Penny M Kris-Etherton

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies
    P M Kris-Etherton
    Nutrition Department, Pennsylvania State University, University Park 16802 6504, USA
    Am J Clin Nutr 65:1590S-1596S. 1997
  2. ncbi request reprint Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 40:1193-200. 2005
  3. pmc Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins
    Michael A Roussell
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, USA
    Am J Clin Nutr 95:9-16. 2012
  4. pmc Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial
    Ellen M Evans
    Department of Kinesiology, University of Georgia, 101A Ramsey 300 River Road, Athens, GA, 30602, USA
    Nutr Metab (Lond) 9:55. 2012
  5. pmc Trans fatty acid intakes and food sources in the U.S. population: NHANES 1999-2002
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 319 Chandlee Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 47:931-40. 2012
  6. pmc Relative fat oxidation is higher in children than adults
    John C Kostyak
    Department of Biology, University of Delaware, 305 Wolf Hall, Newark, Delaware 9716, USA
    Nutr J 6:19. 2007
  7. ncbi request reprint Dietary guidelines 2005--contributions of registered dietitians to the evolution and dissemination of the guidelines
    Penny M Kris-Etherton
    Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Rockville, MD, USA
    J Am Diet Assoc 105:1362-4. 2005
  8. doi request reprint Dietary reference intakes for DHA and EPA
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, 319 Chandlee Laboratory, University Park, PA 16802, USA
    Prostaglandins Leukot Essent Fatty Acids 81:99-104. 2009
  9. ncbi request reprint Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis
    P M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Nutr 24:511-38. 2004
  10. ncbi request reprint Milk products, dietary patterns and blood pressure management
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 110 Chandlee Laboratory, Penn State University, University Park, PA 16802, USA
    J Am Coll Nutr 28:103S-19S. 2009

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies
    P M Kris-Etherton
    Nutrition Department, Pennsylvania State University, University Park 16802 6504, USA
    Am J Clin Nutr 65:1590S-1596S. 1997
    ..Feeding periods must be of adequate duration for stabilization of endpoints. Attention to these study design issues is imperative for meaningful conclusions to be reached about the effects of individual fatty acids...
  2. ncbi request reprint Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 40:1193-200. 2005
    ..For stearic acid to become the primary replacement for TFA, it is essential that its physical properties and biological effects be well understood...
  3. pmc Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins
    Michael A Roussell
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, USA
    Am J Clin Nutr 95:9-16. 2012
    ..A Step I diet with lean beef compared with lean white meat both decrease LDL cholesterol. To our knowledge, no studies have evaluated a low-saturated fatty acid (SFA) (<7% calories) diet that contains lean beef...
  4. pmc Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial
    Ellen M Evans
    Department of Kinesiology, University of Georgia, 101A Ramsey 300 River Road, Athens, GA, 30602, USA
    Nutr Metab (Lond) 9:55. 2012
    ..ABSTRACT: Limited data on sex differences in body composition changes in response to higher protein diets (PRO) compared to higher carbohydrate diets (CARB) suggest that a PRO diet helps preserve lean mass (LM) in women more so than in men...
  5. pmc Trans fatty acid intakes and food sources in the U.S. population: NHANES 1999-2002
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 319 Chandlee Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Lipids 47:931-40. 2012
    ....
  6. pmc Relative fat oxidation is higher in children than adults
    John C Kostyak
    Department of Biology, University of Delaware, 305 Wolf Hall, Newark, Delaware 9716, USA
    Nutr J 6:19. 2007
    ..The dietary fat recommendations are higher for children 4 to 18 yrs (i.e., 25 to 35% of energy) compared with adults (i.e., 20 to 35% of energy). Despite this, many parents and children restrict dietary fat for health reasons...
  7. ncbi request reprint Dietary guidelines 2005--contributions of registered dietitians to the evolution and dissemination of the guidelines
    Penny M Kris-Etherton
    Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Rockville, MD, USA
    J Am Diet Assoc 105:1362-4. 2005
  8. doi request reprint Dietary reference intakes for DHA and EPA
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, 319 Chandlee Laboratory, University Park, PA 16802, USA
    Prostaglandins Leukot Essent Fatty Acids 81:99-104. 2009
    ..Because of the many health benefits of DHA and EPA, it is important and timely that the National Academies establish DRIs for the individual long-chain (20 carbons or greater) omega-3 fatty acids...
  9. ncbi request reprint Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis
    P M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Nutr 24:511-38. 2004
    ..The discovery of novel health effects of bioactive compounds will provide the scientific basis for future efforts to use biotechnology to modify/fortify foods and food components as a means to improve public health...
  10. ncbi request reprint Milk products, dietary patterns and blood pressure management
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 110 Chandlee Laboratory, Penn State University, University Park, PA 16802, USA
    J Am Coll Nutr 28:103S-19S. 2009
    ..A growing evidence base shows that dairy product consumption is involved in the regulation of BP. Consequently, inclusion of dairy products in a heart healthy diet is an important focal point to attain BP benefits...
  11. ncbi request reprint Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications
    Brenda C Davis
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 78:640S-646S. 2003
    ..Because of the beneficial effects of n-3 fatty acids, it is recommended that vegetarians make dietary changes to optimize n-3 fatty acid status...
  12. ncbi request reprint The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 138:1746S-1751S. 2008
    ..Nuts and peanuts are food sources that are a composite of numerous cardioprotective nutrients and if routinely incorporated in a healthy diet, population risk of CHD would therefore be expected to decrease markedly...
  13. ncbi request reprint N-3 fatty acids: food or supplements?
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Am Diet Assoc 108:1125-30. 2008
  14. ncbi request reprint Polyunsaturated fatty acids and cardiovascular health
    Penny M Kris-Etherton
    Department of Nutritional Sciences, 126 South Henderson Building, Pennsylvania State University, University Park, PA 16802, USA
    Nutr Rev 62:414-26. 2004
    ..Research is needed to establish the optimal level of dietary PUFAs that maximally affects the greatest number of health risk factors...
  15. ncbi request reprint High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations
    P M Kris-Etherton
    Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 70:1009-15. 1999
    ..High-monounsaturated fatty acid (MUFA), cholesterol-lowering diets do not raise triacylglycerol or lower HDL cholesterol, but little is known about how peanut products, a rich source of MUFAs, affect CVD risk...
  16. ncbi request reprint Polyunsaturated fatty acids in the food chain in the United States
    P M Kris-Etherton
    Graduate Program in Nutrition and the Department of Dairy and Animal Science, The Pennsylvania State University, University Park, and Kraft Foods, KGF Technology Center, Glenview, IL, USA
    Am J Clin Nutr 71:179S-88S. 2000
    ....
  17. ncbi request reprint Is there an optimal diet for the hypertriglyceridemic patient?
    P M Kris-Etherton
    Nutrition Department, The Pennsylvania State University, S 126 Henderson Building, University Park, PA 16802, USA
    J Cardiovasc Risk 7:333-7. 2000
    ..In addition, fish oil supplements can help further to reduce plasma triglycerides. Thus, the combined effects of multiple dietary interventions provide the most potent means of maximally lowering the plasma triglyceride level...
  18. ncbi request reprint Dietary fat: assessing the evidence in support of a moderate-fat diet; the benchmark based on lipoprotein metabolism
    P M Kris-Etherton
    Nutrition Department, The Pennsylvania State University, University Park, PA, USA
    Proc Nutr Soc 61:287-98. 2002
    ..Nonetheless, the guiding principle is that moderation in total fat is the defining benchmark for a contemporary diet that reduces risk of chronic disease...
  19. ncbi request reprint Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease
    Penny M Kris-Etherton
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Curr Opin Lipidol 13:397-407. 2002
    ....
  20. ncbi request reprint Nuts and their bioactive constituents: effects on serum lipids and other factors that affect disease risk
    P M Kris-Etherton
    Graduate Program in Nutrition and the Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 70:504S-511S. 1999
    ..Further studies are needed to identify these constituents and establish their relative cholesterol-lowering potency...
  21. pmc Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia
    Claire E Berryman
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 143:788-94. 2013
    ..02). Walnut oil favorably affected endothelial function and whole walnuts increased cholesterol efflux. These 2 novel mechanisms may explain in part the cardiovascular benefits of walnuts...
  22. ncbi request reprint Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004
    ..05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05). ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects...
  23. ncbi request reprint Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy
    Sheila G West
    Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Womens Health (Larchmt) 14:253-62. 2005
    ..However, it is not clear whether adding soy to a low-fat diet has additional lipid-lowering benefits, and few previous studies have examined these effects in women using hormone replacement therapy (HRT+)...
  24. pmc A high legume low glycemic index diet improves serum lipid profiles in men
    Zhiying Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Lipids 45:765-75. 2010
    ..However, IR individuals do not achieve the full benefits of the same diet on cardiovascular disease (CVD) lipid risk factors...
  25. pmc An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
    Amy E Griel
    Department of Nutritional Sciences, 126 S Henderson Bldg, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr J 6:2. 2007
    ..The results indicate that plant sources of dietary n-3 PUFA may have a protective effect on bone metabolism via a decrease in bone resorption in the presence of consistent levels of bone formation...
  26. ncbi request reprint n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    Sarah K Gebauer
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 83:1526S-1535S. 2006
    ..Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d...
  27. doi request reprint Lifestyle approaches and dietary strategies to lower LDL-cholesterol and triglycerides and raise HDL-cholesterol
    Heather I Katcher
    Department of Nutritional Sciences, Pennsylvania State University, 119 Chandlee Lab, University Park, PA 16802, USA
    Endocrinol Metab Clin North Am 38:45-78. 2009
    ..Based on a very large evidence base, it is clear that diet and lifestyle practices can markedly affect these major CHD lipid risk factors, and consequently decrease CHD risk substantively...
  28. ncbi request reprint Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
    Penny M Kris-Etherton
    Graduate Program in Nutrition, Pennsylvania State University, University Park, Pennsylvania, USA
    Am J Med 113:71S-88S. 2002
    ..From a practical perspective, this translates to recommending a diet rich in a variety of fruits, vegetables, whole grains, legumes, oils, and nuts...
  29. ncbi request reprint Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults
    Kirsten F Hilpert
    Department of Nutritional Sciences, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 135:1075-9. 2005
    ..5%) compared with the run-in diet. These results suggest that inflammation may not only attenuate lipid responses, but also aggravate dyslipidemia in hypercholesterolemic subjects consuming a cholesterol-lowering diet...
  30. pmc Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function
    Sheila G West
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Coll Nutr 29:595-603. 2010
    ..In a previous article, we showed significant reductions in low-density lipoprotein cholesterol and several markers of inflammation with increasing intake of alpha-linolenic acid (ALA) from walnuts and flax...
  31. ncbi request reprint Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study
    Sarah K Gebauer
    Integrative Biosciences and Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 88:651-9. 2008
    ..Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms...
  32. ncbi request reprint Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Biochem Biophys Res Commun 336:909-17. 2005
    ..The results indicate that the anti-inflammatory effects of polyunsaturated fatty acids may be, in part, due to the inhibition of NF-kappaB activation via activation of PPARgamma...
  33. ncbi request reprint Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells
    Shaomei Yu-Poth
    Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 135:2541-5. 2005
    ..Furthermore, the effects of the fatty acids appeared to be independent of any change in SREBP-1 protein...
  34. ncbi request reprint Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors
    Amy E Binkoski
    Department of Nutrition and Dietetics, Messiah College, Grantham, PA, USA
    J Am Diet Assoc 105:1080-6. 2005
    ....
  35. ncbi request reprint The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
    Heather I Katcher
    The Huck Institutes of the Life Sciences, Department of Nutritional Sciences, Core Endocrine Laboratory, Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 87:79-90. 2008
    ..However, few clinical trials have tested whether incorporating whole grains into a hypocaloric diet increases weight loss and improves CVD risk factors...
  36. doi request reprint Food-intake patterns assessed by using front-of-pack labeling program criteria associated with better diet quality and lower cardiometabolic risk
    Alice H Lichtenstein
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA AHL the Clinical Nutrition Department, University of Texas Southwestern Medical Center, Dallas, TX JSC the Department of Nutrition and Food Sciences, University of Vermont, Burlington, VT RKJ the Department of Nutritional Sciences, Pennsylvania State University, University Park, PA PMK E the American Heart Association, Dallas, TX AP, LR, KFS, and DKV and the Nutrition Impact LLC, Battle Creek, MI VLF
    Am J Clin Nutr 99:454-62. 2014
    ..Front-of-pack labeling systems may provide additional guidance to that already available to facilitate the identification of foods that improve diet quality...
  37. ncbi request reprint Position of the American Dietetic Association and Dietitians of Canada: dietary fatty acids
    Penny M Kris-Etherton
    Penn State University, University Park, PA, USA
    J Am Diet Assoc 107:1599-611. 2007
    ..Registered dietitians play a pivotal role in translating dietary recommendations for fat and fatty acids into healthful dietary patterns for different population groups...
  38. ncbi request reprint Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 85:385-91. 2007
    ..Atherosclerosis is a chronic inflammatory disease. We previously reported that a diet high in alpha-linolenic acid (ALA) reduces lipid and inflammatory cardiovascular disease risk factors in hypercholesterolemic subjects...
  39. pmc Pistachios increase serum antioxidants and lower serum oxidized-LDL in hypercholesterolemic adults
    Colin D Kay
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 140:1093-8. 2010
    ....
  40. pmc Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 93:243-52. 2011
    ..Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses...
  41. pmc Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial
    Michael R Flock
    Department of Nutritional Sciences, Penn State University, University Park, PA
    J Am Heart Assoc 2:e000513. 2013
    ..The objective of this study was to develop a predictive model of the O3I response to EPA+DHA supplementation in healthy adults, specifically identifying factors that determine the response...
  42. pmc Predicted changes in fatty acid intakes, plasma lipids, and cardiovascular disease risk following replacement of trans fatty acid-containing soybean oil with application-appropriate alternatives
    Michael Lefevre
    Department of Nutrition, Dietetics and Food Science, Utah State University, 9815 Old Main Hill, Logan, UT 84322 9815, USA
    Lipids 47:951-62. 2012
    ..0 % of energy and predicted CVD risk by 1.5 %. Based solely on changes in plasma lipids and lipoproteins, all PHSBO replacement models reduced estimated CVD risk, albeit less than previously reported using simpler replacement models...
  43. doi request reprint Dietary Guidelines for Americans 2010: implications for cardiovascular disease
    Michael R Flock
    Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Lab, University Park, PA 16802, USA
    Curr Atheroscler Rep 13:499-507. 2011
    ..Healthy dietary patterns that emphasize nutrient-dense foods will significantly benefit public health, in part, by reducing CVD risk...
  44. ncbi request reprint Iron supplementation does not affect the susceptibility of LDL to oxidative modification in women with low iron status
    Amy E Binkoski
    Graduate Program in Nutrition, The Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:99-103. 2004
    ..As expected, lag time was increased after the women consumed the low fat, low SFA diet. Therefore, the results of this study do not support a relationship between iron status and LDL oxidation...
  45. ncbi request reprint Provision of foods differing in energy density affects long-term weight loss
    Barbara J Rolls
    The Pennsylvania State University, 226 Henderson Building, University Park, PA 16802, USA
    Obes Res 13:1052-60. 2005
    ..This 1-year clinical trial tested the effect on weight loss of a diet incorporating one or two servings per day of foods equal in energy but differing in energy density...
  46. doi request reprint Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation
    Michael R Flock
    The Pennsylvania State University, Nutritional Sciences, University Park, PA, United States
    Diabetes Metab Res Rev 29:431-45. 2013
    ....
  47. ncbi request reprint Postprandial effect of n-3 polyunsaturated fatty acids on apolipoprotein B-containing lipoproteins and vascular reactivity in type 2 diabetes
    Kirsten F Hilpert
    Department of Nutritional Sciences and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 85:369-76. 2007
    ..Plasma lipoproteins may be classified by their apolipoprotein composition. The lipoprotein subclass containing apolipoproteins B and C (LpB:C) is considered the most atherogenic...
  48. doi request reprint Mechanistic examination of walnuts in prevention of breast cancer
    John P Vanden Heuvel
    Department of Nutritional Sciences, Center of Excellence in Nutrigenomics, The Pennsylvania State University, University Park, PA, USA
    Nutr Cancer 64:1078-86. 2012
    ..Taken together, these data support an effect of walnut and its bioactive constituents on mammary epithelial cells and that multiple molecular targets may be involved...
  49. pmc Diets containing pistachios reduce systolic blood pressure and peripheral vascular responses to stress in adults with dyslipidemia
    Sheila G West
    Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
    Hypertension 60:58-63. 2012
    ..There was no effect of diet on fasting flow-mediated dilation. Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers...
  50. ncbi request reprint Effects of dairy products on intracellular calcium and blood pressure in adults with essential hypertension
    Kirsten F Hilpert
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Am Coll Nutr 28:142-9. 2009
    ..Consumption of dairy foods has been associated with lower blood pressure in certain populations...
  51. ncbi request reprint The role of diet and nutritional supplements in preventing and treating cardiovascular disease
    Alison M Hill
    Department of Nutritional Sciences, Pennsylvania State University, PA 16802, USA
    Curr Opin Cardiol 24:433-41. 2009
    ..Considerable research has focused on implementing these guidelines for maximal cardiovascular risk reduction, and this review will discuss the role of specific dietary strategies and select nutrition supplements in achieving this goal...
  52. ncbi request reprint Tree nuts and the lipid profile: a review of clinical studies
    Amy E Griel
    Pennsylvania State University, S 126 Henderson Building, University Park, PA 16802, USA
    Br J Nutr 96:S68-78. 2006
    ....
  53. ncbi request reprint Improved diet quality with peanut consumption
    Amy E Griel
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Am Coll Nutr 23:660-8. 2004
    ..To evaluate the diet quality of free-living men, women, and children choosing peanuts and peanut products...
  54. ncbi request reprint Effect of cow milk on food folate bioavailability in young women
    Mary Frances Picciano
    Department of Nutrition, Pennsylvania State University, University Park, USA
    Am J Clin Nutr 80:1565-9. 2004
    ..The findings of animal and human studies suggest that a certain component in milk enhances food folate bioavailability...
  55. doi request reprint Long-chain omega-3 fatty acids: time to establish a dietary reference intake
    Michael R Flock
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Nutr Rev 71:692-707. 2013
    ..Given the many health benefits of EPA and DHA that have been described since the 2002 IOM report, there is now a strong justification for establishing a DRI for these fatty acids. ..
  56. pmc Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study
    Ann C Skulas-Ray
    Departments of Nutritional Sciences ACS, PMKE, SGW and Biobehavioral Health SGW, Pennsylvania State University, University Park, PA 16802, USA
    Ann Behav Med 44:301-8. 2012
    ..Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms...
  57. pmc Effects of adiposity on plasma lipid response to reductions in dietary saturated fatty acids and cholesterol
    Michael R Flock
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Adv Nutr 2:261-74. 2011
    ..Thus, normalizing adipose tissue mass is an important goal for maximizing the diet response to a plasma cholesterol-lowering diet...
  58. ncbi request reprint Effect of pistachio oil on gene expression of IFN-induced protein with tetratricopeptide repeats 2: a biomarker of inflammatory response
    Jun Zhang
    Department of Nutritional Sciences, PA, USA
    Mol Nutr Food Res 54:S83-92. 2010
    ....
  59. pmc A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men
    Ann C Skulas-Ray
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 141:1451-7. 2011
    ..02). There were no treatment differences in glucose, total thiols, lipophilic ORAC, or total ORAC. The incorporation of spices into the diet may help normalize postprandial insulin and TG and enhance antioxidant defenses...
  60. ncbi request reprint High-soluble-fiber foods in conjunction with a telephone-based, personalized behavior change support service result in favorable changes in lipids and lifestyles after 7 weeks
    Penny M Kris-Etherton
    Nutrition Department, The Pennsylvania State University, University Park, USA
    J Am Diet Assoc 102:503-10. 2002
    ....
  61. ncbi request reprint The diversity of health effects of individual trans fatty acid isomers
    Sarah K Gebauer
    Department of Nutritional Sciences, The Pennsylvania State University, S126 Henderson Building, University Park, PA 16802, USA
    Lipids 42:787-99. 2007
    ..These initiatives and regulations, along with potential TFA alternatives, are presented herein...
  62. doi request reprint Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action
    Jun Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr Biochem 23:400-9. 2012
    ..In conclusion, repression of SCD1 by ALA favorably increased cholesterol efflux and decreased cholesterol accumulation in foam cells. This may be one mechanism by which dietary omega-3 PUFAs promote atherosclerosis regression...
  63. pmc Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells
    Jun Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA
    Nutr Metab (Lond) 8:61. 2011
    ..abstract:..
  64. doi request reprint Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Pennsylvania State University, Department of Nutritional Sciences, University Park, PA, USA
    Expert Opin Pharmacother 9:1237-48. 2008
    ..Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides (> 500 mg/dl). Current guidelines recommend that triglycerides should be less < 150 mg/dl...
  65. doi request reprint Cocoa-based protein and carbohydrate drink decreases perceived soreness after exhaustive aerobic exercise: a pragmatic preliminary analysis
    Nicole M McBrier
    Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Strength Cond Res 24:2203-10. 2010
    ..Consuming the drink after exercise resulted in a mean change of 2.6 +/- 6 compared to 13.7 +/- 10 for the control. In summary, the drink was effective in decreasing the level of self-reported perceived soreness after exhaustive exercise...
  66. pmc Consumption of a legume-enriched, low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal cancer
    Terryl J Hartman
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16870, USA
    J Nutr 140:60-7. 2010
    ..Only the changes in glucose differed between the diet periods. Serum C-peptide and plasma insulin levels did not change in participants consuming either diet. Healthful dietary changes can improve biomarkers of IR and inflammation...
  67. ncbi request reprint A macadamia nut-rich diet reduces total and LDL-cholesterol in mildly hypercholesterolemic men and women
    Amy E Griel
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, 16802, USA
    J Nutr 138:761-7. 2008
    ..Nuts as an isocaloric substitute for high SFA foods increase the proportion of unsaturated fatty acids and decrease SFA, thereby lowering CVD risk...
  68. doi request reprint Partial sleep deprivation and energy balance in adults: an emerging issue for consideration by dietetics practitioners
    Julie D Shlisky
    Department of Nutritional Sciences, 110 Chandlee Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    J Acad Nutr Diet 112:1785-97. 2012
    ..Evaluating sleep patterns and recommending regular, sufficient sleep for individuals striving to manage weight may be prudent...
  69. pmc The effect of walnut intake on factors related to prostate and vascular health in older men
    Kim J Spaccarotella
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr J 7:13. 2008
    ..Tocopherols may protect against prostate cancer and cardiovascular disease (CVD)...
  70. ncbi request reprint Beyond saturated fat: the importance of the dietary fatty acid profile on cardiovascular disease
    Amy E Griel
    Department of Nutritional Sciences, Integrative Biosciences Graduate Program in Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
    Nutr Rev 64:257-62. 2006
    ..6%-16.0% energy) was associated with less progression of coronary atherosclerosis, whereas carbohydrate intake (67% energy) was associated with a greater degree of progression in postmenopausal women...
  71. doi request reprint Effects of whole grains on coronary heart disease risk
    Kristina A Harris
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 12:368-76. 2010
    ..Understanding how individual grains, in both natural and processed states, affect CHD risk can inform nutrition recommendations and policies and ultimately benefit public health...
  72. ncbi request reprint Iron status in association with cardiovascular disease risk in 3 controlled feeding studies
    Jessica L Derstine
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 77:56-62. 2003
    ....
  73. ncbi request reprint Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence
    Colin D Kay
    Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 8:510-22. 2006
    ..Additional research is needed to better understand the mechanism(s) by which antioxidant-rich foods and beverages favorably affect endothelial function and the extent to which this reflects direct antioxidant effects...
  74. ncbi request reprint Contemporary strategies for weight loss and cardiovascular disease risk factor modification
    Alison M Hill
    Department of Nutritional Sciences, S 126 Henderson Building South, The Pennsylvania State University, University Park, PA 16802, USA
    Curr Atheroscler Rep 10:486-96. 2008
    ..This article summarizes our current understanding of effective weight loss programs...
  75. pmc Examining breast cancer growth and lifestyle risk factors: early life, childhood, and adolescence
    Elizabeth H Ruder
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Clin Breast Cancer 8:334-42. 2008
    ..Further study is also needed to clarify the biologic mechanisms influencing the observed associations...
  76. ncbi request reprint The changing roles of dietary carbohydrates: from simple to complex
    Amy E Griel
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Arterioscler Thromb Vasc Biol 26:1958-65. 2006
    ..Consequently, a review of the evidence for and against high-carbohydrate diets is important to put this controversy into perspective. The current dietary recommendations for carbohydrate intake are supported by the evidence...
  77. ncbi request reprint Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells
    Shaomei Yu-Poth
    Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 134:68-71. 2004
    ..Furthermore, CLA had no effect on SREBP-1 abundance. These results suggest that CLA upregulates LDLr expression via a mechanism that is independent of ACAT and SREBP-1...
  78. ncbi request reprint Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides
    Rodney A Velliquette
    The Pennsylvania State University, University Park, PA, USA
    J Clin Lipidol 3:281-8. 2009
    ..Polyunsaturated fatty acids lower serum triglycerides by a mechanism that may involve the inhibition of stearoyl-CoA desaturase (SCD)...
  79. ncbi request reprint Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health
    Penny M Kris-Etherton
    Nutrition Department, The Pennsylvania State University, University Park, Pennsylvania, USA
    Curr Opin Lipidol 13:41-9. 2002
    ..Thus, approximate estimates of flavonoid rich chocolate needed to exert acute and chronic effects are 38 and 125 g, respectively. Collectively, the antioxidant effects of flavonoid-rich foods may reduce cardiovascular disease risk...
  80. ncbi request reprint Effects of moderate (MF) versus lower fat (LF) diets on lipids and lipoproteins: a meta-analysis of clinical trials in subjects with and without diabetes
    Yumei Cao
    Department of Nutritional Sciences, Pennsylvania State University, 319 Chandlee Lab, University Park, PA 16802 USA
    J Clin Lipidol 3:19-32. 2009
    ..Lower fat (LF) diets increase triglyceride (TG) and decrease high-density lipoprotein cholesterol (HDL-C); moderate fat (MF) diets decrease TG and lower HDL-C less...
  81. pmc Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol
    Jun Zhang
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, 16802, USA
    Assay Drug Dev Technol 9:136-46. 2011
    ..This fluorescent mimic of cholesterol provides a safe, sensitive, and reproducible alternative to radioactive assays in efflux experiments and has great potential as a valuable tool when incorporated into a drug discovery program...
  82. ncbi request reprint MyPyramid food intake pattern modeling for the Dietary Guidelines Advisory Committee
    Patricia Britten
    USDA Center for Nutrition Policy and Promotion, Alexandria, VA 22302, USA
    J Nutr Educ Behav 38:S143-52. 2006
    ..Modeling analyses can help researchers explore the overall effect of specific dietary recommendations on intake patterns...
  83. ncbi request reprint Dietary modeling shows that the substitution of canola oil for fats commonly used in the United States would increase compliance with dietary recommendations for fatty acids
    Guy H Johnson
    Department of Food Science and Human Nutrition, The University of Illinois, Urbana Champaign, USA
    J Am Diet Assoc 107:1726-34. 2007
    ..To examine the effect of substituting canola oil for selected vegetable oils and canola oil-based margarine for other spreads on energy, fatty acid, and cholesterol intakes among US adults...
  84. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  85. ncbi request reprint A quantitative analysis of fish consumption and coronary heart disease mortality
    Ariane König
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:335-46. 2005
    ..9%. Small quantities of fish consumption were associated with risk reductions in nonfatal MI risk by 27%, but additional fish consumption conferred no incremental benefits...
  86. ncbi request reprint Antioxidant vitamin supplements and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 110:637-41. 2004
  87. ncbi request reprint A quantitative risk-benefit analysis of changes in population fish consumption
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:325-34. 2005
    ....
  88. ncbi request reprint A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adults
    Matthew P Thorpe
    Division of Nutritional Sciences, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 138:1096-100. 2008
    ..4 g.kg(-1).d(-1) protein and 3 dairy servings increased urinary calcium excretion but provided improved calcium intake and attenuated bone loss over 4 mo of weight loss and 8 additional mo of weight maintenance...
  89. ncbi request reprint The Minnesota Heart Survey: nutrition successes pave the way for strategic opportunities for food and nutrition professionals
    Penny M Kris-Etherton
    J Am Diet Assoc 107:209-12. 2007
  90. ncbi request reprint Impact of peanuts and tree nuts on body weight and healthy weight loss in adults
    Richard D Mattes
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907 2059, USA
    J Nutr 138:1741S-1745S. 2008
    ..This consistent literature suggests nuts may be included in the diet, in moderation, to enhance palatability and nutrient quality without posing a threat for weight gain...
  91. ncbi request reprint Effects of moderate-fat (from monounsaturated fat) and low-fat weight-loss diets on the serum lipid profile in overweight and obese men and women
    Christine L Pelkman
    Department of Exercise and Nutrition Sciences, The State University of New York at Buffalo, NY, USA
    Am J Clin Nutr 79:204-12. 2004
    ..Previous studies in weight-stable persons showed that a moderate-fat diet results in a more favorable lipid and lipoprotein profile (ie, lower serum triacylglycerol and higher HDL cholesterol) than does a low-fat diet...
  92. doi request reprint The effectiveness of medical nutrition therapy delivered by registered dietitians for disorders of lipid metabolism: a call for further research
    Mikelle McCoin
    University of California, Berkeley, CA 94720, USA
    J Am Diet Assoc 108:233-9. 2008
  93. ncbi request reprint Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:151-2. 2003
  94. ncbi request reprint Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states
    Lars Berglund
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 86:1611-20. 2007
    ..In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved...
  95. ncbi request reprint Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets
    David J Baer
    Diet and Human Performance Laboratory, Agricultural Research Service, U S Department of Agriculture, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA
    J Nutr 133:4129-34. 2003
    ..On the basis of these results, reduced stearic acid absorption does not appear to be responsible for the differences in plasma lipoprotein responses to stearic acid relative to other saturated or unsaturated fatty acids...
  96. ncbi request reprint Soy protein with or without isoflavones: in search of a cardioprotective mechanism of action
    Penny M Kris-Etherton
    Am J Clin Nutr 81:5-6. 2005
  97. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Arterioscler Thromb Vasc Biol 23:e20-30. 2003
  98. ncbi request reprint A quantitative analysis of fish consumption and stroke risk
    Colleen Bouzan
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:347-52. 2005
    ..0% per serving per week)...
  99. doi request reprint The evidence for dietary prevention and treatment of cardiovascular disease
    Linda Van Horn
    Preventive Medicine, Northwestern University Freinberg School of Medicine, Chicago, IL 60611, USA
    J Am Diet Assoc 108:287-331. 2008
    ..com). Potential mechanisms and needs for future research are summarized for each relevant nutrient, food, or food component...
  100. ncbi request reprint An update of trans-fat reduction in the American diet
    Susan Borra
    International Food Information Council Foundation, Washington, DC, USA
    J Am Diet Assoc 107:2048-50. 2007
  101. ncbi request reprint Dietary guidelines vs beverage guidance system
    Connie Weaver
    Am J Clin Nutr 84:1245-6; author reply 1246-8. 2006

Research Grants8

  1. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2000
    ..g. eat more whole grain bread products and less saturated fat from animal products) compared with usual care study participants. ..
  2. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2000
    ..g. eat more whole grain bread products and less saturated fat from animal products ) compared with usual care study participants. ..
  3. COMPARE DIET, LIFE STYLE, CARDIOVASCULAR DISEASE RISK
    Penny Kris Etherton; Fiscal Year: 2000
    ..abstract_text> ..
  4. SOY PROTEIN AND PLAMA LIPIDS. LIPOPROTEINS, VASCULAR REACTIVITY, CAM, PLATELETS
    Penny Kris Etherton; Fiscal Year: 2000
    ..The soy protein will be incorporated into baked goods and snack foods in a very palatable way. The investigators hope to learn more about recognized effects of soy intake on the reduction of risk for heart disease. ..
  5. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2001
    ..g. eat more whole grain bread products and less saturated fat from animal products ) compared with usual care study participants. ..
  6. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2001
    ..g. eat more whole grain bread products and less saturated fat from animal products ) compared with usual care study participants. ..
  7. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2002
    ..g. eat more whole grain bread products and less saturated fat from animal products ) compared with usual care study participants. ..
  8. NUTRITION COUNSELING TO REDUCE CARDIOVASCULAR RISKS IN HYPERCHOLESTEROLEMIA
    Penny Kris Etherton; Fiscal Year: 2002
    ..g. eat more whole grain bread products and less saturated fat from animal products ) compared with usual care study participants. ..