Research Topics
Genomes and Genes | Lisa S PoritzSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Percutaneous drainage and ileocolectomy for spontaneous intraabdominal abscess in Crohn's diseaseLisa S Poritz
Section of Colon and Rectal Surgery H137, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
J Gastrointest Surg 11:204-8. 2007..The aim of the present study was to evaluate the success of this protocol with regard to length of stay, complications associated with the protocol, and its ability to avoid stoma creation...
Tumor volume and percent positive lymph nodes as a predictor of 5-year survival in colorectal cancerLisa S Poritz
Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
Surgery 150:649-55. 2011..Tumor size is not part of the staging system for CRC and in itself is not a predictor of survival. We hypothesize, however, that tumor size is important in determining disease free survival...- Increase in the tight junction protein claudin-1 in intestinal inflammationLisa S Poritz
Division of Colon and Rectal Surgery, Department of Surgery, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
Dig Dis Sci 56:2802-9. 2011..Our group has also shown an increase in claudin-1 in experimental colitis... - Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitisLisa S Poritz
Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
J Surg Res 140:12-9. 2007..This study looked at the expression of the TJ protein ZO-1 and the corresponding permeability changes in dextran sulfate sodium (DSS) induced colitis in a mouse model... - Tumor necrosis factor alpha disrupts tight junction assemblyLisa S Poritz
Department of Surgery, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Surg Res 116:14-8. 2004..Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin, and the claudins are key proteins in the TJ. Hypothesis: TNFalpha disrupts the TJ... - Surgical management of entero and colocutaneous fistulae in Crohn's disease: 17 year's experienceLisa S Poritz
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Int J Colorectal Dis 19:481-5; discussion 486. 2004..Fistulous disease is common in Crohn's disease, and entero- and colocutaneous fistulae are particularly debilitating and difficult to manage. We present the results of surgical management of these fistulas... - How should complex perianal Crohn's disease be treated in the Remicade eraLisa S Poritz
Department of Surgery, The Milton S. Hershey Medical Center, Pennsylvania State University, PA 17033, USA
J Gastrointest Surg 10:633-4. 2006 - Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cellsLisa S Poritz
Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
J Surg Res 162:290-8. 2010..This has been termed Stat6(null) and Stat6(high) is the normal phenotype. The purpose of this study was to investigate the defect in Stat6 activation in Stat6(null) cells... - Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost?Lisa S Poritz
Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, 17033, USA
Dis Colon Rectum 48:1685-90. 2005..The purpose of this study was to evaluate the success and cost of cyclosporine... - Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell linesWei Yu
Department of Surgery, Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Dig Dis Sci 55:3171-80. 2010..Nkx2-3 has been reported to be up-regulated in B cell lines and intestinal tissues from Crohn's disease patients and down-regulated in colorectal cancer... 
NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cellsWei Yu
Department of Surgery, Pennsylvania State University, Hershey, Pennsylvania, United States of America
PLoS ONE 6:e20454. 2011..CONCLUSION/RELEVANCE: NKX2-3 may play an important role in IBD pathogenesis by regulating endothelin-1 and VEGF signaling in HIMECs...- PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3Wei Yu
Department of Surgery, Pennsylvania State University, Hershey, PA, USA
Dis Markers 32:83-91. 2012..These results suggest that PTPN2 may have an important role in CD pathogenesis and may represent a potential diagnostic and therapeutic target for IBD... - NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFATGerrit John
Department of Surgery, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Mol Genet Metab 104:174-9. 2011..The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by ChIP assay. We speculate that the rs11190140 may regulate NKX2-3 expression and have a role in IBD pathogenesis... - Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1Wei Yu
Department of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Inflammation 35:889-99. 2012..mRNA expressions of NKX2-3 and EGR1 were increased in diseased intestinal tissues from 19 CD patients. NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1... - Genetic risk profiling and gene signature modeling to predict risk of complications after IPAARishabh Sehgal
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
Dis Colon Rectum 55:239-48. 2012..To date, approximately 83 single nucleotide polymorphisms within 55 genes have been associated with IBD... - NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosisRishabh Sehgal
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
Dis Colon Rectum 53:1487-94. 2010..We hypothesize that IPAA patients with complications (Crohn's disease-like/pouchitis) have a higher rate of NOD2 mutations compared with asymptomatic IPAA patients... - Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's diseaseRishabh Sehgal
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Dis Colon Rectum 55:115-21. 2012..At the time of this study, approximately 80 single-nucleotide polymorphisms within 55 genes had been associated with IBD... - Stat6(null phenotype) human lymphocytes exhibit increased apoptosisEva Galka
Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Section of Colon and Rectal Surgery, MCH137, Hershey, Pennsylvania, USA
J Surg Res 122:14-20. 2004.... - Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel diseaseZhenwu Lin
Department of Surgery, Pennsylvania State University College of Medicine, Hershey, USA
Ann Hum Genet 75:559-68. 2011..The results suggest that differential allelic expression may affect penetrance of the SNP rs721917 disease-susceptibility allele in IBD. The potential impact of SP-D monoallelic expression on incomplete penetrance is discussed... - Modified two-stage ileal pouch-anal anastomosis: equivalent outcomes with less resource utilizationBrian R Swenson
Department of Surgery, The Penn State College of Medicine, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Dis Colon Rectum 48:256-61. 2005..However, it has the advantage of overall lower hospital costs and probably a shorter length of hospital stay... - Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's diseaseTara M Connelly
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
Dis Colon Rectum 55:1145-52. 2012.... - Risk factors for surgical site infections after colorectal resection in diabetic patientsRishabh Sehgal
Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
J Am Coll Surg 212:29-34. 2011..However, there is no clear consensus as to which other risk factors play a significant role. The goal of this study was to identify risk factors associated with SSI in patients with DM undergoing colorectal resection... - Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4Douglas M Wisner
Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Surg Res 144:1-7. 2008..Interferon-gamma (IFNgamma) and interleukin-4 (IL-4) negatively regulate each other and may have opposing roles in inflammatory bowel disease. Hypothesis: IFNgamma and IL-4 will have opposing effects on the expression of claudin-2... - DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibilityZhenwu Lin
Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Swiss Med Wkly 141:w13290. 2011..In this study, we examined the genetic association of another DLG5 SNP P1371Q (rs2289310) with IBD and its interaction with R30Q in disease susceptibility... - Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAALiam A Haveran
Division of Colon and Rectal Surgery, Penn State Hershey Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Dis Colon Rectum 54:15-20. 2011..This study evaluated the effectiveness in our hands of infliximab and/or azathioprine/6-mercaptopurine in treating this patient population... - Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patientsZhenwu Lin
Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, MC H 137, Hershey, PA, 17033, USA
Dig Dis Sci 57:3145-53. 2012..We previously identified seven disease-associated DNA methylation loci from intestinal tissues of IBD patients using the Illumina GoldenGate BeadArray assay... - Dehydration is the most common indication for readmission after diverting ileostomy creationEvangelos Messaris
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Dis Colon Rectum 55:175-80. 2012..Early readmission after discharge from the hospital is an undesirable outcome. Ileostomies are commonly used to prevent symptomatic anastomotic complications in colorectal resections... - Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgammaWen Jie Zhang
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Int J Oncol 24:447-53. 2004..Moreover, observations from signal transduction studies in our human B lymphocyte model may be compatible with those in the chosen mouse B lymphocyte for establishing signaling networks by the Alliance for Cellular Signaling (AfCS)... - Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's diseaseWei Yu
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA
J Crohns Colitis 3:189-95. 2009..To replicate the association of Nkx2-3 rs10883365 SNP with Crohn's disease in patients from a familial IBD registry from the central Pennsylvania area and study mRNA and protein expression of Nkx2-3 in CD patients... - Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell linesDanielle M Pastor
Department of Surgery, Penn State Milton S Hershey Medical Center and College of Medicine, Hershey, Pennsylvania, USA
Dis Colon Rectum 53:257-63. 2010.... - Surgical management of ulcerative colitis in the presence of primary sclerosing cholangitisLisa S Poritz
Department of Surgery, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, USA
Dis Colon Rectum 46:173-8. 2003..Patients with well-controlled primary sclerosing cholangitis can undergo ileal pouch-anal anastomosis surgery safely... - Management of peristomal pyoderma gangrenosumLisa S Poritz
Division of Colon and Rectal Surgery, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
J Am Coll Surg 206:311-5. 2008..Pyoderma gangrenosum (PG) occurs in about 1% to 5% of patients with inflammatory bowel disease (IBD). Peristomal pyoderma gangrenosum (PPG) is particularly difficult to manage... - Enhanced intestinal expression of the proteasome subunit low molecular mass polypeptide 2 in patients with inflammatory bowel diseaseLeo R Fitzpatrick
Department of Surgery, Section of Colon and Rectal Surgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Dis Colon Rectum 50:337-48; discussion 348-50. 2007..Moreover, we examined the association between low molecular mass polypeptide 2 expression and histologic pathology in these patients... - PPI Therapy and Albumin are Better Predictors of Recurrent Clostridium difficile Colitis than Choice of AntibioticsAlizah Rotramel
Division of Colon and Rectal Surgery, Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, H137, Hershey, PA, 17033, USA
J Gastrointest Surg 16:2267-73. 2012..Recurrent Clostridium difficile colitis (RCDC) is common, but data regarding recurrence rates and predisposing factors are sparse... - Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel diseaseWei Yu
Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Mol Genet Metab 100:88-95. 2010..05). Our present results demonstrate that a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of IBD, such as EDN1... - Remicade does not abolish the need for surgery in fistulizing Crohn's diseaseLisa S Poritz
Department of Surgery, The Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
Dis Colon Rectum 45:771-5. 2002..Seventy-three percent of the patients either required surgery or still had open fistulas after infliximab therapy. Infliximab was much more effective in treating perianal disease than abdominal enterocutaneous disease... - Parastomal hernia repair: a single center experienceDanielle M Pastor
Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
JSLS 13:170-5. 2009..Despite multiple options for operative repair of parastomal hernia, results are frequently disappointing. We review our experience with parastomal hernia repair... - Factors affecting surgical risk in elderly patients with inflammatory bowel diseaseMichael J Page
Section of Colon and Rectal Surgery H-149, The Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
J Gastrointest Surg 6:606-13. 2002..The fact that the higher complication rate seen in older patients with IBD is associated with disease-defined surgical indications suggests that IBD in elderly patients may be more aggressive than what is observed in younger individuals...
Research Grants
- Alteration Of The Tight Junction Complex In PouchitisLisa Poritz; Fiscal Year: 2007....