Research Topics
Genomes and Genes | Bernhard LuscherSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
GABAA receptor trafficking-mediated plasticity of inhibitory synapsesBernhard Luscher
Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Neuron 70:385-409. 2011..In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABA(A)R trafficking...
Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapsesBernhard Luscher
Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Pharmacol Ther 102:195-221. 2004....- The GABAergic deficit hypothesis of major depressive disorderB Luscher
Departments of Biology, Pennsylvania State University, University Park, PA 16802, USA
Mol Psychiatry 16:383-406. 2011..The GABAergic hypothesis of MDD suggests that alterations in GABAergic transmission represent fundamentally important aspects of the etiological sequelae of MDDs that are reversed by monoaminergic AD action... - Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptorsXu Yuan
Department of Biology, Penn State University, Life Sciences Building, University Park, PA 16802, USA
Mol Cell Neurosci 38:277-89. 2008..Our results indicate a specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A)Rs... - GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapsesCheng Fang
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurosci 26:12758-68. 2006..We conclude that GODZ-mediated palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses... - Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic culturesLunbin Deng
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurosci 27:10860-9. 2007..We conclude that the sequential formation of GABAergic and glutamatergic synapses in immature neurons is likely governed by a sequential expression of GABA(A) and glutamate receptors during neuronal development... - GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression statesJohn C Earnheart
Department of Biology and Penn State Neuroscience Institute, Penn State University, University Park, Pennsylvania 16802, USA
J Neurosci 27:3845-54. 2007.... - The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZCheryl A Keller
Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurosci 24:5881-91. 2004.... - GABAergic control of critical developmental periods for anxiety- and depression-related behavior in miceQiuying Shen
Department of Biology, Pennsylvania State University, University Park, PA, USA
PLoS ONE 7:e47441. 2012.... - γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targetingXia Wu
Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 287:27417-30. 2012..Therefore, the α subunits, together with the γ2 and δ subunits, play a critical role in governing synaptic versus extrasynaptic targeting of GABA(A)-Rs, possibly through differential interactions with gephyrin... - Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal culturesJin-Shun Qi
Department of Biology, 201 Life Sciences Building, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Physiol 577:579-90. 2006..Thus, in addition to synaptic alteration of GABAergic transmission, regulation of tonic inhibition may also play an important role during epileptogenesis... - gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depressionQiuying Shen
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, 16801, USA
Biol Psychiatry 68:512-20. 2010..Here we characterized gamma2-deficient mice with respect to hypothalamic-pituitary-adrenal (HPA) axis abnormalities and antidepressant drug responses... - The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapsesClaude Schweizer
Department of Biology, Penn State University, University Park, PA, USA
Mol Cell Neurosci 24:442-50. 2003.... - Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouseCatherine Pannell
Laboratory of Neuroendocrinology, The Babraham Institute, Babraham, Cambridge, UK
Neuroendocrinology 76:93-8. 2002....
Research Grants
- Analysis of the neural substrate of anxietyBernhard Luscher; Fiscal Year: 2009..Together these studies will greatly advance our undestanding of the mechanism underlying anxiety and depressive disorders. ..
- Clustering and Synaptic Targeting of GABA-A ReceptorsBernhard Luscher; Fiscal Year: 2006..abstract_text> ..
- Mapping the Neural Substrate of AnxietyBernhard Luscher; Fiscal Year: 2003..To test this hypothesis, Cre-induced inactivation of the y2 subunit gene, which is essential for benzodizepine action, will be used to map the brain regions mediating the anxiolytic effect of benzodiazepines. ..