HERBERT LIPOWSKY

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi Shear-dependent adhesion of leukocytes and lectins to the endothelium and concurrent changes in thickness of the glycocalyx of post-capillary venules in the low-flow state
    Herbert H Lipowsky
    Department of Bioengineering, Penn State University, University Park, Pennsylvania, USA
    Microcirculation 20:149-57. 2013
  2. ncbi The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Bldg, University Park, PA 16802, USA
    Ann Biomed Eng 40:840-8. 2012
  3. ncbi Microvascular rheology and hemodynamics
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    Microcirculation 12:5-15. 2005
  4. ncbi Relative roles of doxycycline and cation chelation in endothelial glycan shedding and adhesion of leukocytes
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania16802, USA
    Am J Physiol Heart Circ Physiol 300:H415-22. 2011
  5. ncbi Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, 16802, USA
    Am J Physiol Heart Circ Physiol 301:H2235-45. 2011
  6. ncbi Effect of fibrinogen on leukocyte margination and adhesion in postcapillary venules
    Mark J Pearson
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Microcirculation 11:295-306. 2004
  7. ncbi Measurement of solute transport in the endothelial glycocalyx using indicator dilution techniques
    Lujia Gao
    Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Building, University Park, PA 16802, USA
    Ann Biomed Eng 37:1781-95. 2009
  8. ncbi Inhibition of glycan shedding and leukocyte-endothelial adhesion in postcapillary venules by suppression of matrixmetalloprotease activity with doxycycline
    Aaron W Mulivor
    Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, USA
    Microcirculation 16:657-66. 2009

Research Grants

  1. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2002
  2. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 1991
  3. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 1993
  4. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009

Collaborators

  • Aaron W Mulivor
  • Lujia Gao
  • Mark J Pearson

Detail Information

Publications8

  1. ncbi Shear-dependent adhesion of leukocytes and lectins to the endothelium and concurrent changes in thickness of the glycocalyx of post-capillary venules in the low-flow state
    Herbert H Lipowsky
    Department of Bioengineering, Penn State University, University Park, Pennsylvania, USA
    Microcirculation 20:149-57. 2013
    ..To elucidate shear-dependent effects of deformation of the endothelial glycocalyx on adhesion of circulating ligands in post-capillary venules, and delineate effect of MMPs...
  2. ncbi The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Bldg, University Park, PA 16802, USA
    Ann Biomed Eng 40:840-8. 2012
    ..Future therapeutic strategies for treating pathologies such as the low flow state and inflammation may benefit by further exploration of the mechanics of the glycocalyx in light of protease activation and shear-dependent effects...
  3. ncbi Microvascular rheology and hemodynamics
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    Microcirculation 12:5-15. 2005
    ..Thus, future studies aimed at the molecular rheology of the endothelial surface layer may provide new insights into determinants of the resistance to flow...
  4. ncbi Relative roles of doxycycline and cation chelation in endothelial glycan shedding and adhesion of leukocytes
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania16802, USA
    Am J Physiol Heart Circ Physiol 300:H415-22. 2011
    ..Thus, MMP inhibitors have both a proadhesion effect by reducing sheddase activity while exerting an antiadhesion effect by inhibiting glycocalyx shedding and subsequent exposure of adhesion molecules on the EC surface...
  5. ncbi Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation
    Herbert H Lipowsky
    Department of Bioengineering, The Pennsylvania State University, University Park, 16802, USA
    Am J Physiol Heart Circ Physiol 301:H2235-45. 2011
    ....
  6. ncbi Effect of fibrinogen on leukocyte margination and adhesion in postcapillary venules
    Mark J Pearson
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Microcirculation 11:295-306. 2004
    ..Thus, modest levels of RCA caused by increased Fb may greatly enhance margination and with an enhancement of adhesiveness synergistically promote firm WBC-EC adhesion in the low flow state...
  7. ncbi Measurement of solute transport in the endothelial glycocalyx using indicator dilution techniques
    Lujia Gao
    Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Building, University Park, PA 16802, USA
    Ann Biomed Eng 37:1781-95. 2009
    ..Thus the present method may provide a useful tool for elucidating structural and molecular alterations in the glycocalyx as occur with ischemia, metabolic and inflammatory events...
  8. ncbi Inhibition of glycan shedding and leukocyte-endothelial adhesion in postcapillary venules by suppression of matrixmetalloprotease activity with doxycycline
    Aaron W Mulivor
    Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, USA
    Microcirculation 16:657-66. 2009
    ....

Research Grants17

  1. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2002
    ....
  2. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 1991
    ....
  3. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 1993
    ....
  4. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..The results of these studies will provide insight into the role of hemodynamic interactions with the microvessel wall and aid development of therapeutic strategies to treat ischemia and inflammation. ..