Laura C Klein

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats
    L C Klein
    Department of Biobehavioral Health, Pennsylvania State University, University Park 16802 6509, USA
    Exp Clin Psychopharmacol 9:251-61. 2001
  2. ncbi request reprint Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence
    Laura Cousino Klein
    Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802, USA
    Addict Behav 29:921-7. 2004
  3. ncbi request reprint Overview of the safety of citalopram
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychopharmacol Bull 37:96-121. 2003
  4. ncbi request reprint Smoking abstinence impairs time estimation accuracy in cigarette smokers
    Laura Cousino Klein
    Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania, USA
    Psychopharmacol Bull 37:90-5. 2003
  5. ncbi request reprint Recent advances in nicotine and tobacco research. Ninth SRNT annual meeting. New Orleans, Louisiana, USA. 19-22 February 2003
    Laura Cousino Klein
    Pennsylvania State University, University Park, PA 16082, USA
    Nicotine Tob Res 5:761-94. 2003
  6. ncbi request reprint Laternal nicotine exposure increases nicotine preference in periadolescent male but not female C57B1/6J mice
    Laura Cousino Klein
    Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nicotine Tob Res 5:117-24. 2003
  7. pmc Application of a naturalistic psychogenic stressor in periadolescent mice: effect on serum corticosterone levels differs by strain but not sex
    Christine H Kapelewski
    Biobehavioral Health Department, 315 East Health and Human Development Building, The Pennsylvania State University University Park, PA, USA
    BMC Res Notes 3:170. 2010
  8. ncbi request reprint Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders
    Laura Cousino Klein
    Department of Biobehavioral Health, Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802, USA
    Curr Psychiatry Rep 4:441-8. 2002
  9. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
  10. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats
    L C Klein
    Department of Biobehavioral Health, Pennsylvania State University, University Park 16802 6509, USA
    Exp Clin Psychopharmacol 9:251-61. 2001
    ..NIC exposure increased adult corticosterone and ACTH levels in a dose-dependent manner. Results suggest important effects of adolescent NIC exposure, including altered neuroendocrine status and opioid consumption...
  2. ncbi request reprint Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence
    Laura Cousino Klein
    Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802, USA
    Addict Behav 29:921-7. 2004
    ..This first study on leptin responses in female smokers suggests that leptin levels do not change following a 24-h smoking abstinence period and that leptin may not contribute to increased hunger following smoking abstinence...
  3. ncbi request reprint Overview of the safety of citalopram
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychopharmacol Bull 37:96-121. 2003
    ....
  4. ncbi request reprint Smoking abstinence impairs time estimation accuracy in cigarette smokers
    Laura Cousino Klein
    Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania, USA
    Psychopharmacol Bull 37:90-5. 2003
    ..These results suggest that, in a controlled laboratory setting, smoking abstinence has a negative impact on time perception, which may contribute to the performance decrements and discomfort that smokers report during an attempt to quit...
  5. ncbi request reprint Recent advances in nicotine and tobacco research. Ninth SRNT annual meeting. New Orleans, Louisiana, USA. 19-22 February 2003
    Laura Cousino Klein
    Pennsylvania State University, University Park, PA 16082, USA
    Nicotine Tob Res 5:761-94. 2003
    ..The scientific excellence and innovation presented at this year's meeting signifies SRNT's continued contributions to advancing our understanding of nicotine addiction and tobacco use...
  6. ncbi request reprint Laternal nicotine exposure increases nicotine preference in periadolescent male but not female C57B1/6J mice
    Laura Cousino Klein
    Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nicotine Tob Res 5:117-24. 2003
    ..Differential outcomes for males and females suggest that different processes underlie sex differences in nicotine consumption following maternal nicotine exposure...
  7. pmc Application of a naturalistic psychogenic stressor in periadolescent mice: effect on serum corticosterone levels differs by strain but not sex
    Christine H Kapelewski
    Biobehavioral Health Department, 315 East Health and Human Development Building, The Pennsylvania State University University Park, PA, USA
    BMC Res Notes 3:170. 2010
    ....
  8. ncbi request reprint Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders
    Laura Cousino Klein
    Department of Biobehavioral Health, Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802, USA
    Curr Psychiatry Rep 4:441-8. 2002
    ....
  9. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  10. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007
    ....
  11. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004
    ..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies...
  12. pmc Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:62-73. 2009
    ..PET imaging in awake monkeys suggested that anesthesia influenced the binding potential of [(11)C]1 and [(11)C]4 at the NET...
  13. ncbi request reprint Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
    S Neil Vaishnavi
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Biol Psychiatry 55:320-2. 2004
    ....
  14. pmc Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression
    Jennifer C Felger
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Biol Psychiatry 62:1324-33. 2007
    ..To establish a nonhuman primate model of cytokine-induced depression, we examined the effects of IFN-alpha on rhesus monkeys...
  15. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
    ....
  16. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
    ..Newer, pegylated preparations of IFN-alpha have a longer half-life, require once-per-week dosing, and may be associated with reduced neuropsychiatric burden. Limited data exist on depression during pegylated IFN-alpha therapy...
  17. doi request reprint The neurobiological toll of child abuse and neglect
    Gretchen N Neigh
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Trauma Violence Abuse 10:389-410. 2009
    ..Recognition of the biological consequences and transgenerational impact of violence and abuse has critical importance for both disease research and public health policy...
  18. pmc Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:178-87. 2008
    ..These data support an effect of time of day and estrous cycle stage on PPI in female rats. The estrous cycle variations in PPI are mediated in part by endogenous NT...
  19. ncbi request reprint Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents
    Jonathan McConathy
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:593-605. 2005
    ..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists...
  20. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
    ....
  21. ncbi request reprint Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem 16:783-93. 2008
    ..4) was measured. These new C-11- and F-18-labeled tracers will be utilized in comparative microPET studies to evaluate their potential as PET radioligands for imaging brain NET in nonhuman primates...
  22. ncbi request reprint Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring
    Paul M Plotsky
    Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychopharmacology 30:2192-204. 2005
    ....
  23. ncbi request reprint The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 63:398-405. 2008
    ..We determined the impact of childhood trauma on dexamethasone/CRF test results in patients with MDD...
  24. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  25. pmc Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain
    Jonathon A Nye
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Nucl Med 49:2018-25. 2008
    ..The purpose of this study was to develop a reliable kinetic model to describe the uptake of (11)C-HOMADAM in the healthy human brain...
  26. ncbi request reprint Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    CNS Spectr 9:23-31. 2004
    ..Each SSRI apparently has its own unique pharmacologic properties that likely underlie their observed differences in clinical use...
  27. ncbi request reprint Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation
    Lotta Arborelius
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 176:248-55. 2004
    ..Prolonged, daily maternal separation of rat pups induces several behavioral, endocrine and neurochemical changes similar to those observed in human depression...
  28. ncbi request reprint Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:9303-12. 2004
    ..The marked increase in CRFergic neurotransmission is hypothesized to play a major role in benzodiazepine withdrawal...
  29. doi request reprint The link between childhood trauma and depression: insights from HPA axis studies in humans
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:693-710. 2008
    ..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma...
  30. ncbi request reprint Genetic analysis of the hypothalamic neurotensin system
    Steven J Garlow
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA
    Neuropsychopharmacology 31:535-43. 2006
    ..These results further strengthen the hypothesis that the NT system is involved in mediating the actions of antipsychotic agents and drugs of abuse...
  31. ncbi request reprint Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:3044-7. 2007
    ..Despite high in vitro affinity for the human NET, the high uptake of [(11)C]1 in the caudate and putamen excludes its use as an in vivo PET imaging agent for the NET...
  32. ncbi request reprint Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 32:2384-92. 2007
    ..These data indicate that IFN-alpha as well as other cytokines of the innate immune response may target basal ganglia nuclei, thereby contributing to fatigue-related symptoms in medically ill patients...
  33. doi request reprint Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine
    Michael J Owens
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 33:3201-12. 2008
    ..NET antagonism has been posited to contribute to the antidepressant effects of these compounds. The clinical significance of the magnitude of NET antagonism by both medications remains unclear at present...
  34. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  35. ncbi request reprint Alterations in diurnal cortisol rhythm and acoustic startle response in nonhuman primates with adverse rearing
    Mar M Sanchez
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
    Biol Psychiatry 57:373-81. 2005
    ..This study attempts to model more subtle developmental perturbations that may increase the vulnerability for anxiety/mood disorders but lack the severe deficits associated with motherless rearing...
  36. ncbi request reprint Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
    J Douglas Bremner
    Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    J Psychopharmacol 19:159-65. 2005
    ..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD...
  37. ncbi request reprint Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:906-14. 2003
    ..Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune activation may contribute to development of depressive symptoms during interferon (IFN)-alpha therapy...
  38. ncbi request reprint The neurobiology of depression: inroads to treatment and new drug discovery
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:5-13. 2005
    ..In addition, studies of the CRF system have suggested molecular targets for new drug development, biological risk factors, and predictors of treatment response...
  39. ncbi request reprint A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression
    Dominique L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 67:288-96. 2006
    ..This study compared the efficacy and safety of paroxetine and desipramine with those of placebo in the treatment of depressive disorders in adult women with breast cancer, stages I-IV...
  40. ncbi request reprint Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  41. doi request reprint Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis
    Gretchen N Neigh
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Cereb Blood Flow Metab 29:1673-82. 2009
    ..Therefore, sustained changes in activity of the HPA axis and the CRF system after CA/CPR may contribute to the postischemic increase in affective disorders...
  42. ncbi request reprint Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
    ....
  43. pmc Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress
    Gretchen N Neigh
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Cereb Blood Flow Metab 30:1100-4. 2010
    ..These data indicate that in addition to the well-documented stress-induced changes in neurons and glia, cerebral vasculature is also altered by exposure to stressors...
  44. ncbi request reprint The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems
    Michelle L Gilmor
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, WMB Suite 4000, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 305:434-9. 2003
    ..The distinct actions of each drug on CRF systems may underlie their synergistic clinical effects...
  45. ncbi request reprint The neural correlates of social anxiety disorder and response to pharmacotherapy
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:2243-53. 2006
    ....
  46. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:569-76. 2003
    ..These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF...
  47. ncbi request reprint Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse
    D Jeffrey Newport
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 55:10-20. 2004
    ..Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma...
  48. ncbi request reprint Neuropharmacology of paroxetine
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychopharmacol Bull 37:8-18. 2003
    ..The application of these findings of in vivo NET inhibition by paroxetine in the treatment of mood and anxiety disorders will be informed by further clinical studies...
  49. pmc Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in rats
    David A Gutman
    Center for Comprehensive Informatics, Emory University, 36 Eagle Row, Room 572, Suite 4000, Atlanta, GA 30322, USA
    Neuropharmacology 60:1135-41. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  50. ncbi request reprint Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, USA
    Am J Psychiatry 161:1575-80. 2004
    ....
  51. ncbi request reprint Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Brain Behav Immun 19:23-7. 2005
    ....
  52. ncbi request reprint Functional brain imaging alterations in acne patients treated with isotretinoin
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 162:983-91. 2005
    ..The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients...
  53. ncbi request reprint Efficacy of risperidone versus olanzapine in patients with schizophrenia previously on chronic conventional antipsychotic therapy: a switch study
    Xiaohong Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, United States
    J Psychiatr Res 40:669-76. 2006
    ..The results indicate that both atypical antipsychotic medications provided significant additional improvement in symptom severity in patients with schizophrenia previously on conventional antipsychotic agents...
  54. pmc Anterior cingulate activation and error processing during interferon-alpha treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1001 Woodruff Circle, Atlanta, GA 30322, USA
    Biol Psychiatry 58:190-6. 2005
    ..Interferon (IFN)-alpha is notorious for causing behavioral symptoms, including depression, fatigue, and cognitive dysfunction, and has been used to investigate the effects of cytokines on the brain...
  55. ncbi request reprint Neurotensin: role in psychiatric and neurological diseases
    Ricardo Caceda
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322 4990, USA
    Peptides 27:2385-404. 2006
    ..NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction...
  56. ncbi request reprint Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    Thaddeus W W Pace
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1630-3. 2006
    ..The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress...
  57. ncbi request reprint The diagnosis of major depression in patients with cancer: a comparative approach
    Ying Guo
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Research Memorial Building, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Psychosomatics 47:376-84. 2006
    ..This study may serve as a prototype to generate valid instruments accurate for the diagnosis of major depression in other populations of cancer patients...
  58. pmc The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology
    Elizabeth I Martin
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Psychiatr Clin North Am 32:549-75. 2009
    ..The goal of this article is to describe the key biological similarities and differences between anxiety disorders...
  59. ncbi request reprint Use of atypical antipsychotics in refractory depression and anxiety
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:13-21. 2005
    ..Further double-blind, placebo-controlled studies of augmentation of antidepressants with atypical antipsychotics in refractory depression and anxiety are justified based on the available literature...
  60. ncbi request reprint The role of dopamine in the pathophysiology of depression
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 64:327-37. 2007
  61. ncbi request reprint Involvement of neuropeptide systems in schizophrenia: human studies
    Ricardo Caceda
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, Georgia 30322, USA
    Int Rev Neurobiol 78:327-76. 2007
    ..Clearly, additional investigation into the role of neuropeptide systems in the etiology, pathophysiology, and treatment of schizophrenia is warranted...
  62. ncbi request reprint Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine
    Becky Kinkead
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 315:256-64. 2005
    ..These results provide evidence that the effects of antipsychotic drugs (APDs) may be differentially affected by the state of NT neurotransmission and, moreover, that APDs differ in their dependence on an intact NT system...
  63. doi request reprint Caffeine and stress alter salivary alpha-amylase activity in young men
    Laura C Klein
    Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA
    Hum Psychopharmacol 25:359-67. 2010
    ..We examined the effects of caffeine and a psychological stressor on salivary alpha-amylase (sAA) in healthy young males (age 18-30 years) who consumed caffeine on a daily basis...
  64. pmc Frontiers in the use of biomarkers of health in research on stress and aging
    Jennifer R Piazza
    Department of Human Development and Family Studies, Pennsylvania State University, 118 Henderson Building, University Park, PA 16802, USA
    J Gerontol B Psychol Sci Soc Sci 65:513-25. 2010
    ..We recommend that future research examining physical health and aging incorporate dynamic and multivariate methods for assessing links between stressors and biomarkers...
  65. ncbi request reprint Effect of the monoamine oxidase inhibition on rewarding effects of nicotine in rodents
    Christine H Kapelewski
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA
    Curr Drug Abuse Rev 4:110-21. 2011
    ..These data will enhance our understanding of the neuropharmacological effects of smoking and the value of implementing MAO inhibitors as pharmacotherapies for smoking cessation...
  66. pmc Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences
    David A Blizard
    Center for Developmental and Health Genetics, The Pennsylvania State University, University Park, PA 16802, USA
    Physiol Genomics 36:158-66. 2009
    ..Evidence for a role for mitochondrial DNA was found for both HR and SBP. QTL for HR and SBP may differ in males and females and may be sensitive to different environmental contexts...