C Niyibizi

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Gene transfer to the tendon-bone insertion site
    Christian Lattermann
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Knee Surg Sports Traumatol Arthrosc 12:510-5. 2004
  2. ncbi request reprint Gene therapy approaches for osteogenesis imperfecta
    C Niyibizi
    Department of Orthopaedic Surgery, Ferguson Laboratories for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 11:408-16. 2004
  3. pmc Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo
    Feng Li
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    BMC Cell Biol 13:35. 2012
  4. ncbi request reprint The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells
    Christopher Niyibizi
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mol Ther 9:955-63. 2004
  5. ncbi request reprint Transfer of proalpha2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of alpha1(I) and alpha2(I) heterotrimers in vitro and in vivo
    C Niyibizi
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Cell Biochem 83:84-91. 2001
  6. doi request reprint Distribution of murine adipose-derived mesenchymal stem cells in vivo following transplantation in developing mice
    Xinbo Liao
    Pennsylvania State University College of Medicine, Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal Sciences, Hershey PA 17033, USA
    Stem Cells Dev 17:303-14. 2008
  7. ncbi request reprint Progenitors systemically transplanted into neonatal mice localize to areas of active bone formation in vivo: implications of cell therapy for skeletal diseases
    Xujun Wang
    Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal SciencesPenn State College of Medicine, Mail Code H089, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Stem Cells 24:1869-78. 2006
  8. ncbi request reprint Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)
    M L Balk
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Bone 21:7-15. 1997
  9. ncbi request reprint Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism
    J K Suh
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Osteoarthritis Cartilage 7:71-80. 1999
  10. pmc Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures
    Koichiro Kawamura
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Exp Hematol 33:865-72. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Gene transfer to the tendon-bone insertion site
    Christian Lattermann
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Knee Surg Sports Traumatol Arthrosc 12:510-5. 2004
    ..This study has shown the feasibility of gene delivery to the tendon-bone interface and provides the basis for the application adenoviral delivery of growth factor genes to the tendon-bone insertion site...
  2. ncbi request reprint Gene therapy approaches for osteogenesis imperfecta
    C Niyibizi
    Department of Orthopaedic Surgery, Ferguson Laboratories for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 11:408-16. 2004
    ..The present review will discuss the molecular changes seen in OI, the current treatment options and the gene therapy approaches being investigated as potential future treatments for OI...
  3. pmc Cells derived from murine induced pluripotent stem cells (iPSC) by treatment with members of TGF-beta family give rise to osteoblasts differentiation and form bone in vivo
    Feng Li
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    BMC Cell Biol 13:35. 2012
    ..There is great interest in these cells because of their potential for application in regenerative medicine...
  4. ncbi request reprint The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells
    Christopher Niyibizi
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mol Ther 9:955-63. 2004
    ..These data demonstrate that MSCs persist in immunocompetent neonatal mice, maintain a high level of gene expression, and may participate in skeletal growth and development of the recipient animals...
  5. ncbi request reprint Transfer of proalpha2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of alpha1(I) and alpha2(I) heterotrimers in vitro and in vivo
    C Niyibizi
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Cell Biochem 83:84-91. 2001
    ..These data encourage further studies in gene replacement for some forms of OI and use of bone marrow stromal cells as vehicles to deliver therapeutic genes to bone...
  6. doi request reprint Distribution of murine adipose-derived mesenchymal stem cells in vivo following transplantation in developing mice
    Xinbo Liao
    Pennsylvania State University College of Medicine, Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal Sciences, Hershey PA 17033, USA
    Stem Cells Dev 17:303-14. 2008
    ..These data suggest that exposure of ADSCs to bone microenvironment or to TGF-beta1 prior to transplantation enhances their survival in the skeletal tissues following transplantation...
  7. ncbi request reprint Progenitors systemically transplanted into neonatal mice localize to areas of active bone formation in vivo: implications of cell therapy for skeletal diseases
    Xujun Wang
    Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal SciencesPenn State College of Medicine, Mail Code H089, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Stem Cells 24:1869-78. 2006
    ....
  8. ncbi request reprint Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)
    M L Balk
    Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Bone 21:7-15. 1997
    ..Under basal conditions, however, the stromal cells from oim mice exhibited significantly lower levels of alkaline phosphatase activity than their normal littermates...
  9. ncbi request reprint Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism
    J K Suh
    Department of Orthopaedic Surgery, University of Pittsburgh, PA 15213, USA
    Osteoarthritis Cartilage 7:71-80. 1999
    ....
  10. pmc Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures
    Koichiro Kawamura
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Exp Hematol 33:865-72. 2005
    ..The growth factor genes evaluated in the present study were transforming growth factor 1 (TGF-beta1) and insulin-like growth factor 1 (IGF-1)...
  11. ncbi request reprint Novel approaches to fracture healing
    C Niyibizi
    University of Pittsburgh School of Medicine, Musculoskeletal Research Center, Department of Orthopaedic Surgery, 200 Lothrop Street, RM C313, Pittsburgh, PA 15213, USA
    Expert Opin Investig Drugs 9:1573-80. 2000
    ..This review discusses these novel approaches and presents an assessment of their future clinical applicability...
  12. ncbi request reprint Type V collagen is increased during rabbit medial collateral ligament healing
    C Niyibizi
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, Presbyterian University Hospital, University of Pittsburgh School of Medicine, PA 15213, USA
    Knee Surg Sports Traumatol Arthrosc 8:281-5. 2000
    ....
  13. ncbi request reprint Distribution of single-cell expanded marrow derived progenitors in a developing mouse model of osteogenesis imperfecta following systemic transplantation
    Feng Li
    Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal Sciences, Pennsylvania State University College of Medicine, H089, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Stem Cells 25:3183-93. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  14. ncbi request reprint Antisense oligonucleotides reduce synthesis of procollagen alpha1 (V) chain in human patellar tendon fibroblasts: potential application in healing ligaments and tendons
    Takatoshi Shimomura
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Connect Tissue Res 44:167-72. 2003
    ....
  15. ncbi request reprint Approaches for skeletal gene therapy
    Christopher Niyibizi
    Department of Orthopaedic Surgery, Ferguson Laboratories for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Rev Eukaryot Gene Expr 12:163-73. 2002
    ..The challenges that the investigators face in their quest for the skeletal gene therapy are also discussed...
  16. ncbi request reprint Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects
    Nobuo Adachi
    Department of Orthopaedic Surgery, Children s Hospital of Pittsburgh, and University of Pittsburgh, Pennsylvania 15213, USA
    J Rheumatol 29:1920-30. 2002
    ....
  17. doi request reprint The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells
    Lars Gilbertson
    Department of Orthopedic Surgery, University of Pittsburgh, E1641 BST Pittsburgh, PA 15261, USA
    Spine J 8:449-56. 2008
    ..However, no reports have compared the actions of BMP-2 and -12 on human annulus fibrosus (AF) and nucleus pulposus (NP) cells nor evaluated adenoviral-mediated gene therapy in human AF cells...