Lisa S Poritz

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Percutaneous drainage and ileocolectomy for spontaneous intraabdominal abscess in Crohn's disease
    Lisa S Poritz
    Section of Colon and Rectal Surgery H137, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Gastrointest Surg 11:204-8. 2007
  2. doi request reprint Chronic use of PPI and H2 antagonists decreases the risk of pouchitis after IPAA for ulcerative colitis
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, 17033 PA, USA
    J Gastrointest Surg 17:1027-31. 2013
  3. ncbi request reprint Surgical management of entero and colocutaneous fistulae in Crohn's disease: 17 year's experience
    Lisa S Poritz
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Int J Colorectal Dis 19:481-5; discussion 486. 2004
  4. doi request reprint Tumor volume and percent positive lymph nodes as a predictor of 5-year survival in colorectal cancer
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Surgery 150:649-55. 2011
  5. doi request reprint Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 162:290-8. 2010
  6. ncbi request reprint Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    Lisa S Poritz
    Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 140:12-9. 2007
  7. ncbi request reprint How should complex perianal Crohn's disease be treated in the Remicade era
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, PA 17033, USA
    J Gastrointest Surg 10:633-4. 2006
  8. ncbi request reprint Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost?
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, 17033, USA
    Dis Colon Rectum 48:1685-90. 2005
  9. doi request reprint Increase in the tight junction protein claudin-1 in intestinal inflammation
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Dig Dis Sci 56:2802-9. 2011
  10. ncbi request reprint Tumor necrosis factor alpha disrupts tight junction assembly
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Surg Res 116:14-8. 2004

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Percutaneous drainage and ileocolectomy for spontaneous intraabdominal abscess in Crohn's disease
    Lisa S Poritz
    Section of Colon and Rectal Surgery H137, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Gastrointest Surg 11:204-8. 2007
    ..The aim of the present study was to evaluate the success of this protocol with regard to length of stay, complications associated with the protocol, and its ability to avoid stoma creation...
  2. doi request reprint Chronic use of PPI and H2 antagonists decreases the risk of pouchitis after IPAA for ulcerative colitis
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, 17033 PA, USA
    J Gastrointest Surg 17:1027-31. 2013
    ..The change in gastric pH with the use of proton pump inhibitors and H(2) antagonists may lead to alteration of enteric bacteria. We hypothesized that chronic use of these medications would decrease the incidence of pouchitis...
  3. ncbi request reprint Surgical management of entero and colocutaneous fistulae in Crohn's disease: 17 year's experience
    Lisa S Poritz
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Int J Colorectal Dis 19:481-5; discussion 486. 2004
    ..Fistulous disease is common in Crohn's disease, and entero- and colocutaneous fistulae are particularly debilitating and difficult to manage. We present the results of surgical management of these fistulas...
  4. doi request reprint Tumor volume and percent positive lymph nodes as a predictor of 5-year survival in colorectal cancer
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Surgery 150:649-55. 2011
    ..Tumor size is not part of the staging system for CRC and in itself is not a predictor of survival. We hypothesize, however, that tumor size is important in determining disease free survival...
  5. doi request reprint Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 162:290-8. 2010
    ..This has been termed Stat6(null) and Stat6(high) is the normal phenotype. The purpose of this study was to investigate the defect in Stat6 activation in Stat6(null) cells...
  6. ncbi request reprint Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis
    Lisa S Poritz
    Department of Surgery and Department of Pathology, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Surg Res 140:12-9. 2007
    ..This study looked at the expression of the TJ protein ZO-1 and the corresponding permeability changes in dextran sulfate sodium (DSS) induced colitis in a mouse model...
  7. ncbi request reprint How should complex perianal Crohn's disease be treated in the Remicade era
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, PA 17033, USA
    J Gastrointest Surg 10:633-4. 2006
  8. ncbi request reprint Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost?
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, 17033, USA
    Dis Colon Rectum 48:1685-90. 2005
    ..The purpose of this study was to evaluate the success and cost of cyclosporine...
  9. doi request reprint Increase in the tight junction protein claudin-1 in intestinal inflammation
    Lisa S Poritz
    Division of Colon and Rectal Surgery, Department of Surgery, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Dig Dis Sci 56:2802-9. 2011
    ..Our group has also shown an increase in claudin-1 in experimental colitis...
  10. ncbi request reprint Tumor necrosis factor alpha disrupts tight junction assembly
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Surg Res 116:14-8. 2004
    ..Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin, and the claudins are key proteins in the TJ. Hypothesis: TNFalpha disrupts the TJ...
  11. doi request reprint Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines
    Wei Yu
    Department of Surgery, Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Dig Dis Sci 55:3171-80. 2010
    ..Nkx2-3 has been reported to be up-regulated in B cell lines and intestinal tissues from Crohn's disease patients and down-regulated in colorectal cancer...
  12. pmc NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells
    Wei Yu
    Department of Surgery, Pennsylvania State University, Hershey, Pennsylvania, United States of America
    PLoS ONE 6:e20454. 2011
    ..To understand the cellular function of NKX2-3 and its potential role underlying IBD pathogenesis, we investigated the genes regulated by NKX2-3 in HIMEC using cDNA microarray...
  13. doi request reprint NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis
    Rishabh Sehgal
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Dis Colon Rectum 53:1487-94. 2010
    ..We hypothesize that IPAA patients with complications (Crohn's disease-like/pouchitis) have a higher rate of NOD2 mutations compared with asymptomatic IPAA patients...
  14. pmc PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3
    Wei Yu
    Department of Surgery, Pennsylvania State University, Hershey, PA, USA
    Dis Markers 32:83-91. 2012
    ..These results suggest that PTPN2 may have an important role in CD pathogenesis and may represent a potential diagnostic and therapeutic target for IBD...
  15. doi request reprint NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes
    Zhenwu Lin
    Division of Colon and Rectal Surgery, Department of Surgery, Pennsylvania State University College of Medicine, H137, 500 University Drive, Hershey, PA 17033, USA
    Dig Dis Sci 58:2599-607. 2013
    ..Genetic and functional studies have associated variants in the NOD2/CARD15 gene with Crohn's disease...
  16. doi request reprint NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT
    Gerrit John
    Department of Surgery, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mol Genet Metab 104:174-9. 2011
    ..The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by ChIP assay. We speculate that the rs11190140 may regulate NKX2-3 expression and have a role in IBD pathogenesis...
  17. doi request reprint Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1
    Wei Yu
    Department of Colon and Rectal Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Inflammation 35:889-99. 2012
    ..mRNA expressions of NKX2-3 and EGR1 were increased in diseased intestinal tissues from 19 CD patients. NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1...
  18. doi request reprint Genetic risk profiling and gene signature modeling to predict risk of complications after IPAA
    Rishabh Sehgal
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Dis Colon Rectum 55:239-48. 2012
    ..To date, approximately 83 single nucleotide polymorphisms within 55 genes have been associated with IBD...
  19. doi request reprint A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease
    Tara M Connelly
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Dis Colon Rectum 56:1068-74. 2013
    ..The STAT5 gene is known to influence colonic permeability, mucosal regeneration, and interleukin 2 production, although its role in the distribution of Crohn's disease is unclear...
  20. doi request reprint Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease
    Rishabh Sehgal
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Dis Colon Rectum 55:115-21. 2012
    ..At the time of this study, approximately 80 single-nucleotide polymorphisms within 55 genes had been associated with IBD...
  21. ncbi request reprint Stat6(null phenotype) human lymphocytes exhibit increased apoptosis
    Eva Galka
    Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Section of Colon and Rectal Surgery, MCH137, Hershey, Pennsylvania, USA
    J Surg Res 122:14-20. 2004
    ....
  22. doi request reprint Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease
    Tara M Connelly
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Dis Colon Rectum 55:1145-52. 2012
    ....
  23. doi request reprint Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patients
    Zhenwu Lin
    Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, MC H 137, Hershey, PA 17033, USA
    Dig Dis Sci 57:3145-53. 2012
    ..We previously identified seven disease-associated DNA methylation loci from intestinal tissues of IBD patients using the Illumina GoldenGate BeadArray assay...
  24. pmc Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease
    Zhenwu Lin
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey, USA
    Ann Hum Genet 75:559-68. 2011
    ..The results suggest that differential allelic expression may affect penetrance of the SNP rs721917 disease-susceptibility allele in IBD. The potential impact of SP-D monoallelic expression on incomplete penetrance is discussed...
  25. ncbi request reprint Modified two-stage ileal pouch-anal anastomosis: equivalent outcomes with less resource utilization
    Brian R Swenson
    Department of Surgery, The Penn State College of Medicine, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Dis Colon Rectum 48:256-61. 2005
    ..The present study sought to evaluate the safety, results, cost, and length of hospital stay using this modified approach compared to that of the traditional three-stage ileal pouch-anal anastomosis...
  26. ncbi request reprint Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4
    Douglas M Wisner
    Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Surg Res 144:1-7. 2008
    ..Interferon-gamma (IFNgamma) and interleukin-4 (IL-4) negatively regulate each other and may have opposing roles in inflammatory bowel disease. Hypothesis: IFNgamma and IL-4 will have opposing effects on the expression of claudin-2...
  27. doi request reprint Risk factors for surgical site infections after colorectal resection in diabetic patients
    Rishabh Sehgal
    Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Am Coll Surg 212:29-34. 2011
    ..However, there is no clear consensus as to which other risk factors play a significant role. The goal of this study was to identify risk factors associated with SSI in patients with DM undergoing colorectal resection...
  28. doi request reprint DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility
    Zhenwu Lin
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Swiss Med Wkly 141:w13290. 2011
    ..In this study, we examined the genetic association of another DLG5 SNP P1371Q (rs2289310) with IBD and its interaction with R30Q in disease susceptibility...
  29. doi request reprint Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA
    Liam A Haveran
    Division of Colon and Rectal Surgery, Penn State Hershey Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Dis Colon Rectum 54:15-20. 2011
    ..This study evaluated the effectiveness in our hands of infliximab and/or azathioprine/6-mercaptopurine in treating this patient population...
  30. doi request reprint Dehydration is the most common indication for readmission after diverting ileostomy creation
    Evangelos Messaris
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Dis Colon Rectum 55:175-80. 2012
    ..Early readmission after discharge from the hospital is an undesirable outcome. Ileostomies are commonly used to prevent symptomatic anastomotic complications in colorectal resections...
  31. ncbi request reprint Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma
    Wen Jie Zhang
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:447-53. 2004
    ..Moreover, observations from signal transduction studies in our human B lymphocyte model may be compatible with those in the chosen mouse B lymphocyte for establishing signaling networks by the Alliance for Cellular Signaling (AfCS)...
  32. ncbi request reprint Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease
    Wei Yu
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    J Crohns Colitis 3:189-95. 2009
    ..To replicate the association of Nkx2-3 rs10883365 SNP with Crohn's disease in patients from a familial IBD registry from the central Pennsylvania area and study mRNA and protein expression of Nkx2-3 in CD patients...
  33. doi request reprint Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines
    Danielle M Pastor
    Department of Surgery, Penn State Milton S Hershey Medical Center and College of Medicine, Hershey, Pennsylvania, USA
    Dis Colon Rectum 53:257-63. 2010
    ....
  34. doi request reprint PPI therapy and albumin are better predictors of recurrent Clostridium difficile colitis than choice of antibiotics
    Alizah Rotramel
    Division of Colon and Rectal Surgery, Department of Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
    J Gastrointest Surg 16:2267-73. 2012
    ..Recurrent Clostridium difficile colitis (RCDC) is common, but data regarding recurrence rates and predisposing factors are sparse...
  35. ncbi request reprint Surgical management of ulcerative colitis in the presence of primary sclerosing cholangitis
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, USA
    Dis Colon Rectum 46:173-8. 2003
    ..The surgical management of ulcerative colitis in the patient with primary sclerosing cholangitis is controversial...
  36. doi request reprint Management of peristomal pyoderma gangrenosum
    Lisa S Poritz
    Division of Colon and Rectal Surgery, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Am Coll Surg 206:311-5. 2008
    ..Pyoderma gangrenosum (PG) occurs in about 1% to 5% of patients with inflammatory bowel disease (IBD). Peristomal pyoderma gangrenosum (PPG) is particularly difficult to manage...
  37. ncbi request reprint Enhanced intestinal expression of the proteasome subunit low molecular mass polypeptide 2 in patients with inflammatory bowel disease
    Leo R Fitzpatrick
    Department of Surgery, Section of Colon and Rectal Surgery, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Dis Colon Rectum 50:337-48; discussion 348-50. 2007
    ..Moreover, we examined the association between low molecular mass polypeptide 2 expression and histologic pathology in these patients...
  38. doi request reprint Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease
    Wei Yu
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Genet Metab 100:88-95. 2010
    ..05). Our present results demonstrate that a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of IBD, such as EDN1...
  39. ncbi request reprint Remicade does not abolish the need for surgery in fistulizing Crohn's disease
    Lisa S Poritz
    Department of Surgery, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Dis Colon Rectum 45:771-5. 2002
    ..Our aim was to evaluate the role of infliximab in supplanting surgery for fistulizing Crohn's disease...
  40. pmc Parastomal hernia repair: a single center experience
    Danielle M Pastor
    Division of Colon and Rectal Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    JSLS 13:170-5. 2009
    ..Despite multiple options for operative repair of parastomal hernia, results are frequently disappointing. We review our experience with parastomal hernia repair...
  41. ncbi request reprint Factors affecting surgical risk in elderly patients with inflammatory bowel disease
    Michael J Page
    Section of Colon and Rectal Surgery H 149, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Gastrointest Surg 6:606-13. 2002
    ..The fact that the higher complication rate seen in older patients with IBD is associated with disease-defined surgical indications suggests that IBD in elderly patients may be more aggressive than what is observed in younger individuals...

Research Grants2