A Parker
Department of Kinesiology, The Pennsylvania State University, 105 Noll Laboratory, University Park, PA 16802 6900, USA
Eur J Appl Physiol 103:343-51. 2008....- Age and regional specificity of peak limb vascular conductance in womenSamuel J Ridout
Noll Laboratory, The Pennsylvania State University, University Park, PA 16802-6900, USA
J Appl Physiol 99:2067-74. 2005..Further research will be required to determine whether the decline in lower extremity vasodilator capacity with age explains diminished exercising leg vasodilation in older women... - Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteriesBeth A Parker
Dept. of Kinesiology, The Pennsylvania State University, University Park, PA 16802-6900, USA
Am J Physiol Heart Circ Physiol 291:H3043-9. 2006.... - Different vasodilator responses of human arms and legsSean C Newcomer
Department of Kinesiology, The Pennsylvania State University, University Park 16802 6900, USA
J Physiol 556:1001-11. 2004..05) in the forearm (925 +/- 164%) than in the leg (326 +/- 65%). These data indicate that vascular responses to both endothelium-dependent and -independent vasodilator agents are blunted in the leg compared to the forearm... - Femoral shear rate response to knee extensor exercise: an age and sex comparisonJoaquin U Gonzales
Noll Laboratory, Department of Kinesiology, Pennsylvania State University, and the General Clinical Research Center, University Park, PA, USA
Biorheology 46:145-54. 2009..6+/-0.4 vs. 8.6+/-0.4 s(-1) per W, p<0.05). These results suggest that age and sex differences are present in CFA shear rates during exercise which could have implications for vascular adaptability with exercise training... - Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulationDennis W Koch
Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16801-6900, USA
J Physiol 551:337-44. 2003..This could reflect a reduced ability of local substances (e.g. nitric oxide) to impair vasoconstriction in response to sympathetic stimulation during exercise in older humans... - Flow-mediated dilationBeth A Parker
Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, USA
J Appl Physiol 99:1620. 2005 - Hormone therapy is associated with preserved smooth muscle structure and dilation in the arterial vasculature of the leg in older womenBeth A Parker
Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
Maturitas 59:46-54. 2008..01). Collectively, these results suggest that long-term, continuous HT may alleviate the detrimental effects of aging on both structural changes and smooth muscle dilation of the popliteal artery in healthy women... - Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacityKevin R Short
Department of Internal Medicine, Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
Diabetes 52:1888-96. 2003..Thus, the muscle mitochondrial response to 4 months of aerobic exercise training was similar in all age-groups, although the older people did not have an improvement in insulin sensitivity... - Age and aerobic exercise training effects on whole body and muscle protein metabolismKevin R Short
Endocrinology Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Endocrinol Metab 286:E92-101. 2004..This study also demonstrates that aerobic exercise can enhance muscle protein synthesis irrespective of age... - Metabolic and vascular limb differences affected by exercise, gender, age, and diseaseRussell S Richardson
Department of Medicine, University of California San Diego, La Jolla, CA 92009, USA
Med Sci Sports Exerc 38:1792-6. 2006.... - Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise trainingKevin R Short
Division of Endocrinology, Department of Internal Medicine, Mayo Clinic School of Medicine, 200 First St. SW, Rochester, MN 55905, USA
J Appl Physiol 99:95-102. 2005..In response to endurance exercise, regulation of MHC isoform transcripts remains robust in older muscle, but this did not result in corresponding changes in MHC protein expression...
Research Grants
- REGULATION OF MUSCLE BLOOD FLOW IN OLD AGEDavid Proctor; Fiscal Year: 2003..These investigations should contribute significantly to our understanding of the decline in physical functional capacity and increased incidence of chronic disease in older humans. ..
- REGULATION OF MUSCLE BLOOD FLOW IN OLDER WOMEN AND MENDavid Proctor; Fiscal Year: 2009..abstract_text> ..