Joshua E Muscat

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Nicotine dependence phenotype and lung cancer risk
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Blvd, Hershey, PA 17033, USA
    Cancer 117:5370-6. 2011
  2. pmc Menthol smoking in relation to time to first cigarette and cotinine: results from a community-based study
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Regul Toxicol Pharmacol 63:166-70. 2012
  3. pmc The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk
    Joshua E Muscat
    Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Causes Control 23:497-503. 2012
  4. pmc Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation
    Joshua E Muscat
    Penn State College of Medicine, Department of Public Health Science, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 18:35-41. 2009
  5. pmc Time to first cigarette after waking predicts cotinine levels
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 18:3415-20. 2009
  6. pmc Perineal talc use and ovarian cancer: a critical review
    Joshua E Muscat
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Eur J Cancer Prev 17:139-46. 2008
  7. ncbi request reprint Mobile telephones and rates of brain cancer
    Joshua E Muscat
    Penn State College of Medicine, 500 University Blvd, MC H 069 Hershey, PA 17033, USA
    Neuroepidemiology 27:55-6. 2006
  8. pmc A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA
    Biomarkers 16:206-11. 2011
  9. pmc Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Blvd, Hershey, PA 17033, USA
    Cancer 117:5377-82. 2011
  10. ncbi request reprint The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer
    Carla J Gallagher
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Epidemiol Biomarkers Prev 16:823-8. 2007

Research Grants

  1. Epidemiology of protein glutathiolation
    Joshua Muscat; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. pmc Nicotine dependence phenotype and lung cancer risk
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Blvd, Hershey, PA 17033, USA
    Cancer 117:5370-6. 2011
    ..A behavioral phenotype that characterizes nicotine dependence, the time to first cigarette after waking, is hypothesized to increase the risk of lung cancer...
  2. pmc Menthol smoking in relation to time to first cigarette and cotinine: results from a community-based study
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Regul Toxicol Pharmacol 63:166-70. 2012
    ..These results show that while menthol in tobacco is associated with an indicator of nicotine dependence in blacks, menthol was not associated with biological uptake of nicotine in black and white smokers...
  3. pmc The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk
    Joshua E Muscat
    Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Causes Control 23:497-503. 2012
    ..The time to first cigarette after waking in the morning is a behavior associated with several dimensions of nicotine dependence including the dose of smoke uptake. We hypothesized that a short TTFC increases the risk of laryngeal cancer...
  4. pmc Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation
    Joshua E Muscat
    Penn State College of Medicine, Department of Public Health Science, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 18:35-41. 2009
    ..Collectively, these results show that menthol does not affect biological exposure to tobacco smoke constituents but indicates that menthol might inhibit the detoxification of the potent lung carcinogen NNAL...
  5. pmc Time to first cigarette after waking predicts cotinine levels
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 18:3415-20. 2009
    ..Similar findings were observed for urinary cotinine. These findings suggest that the time to first cigarette is a strong predictor of nicotine uptake and should be considered in the design of smoking interventions...
  6. pmc Perineal talc use and ovarian cancer: a critical review
    Joshua E Muscat
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Eur J Cancer Prev 17:139-46. 2008
    ..Talc is not genotoxic. Mechanistic, pathology and animal model studies have not found evidence for a carcinogenic effect. In summary, these data collectively do not indicate that cosmetic talc causes ovarian cancer...
  7. ncbi request reprint Mobile telephones and rates of brain cancer
    Joshua E Muscat
    Penn State College of Medicine, 500 University Blvd, MC H 069 Hershey, PA 17033, USA
    Neuroepidemiology 27:55-6. 2006
    ..The rates did not change during this period, despite the exponential increase in mobile phone subscriptions starting in 1984. These results indicate that mobile phone use is unrelated to the risk of neuronal cancers...
  8. pmc A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA
    Biomarkers 16:206-11. 2011
    ..The validity of urinary correction standards has not been established for most analytes...
  9. pmc Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer
    Joshua E Muscat
    Department of Public Health Sciences, Penn State College of Medicine, 500 University Blvd, Hershey, PA 17033, USA
    Cancer 117:5377-82. 2011
    ..A behavioral phenotype that characterizes nicotine dependence, the time to first cigarette after waking, is hypothesized to increase the risk of head and neck cancer...
  10. ncbi request reprint The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer
    Carla J Gallagher
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Epidemiol Biomarkers Prev 16:823-8. 2007
    ....
  11. pmc Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms
    Gang Chen
    Molecular Epidemiology and Cancer Control Program, Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Res 70:7543-52. 2010
    ....
  12. pmc Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers
    Joshua E Muscat
    Penn State Cancer Institute, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17036, USA
    Biochem Pharmacol 76:929-37. 2008
    ..Collectively, these results indicated that phenotypic differences in NAT2 alone or in combination with CYP1A2 might help explain the higher incidence rates of transitional cell bladder cancer in whites...
  13. pmc The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case-control study in Caucasians
    Carla J Gallagher
    Departments of Public Health Sciences, Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Cancer Detect Prev 31:310-5. 2007
    ..A deletion polymorphism in the UGT2B17 gene is associated with a substantial reduction in glucuronidation activity in vitro...
  14. pmc Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk
    Carla J Gallagher
    Penn State Cancer Institute, Department of Pharmacology, Penn State College of Medicine, Hershey, 17033, USA
    Free Radic Biol Med 46:20-4. 2009
    ..This study suggests that subjects with the SOD2 TCG haplotype may be at decreased risk for lung adenocarcinoma and that this association may depend on smoking amount...
  15. ncbi request reprint Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    Joshua E Muscat
    Department of Health Evaluation Sciences, Pennsylvania State Cancer Institute, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Cancer 103:1420-6. 2005
    ..It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and in the detoxification of NNK metabolites...
  16. pmc Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population
    Nathan R Jones
    Molecular Epidemiology and Cancer Control Programs, Penn State Hershey Cancer Institute, Penn State College of Medicine, 500 University Drive, Hershey, PA, USA
    Cancer Epidemiol 35:175-81. 2011
    ..The human excision repair cross-complementation group 1 (ERCC1) protein is essential for a functional NER system and genetic variation in ERCC1 may contribute to impaired DNA repair capacity and increased lung and H&N cancer risk...
  17. pmc The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk
    Andrea Y Angstadt
    Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer 119:2477-85. 2013
    ....
  18. pmc Association of selenium status and blood glutathione concentrations in blacks and whites
    John P Richie
    Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nutr Cancer 63:367-75. 2011
    ..05) but was unchanged in Blacks. These results indicate a direct association between selenium and GSH in the blood of both free-living and selenium-supplemented individuals, with race being an important modifying factor...
  19. pmc A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers
    Sailendra N Nichenametla
    Department of Public Health Sciences, Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania
    Mol Carcinog 52:791-9. 2013
    ..001) compared to subjects without GAG-7 allele. These findings suggest that GSH synthesis affects the risk of lung and aerodigestive tract cancers, and further implicates a role for oxidative stress in the development of these cancers...
  20. ncbi request reprint Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism
    Gang Chen
    Cancer Prevention and Control Program, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Cancer Res 67:9024-9. 2007
    ....
  21. ncbi request reprint Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes
    Philip Lazarus
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pharmacogenet Genomics 15:769-78. 2005
    ..05) or UGT2B7 (*2/*2) (P<0.02) genotypes. These data suggest that the UGT2B17 deletion polymorphism is associated with a reduced rate of NNAL detoxification in vivo and may increase individual susceptibility to tobacco-related cancers...
  22. doi request reprint Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study
    Joseph H Ashmore
    Department of Nutritional Sciences, Pennsylvania State University, College of Health and Human Development, State College, PA, USA
    Genes Chromosomes Cancer 52:945-53. 2013
    ..042) SNP exhibited gene-diet interactions with methionine intake. These findings suggest that allelic variants in genes involved in FOCM interact with dietary factors including folate and methionine to modify risk for CRC...
  23. pmc Blood iron, glutathione, and micronutrient levels and the risk of oral cancer
    John P Richie
    Department of Public Health Sciences, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nutr Cancer 60:474-82. 2008
    ..6 (95% CI = 1.3-3.7). These findings suggest that mild iron deficiency and low GSH levels, which are associated with increased oxidative stress, increase the risk of oral cavity cancer...
  24. ncbi request reprint Charcoal cigarette filters and lung cancer risk in Aichi Prefecture, Japan
    Joshua E Muscat
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Division of Population Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Sci 96:283-7. 2005
    ..As the detection of a modest benefit or risk (e.g. 10-20%) that can have significant public health impact requires large samples, the findings should be confirmed or refuted in larger studies...
  25. doi request reprint Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence
    Paige E Miller
    The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nutr Cancer 62:413-24. 2010
    ..Continued research efforts are needed to evaluate the cumulative and interactive effects of numerous dietary exposures on colorectal cancer risk...
  26. pmc Diet index-based and empirically derived dietary patterns are associated with colorectal cancer risk
    Paige E Miller
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 140:1267-73. 2010
    ..31-0.99; OR = 0.44, 95% CI = 0.24-0.77, respectively). Following the Dietary Guidelines or a dietary pattern lower in meat, potatoes, high fat, and refined foods and higher in fruits and vegetables may reduce colorectal cancer risk...
  27. ncbi request reprint Nitric oxide-releasing medications and colorectal cancer risk: the framingham study
    Joshua E Muscat
    Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
    Anticancer Res 25:4471-4. 2005
    ..Experimental NO-donating aspirin also releases NO in a similar manner, and is a potent in vitro inhibitor of colon cancer...
  28. ncbi request reprint Lung cancer risk in white and black Americans
    Steven D Stellman
    American Health Foundation, One Dana Road, Valhalla, NY 10595, USA
    Ann Epidemiol 13:294-302. 2003
    ....
  29. ncbi request reprint Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk
    Abul Elahi
    Cancer Epidemiology and Prevention Program, H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    Cancer 98:872-80. 2003
    ..The current study was conducted to determine the prevalence of genetic polymorphisms in the UGT1A10-specific region of the UDP-glucuronosyltransferase family 1A locus and their relationship with risk for orolaryngeal carcinoma...
  30. ncbi request reprint Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers
    Joel L Schwartz
    Institute for Cancer Prevention, One Dana Road, Valhalla, NY 10595, USA
    Oral Oncol 39:842-54. 2003
    ..Flow cytometric evaluation of oral cytology harvested keratinocytes can be used to measure exposure to tobacco carcinogens, and possibly establish a link to premalignant and malignant transformation before a lesion is noted...
  31. ncbi request reprint Enhanced protein glutathiolation and oxidative stress in cigarette smokers
    Joshua E Muscat
    Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
    Free Radic Biol Med 36:464-70. 2004
    ..1%, n = 8). GSSP levels are stable over time but increase in response to the abundant free radicals in cigarette smoke. These findings support the use of GSSP as a sensitive biomarker of oxidative stress...
  32. ncbi request reprint Influence of type of cigarette on peripheral versus central lung cancer
    Daniel R Brooks
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Cancer Epidemiol Biomarkers Prev 14:576-81. 2005
    ..We reviewed radiologic data to evaluate the hypothesis that tumors in smokers of cigarettes with lower-tar yield are more likely to occur peripherally than tumors in smokers of higher-yield cigarettes...
  33. ncbi request reprint Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New York
    Joshua E Muscat
    Institute for Cancer Prevention, Valhalla, New York 10595, USA
    Cancer Epidemiol Biomarkers Prev 12:1474-8. 2003
    ..9-5.1). In contrast to previous data showing no relationship between OC exposure and risk of breast cancer in these women, adipose PCB concentrations were associated with tumor recurrence. Pesticide levels were not related to recurrence...
  34. ncbi request reprint Modifiable family and school environmental factors associated with smoking status among adolescents in Guangzhou, China
    Xiaozhong Wen
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, China
    Prev Med 45:189-97. 2007
    ..To identify modifiable family and school environmental factors associated with Chinese adolescent smoking behaviors including never-smoking, experimental smoking, regular smoking, and attempting to quit...
  35. doi request reprint Differences in students' smoking-related knowledge, attitudes, and behaviors among public, factory, and private secondary schools in Guangzhou, China
    Xiaozhong Wen
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou 510080, China
    J Sch Health 78:46-53. 2008
    ..The purpose of this study was to examine the differences in smoking-related knowledge, attitudes, and behaviors among Chinese students in 3 types of secondary schools...
  36. ncbi request reprint Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs
    Joshua E Muscat
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer 97:1732-6. 2003
    ..To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans...

Research Grants2

  1. Epidemiology of protein glutathiolation
    Joshua Muscat; Fiscal Year: 2007
    ..Determine the effects of MAC supplementation after adjustment for age, genetic polymorphisms and other factors. ..