- Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasitesGráinne H Long
Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
BMC Evol Biol 8:128. 2008..Here we studied the effects of immunopathology on infection-induced host mortality rate and lifetime transmission potential - key components of parasite fitness - using the rodent malaria model, Plasmodium chabaudi chabaudi...
- Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infectionGráinne H Long
Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
Int J Parasitol 38:1073-81. 2008..These results suggest that the effects of candidate malaria interventions on infectivity should be examined alongside effects on disease severity so that the epidemiological consequences of such interventions can be evaluated...
- Dynamic models of immune responses: what is the ideal level of detail?Juilee Thakar
Center for Infectious Disease Dynamics and Department of Physics, Pennsylvania State University, University Park, PA 16802, USA
Theor Biol Med Model 7:35. 2010..Dynamic models constructed to study the interactions between pathogens and hosts' immune responses have revealed key regulatory processes in the infection...