Steven W Levison

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Ciliary neurotrophic factor stimulates nuclear hypertrophy and increases the GFAP content of cultured astrocytes
    S W Levison
    Department of Neuroscience and Anatomy, H109, Pennsylvania State University, College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Brain Res 803:189-93. 1998
  2. ncbi request reprint Cycling cells in the adult rat neocortex preferentially generate oligodendroglia
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State College of Medicine, Hershey 17033, USA
    J Neurosci Res 57:435-46. 1999
  3. ncbi request reprint Selective apoptosis within the rat subependymal zone: a plausible mechanism for determining which lineages develop from neural stem cells
    S W Levison
    Department of Neuroscience, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Dev Neurosci 22:106-15. 2000
  4. ncbi request reprint IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 32:328-37. 2000
  5. ncbi request reprint Hypoxia/ischemia depletes the rat perinatal subventricular zone of oligodendrocyte progenitors and neural stem cells
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 23:234-47. 2001
  6. ncbi request reprint Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
  7. ncbi request reprint Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia
    Steven W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 25:184-96. 2003
  8. ncbi request reprint Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable
    Michael J Romanko
    Department of Neural and Behavioral Sciences, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 24:814-25. 2004
  9. ncbi request reprint The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
  10. doi request reprint Ciliary neurotrophic factor and interleukin-6 differentially activate microglia
    J Kyle Krady
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 86:1538-47. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Ciliary neurotrophic factor stimulates nuclear hypertrophy and increases the GFAP content of cultured astrocytes
    S W Levison
    Department of Neuroscience and Anatomy, H109, Pennsylvania State University, College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Brain Res 803:189-93. 1998
    ..Together with our in vivo studies (Levison et al., 1996: Exp. Neurol. 141: 256), these data support the concept that CNTF is responsible for many of the progressive astroglial changes that appear after CNS injury and disease...
  2. ncbi request reprint Cycling cells in the adult rat neocortex preferentially generate oligodendroglia
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State College of Medicine, Hershey 17033, USA
    J Neurosci Res 57:435-46. 1999
    ..These slowly cycling cells likely express the NG2 proteoglycan because a subset of the clonal clusters contained NG2(+) cells and these NG2(+) cells accumulated with time...
  3. ncbi request reprint Selective apoptosis within the rat subependymal zone: a plausible mechanism for determining which lineages develop from neural stem cells
    S W Levison
    Department of Neuroscience, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Dev Neurosci 22:106-15. 2000
    ..Furthermore, they suggest that different mechanisms control neuronal versus glial cell numbers...
  4. ncbi request reprint IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 32:328-37. 2000
    ....
  5. ncbi request reprint Hypoxia/ischemia depletes the rat perinatal subventricular zone of oligodendrocyte progenitors and neural stem cells
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 23:234-47. 2001
    ..The resulting dysgenesis of the brain that occurs subsequent to perinatal hypoxic/ischemic injury may contribute to the cognitive and motor dysfunction that results from asphyxia of the newborn...
  6. ncbi request reprint Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
    ....
  7. ncbi request reprint Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia
    Steven W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 25:184-96. 2003
    ..Therefore, the microglia that reside in the SVZDL are immigrants from nonneural precursors...
  8. ncbi request reprint Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable
    Michael J Romanko
    Department of Neural and Behavioral Sciences, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 24:814-25. 2004
    ..The demise of these early progenitors may lead to the depletion of neuronal and late oligodendrocyte progenitors, contributing to cerebral dysgenesis after perinatal insults...
  9. ncbi request reprint The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age...
  10. doi request reprint Ciliary neurotrophic factor and interleukin-6 differentially activate microglia
    J Kyle Krady
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 86:1538-47. 2008
    ..We conclude that CNTF modifies microglial activation to support neuronal survival and that IL-6 enhances their capacity to do harm, as a result of different modes of intracellular signaling...
  11. ncbi request reprint Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    J Kyle Krady
    Dept of Neural and Behavioral Sciences, H109, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Diabetes 54:1559-65. 2005
    ....
  12. ncbi request reprint Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia
    Ryan J Felling
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Neurosci 26:4359-69. 2006
    ....
  13. ncbi request reprint Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury
    Anirban Basu
    Departments of Neural and Behavioral Sciences, Radiology and Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:17-29. 2005
    ..Additionally, these data incriminate the IL-1R1 as a master proinflammatory cytokine receptor...
  14. ncbi request reprint Astrocytic ceruloplasmin expression, which is induced by IL-1beta and by traumatic brain injury, increases in the absence of the IL-1 type 1 receptor
    Christopher J Kuhlow
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 44:76-84. 2003
    ..Furthermore, as the IL-1R1 has been proposed to be a target for achieving neuroprotection after injury, these data suggest that the protection afforded by ceruloplasmin will be retained even when the IL-1R1 is antagonized...
  15. ncbi request reprint Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production
    Phillip J Albrecht
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neurobiol Dis 13:89-101. 2003
    ..Altogether, these results strongly implicate CNTF as an important cytokine in demyelinating disease and as an upstream regulator of FGF-2 production in astrocytes during early remyelination...
  16. ncbi request reprint Transforming growth factor beta1 prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized
    Anirban Basu
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:109-20. 2002
    ..We conclude that the TGFbeta receptor signaling cascades intersect with IL-1, but they may not interact with IL-6 or TNFalpha signaling pathways that lead to activation...
  17. ncbi request reprint Roles of the mammalian subventricular zone in cell replacement after brain injury
    Michael J Romanko
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Prog Neurobiol 74:77-99. 2004
    ..By reviewing, comparing and contrasting the responses of the SVZs to different injuries, our goal is to provide a foundation from which current and future studies on the potential of the SVZs for cell replacement can be evaluated...
  18. ncbi request reprint Roles of the mammalian subventricular zone in brain development
    Christine Y Brazel
    Department of Neuroscience and Anatomy, H109 Pennsylvania State University College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Prog Neurobiol 69:49-69. 2003
    ..This review provides a critical analysis of the literature, from which current and future studies on the SVZ can be formulated and evaluated...
  19. ncbi request reprint Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia
    Michael J Romanko
    Molecular Medicine Graduate Program, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurochem 103:1121-31. 2007
    ..These studies reveal targets for neuroprotective agents to protect precursors from cell death towards the goal of restoring normal brain development after H/I...
  20. ncbi request reprint Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival
    Phillip J Albrecht
    Department of Neuroscience and Anatomy, Milton S Hershey College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Exp Neurol 173:46-62. 2002
    ..The significance of these findings is discussed by presenting a new model depicting the sequential activation of astrocytes by cytokines and growth factors in the context of CNS injury and repair...
  21. ncbi request reprint Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors
    J K Ness
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 23:203-8. 2001
    ..The delayed time course of apoptosis in pro-OLs supports the feasibility of interventions to improve clinical outcomes for newborns surviving birth asphyxia...
  22. ncbi request reprint Damage to the choroid plexus, ependyma and subependyma as a consequence of perinatal hypoxia/ischemia
    Raymond P Rothstein
    Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Dev Neurosci 24:426-36. 2002
    ..As the medial aspect of the SVZ contains neural stem cells, we predict that neural stem cells will be especially resistant to perinatal H/I brain damage...
  23. ncbi request reprint Differential expression of protein tyrosine kinase genes during microglial activation
    J Kyle Krady
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:11-24. 2002
    ..Because reactive microglia can exacerbate the severity of neurological diseases, the identification of specific kinases that participate in microglial activation represents an important advance toward the development of new therapeutics...
  24. ncbi request reprint Acute exposure to CNTF in vivo induces multiple components of reactive gliosis
    S W Levison
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Exp Neurol 141:256-68. 1996
    ..These data are consistent with a model whereby CNTF (which is synthesized by astrocytes) would be released when the integrity of the astrocyte membrane is compromised, whereupon it would elicit an inflammatory response...
  25. ncbi request reprint The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury
    Anirban Basu
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Neurosci 22:6071-82. 2002
    ....
  26. ncbi request reprint Enhanced neurogenesis following stroke
    Ryan J Felling
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 73:277-83. 2003
    ..Based on these encouraging results, we may eventually be able to manipulate these precursors to improve recovery of function in individuals afflicted by this devastating injury...
  27. ncbi request reprint The FLT3 tyrosine kinase receptor inhibits neural stem/progenitor cell proliferation and collaborates with NGF to promote neuronal survival
    C Y Brazel
    Department of Neuroscience and Anatomy, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Cell Neurosci 18:381-93. 2001
    ..We conclude that FL serves as an adjunct trophic factor in the nervous system, which differs from its role in the hematopoietic system...
  28. ncbi request reprint Diabetic retinopathy: more than meets the eye
    Thomas W Gardner
    Department of Ophthalmology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Surv Ophthalmol 47:S253-62. 2002
    ..Together, these new observations provide a broader clinical and research perspective on diabetic retinal vascular dysfunction than previously considered, and provide new avenues for improved treatments to prevent loss of vision...
  29. ncbi request reprint Pro-regenerative properties of cytokine-activated astrocytes
    Christina M Liberto
    Department of Neural and Behavioral Sciences, Pennsylvania State University, Hershey, PA 17033, USA
    J Neurochem 89:1092-100. 2004
    ..Accordingly, a re-assessment of cytokine-activated astrocytes is necessary. Here, we review studies that promote the thesis that cytokines elicit potent neuroprotective and regenerative responses from astrocytes...
  30. ncbi request reprint Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage
    Teresa L Wood
    Department of Neurology and Neuroscience, New Jersey Medical School, University of Medicine and Dentistry New Jersey, Newark, NJ 07103, USA
    Dev Neurosci 29:302-10. 2007
    ..These results suggest that delayed administration of IGF-1 will rescue OPs in the immature white matter and promote myelination following hypoxia-ischemia...
  31. ncbi request reprint Sustained neocortical neurogenesis after neonatal hypoxic/ischemic injury
    Zhengang Yang
    Department of Neurology and Neurosciences, UMDNJ New Jersey Medical School, New Jersey Institute of Technology, Newark, NJ 07103, USA
    Ann Neurol 61:199-208. 2007
    ..Here we tested the hypothesis that the subventricular zone of the immature brain regenerates neocortical neurons, and that this response is sustained...
  32. ncbi request reprint CNTF-activated astrocytes release a soluble trophic activity for oligodendrocyte progenitors
    Phillip J Albrecht
    Center for Neuropharmacolgy and Neuroscience, Albany Medical Center, Albany, NY 12208, USA
    Neurochem Res 32:263-71. 2007
    ..Cumulatively, these results confirm previous data indicating that astrocytes release potent mitogens for oligodendroglia, and demonstrate that CNTF stimulates astrocytes to release an OPC survival-promoting activity...
  33. ncbi request reprint Astrocytes and developmental white matter disorders
    Ellora Sen
    National Brain Research Centre, Manesar, Gurgaon 122050, Haryana, India
    Ment Retard Dev Disabil Res Rev 12:97-104. 2006
    ....
  34. pmc Gray matter oligodendrocyte progenitors and neurons die caspase-3 mediated deaths subsequent to mild perinatal hypoxic/ischemic insults
    Raymond P Rothstein
    Department of Neurology and Neuroscience, Laboratory for Regenerative Neurobiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Dev Neurosci 27:149-59. 2005
    ....
  35. pmc Perinatal hypoxia/ischemia damages and depletes progenitors from the mouse subventricular zone
    Christine Y Brazel
    Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA
    Dev Neurosci 26:266-74. 2004
    ..The demise of these early progenitors likely leads to depletion of neuronal and late oligodendrocyte progenitors, contributing to cerebral dysgenesis...
  36. ncbi request reprint Perinatal hypoxic/ischemic brain injury induces persistent production of striatal neurons from subventricular zone progenitors
    Zhengang Yang
    Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, PR China
    Dev Neurosci 29:331-40. 2007
    ..Altogether, these observations indicate the neonatal brain initiates a prolonged regenerative response from the precursors of the subventricular zone (SVZ) that results in persistent production of new striatal neurons...
  37. pmc 17beta-estradiol protects the neonatal brain from hypoxia-ischemia
    Joseph Nunez
    Department of Psychology, Michigan State University, 138 Giltner Hall, East Lansing, MI 48824, USA
    Exp Neurol 208:269-76. 2007
    ..We conclude that 17beta-estradiol acts as a potent neuroprotective agent against hypoxia-ischemia induced damage to the developing brain, and that pretreating infants at risk for hypoxic-ischemic injury may be advisable...
  38. ncbi request reprint Interleukin-1: a master regulator of neuroinflammation
    Anirban Basu
    National Brain Research Center, Manesar, Gurgaon, India
    J Neurosci Res 78:151-6. 2004
    ..e., neuroinflammation). The IL-1 system thus provides an attractive target for therapeutic intervention to ameliorate the destructive consequences of neuroinflammation...
  39. ncbi request reprint Divergent glial fibrillary acidic protein and its mRNA in the activated supraoptic nucleus
    B E Lally
    Department of Neurobiology and Anatomy, West Virginia University, School of Medicine, P O Box 9128, Morgantown, WV 26506 8159, USA
    Neurosci Lett 380:295-9. 2005
    ..These data indicate a divergence in GFAP mRNA and protein expression in the SON...
  40. pmc Neonatal hypoxic/ischemic brain injury induces production of calretinin-expressing interneurons in the striatum
    Zhengang Yang
    Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, People s Republic of China
    J Comp Neurol 511:19-33. 2008
    ..Our studies indicate that, although the postnatal SVZ has the capacity to produce a range of neurons, only a subset of this repertoire is manifested in the brain after injury...