Bernhard Luscher

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice
    Qiuying Shen
    Department of Biology, Pennsylvania State University, University Park, PA, USA
    PLoS ONE 7:e47441. 2012
  2. pmc GABAA receptor trafficking-mediated plasticity of inhibitory synapses
    Bernhard Luscher
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Neuron 70:385-409. 2011
  3. pmc The GABAergic deficit hypothesis of major depressive disorder
    B Luscher
    Departments of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Mol Psychiatry 16:383-406. 2011
  4. ncbi Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
    Bernhard Luscher
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Pharmacol Ther 102:195-221. 2004
  5. pmc Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors
    Xu Yuan
    Department of Biology, Penn State University, Life Sciences Building, University Park, PA 16802, USA
    Mol Cell Neurosci 38:277-89. 2008
  6. pmc Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin
    Melissa J Alldred
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 25:594-603. 2005
  7. pmc GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses
    Cheng Fang
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 26:12758-68. 2006
  8. ncbi Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures
    Lunbin Deng
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 27:10860-9. 2007
  9. pmc GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states
    John C Earnheart
    Department of Biology and Penn State Neuroscience Institute, Penn State University, University Park, Pennsylvania 16802, USA
    J Neurosci 27:3845-54. 2007
  10. pmc Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures
    Jin Shun Qi
    Department of Biology, 201 Life Sciences Building, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 577:579-90. 2006

Research Grants

  1. Analysis of the neural substrate of anxiety
    Bernhard Luscher; Fiscal Year: 2009
  2. Mapping the Neural Substrate of Anxiety
    Bernhard Luscher; Fiscal Year: 2003
  3. Clustering and Synaptic Targeting of GABA-A Receptors
    Bernhard Luscher; Fiscal Year: 2006

Collaborators

  • Jun Yao
  • Hanns Mohler
  • Isabelle M Mansuy
  • Jin Shun Qi
  • Zheng Wu
  • Takuji Iwasato
  • Marco Sassoè-Pognetto
  • Jean Marc Fritschy
  • Gong Chen
  • Qiuying Shen
  • John C Earnheart
  • Lunbin Deng
  • Xu Yuan
  • Cheng Fang
  • Cheryl A Keller
  • Xia Wu
  • Claude Schweizer
  • Melissa J Alldred
  • Catherine Pannell
  • Thomas Fuchs
  • Yao Guo
  • Gang Ning
  • Rashid Ali
  • Angel L De Blas
  • Nadia Sahir
  • Robert L Macdonald
  • Rachnanjali Lal
  • Anne Milasincic Andrews
  • Beth A Luellen
  • David Norris
  • David D Tran
  • Richard J Bram
  • Florence Crestani
  • Shigeyoshi Itohara
  • Ning Dong
  • Yuko Fukata
  • Masaki Fukata
  • Sue E Lingenfelter
  • Jonas Mulder-Rosi
  • Patrizia Panzanelli
  • Michelle L Martin
  • Melissa Alldred
  • Sylvia Balsiger
  • Horst Bluethmann
  • Allan E Herbison
  • Sharon X Simonian
  • Glenda E Gillies

Detail Information

Publications15

  1. pmc GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice
    Qiuying Shen
    Department of Biology, Pennsylvania State University, University Park, PA, USA
    PLoS ONE 7:e47441. 2012
    ....
  2. pmc GABAA receptor trafficking-mediated plasticity of inhibitory synapses
    Bernhard Luscher
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Neuron 70:385-409. 2011
    ..In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABA(A)R trafficking...
  3. pmc The GABAergic deficit hypothesis of major depressive disorder
    B Luscher
    Departments of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Mol Psychiatry 16:383-406. 2011
    ..The GABAergic hypothesis of MDD suggests that alterations in GABAergic transmission represent fundamentally important aspects of the etiological sequelae of MDDs that are reversed by monoaminergic AD action...
  4. ncbi Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
    Bernhard Luscher
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Pharmacol Ther 102:195-221. 2004
    ....
  5. pmc Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors
    Xu Yuan
    Department of Biology, Penn State University, Life Sciences Building, University Park, PA 16802, USA
    Mol Cell Neurosci 38:277-89. 2008
    ..Our results indicate a specific role of CAML in functional expression and endocytic recycling of postsynaptic GABA(A)Rs...
  6. pmc Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin
    Melissa J Alldred
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 25:594-603. 2005
    ..Our study points to a novel mechanism involved in targeting of GABA(A) receptors and gephyrin to inhibitory synapses...
  7. pmc GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses
    Cheng Fang
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 26:12758-68. 2006
    ..We conclude that GODZ-mediated palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses...
  8. ncbi Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures
    Lunbin Deng
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 27:10860-9. 2007
    ..We conclude that the sequential formation of GABAergic and glutamatergic synapses in immature neurons is likely governed by a sequential expression of GABA(A) and glutamate receptors during neuronal development...
  9. pmc GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states
    John C Earnheart
    Department of Biology and Penn State Neuroscience Institute, Penn State University, University Park, Pennsylvania 16802, USA
    J Neurosci 27:3845-54. 2007
    ....
  10. pmc Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures
    Jin Shun Qi
    Department of Biology, 201 Life Sciences Building, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Physiol 577:579-90. 2006
    ..Thus, in addition to synaptic alteration of GABAergic transmission, regulation of tonic inhibition may also play an important role during epileptogenesis...
  11. pmc The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ
    Cheryl A Keller
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 24:5881-91. 2004
    ....
  12. pmc gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression
    Qiuying Shen
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, 16801, USA
    Biol Psychiatry 68:512-20. 2010
    ..Here we characterized gamma2-deficient mice with respect to hypothalamic-pituitary-adrenal (HPA) axis abnormalities and antidepressant drug responses...
  13. pmc γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting
    Xia Wu
    Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 287:27417-30. 2012
    ..Therefore, the α subunits, together with the γ2 and δ subunits, play a critical role in governing synaptic versus extrasynaptic targeting of GABA(A)-Rs, possibly through differential interactions with gephyrin...
  14. ncbi The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses
    Claude Schweizer
    Department of Biology, Penn State University, University Park, PA, USA
    Mol Cell Neurosci 24:442-50. 2003
    ....
  15. ncbi Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse
    Catherine Pannell
    Laboratory of Neuroendocrinology, The Babraham Institute, Babraham, Cambridge, UK
    Neuroendocrinology 76:93-8. 2002
    ....

Research Grants14

  1. Analysis of the neural substrate of anxiety
    Bernhard Luscher; Fiscal Year: 2009
    ..Together these studies will greatly advance our undestanding of the mechanism underlying anxiety and depressive disorders. ..
  2. Mapping the Neural Substrate of Anxiety
    Bernhard Luscher; Fiscal Year: 2003
    ..To test this hypothesis, Cre-induced inactivation of the y2 subunit gene, which is essential for benzodizepine action, will be used to map the brain regions mediating the anxiolytic effect of benzodiazepines. ..
  3. Clustering and Synaptic Targeting of GABA-A Receptors
    Bernhard Luscher; Fiscal Year: 2006
    ..abstract_text> ..