Affiliation: Pennsylvania State University
Pogacnik J, Messaris E, Deiling S, Connelly T, Berg A, Stewart D, et al
. Increased risk of incisional hernia after sigmoid colectomy for diverticulitis compared with colon cancer. J Am Coll Surg. 2014;218:920-8 pubmed publisher
..This might be due to a connective tissue disorder, which predisposes to development of both diverticula and hernias. ..
Choi C, Berg A, Sangster W, Schieffer K, Harris L, Deiling S, et al
. Combined Medical and Surgical Approach Improves Healing of Septic Perianal Crohn's Disease. J Am Coll Surg. 2016;223:506-514.e1 pubmed publisher
..Overall, there is an approximate 60% rate of healing SPCD using a combined medical and surgical approach. About 20% of SPCD patients will require a permanent stoma. There were no clear genetic predictors of healing SPCD. ..
Connelly T, Berg A, Harris L, Hegarty J, Ruggiero F, Deiling S, et al
. T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease. J Surg Res. 2014;190:457-64 pubmed publisher
..Whether changes in TAGAP expression are a result of disease response or inherent to the disease pathophysiology itself remains to be determined. This gene warrants further investigation for its role in CD. ..
Schieffer K, Williams E, Yochum G, Koltun W. Review article: the pathogenesis of pouchitis. Aliment Pharmacol Ther. 2016;44:817-35 pubmed publisher
..More likely, pouchitis occurs through a combination of both dysregulated host inflammatory mechanisms and interaction with luminal microbiota. ..
Connelly T, Choi C, Berg A, Harris L, Coble J, Koltun W. Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes. J Surg Res. 2017;214:262-269 pubmed publisher
..This study strengthens the role for a genetic predisposition to diverticulitis that involves the TNFSF15 gene. ..