Charles Lang

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 30:1297-307. 2006
  2. pmc Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 298:E1283-94. 2010
  3. pmc Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice
    Susan M Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 7:e38910. 2012
  4. doi request reprint Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 305:E416-28. 2013
  5. pmc Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA
    Am J Physiol Regul Integr Comp Physiol 304:R887-98. 2013
  6. pmc Direct central nervous system effect of alcohol alters synthesis and degradation of skeletal muscle protein
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Alcohol Alcohol 48:138-45. 2013
  7. ncbi request reprint Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
    Charles H Lang
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Curr Opin Clin Nutr Metab Care 5:271-9. 2002
  8. pmc BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice
    Charles H Lang
    Department of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 299:R935-44. 2010
  9. pmc Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 140:932-8. 2010
  10. pmc Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue
    Qianning Jiao
    Cell and Molecular Physiology H166 Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Am J Physiol Endocrinol Metab 297:E1222-32. 2009

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 30:1297-307. 2006
    ..The goal of the present study was to identify signaling mechanisms responsible for the inhibitory effect of ethanol (EtOH) and Ind on protein synthesis...
  2. pmc Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 298:E1283-94. 2010
    ..These data support the idea that the LPS-induced reduction in mTOR activity is relatively more important in regulating skeletal muscle mass in response to nutrient stimulation than under basal conditions...
  3. pmc Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice
    Susan M Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 7:e38910. 2012
    ....
  4. doi request reprint Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 305:E416-28. 2013
    ..These data suggest that whereas α-HICA does not slow the loss of muscle produced by disuse, it does speed recovery at least in part by maintaining an increased rate of protein synthesis. ..
  5. pmc Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA
    Am J Physiol Regul Integr Comp Physiol 304:R887-98. 2013
    ....
  6. pmc Direct central nervous system effect of alcohol alters synthesis and degradation of skeletal muscle protein
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Alcohol Alcohol 48:138-45. 2013
    ..However, alcohol in the general circulation diffuses rapidly into the central nervous system (CNS). Therefore, this study determined whether localized elevation of alcohol within the CNS is capable of decreasing muscle protein synthesis...
  7. ncbi request reprint Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
    Charles H Lang
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Curr Opin Clin Nutr Metab Care 5:271-9. 2002
    ..This review focuses on recent developments pertaining to the importance of alterations in the growth hormone-insulin-like growth factor-I axis as a mechanism for the observed defects in muscle protein balance...
  8. pmc BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice
    Charles H Lang
    Department of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 299:R935-44. 2010
    ....
  9. pmc Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 140:932-8. 2010
    ..These data suggest that whereas the sustained elevation in plasma BCAA is not sufficient to ameliorate the catabolic effect of acute alcohol intoxication on muscle protein synthesis, it does improve the anabolic effect of IGF-I...
  10. pmc Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue
    Qianning Jiao
    Cell and Molecular Physiology H166 Penn State College of Medicine, Hershey, PA 17033 0850, USA
    Am J Physiol Endocrinol Metab 297:E1222-32. 2009
    ....
  11. ncbi request reprint Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism
    Charles H Lang
    Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology H166, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 28:1758-67. 2004
    ....
  12. pmc Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Nutr Metab (Lond) 6:4. 2009
    ..abstract:..
  13. pmc Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Med 12:291-9. 2006
    ..Our data demonstrate the sepsis-induced leucine resistance in skeletal muscle results from the cooperative interaction of both TNFalpha and glucocorticoids...
  14. ncbi request reprint Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology, H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey 17033, USA
    Am J Physiol Endocrinol Metab 287:E721-30. 2004
    ..Hence, sepsis produces a relatively specific Leu resistance in skeletal muscle that impairs the ability of this amino acid to stimulate translation initiation and protein synthesis...
  15. doi request reprint Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation
    Charles H Lang
    Departments of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA
    J Trauma 64:477-86. 2008
    ....
  16. ncbi request reprint Leucine acutely reverses burn-induced alterations in translation initiation in heart
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 22:326-32. 2004
    ..These data suggest that oral administration of leucine can acutely reverse multiple defects in cardiac translation initiation produced by thermal injury...
  17. ncbi request reprint Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 286:R740-50. 2004
    ....
  18. ncbi request reprint Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E1205-15. 2003
    ..Hence, ethanol produces a leucine resistance in skeletal muscle, as evidenced by the impaired phosphorylation of 4E-BP1, eIF4G, S6K1, and mTOR, that is independent of elevations in endogenous glucocorticoids...
  19. ncbi request reprint Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 144:3922-33. 2003
    ..Hence, elevations in circulating and tissue levels of IGFBP-1 may be an important mediator for the muscle catabolism observed in various stress conditions...
  20. ncbi request reprint Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Physiol 203:144-55. 2005
    ..Hence, LPS working via a glucocorticoid-independent mechanism produces a leucine resistance in skeletal muscle that might be expected to impair the ability of this amino acid to stimulate translation initiation and protein synthesis...
  21. ncbi request reprint TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 94:419-31. 2005
    ..Finally, TNFalpha, either directly or indirectly, appears to mediate the sepsis-induced defects in myocardial translation initiation...
  22. doi request reprint Acute alcohol intoxication increases REDD1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 32:796-805. 2008
    ..In this regard, mTOR activity is impaired after over expression of the regulatory protein REDD1. Hence, the present study assessed the ability of REDD1 as a potential mediator of the EtOH-induced decrease in muscle protein synthesis...
  23. ncbi request reprint TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E336-47. 2002
    ....
  24. ncbi request reprint Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 282:R207-15. 2002
    ..TNFBP failed to completely ameliorate any of the burn-induced changes in the IGF system. These results demonstrate that glucocorticoids, but not TNF, mediate many but not all of the burn-induced changes in the IGF system...
  25. ncbi request reprint Role of central IL-1 in regulating peripheral IGF-I during endotoxemia and sepsis
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey 17033, USA
    Am J Physiol 274:R956-62. 1998
    ....
  26. ncbi request reprint Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 292:R328-36. 2007
    ..In summary, the acute muscle wasting accompanying thermal injury is associated with a glucocorticoid-independent increase in the expression of several Ub E3 ligases that can be downregulated by IGF-I...
  27. ncbi request reprint Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 56:49-57. 2007
    ..Hence, the decreased constitutive protein synthesis observed in fast-twitch skeletal muscle in response to peritonitis is mediated by a TNF-dependent mechanism affecting mTOR regulation of translation initiation...
  28. ncbi request reprint Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle
    Charles H Lang
    Dept of Cellular Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Am J Physiol Endocrinol Metab 291:E666-74. 2006
    ..Moreover, hyperlipidemia impairs IGF-I action but does not produce leucine resistance in skeletal muscle...
  29. ncbi request reprint Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R963-72. 2006
    ..Finally, IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions...
  30. ncbi request reprint Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E
    C H Lang
    Department of Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E805-14. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in liver by altering eIF2B activity as well as eIF4F function via changes in eIF4E availability...
  31. ncbi request reprint IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 286:E916-26. 2004
    ..The data support the role of IGF-I as a mediator of chronic alcohol myopathy in rats...
  32. ncbi request reprint Acute response of IGF-I and IGF binding proteins induced by thermal injury
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Am J Physiol Endocrinol Metab 278:E1087-96. 2000
    ..These results characterize burn-induced changes in various components of the IGF system in select tissues and thereby provide potential mechanisms for alterations in the circulating IGF system and for changes in tissue metabolism...
  33. ncbi request reprint Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 278:E1133-43. 2000
    ....
  34. ncbi request reprint Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E1497-506. 2007
    ....
  35. ncbi request reprint Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Pediatr Nephrol 20:306-12. 2005
    ..Collectively, these changes act to limit IGF-I availability in muscle, which disturbs protein balance and results in the loss of protein stores in catabolic and inflammatory conditions...
  36. ncbi request reprint Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    Growth Horm IGF Res 11:250-60. 2001
    ....
  37. ncbi request reprint Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 37:2180-95. 2005
    ..Overall, the biochemical mechanisms contributing to the pathogenesis of loss of skeletal and cardiac muscle are reviewed...
  38. ncbi request reprint Regulation of muscle protein synthesis during sepsis and inflammation
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 293:E453-9. 2007
    ....
  39. ncbi request reprint Alcohol myopathy: impairment of protein synthesis and translation initiation
    C H Lang
    Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 33:457-73. 2001
    ..However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation...
  40. ncbi request reprint Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 279:E1029-38. 2000
    ....
  41. ncbi request reprint Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Alcohol Clin Exp Res 24:322-31. 2000
    ..Acute alcohol intoxication in rats decreases protein synthesis in skeletal muscle and, to a lesser extent, in liver. The purpose of the present study was to examine potential mechanisms for the inhibitory effect of acute ethanol exposure...
  42. ncbi request reprint Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
    C H Lang
    Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E268-76. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in muscle by altering multiple regulatory sites, including eIF2B activity and eIF4E availability...
  43. ncbi request reprint Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise
    M J Fedele
    Noll Physiological Research Center, Pennsylvania State University, University Park, PA 16802, USA
    Am J Physiol Endocrinol Metab 280:E877-85. 2001
    ..01), but not nondiabetic, rats. These results suggest that IGF-I is compensatory for insulin in hypoinsulinemic rats by facilitating an anabolic response after acute resistance exercise...
  44. doi request reprint Regulation of muscle growth by pathogen-associated molecules
    R A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Anim Sci 86:E84-93. 2008
    ..The interplay between inflammatory components and growth factor signaling clearly places muscle at the interface between growth and immunity...
  45. ncbi request reprint Effects of chronic alcohol consumption on regulation of myocardial protein synthesis
    T C Vary
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Heart Circ Physiol 281:H1242-51. 2001
    ..These data suggest that a chronic alcohol-induced impairment in myocardial protein synthesis results in part from inhibition in peptide chain initiation secondary to marked changes in eIF4E availability and p70(S6K) phosphorylation...
  46. ncbi request reprint In vitro and In vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose
    K S Feldman
    Department of Chemistry, The Pennsylvania State University, University Park, 16802, PA, USA
    Bioorg Med Chem Lett 11:1813-5. 2001
    ..These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha...
  47. ncbi request reprint Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells
    L Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 25:1373-82. 2001
    ..We investigated whether ethanol (EtOH) and its major metabolites, acetaldehyde and acetate, can directly modulate protein balance under in vitro conditions...
  48. ncbi request reprint Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway
    R A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Endocrinology 141:3156-64. 2000
    ..Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the regulation of IGFBP-1 synthesis by IL-1beta...
  49. ncbi request reprint Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise
    P A Farrell
    Noll Physiological Research Center and Department of Kinesiology, University Park, Pennsylvania 16802, USA
    J Appl Physiol (1985) 87:1075-82. 1999
    ..These data demonstrate that, despite lower circulating insulin concentrations, diabetic rats can increase muscle mass in response to a physiological stimulus...
  50. ncbi request reprint Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells
    R A Frost
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA 17033, USA
    Minerva Endocrinol 28:53-73. 2003
    ..A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells...
  51. ncbi request reprint Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin
    C H Lang
    Department of Surgery, State University of New York at Stony Brook 11794 8191, USA
    Am J Physiol 273:R371-8. 1997
    ..These data indicate that the acute changes in the GH-IGF axis in humans in response to LPS are comparable with those observed in humans in other traumatic conditions and in animal models of endotoxemia and infection...
  52. ncbi request reprint Differential effects of insulin-like growth factor I (IGF-I) and IGF-binding protein-1 on protein metabolism in human skeletal muscle cells
    R A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Endocrinology 140:3962-70. 1999
    ..BP-1, acting independently of IGF-I, inhibits protein degradation. The IGF-independent response occurs via beta1 integrin binding and stimulation of a rapamycin-sensitive signal transduction pathway...
  53. ncbi request reprint Regulation of protein synthesis after acute resistance exercise in diabetic rats
    P A Farrell
    Noll Physiological Research Center and Department of Kinesiology, University Park 16802 and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 276:E721-7. 1999
    ..This preserved response may be due to a compensatory increase in muscle IGF-I content and a maintained ability to activate eIF2B...
  54. ncbi request reprint Alteration of somatotropic function by proinflammatory cytokines
    R A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
    J Anim Sci 82:E100-109. 2004
    ..Current work is focused on deciphering the mechanism by which muscle becomes GH resistant and the development of therapies to maintain muscle protein stores during infection...
  55. ncbi request reprint Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats
    G H Crist
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850
    FASEB J 12:1301-8. 1998
    ..This study suggests that insulin resistance in obese Zucker rats is tissue specific and that signaling from adenosine receptors may be a factor contributing to tissue-specific insulin resistance...
  56. ncbi request reprint AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells
    Brian J Krawiec
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E1555-67. 2007
    ....
  57. pmc Skeletal and cardiac myopathy in HIV-1 transgenic rats
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 295:E964-73. 2008
    ..Hence, HIV-1 Tg rats develop atrophy of cardiac and skeletal muscle, the latter of which results primarily from an increased protein degradation and may be related to the marked reduction in muscle insulin-like growth factor I...
  58. ncbi request reprint Molecular and cellular events in alcohol-induced muscle disease
    Joaquim Fernández-Solà
    Alcohol Unit, Hospital Clinic, University of Barcelona, Spain
    Alcohol Clin Exp Res 31:1953-62. 2007
    ..Finally, ethanol induces skeletal muscle apoptosis and increases both pro- and antiapoptotic regulatory mechanisms...
  59. ncbi request reprint Alcohol-induced disruption of endocrine signaling
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 31:1269-85. 2007
    ..Lang; (5) The role of reduced plasma estradiol and impaired estrogen signaling in alcohol-induced bone loss, by Martin J. Ronis; and (6) Short-term influence of alcohol on appetite-regulating hormones in man, by Jan Calissendorff...
  60. pmc Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting
    Patricia E Molina
    LSUHSC Department of Physiology and Alcohol Research Center, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 32:138-47. 2008
    ..We hypothesized that alcohol-induced loss in lean body mass is likely to exacerbate the AIDS wasting syndrome, particularly at the terminal stage of AIDS (SAIDS)...
  61. ncbi request reprint Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy
    Roberto Vargas
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 32:128-37. 2008
    ..Therefore, the present study addressed the hypothesis that EtOH accelerates the disuse atrophy and/or impairs the accretion of muscle protein during muscle recovery...
  62. ncbi request reprint Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Penn State University College of Medicine, Hershey, PA 17033, USA
    J Appl Physiol (1985) 103:378-87. 2007
    ..Activation of Akt stimulates muscle hypertrophy and antagonizes the loss of muscle protein. Here we review the many signals that funnel through Akt to alter muscle mass...
  63. ncbi request reprint Nuclear factor kappaB mediates the inhibitory effects of interleukin-1 on growth hormone-inducible gene expression
    Mark D Buzzelli
    Departments of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Trauma 64:1427-35; discussion 1435-6. 2008
    ..The current study examines the role of the nuclear factor kappaB (NFkappaB) pathway and suppressor of cytokine signaling (SOCS)-3 expression as potential mechanisms for IL-1-mediated GH resistance...
  64. pmc Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle
    Thomas C Vary
    Department of Cellular and Molecular Physiology H166, Penn State College Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1777-89. 2008
    ..Therefore, the loss of muscle mass/protein in response to chronic alcohol abuse appears to result primarily from a decrement in muscle protein synthesis, not an increase in degradation...
  65. doi request reprint CCK-induced pancreatic growth is not limited by mitogenic capacity in mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1148-57. 2008
    ..These results indicate that CCK-stimulated growth of the pancreas is not limited by acinar cell mitogenic capacity but is due, at least in part, to inhibition of promitogenic Akt signaling...
  66. ncbi request reprint Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection
    Patricia E Molina
    Department of Physiology, LSUHSC, New Orleans, Louisiana 70112, USA
    Alcohol Clin Exp Res 30:2065-78. 2006
    ..HIV infection has become a more chronic disease during which alcohol-induced metabolic alterations may become more prevalent and pronounced...
  67. ncbi request reprint Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis
    Thomas C Vary
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Shock 26:631-6. 2006
    ..Furthermore, the findings support a role of IL-1 as the proinflammatory mediator responsible for the reduced level of phosphorylated eIF4G...
  68. ncbi request reprint Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E501-12. 2007
    ..Thus, under in vivo conditions in mature adult rats, the sepsis-induced increase in muscle atrogin-1 and MuRF1 mRNA appears both glucocorticoid and TNF independent and is unresponsive to leucine...
  69. ncbi request reprint Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase
    Robert A Frost
    Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1153-64. 2003
    ..Yet, only SP-600125 and not MG-132 blocked LPS-induced IL-6 mRNA expression. This suggests that IL-6 gene expression is a downstream target of JNK in C2C12 myoblasts...
  70. ncbi request reprint Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
    ..Collectively these data indicate that skeletal muscle possesses many of the components of the innate immune system, including increases in both early- and late-phase cytokines and the presence of toll-like receptors...
  71. ncbi request reprint IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication
    Charles H Lang
    Prevention Research Center, 2150 Shattuck Avenue, Suite 900, Berkeley, CA 94704, USA
    Alcohol Clin Exp Res 27:485-94. 2003
    ..The purpose of the present study was to determine whether acute alcohol (EtOH) intoxication impairs the signal transduction pathway used to coordinate insulin-like growth factor (IGF)-I stimulation of myocardial protein synthesis...
  72. ncbi request reprint Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E63-72. 2003
    ..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation...
  73. ncbi request reprint Differential effects of alcohol consumption on eukaryotic elongation factors in heart, skeletal muscle, and liver
    Thomas C Vary
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Alcohol Clin Exp Res 26:1794-802. 2002
    ....
  74. ncbi request reprint Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle
    Vinayshree Kumar
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E917-28. 2002
    ..Hence, acute alcohol intoxication alters selected aspects of translational control under both basal and anabolic hormone-stimulated conditions in skeletal muscle in a glucocorticoid-independent manner...
  75. ncbi request reprint Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 283:R698-709. 2002
    ..Our data suggest that LPS stimulates cytokine expression not only in classical immune tissues but also in skeletal muscle...
  76. ncbi request reprint Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis
    Gladys Yumet
    Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E472-81. 2002
    ..control) in TNF-treated cells 60 min after GH treatment. Collectively, these results suggest that TNF mediates hepatic GH resistance during sepsis by inhibiting the duration of signaling via the janus kinase-2/STAT5 pathway...
  77. ncbi request reprint Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E1092-101. 2002
    ..In contrast, assembly of the mRNA cap-binding complex occurs independently of increases in insulin and, by itself, is insufficient to stimulate rates of protein synthesis in skeletal muscle after leucine administration...
  78. ncbi request reprint Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes 51:928-36. 2002
    ..The insulin-dependent mechanism is associated with increased phosphorylation of 4E-BP1 and S6K1. In contrast, the insulin-independent effect on protein synthesis is mediated by an unknown mechanism...
  79. ncbi request reprint Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 143:492-503. 2002
    ..In addition, C2C12 cells appear to be a good model system to examine GH regulation of Janus kinase/Stat signaling and the regulation of IGF-I mRNA...
  80. ncbi request reprint Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity
    Robert A Frost
    Department of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 286:E809-17. 2004
    ..Endotoxin and epinephrine synergize to increase IL-6 mRNA expression. Optimal IL-6 synthesis may require both stress kinase and histone deacetylase activity...
  81. ncbi request reprint Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Cell Physiol 287:C1482-92. 2004
    ..This decrease was associated with the disruption of the ERK1/2 and p38 MAPK pathways and a reduction in both the level of functional eIF4F complex and rpS6 phosphorylation...
  82. ncbi request reprint Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways
    Robert A Frost
    Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey Medical Center H166, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Cell Physiol 287:C1605-15. 2004
    ..Moreover, the JNK inhibitor prevented the LPS-induced increase in NO synthesis. These data indicate that LPS increases NOS2 mRNA expression in muscle via a TLR4-dependent mechanism...
  83. ncbi request reprint Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling
    Gladys Yumet
    Departments of Surgery, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    Crit Care Med 34:1420-7. 2006
    ..In this study we examine the effects of sepsis on GH-induced IGF-I expression and potential mechanisms for GH resistance...
  84. ncbi request reprint Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes
    Robert A Frost
    Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R773-84. 2006
    ..The data suggest that skeletal muscle and muscle cells recognize pathogen-associated molecules with specific TLRs to initiate an IL-6 transcriptional response...
  85. ncbi request reprint HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, PA 17033, USA
    AIDS Res Hum Retroviruses 21:854-62. 2005
    ..In conclusion, nelfinavir, nevirapine, and zidovudine treatments decreased protein synthesis in myocytes and this effect was correlated with a reduction in the phosphorylation level of proteins that regulate translation initiation...
  86. ncbi request reprint Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 29:1247-56. 2005
    ....
  87. ncbi request reprint Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis
    Brian J Krawiec
    Dept of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 289:E969-80. 2005
    ....
  88. ncbi request reprint IGF-I activates the eIF4F system in cardiac muscle in vivo
    Thomas C Vary
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Pennsylvania 17033, USA
    Mol Cell Biochem 272:209-20. 2005
    ..Furthermore, the results are consistent with a role for assembly of active eIF4G.eIF4E complex and activation of S6K1 in mediating the stimulation of mRNA translation initiation by IGF-I through a PKB/mTOR signaling pathway...
  89. ncbi request reprint Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 289:E382-90. 2005
    ..In conclusion, indinavir acutely impairs basal protein synthesis and translation initiation in skeletal muscle but, in contrast to muscle glucose uptake, does not impair insulin-stimulated signaling of protein synthetic pathways...
  90. ncbi request reprint Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Curr Opin Clin Nutr Metab Care 8:255-63. 2005
    ..A special emphasis is placed on recent studies that examine the interaction of insulin-like growth factor 1 and proinflammatory cytokines as positive and negative regulators of muscle mass...
  91. ncbi request reprint Diminished ERK 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis
    Thomas C Vary
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 22:548-54. 2004
    ....
  92. ncbi request reprint Capsaicin-sensitive nerves regulate the metabolic response to abdominal sepsis
    Patrick Bryant
    Department of Surgery, The Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Surg Res 112:152-61. 2003
    ..In this study, we investigate the role of SANs as mediators of protein catabolism and the insulin-like growth factor (IGF) axis during abdominal sepsis using capsaicin (Cap) to selectively destroy nociceptive sensory axons...
  93. ncbi request reprint In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-alpha production by dimeric gallotannin analogues
    Ken S Feldman
    Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA
    Bioorg Med Chem 10:47-55. 2002
    ....

Research Grants43

  1. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2002
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  2. REGULATION OF IGF SYSTEM AND MUSCLE WASTING BY ALCOHOL
    Charles Lang; Fiscal Year: 1999
    ....
  3. AntiretroviraI induced Defects in Muscle Protein Synthes
    Charles Lang; Fiscal Year: 2006
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  4. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2002
    ..abstract_text> ..
  5. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2004
    ..abstract_text> ..
  6. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  7. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2005
    ..abstract_text> ..
  8. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  9. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles Lang; Fiscal Year: 2009
    ..Our research will determine the mechanism for this muscle atrophy which will ultimately lead to development of novel therapeutic treatment and improve patient outcome. ..
  10. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2000
    ..abstract_text> ..
  11. Regulation of Nutrient Sensing and Muscle Wasting by Alcohol
    Charles Lang; Fiscal Year: 2007
    ..The proposed studies have a translational underpinning in that the data may lead to development of novel clinical interventions designed to reverse alcoholic myopathy during rehabilitation. ..
  12. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  13. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles Lang; Fiscal Year: 2007
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  14. AntiretroviraI induced Defects in Muscle Protein Synthes
    Charles Lang; Fiscal Year: 2009
    ..Such data are needed to both realize the full potential and avoid possible pitfalls of this drug class in long-term treatment of HIV infection. ..
  15. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles Lang; Fiscal Year: 2009
    ..Our research will determine the mechanism for this muscle atrophy which will ultimately lead to development of novel therapeutic treatment and improve patient outcome. ..
  16. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles Lang; Fiscal Year: 2009
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  17. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2003
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  18. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2006
    ..abstract_text> ..
  19. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2001
    ..abstract_text> ..
  20. REGULATION OF IGF SYSTEM AND MUSCLE WASTING BY ALCOHOL
    Charles Lang; Fiscal Year: 2000
    ....
  21. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 1999
    ..These experiments will be conducted on cultured L6 myotubes, and protein synthesis, breakdown and amino acid transport will be quantitated. ..
  22. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2001
    ..abstract_text> ..
  23. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2003
    ..abstract_text> ..
  24. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2004
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  25. REGULATION OF IGF SYSTEM AND MUSCLE WASTING BY ALCOHOL
    Charles Lang; Fiscal Year: 2001
    ....
  26. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles H Lang; Fiscal Year: 2010
    ..Our research will determine the mechanism for this muscle atrophy which will ultimately lead to development of novel therapeutic treatment and improve patient outcome. ..
  27. Regulation of Nutrient Sensing and Muscle Wasting by Alcohol
    Charles H Lang; Fiscal Year: 2010
    ..The proposed studies have a translational underpinning in that the data may lead to development of novel clinical interventions designed to reverse alcoholic myopathy during rehabilitation. ..
  28. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2001
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  29. Regulation of Nutrient Sensing and Muscle Wasting by Alcohol
    Charles Lang; Fiscal Year: 2009
    ..The proposed studies have a translational underpinning in that the data may lead to development of novel clinical interventions designed to reverse alcoholic myopathy during rehabilitation. ..
  30. CYTOKINE REGULATION OF IGF SYSTEM DURING INFECTION
    Charles Lang; Fiscal Year: 2007
    ..abstract_text> ..
  31. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..