Kenneth Lucas

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Cytokine production and cytolytic mechanism of CD4(+) cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures
    Qi Sun
    Bone Marrow Transplantation Program, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Blood 99:3302-9. 2002
  2. ncbi request reprint Interferon-gamma expressing EBV LMP2A-specific T cells for cellular immunotherapy
    Qi Sun
    Division of Hematology Oncology, Department of Pediatrics, Pennsylvania State College of Medicine, Pennsylvania State Milton S Hershey Medical Center, Pennsylvania State Children s Hospital, 500 University Drive, Hershey, PA 17033 0850, USA
    Cell Immunol 246:81-91. 2007
  3. doi request reprint The detection of CMV pp65 and IE1 in glioblastoma multiforme
    Kenneth G Lucas
    Department of Pediatrics, Penn State Hershey Children s Hospital, 500 University Drive, Room C7830, Hershey, PA 17033, USA
    J Neurooncol 103:231-8. 2011
  4. ncbi request reprint Epstein Barr virus induced lymphoma in a child with IPEX syndrome
    Kenneth G Lucas
    Division of Hematology Oncology, Stem Cell Transplantation Program, Department of Pediatrics, Penn State Children s Hospital, 500 University Drive, C7830, MC H085, Hershey, Pennsylvania 17033, USA
    Pediatr Blood Cancer 50:1056-7. 2008
  5. ncbi request reprint Adoptive immunotherapy with allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes for recurrent, EBV-positive Hodgkin disease
    Kenneth G Lucas
    Bone Marrow Transplantation Program, Departments of Pediatrics and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer 100:1892-901. 2004
  6. doi request reprint Matched unrelated umbilical cord blood transplantation for a patient with chemotherapy resistant Wilms tumor
    Kenneth G Lucas
    Stem Cell Transplantation Program, Division of Hematology Oncology, Department of Pediatrics, Penn State Children s Hospital, Hershey, Pennsylvania 17033, USA
    Pediatr Blood Cancer 55:763-5. 2010
  7. ncbi request reprint Immunotherapy with virus-specific cytotoxic T lymphocytes after organ transplantation
    Kenneth G Lucas
    Penn State Children s Hospital, Hershey, PA 17033, USA
    Pediatr Transplant 10:142-4. 2006
  8. doi request reprint Fusion of B lymphoblastoid and tumor cells expressing different antibiotic resistance genes facilitates selection of stable hybridomas
    Kenneth G Lucas
    Department of Pediatrics, Penn State Children s Hospital, Hershey, Pennsylvania 17033, USA
    Hybridoma (Larchmt) 27:401-5. 2008
  9. doi request reprint Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma
    Kenneth G Lucas
    Division of Pediatric Hematology Oncology, Stem Cell Transplantation Program, Penn State Children s Hospital, Hershey, Pennsylvania, USA
    Pediatr Blood Cancer 51:142-4. 2008
  10. ncbi request reprint Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma
    Qi Sun
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Br J Haematol 118:799-808. 2002

Research Grants

  1. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2009
  2. Immunotherapy for EBV Positive Hodgkin's Disease
    Kenneth Lucas; Fiscal Year: 2002
  3. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2006

Collaborators

  • Qi Sun
  • Lei Bao
  • Deepa Kolaseri Krishnadas
  • Melanie A Comito
  • Teresa Shapiro

Detail Information

Publications16

  1. ncbi request reprint Cytokine production and cytolytic mechanism of CD4(+) cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures
    Qi Sun
    Bone Marrow Transplantation Program, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Blood 99:3302-9. 2002
    ..These data suggested that CD4(+) T cells in the therapeutic B-lymphoblastoid cell lines-primed T-cell culture are diverse in producing T(H)1 and T(H)2 cytokines, and may exert specific cytotoxicity via exocytosis of granulysin...
  2. ncbi request reprint Interferon-gamma expressing EBV LMP2A-specific T cells for cellular immunotherapy
    Qi Sun
    Division of Hematology Oncology, Department of Pediatrics, Pennsylvania State College of Medicine, Pennsylvania State Milton S Hershey Medical Center, Pennsylvania State Children s Hospital, 500 University Drive, Hershey, PA 17033 0850, USA
    Cell Immunol 246:81-91. 2007
    ..LMP2A-specific T cells enriched based on IFNgamma-production may provide improved efficacy for the treatment of Epstein-Barr virus related malignancy...
  3. doi request reprint The detection of CMV pp65 and IE1 in glioblastoma multiforme
    Kenneth G Lucas
    Department of Pediatrics, Penn State Hershey Children s Hospital, 500 University Drive, Room C7830, Hershey, PA 17033, USA
    J Neurooncol 103:231-8. 2011
    ..These studies confirm the presence of CMV pp65 or IE1 on approximately half of GBM, with the possibility that CMV positive tumor cells can be recognized by CMV pp65/IE1 specific T cells...
  4. ncbi request reprint Epstein Barr virus induced lymphoma in a child with IPEX syndrome
    Kenneth G Lucas
    Division of Hematology Oncology, Stem Cell Transplantation Program, Department of Pediatrics, Penn State Children s Hospital, 500 University Drive, C7830, MC H085, Hershey, Pennsylvania 17033, USA
    Pediatr Blood Cancer 50:1056-7. 2008
    ..We report a patient with IPEX syndrome who was managed with rapamycin and subsequently developed EBV induced lymphoma...
  5. ncbi request reprint Adoptive immunotherapy with allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes for recurrent, EBV-positive Hodgkin disease
    Kenneth G Lucas
    Bone Marrow Transplantation Program, Departments of Pediatrics and Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer 100:1892-901. 2004
    ..The role of EBV CTL in other tumors for which this virus has been implicated in pathogenesis, such as EBV-positive Hodgkin disease (HD), has not been demonstrated clearly...
  6. doi request reprint Matched unrelated umbilical cord blood transplantation for a patient with chemotherapy resistant Wilms tumor
    Kenneth G Lucas
    Stem Cell Transplantation Program, Division of Hematology Oncology, Department of Pediatrics, Penn State Children s Hospital, Hershey, Pennsylvania 17033, USA
    Pediatr Blood Cancer 55:763-5. 2010
    ..It is possible that high-dose chemotherapy and stem cell transplantation can be curative in patients with tumors that are non-responsive to conventional chemotherapy...
  7. ncbi request reprint Immunotherapy with virus-specific cytotoxic T lymphocytes after organ transplantation
    Kenneth G Lucas
    Penn State Children s Hospital, Hershey, PA 17033, USA
    Pediatr Transplant 10:142-4. 2006
    ..Current challenges in this field include the determination of which patients are at highest risk, and the development of protocols that permit more rapid expansion of virus specific effector cells...
  8. doi request reprint Fusion of B lymphoblastoid and tumor cells expressing different antibiotic resistance genes facilitates selection of stable hybridomas
    Kenneth G Lucas
    Department of Pediatrics, Penn State Children s Hospital, Hershey, Pennsylvania 17033, USA
    Hybridoma (Larchmt) 27:401-5. 2008
    ..The resulting hybridoma cells expressed the neural antigen GD2 as well as MHC Class I, Class II, CD 80, and CD86. A similar strategy could be used to produce stable hybridomas for either vaccination or for CTL expansion...
  9. doi request reprint Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma
    Kenneth G Lucas
    Division of Pediatric Hematology Oncology, Stem Cell Transplantation Program, Penn State Children s Hospital, Hershey, Pennsylvania, USA
    Pediatr Blood Cancer 51:142-4. 2008
    ..This case highlights the possibility of treating patients with refractory metastatic ES with allogeneic SCT...
  10. ncbi request reprint Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma
    Qi Sun
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Br J Haematol 118:799-808. 2002
    ..In conclusion, adoptive immunotherapy with allogeneic EBV-specific CTL is safe and may have efficacy in patients with high-risk or refractory EBV-related tumours...
  11. doi request reprint Complete remission following decitabine/dendritic cell vaccine for relapsed neuroblastoma
    Deepa Kolaseri Krishnadas
    Division of Hematology Oncology, Department of Pediatrics, Stem Cell Transplantation Program, Penn State Children s Hospital, Hershey, Pennsylvania 17033, USA
    Pediatrics 131:e336-41. 2013
    ..This patient was noted to have an increase in MAGE-A3-specific T cells. This is the first report combining demethylating chemotherapy to enhance tumor antigen expression followed by a cancer antigen vaccine...
  12. doi request reprint MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells to facilitate cytotoxic T lymphocyte-mediated tumor cell killing
    Lei Bao
    Department of Pediatrics, Division of Hematology, Oncology, and Stem Cell Transplantation, Penn State Hershey Children s Hospital, 500 University Drive, C7830, Hershey, PA 17033, USA
    Cancer Immunol Immunother 60:1299-307. 2011
    ..These data provide a basis to consider the use of demethylating chemotherapy in neuroblastoma patients, in conjunction with immune therapies that facilitate the expansion of CT antigen-specific CTL...
  13. ncbi request reprint Rapid generation of CMV pp65-specific T cells for immunotherapy
    Lei Bao
    Department of Pediatrics, Division of Hematology Oncology, Penn State Children s Hospital, 500 University Drive, Hershey, PA 17033, USA
    J Immunother 30:557-61. 2007
    ..Using this simplified strategy for expanding CMV pp65 CTL, adoptive immunotherapy with pp65-specific CTL could be made available in a more timely manner for patients who have persistent or therapy refractory CMV infections...
  14. pmc Expansion of cytomegalovirus pp65 and IE-1 specific cytotoxic T lymphocytes for cytomegalovirus-specific immunotherapy following allogeneic stem cell transplantation
    Lei Bao
    Department of Pediatrics, Division of Hematology Oncology, Penn State Hershey Children s Hospital, Hershey, PA 17033, USA
    Biol Blood Marrow Transplant 14:1156-62. 2008
    ....
  15. ncbi request reprint Microchimerism detection by human leucocyte antigen-specific quantitative-polymerase chain reaction analysis in recipients of allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes
    Kenneth G Lucas
    Br J Haematol 129:443-4. 2005
  16. ncbi request reprint Immunotherapy for Epstein-Barr virus-associated tumors
    Melanie A Comito
    Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Penn State Children s Hospital, Hershey 17033, USA
    Leuk Lymphoma 45:1981-7. 2004
    ..We will review the pathogenesis of these disorders, current therapies, and future investigations aimed at targeting EBV antigen expression on these tumors...

Research Grants4

  1. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2009
    ....
  2. Immunotherapy for EBV Positive Hodgkin's Disease
    Kenneth Lucas; Fiscal Year: 2002
    ....
  3. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2006
    ....