Research Topics
Species | DONNA HOPE KORZICKSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
Age-related differences in cardiac ischemia-reperfusion injury: effects of estrogen deficiencyDonna H Korzick
Department of Kinesiology, The Pennsylvania State University, University Park, PA, 16802, USA
Pflugers Arch 465:669-85. 2013....
Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivationDonna H Korzick
Intercollege Program in Physiology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Am J Physiol Heart Circ Physiol 293:H2056-63. 2007....
From syncitium to regulated pump: a cardiac muscle cellular updateDonna H Korzick
Noll Laboratory and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Adv Physiol Educ 35:22-7. 2011..Greater synchrony of Ca(2+)-regulatory mechanisms between ventricular and pacemaker cells should enhance student comprehension of complex regulatory phenomenon in cardiac muscle...- Local delivery of a PKCĪµ-activating peptide limits ischemia reperfusion injury in the aged female rat heartT S Lancaster
Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Am J Physiol Regul Integr Comp Physiol 301:R1242-9. 2011..05). The mechanisms described here may represent important therapeutic candidates for the treatment of acute myocardial infarction in postmenopausal women and age-associated estradiol deficiency... - Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase CDonna H Korzick
Department of Kinesiology, The Pennsylvania State University, 106 Noll Laboratory, University Park, PA 16802, USA
Cardiovasc Res 66:384-92. 2005..Our aim was to determine the role of endothelin-1 (ET-1) on enhanced constrictor responses in aged coronary arteries (CAs) and whether protein kinase C (PKC) signaling mechanisms impact ET-1 responses... - Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expressionDonna H Korzick
Noll Physiological Research Center, Intercollege Program in Physiology, The Penn State University, University Park, PA 16802, USA
Med Sci Sports Exerc 37:381-8. 2005..Thus, diet and physical inactivity may increase CHD risk by altering coronary protein kinase C (PKC) isoform profiles... - Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent ratsDonna H Korzick
106 Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
J Gerontol A Biol Sci Med Sci 59:1089-98. 2004..These results further suggest that alterations in PKC levels underlie, at least in part, EX-induced improvements in alpha(1)-AR contraction... - Regulation of cardiac excitation-contraction coupling: a cellular updateDonna H Korzick
The Noll Physiological Research Center and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Adv Physiol Educ 27:192-200. 2003.... - Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardiumJ Craig Hunter
Noll Physiological Research Center, 106 Noll Lab, Pennsylvania State University, University Park, PA 16802, USA
Mech Ageing Dev 126:535-50. 2005..Collectively, our results provide novel evidence for age and sex-related differences in the magnitude and distribution of cardiac PKC-ERK1/2 SMS consistent with previously described pathological and protective phenotypes, respectively... - Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3betaJohn C Kostyak
Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, United States
Cardiovasc Res 70:325-34. 2006..Our results also suggest, for the first time, a key role for mitochondrial GSK-3beta as a cellular basis for the protection associated with PKCdelta inhibition with ageing... - Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3betaJ C Hunter
Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, USA
Am J Physiol Regul Integr Comp Physiol 292:R800-9. 2007.... - Protein kinase C distribution and translocation in rat myocardium: Methodological considerationsJ Craig Hunter
The Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
J Pharmacol Toxicol Methods 51:129-38. 2005.... - Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanismJennifer L Novotny
Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, USA
Endocrinology 150:889-96. 2009..Collectively, our findings may provide key insight into developing targeted therapeutic interventions in postmenopausal women to reduce ischemia/reperfusion injury, including selective ERalpha mimetics... - Control of the arteriolar myogenic response by transvascular fluid filtrationMin-Ho Kim
Department of Bioengineering, Pennsylvania State University, University Park, PA 16802, USA
Microvasc Res 68:30-7. 2004..Taken together, these results are consistent with the hypothesis that shear stress on arteriolar smooth muscle, induced by transvascular fluid filtration, is a contributing factor that helps control myogenic tone... - Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heartMarvin O Boluyt
University of Michigan, Ann Arbor, MI, USA
Mol Cell Biochem 294:87-96. 2007..E retarded the expression of collagen III mRNA in SEP; but not in the LV. Exercise training and coronary artery occlusion each stimulate cardiac hypertrophy independently and induce different patterns of gene expression... - PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2Kamala K Maddali
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
J Biol Chem 280:43024-9. 2005..These results demonstrate for the first time that 1) endogenous T is a primary modulator of coronary PKCdelta protein and activity in males and 2) T increases Cav1.2 protein expression in a PKCdelta-dependent manner... - Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitineStanley G Koh
Cardiac Muscle Research Laboratory, Boston University School of Medicine, 650 Albany St, X720, Boston, MA 02118, USA
Cardiovasc Drugs Ther 17:7-14. 2003....
Research Grants
- DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RATDONNA KORZICK; Fiscal Year: 2003..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
- Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated CardioprotectiDONNA HOPE KORZICK; Fiscal Year: 2010..e. use of estrogen receptor therapeutics as viable approaches to improve ischemic tolerance in aged women. ..
- Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated CardioprotectiDONNA KORZICK; Fiscal Year: 2009..e. use of estrogen receptor therapeutics as viable approaches to improve ischemic tolerance in aged women. ..