David Proctor

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men
    David N Proctor
    Noll Physiological Research Center, Department of Kinesiology, The Pennsylvania State University, University Park, 16802 6900, USA
    J Appl Physiol 94:1859-69. 2003
  2. ncbi request reprint Longitudinal changes in physical functional performance among the oldest old: insight from a study of Swedish twins
    David N Proctor
    Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA
    Aging Clin Exp Res 18:517-30. 2006
  3. ncbi request reprint Impaired leg vasodilation during dynamic exercise in healthy older women
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park 16802 6900, USA
    J Appl Physiol 95:1963-70. 2003
  4. ncbi request reprint Is there a difference in vascular reactivity of the arms and legs?
    David N Proctor
    Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
    Med Sci Sports Exerc 38:1819-28. 2006
  5. ncbi request reprint Vasodilation and vascular control in contracting muscle of the aging human
    David N Proctor
    Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    Microcirculation 13:315-27. 2006
  6. ncbi request reprint Leg blood flow and VO2 during peak cycle exercise in younger and older women
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park, PA16802 6900, USA
    Med Sci Sports Exerc 36:623-31. 2004
  7. ncbi request reprint Age and regional specificity of peak limb vascular conductance in men
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol 98:193-202. 2005
  8. ncbi request reprint Sex-specific influence of aging on exercising leg blood flow
    Beth A Parker
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol 104:655-64. 2008
  9. ncbi request reprint Blood flow to exercising limbs varies with age, gender, and training status
    Dennis W Koch
    Dept of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Can J Appl Physiol 30:554-75. 2005
  10. ncbi request reprint Sex differences in leg vasodilation during graded knee extensor exercise in young adults
    Beth A Parker
    Dept of Kinesiology, The Pennsylvania State Univ, 105 Noll Laboratory, Univ Park, PA 16802 6900, USA
    J Appl Physiol 103:1583-91. 2007

Research Grants

  1. REGULATION OF MUSCLE BLOOD FLOW IN OLD AGE
    David Proctor; Fiscal Year: 2003
  2. REGULATION OF MUSCLE BLOOD FLOW IN OLDER WOMEN AND MEN
    David Proctor; Fiscal Year: 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men
    David N Proctor
    Noll Physiological Research Center, Department of Kinesiology, The Pennsylvania State University, University Park, 16802 6900, USA
    J Appl Physiol 94:1859-69. 2003
    ..younger men. These results suggest that the ability to augment active limb blood flow and O(2) extraction during submaximal large muscle mass exercise is not impaired but is well preserved with age in healthy men who are normally active...
  2. ncbi request reprint Longitudinal changes in physical functional performance among the oldest old: insight from a study of Swedish twins
    David N Proctor
    Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA
    Aging Clin Exp Res 18:517-30. 2006
    ....
  3. ncbi request reprint Impaired leg vasodilation during dynamic exercise in healthy older women
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park 16802 6900, USA
    J Appl Physiol 95:1963-70. 2003
    ....
  4. ncbi request reprint Is there a difference in vascular reactivity of the arms and legs?
    David N Proctor
    Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
    Med Sci Sports Exerc 38:1819-28. 2006
    ..The article concludes with recent data from our laboratory indicating that limb-specific variation in arterial function may be age-, sex-, and physical activity dependent...
  5. ncbi request reprint Vasodilation and vascular control in contracting muscle of the aging human
    David N Proctor
    Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802 6900, USA
    Microcirculation 13:315-27. 2006
    ..Systematic research involving both humans and animal models will be necessary to fully elucidate the mechanisms underlying compromised muscle blood flow in old age...
  6. ncbi request reprint Leg blood flow and VO2 during peak cycle exercise in younger and older women
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park, PA16802 6900, USA
    Med Sci Sports Exerc 36:623-31. 2004
    ..To test the hypothesis that leg blood flow and leg O2 extraction during peak exercise are reduced with age in healthy normally active women...
  7. ncbi request reprint Age and regional specificity of peak limb vascular conductance in men
    David N Proctor
    Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol 98:193-202. 2005
    ..This could reflect regional differences in habitual muscle use with aging in normally active men...
  8. ncbi request reprint Sex-specific influence of aging on exercising leg blood flow
    Beth A Parker
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol 104:655-64. 2008
    ..Collectively, these findings suggest that local factors contribute to the sex-specific effects of aging on exercising leg hemodynamics in healthy adults...
  9. ncbi request reprint Blood flow to exercising limbs varies with age, gender, and training status
    Dennis W Koch
    Dept of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Can J Appl Physiol 30:554-75. 2005
    ..Such information will be important for designing future interventions aimed at improving muscle blood supply and functional capacity in older persons...
  10. ncbi request reprint Sex differences in leg vasodilation during graded knee extensor exercise in young adults
    Beth A Parker
    Dept of Kinesiology, The Pennsylvania State Univ, 105 Noll Laboratory, Univ Park, PA 16802 6900, USA
    J Appl Physiol 103:1583-91. 2007
    ..0 +/- 0.6 ml.min(-1)xmmHg(-1); women, 22.6 +/- 1.4 mlxmin(-1)xmmHg(-1); P < 0.01). Collectively, these findings suggest that the vasodilatory response to dynamic leg exercise is greater in young women vs. men...
  11. pmc Age and sex influence the balance between maximal cardiac output and peripheral vascular reserve
    Samuel J Ridout
    Noll Laboratory, The Pennsylvania State Univesity, University Park, PA 16802 6900, USA
    J Appl Physiol 108:483-9. 2010
    ..05), with no change in women. These data suggest that 1) aerobic capacity is associated with peripheral vascular reserve in men but not women, and 2) aging is accompanied by a more pronounced sex difference in this relationship...
  12. ncbi request reprint Evidence for reduced sympatholysis in leg resistance vasculature of healthy older women
    Beth A Parker
    Department of Kinesiology, Pennsylvania State University, 105 Noll Laboratory, University Park, PA 16802 6900, USA
    Am J Physiol Heart Circ Physiol 292:H1148-56. 2007
    ..8 +/- 0.2 mm). These results confirm previous findings of diminished reactivity in the conduit arteries of older humans and provide the first evidence of reduced sympatholysis in the leg resistance vasculature of older women...
  13. ncbi request reprint Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training
    Sean C Newcomer
    Department of Kinesiology, Pennsylvania State University, University Park, USA
    Am J Physiol Heart Circ Physiol 289:H308-15. 2005
    ....
  14. doi request reprint Age and microvascular responses to knee extensor exercise in women
    Beth A Parker
    Department of Kinesiology, The Pennsylvania State University, 105 Noll Laboratory, University Park, PA 16802 6900, USA
    Eur J Appl Physiol 103:343-51. 2008
    ....
  15. ncbi request reprint Age and regional specificity of peak limb vascular conductance in women
    Samuel J Ridout
    Noll Laboratory, The Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol 99:2067-74. 2005
    ..Further research will be required to determine whether the decline in lower extremity vasodilator capacity with age explains diminished exercising leg vasodilation in older women...
  16. ncbi request reprint Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries
    Beth A Parker
    Dept of Kinesiology, The Pennsylvania State University, University Park, PA 16802 6900, USA
    Am J Physiol Heart Circ Physiol 291:H3043-9. 2006
    ....
  17. pmc Different vasodilator responses of human arms and legs
    Sean C Newcomer
    Department of Kinesiology, The Pennsylvania State University, University Park 16802 6900, USA
    J Physiol 556:1001-11. 2004
    ..05) in the forearm (925 +/- 164%) than in the leg (326 +/- 65%). These data indicate that vascular responses to both endothelium-dependent and -independent vasodilator agents are blunted in the leg compared to the forearm...
  18. doi request reprint Femoral shear rate response to knee extensor exercise: an age and sex comparison
    Joaquin U Gonzales
    Noll Laboratory, Department of Kinesiology, Pennsylvania State University, and the General Clinical Research Center, University Park, PA, USA
    Biorheology 46:145-54. 2009
    ..6+/-0.4 vs. 8.6+/-0.4 s(-1) per W, p<0.05). These results suggest that age and sex differences are present in CFA shear rates during exercise which could have implications for vascular adaptability with exercise training...
  19. pmc Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation
    Dennis W Koch
    Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16801 6900, USA
    J Physiol 551:337-44. 2003
    ..This could reflect a reduced ability of local substances (e.g. nitric oxide) to impair vasoconstriction in response to sympathetic stimulation during exercise in older humans...
  20. ncbi request reprint Flow-mediated dilation
    Beth A Parker
    Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, USA
    J Appl Physiol 99:1620. 2005
  21. pmc Hormone therapy is associated with preserved smooth muscle structure and dilation in the arterial vasculature of the leg in older women
    Beth A Parker
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Maturitas 59:46-54. 2008
    ..01). Collectively, these results suggest that long-term, continuous HT may alleviate the detrimental effects of aging on both structural changes and smooth muscle dilation of the popliteal artery in healthy women...
  22. ncbi request reprint Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    Kevin R Short
    Department of Internal Medicine, Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 52:1888-96. 2003
    ..Thus, the muscle mitochondrial response to 4 months of aerobic exercise training was similar in all age-groups, although the older people did not have an improvement in insulin sensitivity...
  23. ncbi request reprint Age and aerobic exercise training effects on whole body and muscle protein metabolism
    Kevin R Short
    Endocrinology Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E92-101. 2004
    ..This study also demonstrates that aerobic exercise can enhance muscle protein synthesis irrespective of age...
  24. ncbi request reprint Metabolic and vascular limb differences affected by exercise, gender, age, and disease
    Russell S Richardson
    Department of Medicine, University of California San Diego, La Jolla, CA 92009, USA
    Med Sci Sports Exerc 38:1792-6. 2006
    ....
  25. ncbi request reprint Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training
    Kevin R Short
    Division of Endocrinology, Department of Internal Medicine, Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 99:95-102. 2005
    ..In response to endurance exercise, regulation of MHC isoform transcripts remains robust in older muscle, but this did not result in corresponding changes in MHC protein expression...

Research Grants11

  1. REGULATION OF MUSCLE BLOOD FLOW IN OLD AGE
    David Proctor; Fiscal Year: 2003
    ..These investigations should contribute significantly to our understanding of the decline in physical functional capacity and increased incidence of chronic disease in older humans. ..
  2. REGULATION OF MUSCLE BLOOD FLOW IN OLDER WOMEN AND MEN
    David Proctor; Fiscal Year: 2009
    ..abstract_text> ..