Xin Liu

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
    Xin Liu
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Blood 116:4192-201. 2010
  2. doi request reprint The spectrum of large granular lymphocyte leukemia and Felty's syndrome
    Xin Liu
    Department of Medicine, Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Curr Opin Hematol 18:254-9. 2011
  3. doi request reprint Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, PA 17033 0850, USA
    Leuk Lymphoma 54:1288-96. 2013
  4. pmc Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    Jun Yang
    Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    Blood 115:51-60. 2010
  5. doi request reprint Development and use of ceramide nanoliposomes in cancer
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA
    Methods Enzymol 508:89-108. 2012
  6. pmc Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
    Aijun Liao
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Blood 118:2793-800. 2011
  7. pmc Developing an in vitro model of T cell type of large granular lymphocyte leukemia
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States
    Leuk Res 37:1737-43. 2013
  8. pmc C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia
    Lindsay K Ryland
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, United States of America Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 8:e84648. 2013
  9. pmc HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:34683-93. 2012
  10. pmc Network model of survival signaling in large granular lymphocyte leukemia
    Ranran Zhang
    Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 105:16308-13. 2008

Collaborators

  • Jun Yang
  • Mark Kester
  • Ernst Schonbrunn
  • Dan Zhang
  • Yan Liu
  • Rongshi Li
  • Fanxue Meng
  • Jong K Yun
  • Ravi Kothapalli
  • Thomas P Loughran
  • Rebecca J Watters
  • Hong Gang Wang
  • Tong Ren
  • Mithun Vinod Shah
  • Ranran Zhang
  • Kathleen Broeg
  • Jason Liao
  • Todd E Fox
  • Lindsay K Ryland
  • Hua Cheng
  • Su Fern Tan
  • Nancy Ruth Jarbadan
  • Kenichiro Doi
  • Francis LeBlanc
  • Cesar Aliaga
  • Kendall Thomas Baab
  • Alden Dewey
  • Shen Shu Sung
  • Shantu Amin
  • Colin Campbell
  • Aijun Liao
  • Reka Albert
  • Jeremy K Haakenson
  • Megan Young
  • Sriram Shanmugavelandy
  • Katie Broeg
  • Myles C Cabot
  • Jacob E Choby
  • Ushma A Doshi
  • David J Feith
  • Sriram S Shanmugavelandy
  • Osman Khan
  • Wanda Manieri
  • Yoshinori Takahashi
  • Shao Cong Sun
  • Wen Dong
  • Hongwei Wu
  • Yong Qin
  • Gowdahalli Krishnegowda
  • Andy Awwad
  • Melissa A Tran
  • Yunsheng Yuan
  • Di Xiang
  • GARY DAUGHDRILL
  • Said Sebti
  • Chunwei Cheng
  • Kelly Loughran
  • Todd D Schell
  • Dhimant Desai
  • Leah Hirsch
  • Lindsay Ryland
  • Yongping Li
  • Jeremy S Haley
  • Thomas Loughran
  • Todd Fox
  • Rebecca Watters
  • Juilee Thakar
  • Andrew Rogers
  • Lucy Q Zhang
  • Norman H Lee
  • Ty Arrington
  • Rosalyn Irby
  • Susan B Nyland
  • Bryan Frank

Detail Information

Publications16

  1. pmc Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
    Xin Liu
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Blood 116:4192-201. 2010
    ..These data suggest that in vivo targeting of survivin through delivery of nanoliposomal C₆-ceramide may be a promising therapeutic approach for a fatal leukemia...
  2. doi request reprint The spectrum of large granular lymphocyte leukemia and Felty's syndrome
    Xin Liu
    Department of Medicine, Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Curr Opin Hematol 18:254-9. 2011
    ..This review paper seeks to discuss the underlying pathogenesis and therapeutic algorithm of RA, neutropenia and splenomegaly in the spectrum of LGL leukemia and Felty's syndrome...
  3. doi request reprint Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, PA 17033 0850, USA
    Leuk Lymphoma 54:1288-96. 2013
    ....
  4. pmc Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway
    Jun Yang
    Penn State Hershey Cancer Institute, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
    Blood 115:51-60. 2010
    ..These results suggest that targeting of PDGF-BB, a pivotal regulator for the long-term survival of leukemic LGLs, may be an important therapeutic strategy...
  5. doi request reprint Development and use of ceramide nanoliposomes in cancer
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA
    Methods Enzymol 508:89-108. 2012
    ..Pegylated nanoliposomes eliminate this issue and are able to enhance the intracellular delivery of ceramide to cancer cells...
  6. pmc Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia
    Aijun Liao
    Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Blood 118:2793-800. 2011
    ..These data demonstrate that therapeutic benefit of FTY720 may result from both altered sphingolipid metabolism as well as enhanced degradation of a key component of survival signaling...
  7. pmc Developing an in vitro model of T cell type of large granular lymphocyte leukemia
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States
    Leuk Res 37:1737-43. 2013
    ..This model should be useful for investigating molecular pathogenesis of the disease and for developing new therapeutics targeting T-LGL leukemia. ..
  8. pmc C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia
    Lindsay K Ryland
    Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, United States of America Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 8:e84648. 2013
    ..We conclude that selective inhibition of the glycolytic pathway in CLL cells with nanoliposomal C6-ceramide could potentially be an effective therapy for leukemia by targeting the Warburg effect. ..
  9. pmc HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:34683-93. 2012
    ..The present study demonstrated the oncogenic properties of Tax2 in human T cells and also implicated Tax2 in serving as a molecular tool to generate distinct T cell subtype lines...
  10. pmc Network model of survival signaling in large granular lymphocyte leukemia
    Ranran Zhang
    Penn State Hershey Cancer Institute and Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 105:16308-13. 2008
    ..The model will be useful in identifying potential therapeutic targets for T-LGL leukemia and generating long-term competent CTL necessary for tumor and cancer vaccine development...
  11. pmc Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets
    Francis LeBlanc
    Penn State Hershey Cancer Institute, Experimental Therapeutics, Room 4427, 500 University Drive, PO Box 850, Hershey, PA 17033 0850, USA
    Future Oncol 8:787-801. 2012
    ..The lack of a curative therapy for LGL leukemia means that new treatment options are needed. Insight into the various dysregulated signaling pathways in LGL leukemia may provide novel therapeutic treatment modalities...
  12. pmc Targeting sphingosine-1-phosphate receptors in cancer
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, 17033, USA
    Anticancer Agents Med Chem 11:810-7. 2011
    ..In particular, pharmacological agents targeting these S1PRs will be discussed and their potential will be examined...
  13. pmc Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
    Kenichiro Doi
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:10224-35. 2012
    ..Taken together, these results suggest that maritoclax represents a new class of Mcl-1 inhibitors, which antagonizes Mcl-1 and overcomes ABT-737 resistance by targeting Mcl-1 for degradation...
  14. pmc Why Do CD8+ T Cells become Indifferent to Tumors: A Dynamic Modeling Approach
    Colin Campbell
    Department of Physics, The Pennsylvania State University University Park, PA, USA
    Front Physiol 2:32. 2011
    ..Moreover, the model highlights differences in apoptosis rates that contribute to compromised CD8+ T cell responses and tumor progression, knowledge of which is essential for development of cancer immunotherapy...
  15. pmc T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias
    Rebecca J Watters
    Penn State Hershey Cancer Institute, Pennsylvania State College of Medicine, Hershey, PA 17033 0850, USA
    Leuk Lymphoma 52:2217-25. 2011
    ..In order to establish new therapeutics it is important to understand the current state of LGL leukemia both in the clinic and in basic research...
  16. pmc Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes
    Mithun Vinod Shah
    Penn State Hershey Cancer Institute, Milton S Hershey Medical College, Hershey, PA, USA
    Blood 112:770-81. 2008
    ..Collectively, these results show a role for sphingolipid-mediated signaling as a mechanism for long-term survival of CTLs. Therapeutic targeting of this pathway, such as use of FTY720, may have efficacy in LGL leukemia...