DONNA HOPE KORZICK

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Age-related differences in cardiac ischemia-reperfusion injury: effects of estrogen deficiency
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Pflugers Arch 465:669-85. 2013
  2. ncbi request reprint Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation
    Donna H Korzick
    Intercollege Program in Physiology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Physiol Heart Circ Physiol 293:H2056-63. 2007
  3. pmc From syncitium to regulated pump: a cardiac muscle cellular update
    Donna H Korzick
    Noll Laboratory and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Adv Physiol Educ 35:22-7. 2011
  4. pmc Local delivery of a PKCĪµ-activating peptide limits ischemia reperfusion injury in the aged female rat heart
    T S Lancaster
    Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1242-9. 2011
  5. ncbi request reprint Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, 106 Noll Laboratory, University Park, PA 16802, USA
    Cardiovasc Res 66:384-92. 2005
  6. ncbi request reprint Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression
    Donna H Korzick
    Noll Physiological Research Center, Intercollege Program in Physiology, The Penn State University, University Park, PA 16802, USA
    Med Sci Sports Exerc 37:381-8. 2005
  7. ncbi request reprint Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats
    Donna H Korzick
    106 Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
    J Gerontol A Biol Sci Med Sci 59:1089-98. 2004
  8. ncbi request reprint Regulation of cardiac excitation-contraction coupling: a cellular update
    Donna H Korzick
    The Noll Physiological Research Center and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Adv Physiol Educ 27:192-200. 2003
  9. ncbi request reprint Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium
    J Craig Hunter
    Noll Physiological Research Center, 106 Noll Lab, Pennsylvania State University, University Park, PA 16802, USA
    Mech Ageing Dev 126:535-50. 2005
  10. ncbi request reprint Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3beta
    John C Kostyak
    Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, United States
    Cardiovasc Res 70:325-34. 2006

Collaborators

Detail Information

Publications17

  1. pmc Age-related differences in cardiac ischemia-reperfusion injury: effects of estrogen deficiency
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Pflugers Arch 465:669-85. 2013
    ....
  2. ncbi request reprint Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation
    Donna H Korzick
    Intercollege Program in Physiology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Physiol Heart Circ Physiol 293:H2056-63. 2007
    ....
  3. pmc From syncitium to regulated pump: a cardiac muscle cellular update
    Donna H Korzick
    Noll Laboratory and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Adv Physiol Educ 35:22-7. 2011
    ..Greater synchrony of Ca(2+)-regulatory mechanisms between ventricular and pacemaker cells should enhance student comprehension of complex regulatory phenomenon in cardiac muscle...
  4. pmc Local delivery of a PKCĪµ-activating peptide limits ischemia reperfusion injury in the aged female rat heart
    T S Lancaster
    Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1242-9. 2011
    ..05). The mechanisms described here may represent important therapeutic candidates for the treatment of acute myocardial infarction in postmenopausal women and age-associated estradiol deficiency...
  5. ncbi request reprint Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, 106 Noll Laboratory, University Park, PA 16802, USA
    Cardiovasc Res 66:384-92. 2005
    ..Our aim was to determine the role of endothelin-1 (ET-1) on enhanced constrictor responses in aged coronary arteries (CAs) and whether protein kinase C (PKC) signaling mechanisms impact ET-1 responses...
  6. ncbi request reprint Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression
    Donna H Korzick
    Noll Physiological Research Center, Intercollege Program in Physiology, The Penn State University, University Park, PA 16802, USA
    Med Sci Sports Exerc 37:381-8. 2005
    ..Thus, diet and physical inactivity may increase CHD risk by altering coronary protein kinase C (PKC) isoform profiles...
  7. ncbi request reprint Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats
    Donna H Korzick
    106 Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
    J Gerontol A Biol Sci Med Sci 59:1089-98. 2004
    ..These results further suggest that alterations in PKC levels underlie, at least in part, EX-induced improvements in alpha(1)-AR contraction...
  8. ncbi request reprint Regulation of cardiac excitation-contraction coupling: a cellular update
    Donna H Korzick
    The Noll Physiological Research Center and Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Adv Physiol Educ 27:192-200. 2003
    ....
  9. ncbi request reprint Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium
    J Craig Hunter
    Noll Physiological Research Center, 106 Noll Lab, Pennsylvania State University, University Park, PA 16802, USA
    Mech Ageing Dev 126:535-50. 2005
    ..Collectively, our results provide novel evidence for age and sex-related differences in the magnitude and distribution of cardiac PKC-ERK1/2 SMS consistent with previously described pathological and protective phenotypes, respectively...
  10. ncbi request reprint Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3beta
    John C Kostyak
    Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, United States
    Cardiovasc Res 70:325-34. 2006
    ..Our objective was to determine the contribution of PKCdelta signaling mechanisms to reperfusion injury in the aged heart using local delivery of a novel PKCdelta inhibitory peptide (KID1-1)...
  11. ncbi request reprint Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta
    J C Hunter
    Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 292:R800-9. 2007
    ....
  12. ncbi request reprint Protein kinase C distribution and translocation in rat myocardium: Methodological considerations
    J Craig Hunter
    The Noll Physiological Research Center, The Pennsylvania State University, University Park, PA 16802, USA
    J Pharmacol Toxicol Methods 51:129-38. 2005
    ....
  13. doi request reprint Rapid estrogen receptor-alpha activation improves ischemic tolerance in aged female rats through a novel protein kinase C epsilon-dependent mechanism
    Jennifer L Novotny
    Intercollege Program in Physiology, The Pennsylvania State University, University Park, PA 16802, USA
    Endocrinology 150:889-96. 2009
    ..Collectively, our findings may provide key insight into developing targeted therapeutic interventions in postmenopausal women to reduce ischemia/reperfusion injury, including selective ERalpha mimetics...
  14. ncbi request reprint Control of the arteriolar myogenic response by transvascular fluid filtration
    Min Ho Kim
    Department of Bioengineering, Pennsylvania State University, University Park, PA 16802, USA
    Microvasc Res 68:30-7. 2004
    ..Taken together, these results are consistent with the hypothesis that shear stress on arteriolar smooth muscle, induced by transvascular fluid filtration, is a contributing factor that helps control myogenic tone...
  15. pmc Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart
    Marvin O Boluyt
    University of Michigan, Ann Arbor, MI, USA
    Mol Cell Biochem 294:87-96. 2007
    ..E retarded the expression of collagen III mRNA in SEP; but not in the LV. Exercise training and coronary artery occlusion each stimulate cardiac hypertrophy independently and induce different patterns of gene expression...
  16. ncbi request reprint PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2
    Kamala K Maddali
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 280:43024-9. 2005
    ..These results demonstrate for the first time that 1) endogenous T is a primary modulator of coronary PKCdelta protein and activity in males and 2) T increases Cav1.2 protein expression in a PKCdelta-dependent manner...
  17. ncbi request reprint Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine
    Stanley G Koh
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, 650 Albany St, X720, Boston, MA 02118, USA
    Cardiovasc Drugs Ther 17:7-14. 2003
    ....

Research Grants4

  1. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  2. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..e. use of estrogen receptor therapeutics as viable approaches to improve ischemic tolerance in aged women. ..
  3. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA KORZICK; Fiscal Year: 2009
    ..e. use of estrogen receptor therapeutics as viable approaches to improve ischemic tolerance in aged women. ..