Patricia J McLaughlin

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint The opioid growth factor-opioid growth factor receptor axis: homeostatic regulator of cell proliferation and its implications for health and disease
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem Pharmacol 84:746-55. 2012
  2. doi request reprint Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure
    Patricia J McLaughlin
    Dept of Neural and Behavioral Sciences, The Pennsylvania State Univ College of Medicine, Hershey, PA 17033 0850, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1084-90. 2012
  3. doi request reprint Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: novel therapies for squamous cell carcinoma of the head and neck
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Head Neck 34:513-9. 2012
  4. ncbi request reprint Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:227-32. 2004
  5. doi request reprint Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, MC H109, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 236:1122-32. 2011
  6. doi request reprint Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Exp Biol Med (Maywood) 235:1292-9. 2010
  7. ncbi request reprint Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 26:809-16. 2005
  8. ncbi request reprint Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 28:1577-83. 2006
  9. ncbi request reprint Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 19:421-8. 2007
  10. pmc Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
    BMC Cancer 9:369. 2009

Collaborators

Detail Information

Publications73

  1. doi request reprint The opioid growth factor-opioid growth factor receptor axis: homeostatic regulator of cell proliferation and its implications for health and disease
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem Pharmacol 84:746-55. 2012
    ..In summary, understanding the OGF-OGFr axis as a homeostatic regulator of proliferation has substantial implications for maintaining human health and treatment of disease...
  2. doi request reprint Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure
    Patricia J McLaughlin
    Dept of Neural and Behavioral Sciences, The Pennsylvania State Univ College of Medicine, Hershey, PA 17033 0850, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1084-90. 2012
    ..These mice also can serve as a valuable model to dissect the mechanism of OGF-OGFr action and may be important in understanding the etiology, pathogenesis, and treatment of epithelium-related diseases...
  3. doi request reprint Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: novel therapies for squamous cell carcinoma of the head and neck
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Head Neck 34:513-9. 2012
    ..This study investigated modulation of the OGF-OGFr system by (1) exogenous OGF, (2) upregulation of OGFr using imiquimod, or (3) intermittent opioid receptor blockade with a low dose of naltrexone on progression of established SCCHN...
  4. ncbi request reprint Opioid growth factor inhibition of a human squamous cell carcinoma of the head and neck in nude mice: dependency on the route of administration
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 24:227-32. 2004
    ....
  5. doi request reprint Topical treatment with the opioid antagonist naltrexone facilitates closure of full-thickness wounds in diabetic rats
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, MC H109, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 236:1122-32. 2011
    ..These data suggest that topical application of NTX is a non-toxic and efficacious facilitator for healing full thickness wounds in T1D, with wound contraction serving as a particular target of NTX action...
  6. doi request reprint Inhibition of DNA synthesis in mouse epidermis by topical imiquimod is dependent on opioid receptors
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Exp Biol Med (Maywood) 235:1292-9. 2010
    ..These results suggest that the target of imiquimod on DNA synthesis is dependent on an opioid receptor-mediated pathway, and infers that imiquimod is reliant on the OGF-OGFr axis for modulating cell proliferation...
  7. ncbi request reprint Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of paclitaxel and opioid growth factor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 26:809-16. 2005
    ..These data suggest that the combination of a biotherapy (OGF) and chemotherapy (paclitaxel and carboplatin) may provide an enhanced antitumor effect with respect to SCCHN...
  8. ncbi request reprint Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 28:1577-83. 2006
    ..Gene therapy to reinstate more OGFr, and thus enhance OGFr function, could serve as a useful treatment for inhibiting tumor progression...
  9. ncbi request reprint Overexpression of the opioid growth factor receptor downregulates cell proliferation of human squamous carcinoma cells of the head and neck
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Mol Med 19:421-8. 2007
    ..These data indicate that the OGF receptor is integral to cell replication of SCCHN, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias...
  10. pmc Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
    BMC Cancer 9:369. 2009
    ..This study addressed the question of whether the OGF-OGFr axis is present and functional in human thyroid follicular cell - derived cancer...
  11. ncbi request reprint Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Int J Oncol 33:751-7. 2008
    ....
  12. ncbi request reprint Opioid growth factor (OGF) inhibits the progression of human squamous cell carcinoma of the head and neck transplanted into nude mice
    Patricia J McLaughlin
    Departments of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3727, Hershey, PA 17033 0850, USA
    Cancer Lett 199:209-17. 2003
    ..These results indicate that the OGF-OGFr axis functions in vivo, OGF is a constitutively active molecule, and OGF modulation of SCCHN may have clinical application...
  13. ncbi request reprint Opioid gene expression in the developing and adult rat heart
    P J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey 17033 0850, USA
    Dev Dyn 211:153-63. 1998
    ..The role of PPE and POMC mRNA in adult rat heart requires elucidation...
  14. ncbi request reprint Preproenkephalin gene expression and [Met5]-enkephalin levels in the developing rat heart
    P J McLaughlin
    Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University, The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 0850, USA
    Brain Res Mol Brain Res 60:160-7. 1998
    ....
  15. ncbi request reprint Chronic exposure to the opioid antagonist naltrexone during pregnancy: maternal and offspring effects
    P J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey 17033, USA
    Physiol Behav 62:501-8. 1997
    ....
  16. ncbi request reprint Defects in the opioid growth factor receptor in human squamous cell carcinoma of the head and neck
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, Division of Otolaryngology, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Cancer 97:1701-10. 2003
    ..This study compared protein and gene expression of OGFr in surgical specimens of human squamous cell carcinoma of the head and neck (SCCHN) with normal epithelium...
  17. ncbi request reprint Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: maternal and preweaning effects
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, H 109, 500 University Drive, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 71:171-81. 2002
    ....
  18. ncbi request reprint Exposure to the opioid antagonist naltrexone throughout gestation alters postnatal heart development
    Patricia J McLaughlin
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033 0850, USA
    Biol Neonate 82:207-16. 2002
    ..These data suggest that endogenous opioids function to regulate cardiac growth during the prenatal period, and that disruption of this process has long-term implication for cardiac biology...
  19. pmc Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Exp Eye Res 89:686-92. 2009
    ..These data demonstrate that although NTX or INS accelerates wound healing, concomitant application of NTX and INS to corneal abrasions in diabetic animals does not have an additive effect on re-epithelialization...
  20. ncbi request reprint Combination chemotherapy with gemcitabine and biotherapy with opioid growth factor (OGF) enhances the growth inhibition of pancreatic adenocarcinoma
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, 17033, USA
    Cancer Chemother Pharmacol 56:510-20. 2005
    ..This preclinical evidence shows that combined chemotherapy (e.g. gemcitabine) and biotherapy (OGF) provides an enhanced therapeutic benefit for pancreatic cancer...
  21. ncbi request reprint Topically applied naltrexone restores corneal reepithelialization in diabetic rats
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Ocul Pharmacol Ther 23:89-102. 2007
    ..Complications of diabetes include an increased risk of delayed corneal epithelial wound healing. This study examined the efficacy of naltrexone (NTX), an opioid antagonist, by topical application in facilitating the repair of such lesions...
  22. pmc Regulation of Tenon's capsule fibroblast cell proliferation by the opioid growth factor and the opioid growth factor receptor axis
    Matthew S Klocek
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 51:5054-61. 2010
    ..This study examined whether the interaction of the opioid growth factor (OGF) [Met(5)]-enkephalin with its receptor (OGFr) is a regulator of TCF proliferation...
  23. ncbi request reprint Opioid growth factor receptor is unaltered with the progression of human pancreatic and colon cancers
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 29:489-94. 2006
    ..This information will be relevant in the design of therapeutic modalities, the diagnosis and prognosis of neoplasia, as well as understanding of the processes and mechanisms of carcinogenesis...
  24. ncbi request reprint Opioid growth factor enhances tumor growth inhibition and increases the survival of paclitaxel-treated mice with squamous cell carcinoma of the head and neck
    Jeffrey R Jaglowski
    Department of Neural and Behavioral Sciences H109, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Cancer Chemother Pharmacol 56:97-104. 2005
    ..These data suggest that combined chemotherapy (i.e., paclitaxel) and biotherapy (OGF) provides a valuable alternative to the standard of care for SCCHN patients...
  25. doi request reprint Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The M S Hershey Medical Center, 500 University Drive, Rm C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 233:968-79. 2008
    ..This exciting new knowledge of the mechanism of imidazoquinolines has important physiological relevance, and allows strategies to be developed for the use of these agents that will enhance effectiveness as well as attenuate side-effects...
  26. pmc Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, USA
    Arch Ophthalmol 126:501-6. 2008
    ..To determine whether topical application of naltrexone prevents exuberant granulation tissue formation with neovascularization in diabetic rat corneas...
  27. pmc Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits
    I S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Brain Res Bull 81:248-55. 2010
    ..These studies set the stage for clinical trials using NTX as a therapy for diabetic keratopathy...
  28. doi request reprint Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis
    Renee N Donahue
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1716-25. 2009
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in human ovarian cancer. This information will be important in designing treatment strategies for this deadly disease...
  29. doi request reprint Passive diffusion of naltrexone into human and animal cells and upregulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 297:R844-52. 2009
    ..Taken together, these results suggested that NTX enters cells by passive diffusion in a nonsaturable manner...
  30. ncbi request reprint Corneal safety of topically applied naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Ocul Pharmacol Ther 22:377-87. 2006
    ..Naltrexone (NTX), an opioid antagonist, accelerates wound healing of corneal epithelium in normal and diabetic animals. This study examined the safety of NTX by topical application in the cornea...
  31. pmc The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Mol Cancer 7:5. 2008
    ..The OGF-OGFr axis influences the G0/G1 phase of the cell cycle. In this investigation, we elucidate the pathway of OGF in the cell cycle...
  32. ncbi request reprint Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Mail Code H109, The Milton S Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 125:1082-8. 2007
    ..To determine whether topical application of insulin normalizes delayed corneal wound healing in rats with diabetes mellitus (DB)...
  33. ncbi request reprint Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 33:317-23. 2008
    ..These data support OGFr gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer...
  34. doi request reprint Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1154-61. 2009
    ..The identification of this native biological system in neoplasia may be important in understanding the pathophysiology of neoplasia, and in designing treatment modalities that utilize the body's own chemistry...
  35. ncbi request reprint Overexpression of the opioid growth factor receptor potentiates growth inhibition in human pancreatic cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 30:775-83. 2007
    ..These data identify OGFr at the molecular level as integral to regulating the cell replication of human pancreatic cancer, and support treatment modalities that amplify OGFr in order to decrease the growth of these neoplasias...
  36. ncbi request reprint Opioid growth factor (OGF) inhibits anchorage-independent growth in human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H 109, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 24:1443-8. 2004
    ....
  37. pmc Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Brain Res Bull 81:236-47. 2010
    ..g., vitrectomy), and that conventional therapies such as artificial tears and bandage contact lenses often fail, topical application of NTX merits clinical consideration...
  38. doi request reprint Regulation of cell proliferation by the opioid growth factor receptor is dependent on karyopherin beta and Ran for nucleocytoplasmic trafficking
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 235:1093-101. 2010
    ..These hierarchical levels of nuclear import provide multiple pathways for the subtle regulation of OGF-OGFr as it relates to the control of cell proliferative events...
  39. pmc Internalization of the opioid growth factor, [Met5]-enkephalin, is dependent on clathrin-mediated endocytosis for downregulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 299:R774-85. 2010
    ..RhoOGF clathrin-mediated endocytosis was unrelated to endosomal or Golgi pathways. Taken together, these results suggest that OGF enters cells by active transport in a saturable manner that requires clathrin-mediated endocytosis...
  40. ncbi request reprint Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Cornea 24:614-9. 2005
    ..This study was designed to determine at the molecular level whether interactions between the opioid growth factor (OGF) and OGF receptor (OGFr) play a role in regulating DNA synthesis in the homeostasis of the corneal epithelium...
  41. pmc The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer
    Diego M Avella
    Department of Surgery, Division of Surgical Oncology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 298:R459-66. 2010
    ..These data are the first to report that the OGF-OGFr system is a native biological regulator of cell proliferation in HCC. The findings may provide important insight in designing treatment strategies for this deadly disease...
  42. pmc The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, and Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Biol Cell 20:319-27. 2009
    ..Collectively, these results indicate that both p16(INK4a) and p21(WAF1/CIP1) are required for the OGF-OGFr axis to inhibit cell proliferation in normal cells...
  43. ncbi request reprint Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 124:1620-4. 2006
    ..To determine whether molecular manipulation of the opioid growth factor receptor (OGFr) alters corneal reepithelialization following central corneal abrasion in rats...
  44. ncbi request reprint The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cancer Res 67:10511-8. 2007
    ..These data are the first to reveal that the target of cell proliferative inhibitory action of OGF in human HNSCC is a cyclin-dependent kinase inhibitory pathway, and this may be useful in the diagnosis and treatment of HNSCC...
  45. ncbi request reprint Opioid growth factor modulation of corneal epithelium: uppers and downers
    Joseph W Sassani
    Department of Ophthalmology, Penn State s Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Curr Eye Res 26:249-62. 2003
    ..This paper presents a concise review of the role of the intrinsic opioid growth regulation system (IOGRS) in homeostasis and wound repair of the corneal epithelium...
  46. pmc Spontaneous episodic decreased tear secretion in rats is related to opioidergic signaling pathways
    Ian S Zagon
    Department of Neural and Behavioral Sciences, M S Hershey Medical Center, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
    Invest Ophthalmol Vis Sci 53:3234-40. 2012
    ..To elucidate the factors in tear production, this study examined the role of endogenous opioids and opioid receptors in spontaneous episodic reduced tear volume...
  47. doi request reprint Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer
    Renee N Donahue
    Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033 0850, USA
    Exp Biol Med (Maywood) 237:167-77. 2012
    ....
  48. ncbi request reprint Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Cornea 25:821-9. 2006
    ..To determine how ocular surface epithelium adjusts to an increase in cell replication after treatment with the opioid antagonist naltrexone (NTX)...
  49. pmc Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Milton S Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA
    Arch Ophthalmol 127:1468-73. 2009
    ..To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus...
  50. ncbi request reprint Opioid growth factor inhibits intimal hyperplasia in balloon-injured rat carotid artery
    Ian S Zagon
    Department of Neuroscience and Anatomy, H 109, The Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Vasc Surg 37:636-43. 2003
    ..This study was designed to determine the role of OGF in neointimal hyperplasia...
  51. ncbi request reprint The expression and function of the OGF-OGFr axis - a tonically active negative regulator of growth - in COS cells
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Centre, College of Medicine, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Neuropeptides 37:290-7. 2003
    ..These results indicate that the OGF-OGFr axis is present and functions in COS-7 cells, and in the absence of classical opioid receptors...
  52. doi request reprint Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Brain Res 1310:154-61. 2010
    ..These results indicate that an endogenous opioid, OGF, inhibits the onset and progression of EAE, and suggest that clinical studies on the use of OGF treatment for MS are merited...
  53. doi request reprint Astrocyte proliferation is regulated by the OGF-OGFr axis in vitro and in experimental autoimmune encephalomyelitis
    Anna M Campbell
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Brain Res Bull 90:43-51. 2013
    ....
  54. doi request reprint Dependence on nuclear localization signals of the opioid growth factor receptor in the regulation of cell proliferation
    Fan Cheng
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 234:532-41. 2009
    ..These results indicate that the regulation of cell proliferation by the OGF-OGFr axis is dependent on nucleocytoplasmic translocation and reliant on the integrity of two NLSs in OGFr to interact with transport receptors...
  55. ncbi request reprint Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Diabetes 51:3055-62. 2002
    ..These results indicate a delay in reepithelialization that is dependent on the duration of diabetes and that intervention of endogenous opioid-receptor interfacing with an opioid antagonist can facilitate the process of wound healing...
  56. ncbi request reprint Gene expression of OGFr in the developing and adult rat brain and cerebellum
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Milton S Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Brain Res Bull 63:57-63. 2004
    ....
  57. ncbi request reprint Opioids and migration, chemotaxis, invasion, and adhesion of human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States
    Neuropeptides 41:441-52. 2007
    ....
  58. ncbi request reprint Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea
    Ian S Zagon
    Department of Neuroscience and Anatomy, H109, The Milton S Hershey Medical Center, 500 University Drive, PA 17033, USA
    Brain Res 967:37-47. 2003
    ....
  59. ncbi request reprint Nucleocytoplasmic distribution of opioid growth factor and its receptor in tongue epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, Pennsylvania State University, College of Medicine, 500 University Drive, Rm C3727, Hershey, PA 17033, USA
    Anat Rec A Discov Mol Cell Evol Biol 282:24-37. 2005
    ..Moreover, the unique finding that OGFr was found in the cytoplasm and nucleus in NTX-treated specimens may suggest that NTX-OGFr complexes have the same pathway as OGF-OGFr...
  60. doi request reprint The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice
    Renee N Donahue
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Gynecol Oncol 122:382-8. 2011
    ..The present study investigated the repercussions of upregulating the OGF-OGFr axis by treatment with OGF or LDN on human ovarian tumorigenesis in vivo...
  61. ncbi request reprint Opioids and differentiation in human cancer cells
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, M S Hershey Medical Center, 500 University Drive, H109, Hershey, PA 17033, United States
    Neuropeptides 39:495-505. 2005
    ..The absence of effects on cancer cell differentiation by a variety of other opioids supports the previously reported lack of growth effects of these compounds...
  62. doi request reprint Expression of opioid growth factor (OGF)-OGF receptor (OGFr) axis in human nonmedullary thyroid cancer
    David Goldenberg
    Division of Otolaryngology, Department of Surgery, H091, College of Medicine, The Penn State University, Hershey, Pennsylvania 17033, USA
    Thyroid 18:1165-70. 2008
    ..In the present study we examined the presence and distribution of OGF and OGFr in nonmedullary thyroid cancer, including papillary, follicular, and anaplastic, as well as thyroid tissue from patients with nonmalignant disease...
  63. doi request reprint Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model
    Renee N Donahue
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 236:1036-50. 2011
    ..Given the parallels between short-term NTX in vitro and LDN in vivo, we now demonstrate at the molecular level that the OGF-OGFr axis is a common pathway that is essential for the regulation of cell proliferation by NTX...
  64. doi request reprint Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin
    Renee N Donahue
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 236:883-95. 2011
    ..These preclinical data may offer a non-toxic and efficacious pathway-related treatment that can benefit patients with ovarian cancer...
  65. ncbi request reprint Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States
    Brain Res Bull 72:18-24. 2007
    ..Thus, recurrent erosion following abrasion of the diabetic cornea, with preservation of the basal lamina, cannot be explained by structural abnormalities in the reformation of the epithelial adhesion complex...
  66. ncbi request reprint Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, Penn State College of Medicine, 500 University Dr, Room C3729, Hershey, PA 17033, USA
    Diabetes 55:1141-7. 2006
    ..These results indicate that intensive therapy with insulin, which establishes normoglycemia in rats with diabetes, prevents the delay in wound healing of ocular surface epithelium observed in poorly controlled diabetic animals...
  67. doi request reprint T lymphocyte proliferation is suppressed by the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, United States
    Immunobiology 216:579-90. 2011
    ..The results showing that the OGF-OGFr axis is an immunosuppressant, offers explanation for reports that autoimmune diseases can be modulated by this system...
  68. doi request reprint B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases
    Ian S Zagon
    Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA
    Immunobiology 216:173-83. 2011
    ..Thus, at least exogenous OGF and perhaps endogenous OGF by paracrine/endocrine sources, can be an immunosuppressant. Modulation of the OGF-OGFr axis may be a novel paradigm for the treatment of autoimmune diseases...
  69. ncbi request reprint Opioids and the apoptotic pathway in human cancer cells
    Ian S Zagon
    Department of Neuroscience and Anatomy, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, H 109, Hershey, PA 17033, USA
    Neuropeptides 37:79-88. 2003
    ....
  70. ncbi request reprint The biology of the opioid growth factor receptor (OGFr)
    Ian S Zagon
    Department of Neuroscience and Anatomy, H 109, The Milton S Hershey Medical Center, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Brain Res Brain Res Rev 38:351-76. 2002
    ..This report reviews the history of OGF-OGFr, examines emerging insights into the mechanisms of action of opioid peptide-receptor interfacing, and discusses the clinical significance of these observations...
  71. ncbi request reprint Treatment of advanced pancreatic cancer with opioid growth factor: phase I
    Jill P Smith
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Anticancer Drugs 15:203-9. 2004
    ..Further studies are needed to determine the efficacy of OGF alone or in combination with present modes of therapy for the treatment of pancreatic cancer...
  72. doi request reprint Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis: a new paradigm for the treatment of multiple sclerosis
    Ian S Zagon
    Department of Neural and Behavioral Sciences, H109, The Milton S Hershey Medical Center, 500 University Drive, Room C3729, Hershey, PA 17033, USA
    Exp Biol Med (Maywood) 234:1383-92. 2009
    ....
  73. ncbi request reprint Differential effects of vascular growth factors on arterial and venous angiogenesis
    John Blebea
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    J Vasc Surg 35:532-8. 2002
    ..The differential effects on veins and arteries, however, by any vascular growth factor, have not previously been investigated...