Sang Y Lee

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells
    Fatima Ali-Rahmani
    Department of Neurosurgery, The Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Penn State M S Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 9:e88724. 2014
  2. doi request reprint HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A
    Sang Y Lee
    Department of Neurosurgery, The Pennsylvania State University College of Medicine, MS Hershey Medical Center, Hershey, PA 17033 0850, USA
    Int J Cancer 129:2104-14. 2011
  3. doi request reprint Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues
    Eric C Hall
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Neurobiol Aging 32:1409-19. 2011
  4. pmc Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1
    Ryan M Mitchell
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Neuroinflammation 6:6. 2009
  5. doi request reprint HFE polymorphisms affect cellular glutamate regulation
    Ryan M Mitchell
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, 500 University Drive H110, Hershey, PA 17033, USA
    Neurobiol Aging 32:1114-23. 2011
  6. pmc Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability
    Yiting Liu
    Department of Neurosurgery, Pennsylvania State University, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:13161-70. 2011
  7. doi request reprint Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D
    Eric C Hall
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Biochim Biophys Acta 1802:389-95. 2010
  8. doi request reprint H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients
    Xiaowei W Su
    George M Leader Family Laboratory, Department of Neurosurgery, The Pennsylvania State University College of Medicine, 500 University Drive H110, Hershey, Pennsylvania 17033 0850, USA
    Muscle Nerve 48:242-6. 2013
  9. ncbi request reprint Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE
    Sang Y Lee
    Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    FASEB J 21:564-76. 2007
  10. ncbi request reprint HFE mutations and Alzheimer's disease
    James R Connor
    Department of Neurosurgery, G M Leader Family Laboratory for Alzheimer s Disease Research, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Alzheimers Dis 10:267-76. 2006

Collaborators

Detail Information

Publications11

  1. doi request reprint C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells
    Fatima Ali-Rahmani
    Department of Neurosurgery, The Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Penn State M S Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 9:e88724. 2014
    ..These studies indicate that cancers presenting in carriers of the C282Y-HFE allele might be responsive to treatment designed to selectively reduce cholesterol content in their tumor cells. ..
  2. doi request reprint HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A
    Sang Y Lee
    Department of Neurosurgery, The Pennsylvania State University College of Medicine, MS Hershey Medical Center, Hershey, PA 17033 0850, USA
    Int J Cancer 129:2104-14. 2011
    ....
  3. doi request reprint Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues
    Eric C Hall
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Neurobiol Aging 32:1409-19. 2011
    ..These results suggest H63D HFE increases tau phosphorylation via GSK-3β activity and iron-mediated oxidative stress...
  4. pmc Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1
    Ryan M Mitchell
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Neuroinflammation 6:6. 2009
    ..We tested the hypothesis that the two most common HFE variants, H63D and C282Y, would affect cellular secretion of cytokines and trophic factors...
  5. doi request reprint HFE polymorphisms affect cellular glutamate regulation
    Ryan M Mitchell
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, 500 University Drive H110, Hershey, PA 17033, USA
    Neurobiol Aging 32:1114-23. 2011
    ..This study demonstrates HFE cellular effects that extend beyond iron regulation, and suggests that H63D HFE may promote glutamate toxicity...
  6. pmc Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability
    Yiting Liu
    Department of Neurosurgery, Pennsylvania State University, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:13161-70. 2011
    ..Overall, our studies indicate that the HFE H63D mutant protein is associated with prolonged ER stress and chronically increased neuronal vulnerability...
  7. doi request reprint Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D
    Eric C Hall
    George M Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Biochim Biophys Acta 1802:389-95. 2010
    ..Thus, we have shown another cellular mechanism that HFE polymorphisms influence; further supporting their role as neurodegenerative disease modifiers...
  8. doi request reprint H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients
    Xiaowei W Su
    George M Leader Family Laboratory, Department of Neurosurgery, The Pennsylvania State University College of Medicine, 500 University Drive H110, Hershey, Pennsylvania 17033 0850, USA
    Muscle Nerve 48:242-6. 2013
    ..Investigating the physiological alterations induced by H63D polymorphisms in ALS patients may elucidate mechanisms by which this genotype alters disease...
  9. ncbi request reprint Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE
    Sang Y Lee
    Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    FASEB J 21:564-76. 2007
    ..The results also raise multiple novel questions for future study about the function of the HFE protein...
  10. ncbi request reprint HFE mutations and Alzheimer's disease
    James R Connor
    Department of Neurosurgery, G M Leader Family Laboratory for Alzheimer s Disease Research, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Alzheimers Dis 10:267-76. 2006
    ..This review summarizes the data on HFE mutations in neurodegenerative disorders and what is known about HFE in the brain and the cell biology underlying the HFE mutation...
  11. ncbi request reprint Regulation of Hfe by stress factors in BV-2 cells
    Sang Y Lee
    Department of Neurosurgery, H110, G M Leader Family Laboratory for Alzheimer s Disease Research, M S Hershey Medical Center, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Neurobiol Aging 26:803-12. 2005
    ..These results are the first in a series of studies to understand how mutations in Hfe can be a risk factor for AD...