RICHARD LEGRO

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Introduction: choosing the main outcome of an infertility trial is harder than you think
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People s Republic of China Electronic address
    Fertil Steril 101:1201-2. 2014
  2. ncbi request reprint The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania Electronic address
    Fertil Steril 101:258-269.e8. 2014
  3. doi request reprint Introduction: germline stem cell therapy in humans: two are not enough
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 101:1-2. 2014
  4. doi request reprint Introduction: Back to the future: origins of polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 100:1. 2013
  5. pmc Obesity and PCOS: implications for diagnosis and treatment
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Semin Reprod Med 30:496-506. 2012
  6. pmc Effects of gastric bypass surgery on female reproductive function
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 97:4540-8. 2012
  7. doi request reprint Disclosure of duplicative studies: damned if you don't
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 98:1347-9. 2012
  8. doi request reprint Turner syndrome: new insights into an old disorder
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 98:773-4. 2012
  9. pmc Superovulation and multiple birth: in search of kryptonite
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 97:793-4. 2012
  10. pmc The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, PA, United States
    Contemp Clin Trials 33:470-81. 2012

Detail Information

Publications94

  1. ncbi request reprint Introduction: choosing the main outcome of an infertility trial is harder than you think
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People s Republic of China Electronic address
    Fertil Steril 101:1201-2. 2014
    ..These articles support more complete reporting of maternal, paternal, fetal, and infant outcomes from infertility trials to improve patient care and ultimately public health. ..
  2. ncbi request reprint The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania Electronic address
    Fertil Steril 101:258-269.e8. 2014
    ..To summarize baseline characteristics from a large multicenter infertility clinical trial...
  3. doi request reprint Introduction: germline stem cell therapy in humans: two are not enough
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 101:1-2. 2014
    ..Larger and more complex teams, beyond basic and clinical science expertise, will be necessary to achieve this goal. ..
  4. doi request reprint Introduction: Back to the future: origins of polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 100:1. 2013
    ....
  5. pmc Obesity and PCOS: implications for diagnosis and treatment
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Semin Reprod Med 30:496-506. 2012
    ..However, further studies are needed to identify the best treatments, and the role of lifestyle therapies in women of normal weight with PCOS is uncertain...
  6. pmc Effects of gastric bypass surgery on female reproductive function
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 97:4540-8. 2012
    ..Reproductive function may improve after bariatric surgery, although the mechanisms and time-related changes are unclear...
  7. doi request reprint Disclosure of duplicative studies: damned if you don't
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania Electronic address
    Fertil Steril 98:1347-9. 2012
    ..These practices result in publication bias. We have revised our instructions to authors to include disclosure of similar articles that are published, in press, or submitted to other journals to the editors upon submission...
  8. doi request reprint Turner syndrome: new insights into an old disorder
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 98:773-4. 2012
    ..But many perplexing ethical and clinical issues persist...
  9. pmc Superovulation and multiple birth: in search of kryptonite
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 97:793-4. 2012
    ..The contribution of superovulation and ovulation induction to the multiple pregnancy epidemic in the U.S. is substantial. Further understanding of the contributing factors and, most importantly, preventive strategies are needed...
  10. pmc The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, PA, United States
    Contemp Clin Trials 33:470-81. 2012
    ..5mg of letrozole a day (×5 days). The primary analysis will use an intent-to-treat approach to examine differences in the live birth rate in the two treatment arms...
  11. ncbi request reprint The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Fertil Steril 86:914-33. 2006
    ..To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS)...
  12. ncbi request reprint Long-term, low-dose flutamide does not cause hepatotoxicity in hyperandrogenic women
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Nat Clin Pract Endocrinol Metab 2:188-9. 2006
  13. pmc Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, College of Medicine, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 95:5305-13. 2010
    ..There is no standardized assay of testosterone in women. Liquid chromatography mass spectrometry (LC/MS) has been proposed as the preferable assay by an Endocrine Society Position Statement...
  14. ncbi request reprint Type 2 diabetes and polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 86:S16-7. 2006
    ..Additionally there is some evidence to suggest that polycystic ovaries and chronic anovulation per se are risk factors. Identifying glucose intolerance and treating it are important aspects of the care for women with PCOS...
  15. ncbi request reprint A twenty-first century research agenda for polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, M S Hershey Medical Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Best Pract Res Clin Endocrinol Metab 20:331-6. 2006
    ..Overall, this disorder is a prototype for the benefits of translational science and a transdisciplinary approach to understanding the pathophysiology and therapy for anovulatory infertility...
  16. ncbi request reprint Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study
    Richard S Legro
    Department of Obstetrics Gynecology, 500 University Drive, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:3236-42. 2005
    ..Our study supports that women with PCOS (especially with NGT) should be periodically rescreened for diabetes due to worsening glucose intolerance over time, but this interval may be over several years and not annually...
  17. ncbi request reprint Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, P O Box 850, 500 University Drive, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:2571-9. 2005
    ..These data support the hypothesis that polycystic ovaries are an abnormal finding. However, neither the morphology nor the volume of the ovaries is associated with distinctive metabolic or reproductive phenotypes in women with PCOS...
  18. ncbi request reprint A 27-year-old woman with a diagnosis of polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    JAMA 297:509-19. 2007
    ..Treatment options for Ms R, including those that may affect her weight gain, are reviewed and implications for future fertility are discussed...
  19. ncbi request reprint Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
    N Engl J Med 356:551-66. 2007
    ..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
  20. ncbi request reprint Pregnancy considerations in women with polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Clin Obstet Gynecol 50:295-304. 2007
    ..There are few data to support treatment during pregnancy with metformin in women with PCOS to prevent pregnancy loss or pregnancy complications...
  21. ncbi request reprint The effects of metformin and rosiglitazone, alone and in combination, on the ovary and endometrium in polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Am J Obstet Gynecol 196:402.e1-10; discussion 402.e10-1. 2007
    ..To examine the effects of metformin and rosiglitazone, alone and in combination, on endometrial histology and ovarian steroid production...
  22. pmc Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 93:792-800. 2008
    ..Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood...
  23. pmc Effects of continuous versus cyclical oral contraception: a randomized controlled trial
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 93:420-9. 2008
    ..Continuous oral contraception may better suppress the ovary and endometrium, lending itself to the treatment of other medical conditions...
  24. pmc Insulin resistance in women's health: why it matters and how to identify it
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, 500 University Drive, H103, Hershey, PA 17033, USA
    Curr Opin Obstet Gynecol 21:301-5. 2009
    ..To examine the significance of insulin resistance in women's health and review methods for diagnosing it...
  25. pmc Associations of birthweight and gestational age with reproductive and metabolic phenotypes in women with polycystic ovarian syndrome and their first-degree relatives
    Richard S Legro
    Department of Obstetrics and Gynecology, Penn State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 95:789-99. 2010
    ..S. population data, even corrected for gestational age, and has no substantive association with reproductive and metabolic abnormalities in women with PCOS, their female relatives, or their male relatives...
  26. pmc A variant in the fibrillin-3 gene is associated with TGF-β and inhibin B levels in women with polycystic ovary syndrome
    Nazia Raja-Khan
    Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 94:2916-9. 2010
    ....
  27. doi request reprint Barriers to conducting clinical research in reproductive medicine: United States of America
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 96:817-9. 2011
    ..A decrease in National Institute of Health funding and an increase regulations are significant barriers in conducting research in the United States of America...
  28. ncbi request reprint Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome?
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Hum Reprod 19:1697-704. 2004
    ..Future multicentre trials in women with PCOS should focus on primary clinical end-points...
  29. ncbi request reprint Oocyte donors as gynecologic teaching associates
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey 17033, USA
    Obstet Gynecol 93:147-50. 1999
    ..Oocyte donors were hypothesized as a useful potential pool of gynecologic teaching associates...
  30. ncbi request reprint Detection of insulin resistance and its treatment in adolescents with polycystic ovary syndrome
    Richard S Legro
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA 17003, USA
    J Pediatr Endocrinol Metab 15:1367-78. 2002
    ..The findings of diabetes prevention trials suggest that these interventions may be more efficacious than pharmacological therapy...
  31. ncbi request reprint Molecular progress in infertility: polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Fertil Steril 78:569-76. 2002
    ..To review the evidence that polycystic ovary syndrome is a genetic disease...
  32. ncbi request reprint Self-selected women with polycystic ovary syndrome are reproductively and metabolically abnormal and undertreated
    Richard S Legro
    M S Hershey Medical Center, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 78:51-7. 2002
    ..To determine whether self-selected women with polycystic ovary syndrome (PCOS) are abnormal compared with a control population...
  33. ncbi request reprint Polycystic ovary syndrome. Long term sequelae and management
    R S Legro
    Department of Obstetrics and Gynaecology, M S Hershey Medical Center Pennsylvania State, University College of Medicine, Hershey, PA, USA
    Minerva Ginecol 54:97-114. 2002
    ..Further indications for these agents such as the prevention of pregnancy loss or the conversion to type 2 diabetes still need to be investigated in properly designed studies...
  34. ncbi request reprint Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome
    Richard S Legro
    Division of Women s Health, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 87:2134-8. 2002
    ..Balding was not increased in the brothers of women with PCOS. We conclude that there is a biochemical reproductive endocrine phenotype in men in PCOS families...
  35. ncbi request reprint Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity
    Richard S Legro
    Division of Women s Health, Department of Medicine, Brigham and Women s Hospital, Boston Massachusetts 02115, USA
    J Clin Endocrinol Metab 87:2128-33. 2002
    ..Menstrual irregularity may be related to the magnitude of insulin sensitivity or insulin secretion or to other factors associated with obesity...
  36. ncbi request reprint Polycystic ovary syndrome and cardiovascular disease: a premature association?
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocr Rev 24:302-12. 2003
    ....
  37. ncbi request reprint Polycystic ovary syndrome: the new millenium
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    Mol Cell Endocrinol 184:87-93. 2001
    ..Improving insulin sensitivity has become established as a baseline treatment strategy in PCOS. There are, however, few randomized controlled trials of adequate power to provide an evidence based guide to treatment in PCOS...
  38. ncbi request reprint Is there a male phenotype in polycystic ovary syndrome families?
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, USA
    J Pediatr Endocrinol Metab 13:1307-9. 2000
    ..Identifying a male phenotype would increase the sample size for genetic analyses of the causative gene. It may also improve the phenotyping of female family members by identifying familial traits that are gender independent...
  39. ncbi request reprint The genetics of obesity. Lessons for polycystic ovary syndrome
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Ann N Y Acad Sci 900:193-202. 2000
    ..Isolation of PCOS and obesity genes may allow the development of targeted interventions that will lead to effective and safe treatment of both obesity and PCOS...
  40. ncbi request reprint Rapid maturation of the reproductive axis during perimenarche independent of body composition
    R S Legro
    Department of Obstetrics and Gynecology, College of Medicine and University Hospitals, Pennsylvania State University, Milton S Hershey Medical Center, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1021-5. 2000
    ..These events appear to develop independent of changes in body composition and diet, but may reflect the improved nutrition and socioeconomic status of the late 20th century...
  41. ncbi request reprint Alterations in low-density lipoprotein and high-density lipoprotein subclasses among Hispanic women with polycystic ovary syndrome: influence of insulin and genetic factors
    R S Legro
    Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles, USA
    Fertil Steril 72:990-5. 1999
    ..To examine the influence of hyperandrogenism on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclass levels as well as lipoprotein (a) levels in hyperandrogenic women compared with a control group...
  42. ncbi request reprint Polycystic ovary syndrome. Phenotype to genotype
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, USA
    Endocrinol Metab Clin North Am 28:379-96. 1999
    ..Linkage analysis should be performed between polymorphic markers spaced at regular genetic intervals, and these familial traits may identify critical regions for further investigation...
  43. ncbi request reprint Insulin resistance in polycystic ovary syndrome: treating a phenotype without a genotype
    R S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Mol Cell Endocrinol 145:103-10. 1998
    ..These initial results with anti-diabetic agents, though promising, need to be confirmed in larger, randomized studies...
  44. ncbi request reprint Urinary free cortisol increases in adolescent caucasian females during perimenarche
    Richard S Legro
    Department of Obstetrics and Gynecology, College of Medicine and University Hospitals, Penn State College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:215-9. 2003
    ..3 +/- 3.1 microg/mg per square meter per 24 h) over the age range 12-17 yr represented in this study. An increase in cortisol excretion may be part of normal reproductive maturation...
  45. ncbi request reprint Minimal response of circulating lipids in women with polycystic ovary syndrome to improvement in insulin sensitivity with troglitazone
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:5137-44. 2003
    ..Treatment with an insulin-sensitizing agent may have minimal impact on circulating lipids. Further surveillance and treatment of abnormal lipid levels may be necessary in these women...
  46. ncbi request reprint Diabetes prevalence and risk factors in polycystic ovary syndrome
    R S Legro
    Department of Obstetrics and Gynecology, Milton S Hershey Medical Center, Penn State College of Medicine, Hershey, Pennsylvania, USA
    Obstet Gynecol Clin North Am 28:99-109. 2001
    ..Further study is necessary to document conversion rates to worsening glucose tolerance over time, as well as the cardiovascular risk associated with glucose intolerance in PCOS...
  47. ncbi request reprint Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Obstet Gynecol Surv 59:141-54. 2004
    ..All obese women with PCOS should be screened for the presence of insulin resistance by looking for other stigmata of the insulin resistance syndrome such as hypertension, dyslipidemia, central obesity, and glucose intolerance...
  48. ncbi request reprint Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome
    Ricardo Azziz
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Fertil Steril 79:932-7. 2003
    ..To determine whether amelioration of insulin resistance in polycystic ovary syndrome (PCOS) with the insulin sensitizer troglitazone (TGZ) decreases circulating adrenal androgens (AAs), as reflected by DHEAS levels...
  49. ncbi request reprint Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:48-53. 2006
    ..Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis...
  50. ncbi request reprint Diagnostic criteria in polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Semin Reprod Med 21:267-75. 2003
    ..There are no simple clinically validated biochemical tests of insulin resistance. Further identification of specific causes, and elimination of the multiple phenocopies that make up PCOS, will ease its diagnosis...
  51. pmc Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome
    Susan Sam
    Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 103:7030-5. 2006
    ..Obese mothers have a very high prevalence of metabolic syndrome. These findings suggest that both the reproductive and metabolic abnormalities persist with age in PCOS...
  52. doi request reprint The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
    Ricardo Azziz
    Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Fertil Steril 91:456-88. 2009
    ..To review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research...
  53. ncbi request reprint Polycystic ovary syndrome in adolescents
    Sarah C Kent
    Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, 17003, USA
    Adolesc Med 13:73-88, vi. 2002
    ....
  54. ncbi request reprint The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
    Heather I Katcher
    The Huck Institutes of the Life Sciences, Department of Nutritional Sciences, Core Endocrine Laboratory, Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 87:79-90. 2008
    ..However, few clinical trials have tested whether incorporating whole grains into a hypocaloric diet increases weight loss and improves CVD risk factors...
  55. pmc Hyperandrogenism and hyperinsulinism in children of women with polycystic ovary syndrome: a controlled study
    Sarah C Kent
    Department of Obstetrics and Gynecology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Clin Endocrinol Metab 93:1662-9. 2008
    ..Hyperandrogenia and insulin resistance are heritable family traits, likely to cluster in children of polycystic ovary syndrome (PCOS) mothers...
  56. pmc Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome
    Heather I Katcher
    The Huck Institutes of the Life Sciences, Hershey, Pennsylvania, USA
    Fertil Steril 91:1175-82. 2009
    ..To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS)...
  57. pmc High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity
    Andrea D Coviello
    Division of Endocrinology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 94:4361-6. 2009
    ..Women with polycystic ovary syndrome (PCOS) have twice the risk for metabolic syndrome (MetS) compared to women from the general population. Mothers and sisters of affected women also have an increased prevalence of MetS...
  58. pmc Epinephrine is associated with both erectile dysfunction and lower urinary tract symptoms
    J C Trussell
    Division of Urology, Penn State Milton S Hershey Medical Center, 500 University Drive, P O Box 850, Hershey, PA 17033, USA
    Fertil Steril 93:837-42. 2010
    ..To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls...
  59. ncbi request reprint Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry H073, Penn State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 55:1076-82. 2006
    ..We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance...
  60. pmc PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women
    Chen Chen
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Mol Hum Reprod 15:459-69. 2009
    ..These findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las major determinant of androgen levels in women...
  61. ncbi request reprint Adolescent Caucasian mothers have reduced adult hip bone density
    Tom Lloyd
    Department of Health Evaluation Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Fertil Steril 77:136-40. 2002
    ..To determine the long-term effect of full term teen pregnancy on peak hip bone mineral density...
  62. ncbi request reprint Oral contraceptive use by teenage women does not affect body composition
    Tom Lloyd
    Department of Health Evaluation Sciences, Penn State College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania17033, USA
    Obstet Gynecol 100:235-9. 2002
    ..To assess the effect of oral contraceptive (OC) use during adolescence on body composition parameters and cardiovascular disease risk factors...
  63. ncbi request reprint Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination
    William C Dodson
    Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, Pennsylvania, USA
    Fertil Steril 86:642-6. 2006
    ..To evaluate the association between obesity and the outcome of superovulation and intrauterine insemination (IUI) in infertile ovulatory women...
  64. pmc Diminished paternity and gonadal function with increasing obesity in men
    Eric M Pauli
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Fertil Steril 90:346-51. 2008
    ..To examine the relationship of male obesity and reproductive function...
  65. ncbi request reprint Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: the Penn State Young Women's Health Study
    Moira A Petit
    Department of Health Evaluation Sciences, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Bone 35:750-9. 2004
    ..These data suggest that bone adapts its bending strength primarily to mechanical loading (represented by lean mass and sports exercise score) and that sex steroids are associated with bone geometric structure...
  66. pmc Predictors of pregnancy in women with polycystic ovary syndrome
    Mary E Rausch
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:3458-66. 2009
    ..Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric...
  67. ncbi request reprint Erectile dysfunction: does insulin resistance play a part?
    J C Trussell
    Division of Urology, Penn State Milton S Hershey Medical Center and Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Fertil Steril 88:771-8. 2007
    ..To review MEDLINE literature for correlations between insulin resistance and erectile dysfunction (ED)...
  68. ncbi request reprint A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome
    Kelly Stamets
    Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    Fertil Steril 81:630-7. 2004
    ..We performed this study as a pilot experiment to investigate the short term effects of two diets of varying composition on weight loss as the primary outcome in obese women with polycystic ovary syndrome (PCOS) seeking fertility...
  69. ncbi request reprint Variation in resistin gene promoter not associated with polycystic ovary syndrome
    Margrit Urbanek
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:214-7. 2003
    ..3 and PCOS. Instead, this association is most likely due to a gene or genetic element in this region that has not been identified...
  70. doi request reprint Does polycystic ovary syndrome increase the disparity in metabolic syndrome and cardiovascular-related health for African-American women?
    PONJOLA CONEY
    Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee, USA
    Semin Reprod Med 26:35-8. 2008
    ....
  71. ncbi request reprint Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome
    Jessica K Wickenheisser
    Department of Cellular and Molecular Physiology, Pennsylvania State Hershey College of Medicine, 500 University Drive, C4723, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:4858-65. 2005
    ..Recent experiments have suggested that several genes involved in retinoic acid synthesis may be differentially expressed in PCOS theca cells and may contribute to excessive theca-derived androgen production...
  72. ncbi request reprint Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:66-71. 2005
    ..Finally, the fasting glucose concentration was poorly associated with 2-h glucose concentrations among PCOS women with IGT, suggesting that the fasting glucose concentration is inadequate to predict the presence of IGT in PCOS...
  73. ncbi request reprint Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome
    Mark R Palmert
    Division of Endocrinology, Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 87:1017-23. 2002
    ..However, as DM may be preventable by lifestyle modifications, we would recommend that adolescents with PCOS undergo periodic screening for abnormal glucose tolerance using 2-h postchallenge plasma glucose levels...
  74. ncbi request reprint Absence of secretory endometrium after false-positive home urine luteinizing hormone testing
    Peter G McGovern
    Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Fertil Steril 82:1273-7. 2004
    ..To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing...
  75. pmc Family-based analysis of candidate genes for polycystic ovary syndrome
    Kathryn G Ewens
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 95:2306-15. 2010
    ..D19S884, a polymorphic marker in fibrillin 3 (FBN3), is one of the few association findings that has been replicated in independent sets of families...
  76. ncbi request reprint Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 19:379-90. 2005
    ..These findings implicate alterations in the MAPK pathway in the pathogenesis of excessive ovarian androgen production in PCOS...
  77. ncbi request reprint Valproate potentiates androgen biosynthesis in human ovarian theca cells
    Velen L Nelson-Degrave
    Department of Cellular and Molecular Physiology, Pennsylvania State Hershey College of Medicine, 500 University Drive, C4723, Hershey, PA 17033, USA
    Endocrinology 145:799-808. 2004
    ..These studies provide the first biochemical evidence to support a role for VPA in the genesis of polycystic ovary syndrome-like symptoms, and establish a direct link between VPA treatment and increased ovarian androgen biosynthesis...
  78. ncbi request reprint Histological dating of timed endometrial biopsy tissue is not related to fertility status
    Christos Coutifaris
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Fertil Steril 82:1264-72. 2004
    ..To assess the ability of histological dating to discriminate between women of fertile and infertile couples. The utility of histological dating of endometrium in the evaluation of infertile couples is uncertain...
  79. ncbi request reprint Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline
    Ricardo Azziz
    Cedars Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, California, USA
    J Clin Endocrinol Metab 91:4237-45. 2006
    ....
  80. ncbi request reprint Hysterectomy and loss of fertility: implications for women's mental health
    Phyllis C Leppert
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA
    J Psychosom Res 63:269-74. 2007
    ..The objective of this study was to assess the percentage of women scheduled for hysterectomy who would have liked to have had a child or more children and associated factors...
  81. pmc Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome
    Susan Sam
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Metabolism 57:84-9. 2008
    ..4 [1.9, 2.7] vs 2.0 [1.8, 2.2], P = .02) in brothers compared with control men. We conclude that brothers of women with PCOS have evidence for pancreatic beta-cell dysfunction and may be at increased risk for type 2 diabetes mellitus...
  82. pmc Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome
    Peter G McGovern
    Department of Obstetrics, Gynecology and Women s Health, UMDNJ New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 87:442-4. 2007
    ..Other than failure to demonstrate laboratory evidence of hyperandrogenemia, the most common reasons for subject exclusion were persistent oligospermia and tubal factor infertility...
  83. ncbi request reprint The role of genes and environment in the etiology of PCOS
    Evanthia Diamanti-Kandarakis
    Endocrine Section, First Department of Medicine, University of Athens Medical School, Athens, Greece
    Endocrine 30:19-26. 2006
    ..However, the responsible gene at chromosome 19p13.3 remains to be identified. To date, no gene has been identified that causes or contributes substantially to the development of a PCOS phenotype...
  84. ncbi request reprint Obesity and the role of gut and adipose hormones in female reproduction
    Gabriella G Gosman
    Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Reprod Update 12:585-601. 2006
    ....
  85. ncbi request reprint Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet
    Enrico Carmina
    Department of Clinical Medicine, University of Palermo, Italy
    Hum Reprod 18:2289-93. 2003
    ..The study aim was to determine differences in body mass in two populations of women (USA and Italy) with polycystic ovary syndrome (PCOS), and to assess the effect of diet on body mass and cardiovascular risk factors...
  86. ncbi request reprint Polycystic ovary syndrome
    Robert J Norman
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Lancet 370:685-97. 2007
    ..The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both...
  87. ncbi request reprint Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype
    Margrit Urbanek
    Division of Endocrinology, Metabolism, and Molecular Medicine, 303 East Chicago Avenue, Tarry 15 717, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:4191-8. 2007
    ..We previously mapped a PCOS susceptibility locus to chromosome 19p13.2 near the dinucleotide repeat marker D19S884...
  88. ncbi request reprint Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance
    Andrea D Coviello
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry Building 15 709, Chicago, IL 60611 3008, USA
    J Clin Endocrinol Metab 91:492-7. 2006
    ..Adult women with polycystic ovary syndrome (PCOS) have an increased prevalence of the metabolic syndrome (MBS). The prevalence of MBS is also increasing in adolescents...
  89. pmc A comparison of methods and results in recruiting white and black women into reproductive studies: the MMC-PSU cooperative center on reproduction experience
    Stephanie Sweet
    Department of Medical Education Meharry Medical College, Nashville, TN 37208, USA
    Contemp Clin Trials 29:478-81. 2008
    ....
  90. pmc Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial
    Peter G McGovern
    Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 90:1283-6. 2008
    ....
  91. ncbi request reprint Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial
    Evan R Myers
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, United States
    Contemp Clin Trials 26:271-80. 2005
    ..The PPCOS trial should definitively answer the question of the relative efficacy of metformin, clomiphene, and combination therapy in the treatment of infertile women with PCOS...
  92. pmc Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome
    Nicholas A Cataldo
    Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 93:3124-7. 2008
    ..It has been suggested that metformin in combination with clomiphene can restore ovulation to some clomiphene-resistant anovulators with polycystic ovary syndrome (PCOS)...
  93. ncbi request reprint Dyslipidemia and metabolic syndrome in the sisters of women with polycystic ovary syndrome
    Susan Sam
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry Building 15 709, Chicago, Illinois 60611 3008, USA
    J Clin Endocrinol Metab 90:4797-802. 2005
    ..Dyslipidemia is a feature of polycystic ovary syndrome (PCOS), but its pathogenesis remains controversial...
  94. pmc Metabolic phenotype in the brothers of women with polycystic ovary syndrome
    Susan Sam
    Division of Endocrinology, Metabolism and Molecular Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Diabetes Care 31:1237-41. 2008
    ..Hyperandrogenemia also appears to be the male reproductive phenotype. We performed this study to test the hypothesis that brothers of women with PCOS have metabolic defects similar to those of their proband sisters...

Research Grants38

  1. PHENOTYPING KINDRIDS OF FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 1999
    ..We propose to fully phenotype previously identified kindreds of familial PCOS for clinical, biometric and biochemical abnormalities. ..
  2. PHENOTYPE AND GENOTYPE IN FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2001
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. This study is also being performed at the Hershey Campus. ..
  3. GENOTYPING FAMILIES OF WOMEN WITH PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2001
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. ..
  4. ASSESSING SAFETY/EFFICACY OF TROGLITAZONE IN PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2001
    ..Premenopausal women with PCOS between the ages of 18-40 will be studied. ..
  5. PHENOTYPING KINDRIDS OF FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2001
    ..We propose to fully phenotype previously identified kindreds of familial PCOS for clinical, biometric and biochemical abnormalities. ..
  6. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2002
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  7. PHENOTYPE AND GENOTYPE IN FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2002
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. This study is also being performed at the Hershey Campus. ..
  8. GENOTYPING FAMILIES OF WOMEN WITH PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2002
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. ..
  9. ASSESSING SAFETY/EFFICACY OF TROGLITAZONE IN PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2002
    ..Premenopausal women with PCOS between the ages of 18-40 will be studied. ..
  10. PHENOTYPING KINDRIDS OF FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2002
    ..We propose to fully phenotype previously identified kindreds of familial PCOS for clinical, biometric and biochemical abnormalities. ..
  11. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2003
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  12. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    RICHARD LEGRO; Fiscal Year: 2004
    ..This study could have a major impact on infertility in PCOS women while avoiding the risks and costly burden of OHSS and multiple pregnancy. ..
  13. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  14. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  15. A Randomized Trial of Letrozole vs Clomiphene in Infertile Women with PCOS
    RICHARD LEGRO; Fiscal Year: 2007
    ....
  16. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    RICHARD LEGRO; Fiscal Year: 2009
    ..Our goal is to develop safe and effective treatments to improve the treatment of infertility in women with PCOS, but the findings can be generalized to all women with PCOS. ..
  17. EXERCISE ON INSULIN TOLERANCE IN WOMEN WITH PCOS
    RICHARD LEGRO; Fiscal Year: 2000
    ..The purpose of this study is to examine the effects of a low intensity exercise training on insulin action in women with PCOS. Insulin action will be determined using the minimal model FSIGT. ..
  18. PHENOTYPING KINDRIDS OF FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2000
    ..We propose to fully phenotype previously identified kindreds of familial PCOS for clinical, biometric and biochemical abnormalities. ..
  19. BONE DENSITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 1999
    ..Lumbar and femur bone density measurements will also be obtained. This same tests will be used to calculate total body lean mass and total body fat mass. ..
  20. EFFECTS OF 3 ORAL CONTRACEPTIVES ON VARIOUS METABOLIC PARAMETERS
    RICHARD LEGRO; Fiscal Year: 1999
    ..Descriptive statistics will be provided to assist in evaluation of the metabolic effects of the three regimens. ..
  21. GENOTYPING FAMILIES OF WOMEN WITH PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 1999
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. ..
  22. ASSESSING SAFETY/EFFICACY OF TROGLITAZONE IN PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 1999
    ..Premenopausal women with PCOS between the ages of 18-40 will be studied. ..
  23. PHENOTYPE AND GENOTYPE IN FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 1999
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. This study is also being performed at the Hershey Campus. ..
  24. PHENOTYPE AND GENOTYPE IN FAMILIAL POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2000
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. This study is also being performed at the Hershey Campus. ..
  25. GENOTYPING FAMILIES OF WOMEN WITH PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2000
    ..We will also attempt to determine whether a male, a premenarchal and/or a post-menopausal phenotype exists in familial PCOS. ..
  26. ASSESSING SAFETY/EFFICACY OF TROGLITAZONE IN PCOS--POLYCYSTIC OVARY SYNDROME
    RICHARD LEGRO; Fiscal Year: 2000
    ..Premenopausal women with PCOS between the ages of 18-40 will be studied. ..
  27. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2010
    ..Our goal is to develop safe and effective treatments to improve the treatment of infertility in women with PCOS, but the findings can be generalized to all women with PCOS. ..