J Kyle Krady

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Differential expression of protein tyrosine kinase genes during microglial activation
    J Kyle Krady
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:11-24. 2002
  2. ncbi request reprint Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    J Kyle Krady
    Dept of Neural and Behavioral Sciences, H109, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Diabetes 54:1559-65. 2005
  3. ncbi request reprint Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
  4. pmc The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse
    Rashmi Kumari
    Department of Neural and Behavioral Sciences, College of Medicine, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 30:352-60. 2010
  5. doi request reprint Ciliary neurotrophic factor and interleukin-6 differentially activate microglia
    J Kyle Krady
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 86:1538-47. 2008
  6. ncbi request reprint Transforming growth factor beta1 prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized
    Anirban Basu
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:109-20. 2002
  7. ncbi request reprint Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse
    Rashmi Kumari
    Department of Neural and Behavioral Sciences, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 27:710-8. 2007
  8. ncbi request reprint Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury
    Anirban Basu
    Departments of Neural and Behavioral Sciences, Radiology and Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:17-29. 2005
  9. ncbi request reprint Astrocytic ceruloplasmin expression, which is induced by IL-1beta and by traumatic brain injury, increases in the absence of the IL-1 type 1 receptor
    Christopher J Kuhlow
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 44:76-84. 2003
  10. ncbi request reprint The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Differential expression of protein tyrosine kinase genes during microglial activation
    J Kyle Krady
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:11-24. 2002
    ..Because reactive microglia can exacerbate the severity of neurological diseases, the identification of specific kinases that participate in microglial activation represents an important advance toward the development of new therapeutics...
  2. ncbi request reprint Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    J Kyle Krady
    Dept of Neural and Behavioral Sciences, H109, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Diabetes 54:1559-65. 2005
    ....
  3. ncbi request reprint Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
    ....
  4. pmc The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse
    Rashmi Kumari
    Department of Neural and Behavioral Sciences, College of Medicine, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 30:352-60. 2010
    ....
  5. doi request reprint Ciliary neurotrophic factor and interleukin-6 differentially activate microglia
    J Kyle Krady
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 86:1538-47. 2008
    ..We conclude that CNTF modifies microglial activation to support neuronal survival and that IL-6 enhances their capacity to do harm, as a result of different modes of intracellular signaling...
  6. ncbi request reprint Transforming growth factor beta1 prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized
    Anirban Basu
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 40:109-20. 2002
    ..We conclude that the TGFbeta receptor signaling cascades intersect with IL-1, but they may not interact with IL-6 or TNFalpha signaling pathways that lead to activation...
  7. ncbi request reprint Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse
    Rashmi Kumari
    Department of Neural and Behavioral Sciences, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 27:710-8. 2007
    ..These findings suggest that a compromised inflammatory response may underlie the greater infarct associated with diabetic db/db mice compared with their nondiabetic littermates following a hypoxic/ischemic insult...
  8. ncbi request reprint Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury
    Anirban Basu
    Departments of Neural and Behavioral Sciences, Radiology and Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Cereb Blood Flow Metab 25:17-29. 2005
    ..Additionally, these data incriminate the IL-1R1 as a master proinflammatory cytokine receptor...
  9. ncbi request reprint Astrocytic ceruloplasmin expression, which is induced by IL-1beta and by traumatic brain injury, increases in the absence of the IL-1 type 1 receptor
    Christopher J Kuhlow
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 44:76-84. 2003
    ..Furthermore, as the IL-1R1 has been proposed to be a target for achieving neuroprotection after injury, these data suggest that the protection afforded by ceruloplasmin will be retained even when the IL-1R1 is antagonized...
  10. ncbi request reprint The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age...
  11. ncbi request reprint Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
    ..Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes...
  12. ncbi request reprint The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury
    Anirban Basu
    Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Neurosci 22:6071-82. 2002
    ....
  13. ncbi request reprint IGF-I and microglia/macrophage proliferation in the ischemic mouse brain
    Steven L O'Donnell
    Department of Neuroscience and Anatomy, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Glia 39:85-97. 2002
    ..Taken together with previous data demonstrating that IGF-I promotes proliferation of peripheral macrophages, these data support the hypothesis that IGF-I is an autocrine/paracrine mitogen for microglia/macrophages after H/I...
  14. ncbi request reprint Interleukin-1: a master regulator of neuroinflammation
    Anirban Basu
    National Brain Research Center, Manesar, Gurgaon, India
    J Neurosci Res 78:151-6. 2004
    ..e., neuroinflammation). The IL-1 system thus provides an attractive target for therapeutic intervention to ameliorate the destructive consequences of neuroinflammation...
  15. ncbi request reprint Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury
    Mitch Price
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Brain Res Mol Brain Res 117:58-67. 2003
    ..The discovery of previously unknown genes involved in the response to neurodegeneration will contribute to our understanding of neural development, responses to CNS trauma, and neurodegenerative diseases...