Kouacou V Konan

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes
    Erica Weiskircher
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Virol J 6:185. 2009
  2. pmc Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein
    Jason Aligo
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    Virology 393:68-83. 2009
  3. pmc Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication
    Qingxia Han
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    J Virol 85:6464-79. 2011
  4. pmc Endocytic Rab proteins are required for hepatitis C virus replication complex formation
    David Manna
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    Virology 398:21-37. 2010
  5. pmc Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery
    Michelle Stone
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    J Virol 81:4551-63. 2007

Collaborators

  • Jason Aligo
  • David Manna
  • Qingxia Han
  • Erica Weiskircher
  • Won Do Heo
  • Shuaizheng Jia
  • Michelle Stone
  • Yoojin Hong
  • Kerry Belton
  • Damian B van Rossum
  • Sree V Chintapalli
  • Randen L Patterson
  • Wei Sun Park
  • Chenjia Xu
  • Hasan Koc
  • Gang Ning
  • Tobias Meyer

Detail Information

Publications5

  1. pmc Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes
    Erica Weiskircher
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Virol J 6:185. 2009
    ..Unlike its HCV counterpart, we know little about the subcellular distribution of BVDV NS4B protein. Further, it is not clear whether NS4B is localized to host membrane alterations associated with BVDV infection...
  2. pmc Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein
    Jason Aligo
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    Virology 393:68-83. 2009
    ..Finally, we show that the redistribution of Rab5 to NS4B foci requires an intact CTD, suggesting that Rab5 facilitates NS4B foci formation through interaction with the CTD...
  3. pmc Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication
    Qingxia Han
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    J Virol 85:6464-79. 2011
    ..Finally, we have identified an adaptive mutation in the NS4B TMD2 sequence that has compensatory effects on JFH1 chimera replication. Taken together, these data underscore the functional importance of NS4B TMDs in the HCV life cycle...
  4. pmc Endocytic Rab proteins are required for hepatitis C virus replication complex formation
    David Manna
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    Virology 398:21-37. 2010
    ..Finally, expression of DN Rab5 or Rab7 led to a reticular NS4B subcellular distribution, suggesting that endocytic proteins Rab5 and Rab7, but not Rab11, may facilitate NS4B foci formation...
  5. pmc Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery
    Michelle Stone
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 308 Althouse Laboratory, University Park, PA 16802, USA
    J Virol 81:4551-63. 2007
    ..Finally, Rab5 protein was found to coimmunoprecipitate with HCV NS4B. These studies suggest that EE proteins, including Rab5, may play a role in HCV genome replication or web formation...

Research Grants3

  1. Hepatitis C Virus Replication and Intracellular Membrane Rearrangement
    Kouacou Konan; Fiscal Year: 2007
    ..We hope that these studies will address the role of HCV-associated ultrastructural changes in the viral genome replication and viral persistence. ..
  2. HCV Nonstructural Proteins and Host Protein Secretion
    Kouacou Konan; Fiscal Year: 2006
    ..Information gained from these studies will be useful in the selection of inhibitors or pathogenesis. ..